Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats
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2015
Authors
Brkić, Dragica
Szakonyne-Pasics, Ilona
Gašić, Slavica
Teodorović, Ivana
Rašković, Božidar

Brkić, Nenad
Nesković, Nesko
Article (Published version)

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Subacute and subchronic toxicity of the herbicide Avalon (R), a mixture of bentazone and dicamba, were tested on rats. Avalon (R) was administered at dose levels of 250, 500 and 1000 mg/kg body weight/day for 28 and 90 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were monitored together with biochemistry parameters. The results showed that the mixture caused increases in the activities of ALT, AST and ALP, elevated concentrations of sodium, albumin and albumin/globulin ratio in males. In females, ALT activity, cholesterol and phosphate levels were increased. The changes generally were dose related and, in most cases, females exhibited lower susceptibility than males. The effects of a mixture are, in the most cases, different from the effects of the individual substances. The effects of bentazone were not prevalent which would be expected taking the composition of the mixture into account.
Keywords:
Mixture / Bentazone / Dicamba / Rat / Subacute toxicity / Subchronic toxicitySource:
Environmental Toxicology and Pharmacology, 2015, 39, 3, 1057-1066Publisher:
- Elsevier, Amsterdam
Funding / projects:
- Development of integrated management of harmful organisms in plant production in order to overcome resistance and to improve food quality and safety (RS-46008)
- Endocrine disrupting compounds: reproductive, metabolic, developmental responses and mechanisms of action in selected model organisms and cell lines (RS-173037)
DOI: 10.1016/j.etap.2015.03.004
ISSN: 1382-6689
PubMed: 25863332
WoS: 000357242500008
Scopus: 2-s2.0-84926382754
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Poljoprivredni fakultetTY - JOUR AU - Brkić, Dragica AU - Szakonyne-Pasics, Ilona AU - Gašić, Slavica AU - Teodorović, Ivana AU - Rašković, Božidar AU - Brkić, Nenad AU - Nesković, Nesko PY - 2015 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/3821 AB - Subacute and subchronic toxicity of the herbicide Avalon (R), a mixture of bentazone and dicamba, were tested on rats. Avalon (R) was administered at dose levels of 250, 500 and 1000 mg/kg body weight/day for 28 and 90 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were monitored together with biochemistry parameters. The results showed that the mixture caused increases in the activities of ALT, AST and ALP, elevated concentrations of sodium, albumin and albumin/globulin ratio in males. In females, ALT activity, cholesterol and phosphate levels were increased. The changes generally were dose related and, in most cases, females exhibited lower susceptibility than males. The effects of a mixture are, in the most cases, different from the effects of the individual substances. The effects of bentazone were not prevalent which would be expected taking the composition of the mixture into account. PB - Elsevier, Amsterdam T2 - Environmental Toxicology and Pharmacology T1 - Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats EP - 1066 IS - 3 SP - 1057 VL - 39 DO - 10.1016/j.etap.2015.03.004 ER -
@article{ author = "Brkić, Dragica and Szakonyne-Pasics, Ilona and Gašić, Slavica and Teodorović, Ivana and Rašković, Božidar and Brkić, Nenad and Nesković, Nesko", year = "2015", abstract = "Subacute and subchronic toxicity of the herbicide Avalon (R), a mixture of bentazone and dicamba, were tested on rats. Avalon (R) was administered at dose levels of 250, 500 and 1000 mg/kg body weight/day for 28 and 90 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were monitored together with biochemistry parameters. The results showed that the mixture caused increases in the activities of ALT, AST and ALP, elevated concentrations of sodium, albumin and albumin/globulin ratio in males. In females, ALT activity, cholesterol and phosphate levels were increased. The changes generally were dose related and, in most cases, females exhibited lower susceptibility than males. The effects of a mixture are, in the most cases, different from the effects of the individual substances. The effects of bentazone were not prevalent which would be expected taking the composition of the mixture into account.", publisher = "Elsevier, Amsterdam", journal = "Environmental Toxicology and Pharmacology", title = "Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats", pages = "1066-1057", number = "3", volume = "39", doi = "10.1016/j.etap.2015.03.004" }
Brkić, D., Szakonyne-Pasics, I., Gašić, S., Teodorović, I., Rašković, B., Brkić, N.,& Nesković, N.. (2015). Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats. in Environmental Toxicology and Pharmacology Elsevier, Amsterdam., 39(3), 1057-1066. https://doi.org/10.1016/j.etap.2015.03.004
Brkić D, Szakonyne-Pasics I, Gašić S, Teodorović I, Rašković B, Brkić N, Nesković N. Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats. in Environmental Toxicology and Pharmacology. 2015;39(3):1057-1066. doi:10.1016/j.etap.2015.03.004 .
Brkić, Dragica, Szakonyne-Pasics, Ilona, Gašić, Slavica, Teodorović, Ivana, Rašković, Božidar, Brkić, Nenad, Nesković, Nesko, "Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats" in Environmental Toxicology and Pharmacology, 39, no. 3 (2015):1057-1066, https://doi.org/10.1016/j.etap.2015.03.004 . .