Co(III) complex with (E)-2-(2-(pyridine-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole: structure and activity against 2-D and 3-D cancer cell models
2016
Authors
Elshaflu, HanaBjelogrlić, Snežana
Muller, Christian D.
Todorović, Tamara R.
Rodić, Marko
Marinković, Aleksandar
Filipović, Nenad
Article (Published version)
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Co(III) complex with a 2-hydrazonylthiazole ligand was synthesized and characterized by single-crystal X-ray diffraction. In the inner sphere of the complex, two monoionic ligands are coordinated tridentately forming octahedral geometry around Co(III). Activity of the complex was investigated on MCF-7 breast cancer cell line, with cisplatin (CDDP) as a reference compound. Results showed that after 24-h incubation, Co(III) complex revealed stronger cytotoxic activity compared to CDDP. Treatment of MCF-7 3-D cell model with the complex at 10M concentration achieved complete suppression of spheroid growth in almost the same extent as at 100M. In combination treatments on MCF-7 spheroids, the complex acted synergistically with CDDP, while additive interaction type was achieved when the complex was applied together with paclitaxel. [GRAPHICS] .
Keywords:
Thiazoles / Co(III) complex / X-ray diffraction / anticancer activity / three-drug combination studySource:
Journal of Coordination Chemistry, 2016, 69, 22, 3354-3366Publisher:
- Taylor & Francis Ltd, Abingdon
Funding / projects:
- Interactions of natural products, their derivatives and coordination compounds with proteins and nucleic acids (RS-MESTD-Basic Research (BR or ON)-172055)
- Study of the Synthesis, Structure and Activity of Natural and Synthetic Organic Compounds (RS-MESTD-Basic Research (BR or ON)-172013)
DOI: 10.1080/00958972.2016.1232404
ISSN: 0095-8972
WoS: 000386021200005
Scopus: 2-s2.0-84988615513
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Poljoprivredni fakultetTY - JOUR AU - Elshaflu, Hana AU - Bjelogrlić, Snežana AU - Muller, Christian D. AU - Todorović, Tamara R. AU - Rodić, Marko AU - Marinković, Aleksandar AU - Filipović, Nenad PY - 2016 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/4100 AB - Co(III) complex with a 2-hydrazonylthiazole ligand was synthesized and characterized by single-crystal X-ray diffraction. In the inner sphere of the complex, two monoionic ligands are coordinated tridentately forming octahedral geometry around Co(III). Activity of the complex was investigated on MCF-7 breast cancer cell line, with cisplatin (CDDP) as a reference compound. Results showed that after 24-h incubation, Co(III) complex revealed stronger cytotoxic activity compared to CDDP. Treatment of MCF-7 3-D cell model with the complex at 10M concentration achieved complete suppression of spheroid growth in almost the same extent as at 100M. In combination treatments on MCF-7 spheroids, the complex acted synergistically with CDDP, while additive interaction type was achieved when the complex was applied together with paclitaxel. [GRAPHICS] . PB - Taylor & Francis Ltd, Abingdon T2 - Journal of Coordination Chemistry T1 - Co(III) complex with (E)-2-(2-(pyridine-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole: structure and activity against 2-D and 3-D cancer cell models EP - 3366 IS - 22 SP - 3354 VL - 69 DO - 10.1080/00958972.2016.1232404 ER -
@article{ author = "Elshaflu, Hana and Bjelogrlić, Snežana and Muller, Christian D. and Todorović, Tamara R. and Rodić, Marko and Marinković, Aleksandar and Filipović, Nenad", year = "2016", abstract = "Co(III) complex with a 2-hydrazonylthiazole ligand was synthesized and characterized by single-crystal X-ray diffraction. In the inner sphere of the complex, two monoionic ligands are coordinated tridentately forming octahedral geometry around Co(III). Activity of the complex was investigated on MCF-7 breast cancer cell line, with cisplatin (CDDP) as a reference compound. Results showed that after 24-h incubation, Co(III) complex revealed stronger cytotoxic activity compared to CDDP. Treatment of MCF-7 3-D cell model with the complex at 10M concentration achieved complete suppression of spheroid growth in almost the same extent as at 100M. In combination treatments on MCF-7 spheroids, the complex acted synergistically with CDDP, while additive interaction type was achieved when the complex was applied together with paclitaxel. [GRAPHICS] .", publisher = "Taylor & Francis Ltd, Abingdon", journal = "Journal of Coordination Chemistry", title = "Co(III) complex with (E)-2-(2-(pyridine-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole: structure and activity against 2-D and 3-D cancer cell models", pages = "3366-3354", number = "22", volume = "69", doi = "10.1080/00958972.2016.1232404" }
Elshaflu, H., Bjelogrlić, S., Muller, C. D., Todorović, T. R., Rodić, M., Marinković, A.,& Filipović, N.. (2016). Co(III) complex with (E)-2-(2-(pyridine-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole: structure and activity against 2-D and 3-D cancer cell models. in Journal of Coordination Chemistry Taylor & Francis Ltd, Abingdon., 69(22), 3354-3366. https://doi.org/10.1080/00958972.2016.1232404
Elshaflu H, Bjelogrlić S, Muller CD, Todorović TR, Rodić M, Marinković A, Filipović N. Co(III) complex with (E)-2-(2-(pyridine-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole: structure and activity against 2-D and 3-D cancer cell models. in Journal of Coordination Chemistry. 2016;69(22):3354-3366. doi:10.1080/00958972.2016.1232404 .
Elshaflu, Hana, Bjelogrlić, Snežana, Muller, Christian D., Todorović, Tamara R., Rodić, Marko, Marinković, Aleksandar, Filipović, Nenad, "Co(III) complex with (E)-2-(2-(pyridine-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole: structure and activity against 2-D and 3-D cancer cell models" in Journal of Coordination Chemistry, 69, no. 22 (2016):3354-3366, https://doi.org/10.1080/00958972.2016.1232404 . .