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Environmental waters and bla(NDm-1) in Belgrade, Serbia: Endemicity questioned

Authorized Users Only
2015
Authors
Novović, Katarina
Filipić, B.
Veljović, Katarina
Begović, J.
Mirković, Nemanja
Jovcić, B.
Article (Published version)
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Abstract
New Delhi metallo-beta-lactamase-1 (NDM-1) will soon become the most commonly isolated and distributed metallo-beta-lactamase worldwide due to its rapid international dissemination and its ability to be expressed by numerous Gram-negative pathogens. NDM-positive bacteria pose a significant public health threat in the Indian subcontinent and the Balkans, which have been designated as endemic regions. Our study was focused on urban rivers, a lake and springheads as a potential source of NDM-1-producing strains in Serbia, but also as a source of other metallo-beta-lactamases and extended-spectrum beta-lactamase (ESBL) producing bacteria. A total of 69 beta-lactam resistant isolates, belonging to 12 bacterial genera, were collected from 8 out of 10 different locations in Belgrade, of which the most were from a popular recreational site, Ada Ciganlija Lake. Phenotypic tests revealed 7 (10.14%) ESBL-producing isolates and 39 (56.52%) isolates resistant to imipenem, of which 32 were positive ...for metallo-beta-lactamase (MBL) production. PCR and sequencing revealed the presence of genetic determinants for SHV (3 isolates), DHA-1 (1 isolate) and CMY-2 (1 isolate) beta-lactamases. However, we did not detect any NDM-1-producing strains (previously described cases of NDM-1 from Serbia were limited to Belgrade), so we propose that Serbian NDM-1 is in fact a transplant and a nosocomial, rather than an environmental, issue and that Serbia is not an endemic region for NDM-1.

Keywords:
Antibiotic resistance / Environment / New Delhi metallo-beta-lactamase (NDM-1)
Source:
Science of the Total Environment, 2015, 511, 393-398
Publisher:
  • Elsevier, Amsterdam
Funding / projects:
  • Genes and molecular mechanisms promoting probiotic activity of lactic acid bacteria from Western Balkan (RS-173019)

DOI: 10.1016/j.scitotenv.2014.12.072

ISSN: 0048-9697

PubMed: 25569574

WoS: 000350513900040

Scopus: 2-s2.0-84920575864
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URI
http://aspace.agrif.bg.ac.rs/handle/123456789/3798
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  • Radovi istraživača / Researchers’ publications
Institution/Community
Poljoprivredni fakultet

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