Quinoline based mono- and bis-(thio) carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models
![](/themes/MirageAGROSPACE//images/openAccess.png)
2016
Аутори
Božić, Aleksandra![](/themes/MirageAGROSPACE/images/orcid.png)
Marinković, Aleksandar
![](/themes/MirageAGROSPACE/images/orcid.png)
Bjelogrlić, Snežana
![](/themes/MirageAGROSPACE/images/orcid.png)
Todorović, Tamara R.
![](/themes/MirageAGROSPACE/images/orcid.png)
Cvijetić, Ilija N.
![](/themes/MirageAGROSPACE/images/orcid.png)
Novaković, Irena
![](/themes/MirageAGROSPACE/images/orcid.png)
Muller, Christian D.
![](/themes/MirageAGROSPACE/images/orcid.png)
Filipović, Nenad
![](/themes/MirageAGROSPACE/images/orcid.png)
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
A comparative study of antitumor activity of mono- and bis-quinoline based (thio) carbohydrazones was investigated by a series of tests on two human malignant cell lines: acute monocytic leukemia (THP-1) and pancreatic adenocarcinoma cancer stem cells (AsPC-1). Thiocarbohydrazones (TCHs) revealed superior pro-apoptotic activity over carbohydrazones (CHs) on both tested cell phenotypes, also displaying multi-target profile activities. Programmed cell death triggered by TCHs was partially caspase-dependent, mainly caspase-8 related. Activity against cancer stem cells (CSCs) was evaluated on 2D monolayers and 3D spheroidal models, where two out of three tested bis-TCHs successfully stimulated apoptosis accompanied by a reduction in size of treated spheres. Additionally, all bis-TCHs induced significant decrease in percentage of CD44-expressing AsPC-1 cells that indicate on their ability to induce reprogramming of CSC phenotype. Current results highly support further assessment of bis-TCHs... in order to specify their specific targets in cancer cells and particularly in the CSCs subpopulation.
Извор:
RSC Advances, 2016, 6, 106, 104763-104781Издавач:
- Royal Soc Chemistry, Cambridge
Финансирање / пројекти:
- COST Action CM1106 StemChem - "Chemical Approaches to Targeting Drug Resistance in Cancer Stem Cells"
- Интеракције природних производа, њихових деривата и комплексних једињења са протеинима и нуклеинским киселинама (RS-MESTD-Basic Research (BR or ON)-172055)
- Проучавање синтезе, структуре и активности органских једињења природног и синтетског порекла (RS-MESTD-Basic Research (BR or ON)-172013)
DOI: 10.1039/c6ra23940d
ISSN: 2046-2069
WoS: 000388111900107
Scopus: 2-s2.0-84994477669
Институција/група
Poljoprivredni fakultetTY - JOUR AU - Božić, Aleksandra AU - Marinković, Aleksandar AU - Bjelogrlić, Snežana AU - Todorović, Tamara R. AU - Cvijetić, Ilija N. AU - Novaković, Irena AU - Muller, Christian D. AU - Filipović, Nenad PY - 2016 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/4065 AB - A comparative study of antitumor activity of mono- and bis-quinoline based (thio) carbohydrazones was investigated by a series of tests on two human malignant cell lines: acute monocytic leukemia (THP-1) and pancreatic adenocarcinoma cancer stem cells (AsPC-1). Thiocarbohydrazones (TCHs) revealed superior pro-apoptotic activity over carbohydrazones (CHs) on both tested cell phenotypes, also displaying multi-target profile activities. Programmed cell death triggered by TCHs was partially caspase-dependent, mainly caspase-8 related. Activity against cancer stem cells (CSCs) was evaluated on 2D monolayers and 3D spheroidal models, where two out of three tested bis-TCHs successfully stimulated apoptosis accompanied by a reduction in size of treated spheres. Additionally, all bis-TCHs induced significant decrease in percentage of CD44-expressing AsPC-1 cells that indicate on their ability to induce reprogramming of CSC phenotype. Current results highly support further assessment of bis-TCHs in order to specify their specific targets in cancer cells and particularly in the CSCs subpopulation. PB - Royal Soc Chemistry, Cambridge T2 - RSC Advances T1 - Quinoline based mono- and bis-(thio) carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models EP - 104781 IS - 106 SP - 104763 VL - 6 DO - 10.1039/c6ra23940d ER -
@article{ author = "Božić, Aleksandra and Marinković, Aleksandar and Bjelogrlić, Snežana and Todorović, Tamara R. and Cvijetić, Ilija N. and Novaković, Irena and Muller, Christian D. and Filipović, Nenad", year = "2016", abstract = "A comparative study of antitumor activity of mono- and bis-quinoline based (thio) carbohydrazones was investigated by a series of tests on two human malignant cell lines: acute monocytic leukemia (THP-1) and pancreatic adenocarcinoma cancer stem cells (AsPC-1). Thiocarbohydrazones (TCHs) revealed superior pro-apoptotic activity over carbohydrazones (CHs) on both tested cell phenotypes, also displaying multi-target profile activities. Programmed cell death triggered by TCHs was partially caspase-dependent, mainly caspase-8 related. Activity against cancer stem cells (CSCs) was evaluated on 2D monolayers and 3D spheroidal models, where two out of three tested bis-TCHs successfully stimulated apoptosis accompanied by a reduction in size of treated spheres. Additionally, all bis-TCHs induced significant decrease in percentage of CD44-expressing AsPC-1 cells that indicate on their ability to induce reprogramming of CSC phenotype. Current results highly support further assessment of bis-TCHs in order to specify their specific targets in cancer cells and particularly in the CSCs subpopulation.", publisher = "Royal Soc Chemistry, Cambridge", journal = "RSC Advances", title = "Quinoline based mono- and bis-(thio) carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models", pages = "104781-104763", number = "106", volume = "6", doi = "10.1039/c6ra23940d" }
Božić, A., Marinković, A., Bjelogrlić, S., Todorović, T. R., Cvijetić, I. N., Novaković, I., Muller, C. D.,& Filipović, N.. (2016). Quinoline based mono- and bis-(thio) carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models. in RSC Advances Royal Soc Chemistry, Cambridge., 6(106), 104763-104781. https://doi.org/10.1039/c6ra23940d
Božić A, Marinković A, Bjelogrlić S, Todorović TR, Cvijetić IN, Novaković I, Muller CD, Filipović N. Quinoline based mono- and bis-(thio) carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models. in RSC Advances. 2016;6(106):104763-104781. doi:10.1039/c6ra23940d .
Božić, Aleksandra, Marinković, Aleksandar, Bjelogrlić, Snežana, Todorović, Tamara R., Cvijetić, Ilija N., Novaković, Irena, Muller, Christian D., Filipović, Nenad, "Quinoline based mono- and bis-(thio) carbohydrazones: synthesis, anticancer activity in 2D and 3D cancer and cancer stem cell models" in RSC Advances, 6, no. 106 (2016):104763-104781, https://doi.org/10.1039/c6ra23940d . .