Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide
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2008
Authors
Filipović, Nenad
Bacchi, Alessia

Lazić, Milan
Pelizzi, Giancarlo
Radulović, Siniša
Sladić, Dušan M.

Todorović, Tamara R.

Andjelković, Katarina

Article (Published version)

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A new dinuclear complex of Cd(II) with N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide (H2L) was synthesized and its crystal structure determined. The basic structural unit of the complex is the binuclear [Cd-2(H2O)(2)(H2L)(2)](4+) cation, where each cadmium atom is heptacoordinated by two tridentate H2L ligands, by means of the NNO chelating system, and one water molecule. A 12-membered macrocycle is defined at the core of the binuclear cation. The complex showed a pronounced cytotoxic activity to murine melanoma B16 cells and human cervical cancer HeLa cells.
Keywords:
Cd(II) complex / hydrazone ligand / X-ray analysis / cytotoxic activitySource:
Inorganic Chemistry Communications, 2008, 11, 1, 47-50Publisher:
- Elsevier, Amsterdam
Funding / projects:
- Sinteza, analiza i aktivnost novih organskih polidentatnih liganada i njihovih kompleksa sa d-metalima (RS-142062)
DOI: 10.1016/j.inoche.2007.10.013
ISSN: 1387-7003
WoS: 000253105200013
Scopus: 2-s2.0-38049035877
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Poljoprivredni fakultetTY - JOUR AU - Filipović, Nenad AU - Bacchi, Alessia AU - Lazić, Milan AU - Pelizzi, Giancarlo AU - Radulović, Siniša AU - Sladić, Dušan M. AU - Todorović, Tamara R. AU - Andjelković, Katarina PY - 2008 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/1832 AB - A new dinuclear complex of Cd(II) with N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide (H2L) was synthesized and its crystal structure determined. The basic structural unit of the complex is the binuclear [Cd-2(H2O)(2)(H2L)(2)](4+) cation, where each cadmium atom is heptacoordinated by two tridentate H2L ligands, by means of the NNO chelating system, and one water molecule. A 12-membered macrocycle is defined at the core of the binuclear cation. The complex showed a pronounced cytotoxic activity to murine melanoma B16 cells and human cervical cancer HeLa cells. PB - Elsevier, Amsterdam T2 - Inorganic Chemistry Communications T1 - Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide EP - 50 IS - 1 SP - 47 VL - 11 DO - 10.1016/j.inoche.2007.10.013 ER -
@article{ author = "Filipović, Nenad and Bacchi, Alessia and Lazić, Milan and Pelizzi, Giancarlo and Radulović, Siniša and Sladić, Dušan M. and Todorović, Tamara R. and Andjelković, Katarina", year = "2008", abstract = "A new dinuclear complex of Cd(II) with N',N'(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide (H2L) was synthesized and its crystal structure determined. The basic structural unit of the complex is the binuclear [Cd-2(H2O)(2)(H2L)(2)](4+) cation, where each cadmium atom is heptacoordinated by two tridentate H2L ligands, by means of the NNO chelating system, and one water molecule. A 12-membered macrocycle is defined at the core of the binuclear cation. The complex showed a pronounced cytotoxic activity to murine melanoma B16 cells and human cervical cancer HeLa cells.", publisher = "Elsevier, Amsterdam", journal = "Inorganic Chemistry Communications", title = "Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide", pages = "50-47", number = "1", volume = "11", doi = "10.1016/j.inoche.2007.10.013" }
Filipović, N., Bacchi, A., Lazić, M., Pelizzi, G., Radulović, S., Sladić, D. M., Todorović, T. R.,& Andjelković, K.. (2008). Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. in Inorganic Chemistry Communications Elsevier, Amsterdam., 11(1), 47-50. https://doi.org/10.1016/j.inoche.2007.10.013
Filipović N, Bacchi A, Lazić M, Pelizzi G, Radulović S, Sladić DM, Todorović TR, Andjelković K. Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide. in Inorganic Chemistry Communications. 2008;11(1):47-50. doi:10.1016/j.inoche.2007.10.013 .
Filipović, Nenad, Bacchi, Alessia, Lazić, Milan, Pelizzi, Giancarlo, Radulović, Siniša, Sladić, Dušan M., Todorović, Tamara R., Andjelković, Katarina, "Synthesis, structure and cytotoxic activity evaluation of a dinuclear complex of Cd(II) with N ',N '(2)-bis[(1E)-1-(2-pyridyl)ethylidene]propanedihydrazide" in Inorganic Chemistry Communications, 11, no. 1 (2008):47-50, https://doi.org/10.1016/j.inoche.2007.10.013 . .