Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes

New square-planar Pd(II) and Pt(II) complexes with 8-quinolinecarboxaldehyde selenosemicarbazone have been synthesized and characterized by use of elemental analysis, molar conductivity measurements, and IR and NMR spectroscopy. The cytotoxic activity of the ligand, new Pt(II) and Pd(II) compounds, and previously synthesized Pd(II), Pt(II), Cd(II), and Ni(II) complexes with the analogous ligand, 2-quinolinecarboxaldehyde selenosemicarbazone, was tested against two human cancer cell lines: lung carcinoma (H460) and glioma (U251). The potential of these compounds to induce perturbations of the H460 cell cycle was also evaluated. These substances had an excellent radical-scavenging effect against ABTS radical cations. The best antimicrobial activity, among two yeasts and eight bacterial strains tested, was against Bacillus cereus.

Keywords:

Antimicrobial activity / Antioxidants / Cytotoxicity / Coordination chemistry / Schiff bases

Source:
Monatshefte Fur Chemie, 2014, 145, 7, 1089-1099

Publisher:

Springer Wien, Wien

Funding / projects:

DOI: 10.1007/s00706-014-1197-6

ISSN: 0026-9247

WoS: 000337046200006

Scopus: 2-s2.0-84902270174

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TY  - JOUR
AU  - Filipović, Nenad
AU  - Polović, Natalija
AU  - Rasković, Brankica
AU  - Misirlić-Dencić, Sonja
AU  - Dulović, Marija
AU  - Pantić, Milena
AU  - Nikšić, Miomir
AU  - Mitić, Dragana
AU  - Andjelković, Katarina
AU  - Todorović, Tamara
PY  - 2014
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3412
AB  - New square-planar Pd(II) and Pt(II) complexes with 8-quinolinecarboxaldehyde selenosemicarbazone have been synthesized and characterized by use of elemental analysis, molar conductivity measurements, and IR and NMR spectroscopy. The cytotoxic activity of the ligand, new Pt(II) and Pd(II) compounds, and previously synthesized Pd(II), Pt(II), Cd(II), and Ni(II) complexes with the analogous ligand, 2-quinolinecarboxaldehyde selenosemicarbazone, was tested against two human cancer cell lines: lung carcinoma (H460) and glioma (U251). The potential of these compounds to induce perturbations of the H460 cell cycle was also evaluated. These substances had an excellent radical-scavenging effect against ABTS radical cations. The best antimicrobial activity, among two yeasts and eight bacterial strains tested, was against Bacillus cereus.
PB  - Springer Wien, Wien
T2  - Monatshefte Fur Chemie
T1  - Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes
EP  - 1099
IS  - 7
SP  - 1089
VL  - 145
DO  - 10.1007/s00706-014-1197-6
ER  -

@article{
author = "Filipović, Nenad and Polović, Natalija and Rasković, Brankica and Misirlić-Dencić, Sonja and Dulović, Marija and Pantić, Milena and Nikšić, Miomir and Mitić, Dragana and Andjelković, Katarina and Todorović, Tamara",
year = "2014",
abstract = "New square-planar Pd(II) and Pt(II) complexes with 8-quinolinecarboxaldehyde selenosemicarbazone have been synthesized and characterized by use of elemental analysis, molar conductivity measurements, and IR and NMR spectroscopy. The cytotoxic activity of the ligand, new Pt(II) and Pd(II) compounds, and previously synthesized Pd(II), Pt(II), Cd(II), and Ni(II) complexes with the analogous ligand, 2-quinolinecarboxaldehyde selenosemicarbazone, was tested against two human cancer cell lines: lung carcinoma (H460) and glioma (U251). The potential of these compounds to induce perturbations of the H460 cell cycle was also evaluated. These substances had an excellent radical-scavenging effect against ABTS radical cations. The best antimicrobial activity, among two yeasts and eight bacterial strains tested, was against Bacillus cereus.",
publisher = "Springer Wien, Wien",
journal = "Monatshefte Fur Chemie",
title = "Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes",
pages = "1099-1089",
number = "7",
volume = "145",
doi = "10.1007/s00706-014-1197-6"
}

Filipović, N., Polović, N., Rasković, B., Misirlić-Dencić, S., Dulović, M., Pantić, M., Nikšić, M., Mitić, D., Andjelković, K.,& Todorović, T.. (2014). Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes. in Monatshefte Fur Chemie
Springer Wien, Wien., 145(7), 1089-1099.
https://doi.org/10.1007/s00706-014-1197-6

Filipović N, Polović N, Rasković B, Misirlić-Dencić S, Dulović M, Pantić M, Nikšić M, Mitić D, Andjelković K, Todorović T. Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes. in Monatshefte Fur Chemie. 2014;145(7):1089-1099.
doi:10.1007/s00706-014-1197-6 .

Filipović, Nenad, Polović, Natalija, Rasković, Brankica, Misirlić-Dencić, Sonja, Dulović, Marija, Pantić, Milena, Nikšić, Miomir, Mitić, Dragana, Andjelković, Katarina, Todorović, Tamara, "Biological activity of two isomeric N-heteroaromatic selenosemicarbazones and their metal complexes" in Monatshefte Fur Chemie, 145, no. 7 (2014):1089-1099,
https://doi.org/10.1007/s00706-014-1197-6 . .