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Environmental waters and bla(NDm-1) in Belgrade, Serbia: Endemicity questioned
dc.creator | Novović, Katarina | |
dc.creator | Filipić, B. | |
dc.creator | Veljović, Katarina | |
dc.creator | Begović, J. | |
dc.creator | Mirković, Nemanja | |
dc.creator | Jovcić, B. | |
dc.date.accessioned | 2020-12-17T21:20:04Z | |
dc.date.available | 2020-12-17T21:20:04Z | |
dc.date.issued | 2015 | |
dc.identifier.issn | 0048-9697 | |
dc.identifier.uri | http://aspace.agrif.bg.ac.rs/handle/123456789/3798 | |
dc.description.abstract | New Delhi metallo-beta-lactamase-1 (NDM-1) will soon become the most commonly isolated and distributed metallo-beta-lactamase worldwide due to its rapid international dissemination and its ability to be expressed by numerous Gram-negative pathogens. NDM-positive bacteria pose a significant public health threat in the Indian subcontinent and the Balkans, which have been designated as endemic regions. Our study was focused on urban rivers, a lake and springheads as a potential source of NDM-1-producing strains in Serbia, but also as a source of other metallo-beta-lactamases and extended-spectrum beta-lactamase (ESBL) producing bacteria. A total of 69 beta-lactam resistant isolates, belonging to 12 bacterial genera, were collected from 8 out of 10 different locations in Belgrade, of which the most were from a popular recreational site, Ada Ciganlija Lake. Phenotypic tests revealed 7 (10.14%) ESBL-producing isolates and 39 (56.52%) isolates resistant to imipenem, of which 32 were positive for metallo-beta-lactamase (MBL) production. PCR and sequencing revealed the presence of genetic determinants for SHV (3 isolates), DHA-1 (1 isolate) and CMY-2 (1 isolate) beta-lactamases. However, we did not detect any NDM-1-producing strains (previously described cases of NDM-1 from Serbia were limited to Belgrade), so we propose that Serbian NDM-1 is in fact a transplant and a nosocomial, rather than an environmental, issue and that Serbia is not an endemic region for NDM-1. | en |
dc.publisher | Elsevier, Amsterdam | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/173019/RS// | |
dc.rights | restrictedAccess | |
dc.source | Science of the Total Environment | |
dc.subject | Antibiotic resistance | en |
dc.subject | Environment | en |
dc.subject | New Delhi metallo-beta-lactamase (NDM-1) | en |
dc.title | Environmental waters and bla(NDm-1) in Belgrade, Serbia: Endemicity questioned | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 398 | |
dc.citation.other | 511: 393-398 | |
dc.citation.rank | M21 | |
dc.citation.spage | 393 | |
dc.citation.volume | 511 | |
dc.identifier.doi | 10.1016/j.scitotenv.2014.12.072 | |
dc.identifier.scopus | 2-s2.0-84920575864 | |
dc.identifier.pmid | 25569574 | |
dc.identifier.wos | 000350513900040 | |
dc.type.version | publishedVersion |