Phenolic Compounds from Atriplex littoralis and Their Radiation-Mitigating Activity
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2015
Authors
Godjevac, DejanStanković, Jovana
Novaković, Miroslav
Andjelković, Boban
Dajić-Stevanović, Zora
Petrović, Milica
Stanković, Miroslava
Article (Published version)
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From the aerial parts of Atriplex littoralis, three new flavonoid glycosides named atriplexins I-III (1-3), a known flavonoid glycoside, spinacetin 3-O-beta-D-glucopyranoside (4), arbutin (5), and 4-hydroxybenzyl-beta-D-glucopyranoside (6) were isolated. Their structures were elucidated on the basis of detailed spectroscopic analysis, including ID and 2D NMR (COSY, NOESY, TOCSY, HSQC, HMBC) and HRESITOF MS data. The compounds were tested for in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using a cytochalasin-B-blocked micronucleus (MN) assay in a concentration range of 0.8-7.4 mu M of final culture solution. Chromosomal damage was induced by 2 Gy of gamma-radiation on binudeated human lymphocytes, and the effects of the compounds were tested 2 to 19 h after irradiation. The frequency of micronuclei (MNi) was scored in binudeated cells, and the nuclear proliferation index was calculated. The highest prevention of in vitro biochemical and cytogeneti...c damage of human lymphocytes induced by gamma-radiation was exhibited by 3 (reduction of MN frequency by 31%), followed by 4 and 6.
Source:
Journal of Natural Products, 2015, 78, 9, 2198-2204Publisher:
- Amer Chemical Soc, Washington
Funding / projects:
- Natural products of wild, cultivated and edible plants: structure and bioactivity determination (RS-MESTD-Basic Research (BR or ON)-172053)
- Advancing research in agricultural and food sciences at Faculty of Agriculture, University of Belgrade (EU-FP7-316004)
DOI: 10.1021/acs.jnatprod.5b00273
ISSN: 0163-3864
PubMed: 26290401
WoS: 000362056200007
Scopus: 2-s2.0-84942636560
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Poljoprivredni fakultetTY - JOUR AU - Godjevac, Dejan AU - Stanković, Jovana AU - Novaković, Miroslav AU - Andjelković, Boban AU - Dajić-Stevanović, Zora AU - Petrović, Milica AU - Stanković, Miroslava PY - 2015 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/3711 AB - From the aerial parts of Atriplex littoralis, three new flavonoid glycosides named atriplexins I-III (1-3), a known flavonoid glycoside, spinacetin 3-O-beta-D-glucopyranoside (4), arbutin (5), and 4-hydroxybenzyl-beta-D-glucopyranoside (6) were isolated. Their structures were elucidated on the basis of detailed spectroscopic analysis, including ID and 2D NMR (COSY, NOESY, TOCSY, HSQC, HMBC) and HRESITOF MS data. The compounds were tested for in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using a cytochalasin-B-blocked micronucleus (MN) assay in a concentration range of 0.8-7.4 mu M of final culture solution. Chromosomal damage was induced by 2 Gy of gamma-radiation on binudeated human lymphocytes, and the effects of the compounds were tested 2 to 19 h after irradiation. The frequency of micronuclei (MNi) was scored in binudeated cells, and the nuclear proliferation index was calculated. The highest prevention of in vitro biochemical and cytogenetic damage of human lymphocytes induced by gamma-radiation was exhibited by 3 (reduction of MN frequency by 31%), followed by 4 and 6. PB - Amer Chemical Soc, Washington T2 - Journal of Natural Products T1 - Phenolic Compounds from Atriplex littoralis and Their Radiation-Mitigating Activity EP - 2204 IS - 9 SP - 2198 VL - 78 DO - 10.1021/acs.jnatprod.5b00273 ER -
@article{ author = "Godjevac, Dejan and Stanković, Jovana and Novaković, Miroslav and Andjelković, Boban and Dajić-Stevanović, Zora and Petrović, Milica and Stanković, Miroslava", year = "2015", abstract = "From the aerial parts of Atriplex littoralis, three new flavonoid glycosides named atriplexins I-III (1-3), a known flavonoid glycoside, spinacetin 3-O-beta-D-glucopyranoside (4), arbutin (5), and 4-hydroxybenzyl-beta-D-glucopyranoside (6) were isolated. Their structures were elucidated on the basis of detailed spectroscopic analysis, including ID and 2D NMR (COSY, NOESY, TOCSY, HSQC, HMBC) and HRESITOF MS data. The compounds were tested for in vitro protective effects on chromosome aberrations in peripheral human lymphocytes using a cytochalasin-B-blocked micronucleus (MN) assay in a concentration range of 0.8-7.4 mu M of final culture solution. Chromosomal damage was induced by 2 Gy of gamma-radiation on binudeated human lymphocytes, and the effects of the compounds were tested 2 to 19 h after irradiation. The frequency of micronuclei (MNi) was scored in binudeated cells, and the nuclear proliferation index was calculated. The highest prevention of in vitro biochemical and cytogenetic damage of human lymphocytes induced by gamma-radiation was exhibited by 3 (reduction of MN frequency by 31%), followed by 4 and 6.", publisher = "Amer Chemical Soc, Washington", journal = "Journal of Natural Products", title = "Phenolic Compounds from Atriplex littoralis and Their Radiation-Mitigating Activity", pages = "2204-2198", number = "9", volume = "78", doi = "10.1021/acs.jnatprod.5b00273" }
Godjevac, D., Stanković, J., Novaković, M., Andjelković, B., Dajić-Stevanović, Z., Petrović, M.,& Stanković, M.. (2015). Phenolic Compounds from Atriplex littoralis and Their Radiation-Mitigating Activity. in Journal of Natural Products Amer Chemical Soc, Washington., 78(9), 2198-2204. https://doi.org/10.1021/acs.jnatprod.5b00273
Godjevac D, Stanković J, Novaković M, Andjelković B, Dajić-Stevanović Z, Petrović M, Stanković M. Phenolic Compounds from Atriplex littoralis and Their Radiation-Mitigating Activity. in Journal of Natural Products. 2015;78(9):2198-2204. doi:10.1021/acs.jnatprod.5b00273 .
Godjevac, Dejan, Stanković, Jovana, Novaković, Miroslav, Andjelković, Boban, Dajić-Stevanović, Zora, Petrović, Milica, Stanković, Miroslava, "Phenolic Compounds from Atriplex littoralis and Their Radiation-Mitigating Activity" in Journal of Natural Products, 78, no. 9 (2015):2198-2204, https://doi.org/10.1021/acs.jnatprod.5b00273 . .