Gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N '-diacetate
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2013
Authors
Pantelić, Nebojša
Zmejkovski, Bojana B.
Trifunović-Macedoljan, Jelena
Savić, Aleksandar

Stanković, Dalibor

Damjanović, Ana
Juranić, Zorica
Kaludjerović, Goran N.

Sabo, Tibor J.

article (publishedVersion)

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Show full item recordAbstract
Six novel gold(III) complexes containing O,O'-dialkyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate ([AuCl2{(S,S)-R(2)eddch}]PF6, R = Me, Et, n-Pr, n-Bu, i-Bu, i-Am; 1-6, respectively) were synthesized and characterized by elemental analysis, UV/Visible, IR and NMR spectroscopy, mass spectrometry and differential pulse voltammetry. Density functional theory (DFT) calculations confirmed that diastereoisomer with the N,N' atoms configured (S,S) was the most stable. In vitro antiproliferative activity was determined against human cervix adenocarcinoma HeLa and human myelogenous leukemia K562 tumor cell lines, as well as against rested and stimulated normal immunocompetent human peripheral blood mononuclear cells (PBMC) using 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Complex 6 expressed the highest activity against K562 cells (IC50 = 3.8 +/- 0.5 mu M). Apoptosis, seen as condensation of HeLa cell nuclei was the mode of cell death induced by comple...xes 2-6. Complexes 3-6 induced death of K562 cells inhibiting cell entry in mitosis.
Keywords:
Gold(III) complexes / R(2)edda-type ligands / DFT / Apoptosis / Cell cycle / CytotoxicitySource:
Journal of Inorganic Biochemistry, 2013, 128, 146-153Publisher:
- Elsevier Science Inc, New York
Funding / projects:
- info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// (RS-172035)
- info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS// (RS-175011)
DOI: 10.1016/j.jinorgbio.2013.08.002
ISSN: 0162-0134
PubMed: 23988849