A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate
Само за регистроване кориснике
2014
Аутори
Filipović, NenadMarković, Ivanka
Mitić, Dragana
Polović, Natalija
Milcić, Milos
Dulović, Marija
Jovanović, Maja
Pantić, Milena
Nikšić, Miomir
Andjelković, Katarina
Todorović, Tamara
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
In search for novel biologically active metal based compounds, an evaluation of in vitro cytotoxic, antioxidant, and antimicrobial activity of new Pt(II) complex and its Zn(II), Cu(II), and Co(III) analogues, with NNO tridentately coordinated N-heteroaromatic Schiff base ligand (E)-2-[N-(1-pyridin-2-yl-ethylidene)hydrazino]acetate, was performed. Investigation of antioxidative properties showed that all of the compounds have strong radical scavenging potencies. The Zn(II) complex showed potent inhibition of DNA cleavage by hydroxyl radical. A cytotoxic action of investigated compounds was evaluated on cultures of human promyelocitic leukaemia (HL-60), human glioma (U251), rat glioma (C6), and mouse melanoma (B16) cell lines. It was shown that binuclear pentacoordinated Zn(II) complex possesses a strong dose-dependent cytotoxic activity, of the same order of magnitude as cisplatin on B16, C6, and U251 cells. Furthermore, Zn(II) complex causes oxidative stress-induced apoptotic death of ...HL-60 leukemic cells, associated with caspase activation, phosphatidylserine externalization, and DNA fragmentation.
Кључне речи:
N-heteroaromatic Schiff Base / Zinc / Cytotoxic Activity / Apoptosis / Oxidative StressИзвор:
Journal of Biochemical and Molecular Toxicology, 2014, 28, 3, 99-110Издавач:
- Wiley, Hoboken
Финансирање / пројекти:
- CMST COST Action [CM1106]
- Интеракције природних производа, њихових деривата и комплексних једињења са протеинима и нуклеинским киселинама (RS-172055)
- Модулација сигналних путева који контролишу интрацелуларни енергетски баланс у терапији тумора и неуро-имуно-ендокриних поремећаја (RS-41025)
DOI: 10.1002/jbt.21541
ISSN: 1095-6670
PubMed: 24302597
WoS: 000332141000001
Scopus: 2-s2.0-84895437127
Институција/група
Poljoprivredni fakultetTY - JOUR AU - Filipović, Nenad AU - Marković, Ivanka AU - Mitić, Dragana AU - Polović, Natalija AU - Milcić, Milos AU - Dulović, Marija AU - Jovanović, Maja AU - Pantić, Milena AU - Nikšić, Miomir AU - Andjelković, Katarina AU - Todorović, Tamara PY - 2014 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/3500 AB - In search for novel biologically active metal based compounds, an evaluation of in vitro cytotoxic, antioxidant, and antimicrobial activity of new Pt(II) complex and its Zn(II), Cu(II), and Co(III) analogues, with NNO tridentately coordinated N-heteroaromatic Schiff base ligand (E)-2-[N-(1-pyridin-2-yl-ethylidene)hydrazino]acetate, was performed. Investigation of antioxidative properties showed that all of the compounds have strong radical scavenging potencies. The Zn(II) complex showed potent inhibition of DNA cleavage by hydroxyl radical. A cytotoxic action of investigated compounds was evaluated on cultures of human promyelocitic leukaemia (HL-60), human glioma (U251), rat glioma (C6), and mouse melanoma (B16) cell lines. It was shown that binuclear pentacoordinated Zn(II) complex possesses a strong dose-dependent cytotoxic activity, of the same order of magnitude as cisplatin on B16, C6, and U251 cells. Furthermore, Zn(II) complex causes oxidative stress-induced apoptotic death of HL-60 leukemic cells, associated with caspase activation, phosphatidylserine externalization, and DNA fragmentation. PB - Wiley, Hoboken T2 - Journal of Biochemical and Molecular Toxicology T1 - A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate EP - 110 IS - 3 SP - 99 VL - 28 DO - 10.1002/jbt.21541 ER -
@article{ author = "Filipović, Nenad and Marković, Ivanka and Mitić, Dragana and Polović, Natalija and Milcić, Milos and Dulović, Marija and Jovanović, Maja and Pantić, Milena and Nikšić, Miomir and Andjelković, Katarina and Todorović, Tamara", year = "2014", abstract = "In search for novel biologically active metal based compounds, an evaluation of in vitro cytotoxic, antioxidant, and antimicrobial activity of new Pt(II) complex and its Zn(II), Cu(II), and Co(III) analogues, with NNO tridentately coordinated N-heteroaromatic Schiff base ligand (E)-2-[N-(1-pyridin-2-yl-ethylidene)hydrazino]acetate, was performed. Investigation of antioxidative properties showed that all of the compounds have strong radical scavenging potencies. The Zn(II) complex showed potent inhibition of DNA cleavage by hydroxyl radical. A cytotoxic action of investigated compounds was evaluated on cultures of human promyelocitic leukaemia (HL-60), human glioma (U251), rat glioma (C6), and mouse melanoma (B16) cell lines. It was shown that binuclear pentacoordinated Zn(II) complex possesses a strong dose-dependent cytotoxic activity, of the same order of magnitude as cisplatin on B16, C6, and U251 cells. Furthermore, Zn(II) complex causes oxidative stress-induced apoptotic death of HL-60 leukemic cells, associated with caspase activation, phosphatidylserine externalization, and DNA fragmentation.", publisher = "Wiley, Hoboken", journal = "Journal of Biochemical and Molecular Toxicology", title = "A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate", pages = "110-99", number = "3", volume = "28", doi = "10.1002/jbt.21541" }
Filipović, N., Marković, I., Mitić, D., Polović, N., Milcić, M., Dulović, M., Jovanović, M., Pantić, M., Nikšić, M., Andjelković, K.,& Todorović, T.. (2014). A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate. in Journal of Biochemical and Molecular Toxicology Wiley, Hoboken., 28(3), 99-110. https://doi.org/10.1002/jbt.21541
Filipović N, Marković I, Mitić D, Polović N, Milcić M, Dulović M, Jovanović M, Pantić M, Nikšić M, Andjelković K, Todorović T. A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate. in Journal of Biochemical and Molecular Toxicology. 2014;28(3):99-110. doi:10.1002/jbt.21541 .
Filipović, Nenad, Marković, Ivanka, Mitić, Dragana, Polović, Natalija, Milcić, Milos, Dulović, Marija, Jovanović, Maja, Pantić, Milena, Nikšić, Miomir, Andjelković, Katarina, Todorović, Tamara, "A Comparative Study of In Vitro Cytotoxic, Antioxidant, and Antimicrobial Activity of Pt( II), Zn( II), Cu( II), and Co( III) Complexes with N-heteroaromatic Schiff Base ( E)-2-[ N-( 1-pyridin-2-yl-ethylidene) hydrazino] acetate" in Journal of Biochemical and Molecular Toxicology, 28, no. 3 (2014):99-110, https://doi.org/10.1002/jbt.21541 . .