Приказ основних података о документу

dc.creatorNovović, Katarina
dc.creatorFilipić, B.
dc.creatorVeljović, Katarina
dc.creatorBegović, J.
dc.creatorMirković, Nemanja
dc.creatorJovcić, B.
dc.date.accessioned2020-12-17T21:20:04Z
dc.date.available2020-12-17T21:20:04Z
dc.date.issued2015
dc.identifier.issn0048-9697
dc.identifier.urihttp://aspace.agrif.bg.ac.rs/handle/123456789/3798
dc.description.abstractNew Delhi metallo-beta-lactamase-1 (NDM-1) will soon become the most commonly isolated and distributed metallo-beta-lactamase worldwide due to its rapid international dissemination and its ability to be expressed by numerous Gram-negative pathogens. NDM-positive bacteria pose a significant public health threat in the Indian subcontinent and the Balkans, which have been designated as endemic regions. Our study was focused on urban rivers, a lake and springheads as a potential source of NDM-1-producing strains in Serbia, but also as a source of other metallo-beta-lactamases and extended-spectrum beta-lactamase (ESBL) producing bacteria. A total of 69 beta-lactam resistant isolates, belonging to 12 bacterial genera, were collected from 8 out of 10 different locations in Belgrade, of which the most were from a popular recreational site, Ada Ciganlija Lake. Phenotypic tests revealed 7 (10.14%) ESBL-producing isolates and 39 (56.52%) isolates resistant to imipenem, of which 32 were positive for metallo-beta-lactamase (MBL) production. PCR and sequencing revealed the presence of genetic determinants for SHV (3 isolates), DHA-1 (1 isolate) and CMY-2 (1 isolate) beta-lactamases. However, we did not detect any NDM-1-producing strains (previously described cases of NDM-1 from Serbia were limited to Belgrade), so we propose that Serbian NDM-1 is in fact a transplant and a nosocomial, rather than an environmental, issue and that Serbia is not an endemic region for NDM-1.en
dc.publisherElsevier, Amsterdam
dc.relationinfo:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173019/RS//
dc.rightsrestrictedAccess
dc.sourceScience of the Total Environment
dc.subjectAntibiotic resistanceen
dc.subjectEnvironmenten
dc.subjectNew Delhi metallo-beta-lactamase (NDM-1)en
dc.titleEnvironmental waters and bla(NDm-1) in Belgrade, Serbia: Endemicity questioneden
dc.typearticle
dc.rights.licenseARR
dc.citation.epage398
dc.citation.other511: 393-398
dc.citation.rankM21
dc.citation.spage393
dc.citation.volume511
dc.identifier.doi10.1016/j.scitotenv.2014.12.072
dc.identifier.scopus2-s2.0-84920575864
dc.identifier.pmid25569574
dc.identifier.wos000350513900040
dc.type.versionpublishedVersion


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Приказ основних података о документу