Carbofuran toxicity on rats was studied during subchronic exposure. Female and male rats were administered carbofuran in drinking water in concentrations of 25, 100 and 400ppm for a period of 90 days. Clinical symptoms, water consumption, body weight gain, organ weight, pathological and histopathological changes in the liver and kidneys were observed and biochemical and haematological examinations were carried out. The results obtained show that carbofuran administered to rats caused a significant decrease in water consumption as well as in brain, serum and erythrocyte cholinesterase activities. Statistically significant increases in relation to the control were found in the serum enzyme activities. The haematological data showed that carbofuran had no significant effect on Hb concentration and total RBC, but total WBC showed a significant statistical decrease. The histopathological changes in liver and kidneys were observed. However, cell regeneration in the liver and kidneys was foun...d in all test groups.
Keywords:
carbofuran / water / rats / toxicity
Source:
Environmental Toxicology and Pharmacology, 2008, 25, 3, 334-341
TY - JOUR
AU - Brkić, Dragica
AU - Vitorović, Slavoljub Lj.
AU - Gašić, Slavica
AU - Nešković, Neško
PY - 2008
UR - http://aspace.agrif.bg.ac.rs/handle/123456789/1793
AB - Carbofuran toxicity on rats was studied during subchronic exposure. Female and male rats were administered carbofuran in drinking water in concentrations of 25, 100 and 400ppm for a period of 90 days. Clinical symptoms, water consumption, body weight gain, organ weight, pathological and histopathological changes in the liver and kidneys were observed and biochemical and haematological examinations were carried out. The results obtained show that carbofuran administered to rats caused a significant decrease in water consumption as well as in brain, serum and erythrocyte cholinesterase activities. Statistically significant increases in relation to the control were found in the serum enzyme activities. The haematological data showed that carbofuran had no significant effect on Hb concentration and total RBC, but total WBC showed a significant statistical decrease. The histopathological changes in liver and kidneys were observed. However, cell regeneration in the liver and kidneys was found in all test groups.
PB - Elsevier Science Bv, Amsterdam
T2 - Environmental Toxicology and Pharmacology
T1 - Carbofuran in water: Subchronic toxicity to rats
EP - 341
IS - 3
SP - 334
VL - 25
DO - 10.1016/j.etap.2007.11.002
ER -
@article{
author = "Brkić, Dragica and Vitorović, Slavoljub Lj. and Gašić, Slavica and Nešković, Neško",
year = "2008",
abstract = "Carbofuran toxicity on rats was studied during subchronic exposure. Female and male rats were administered carbofuran in drinking water in concentrations of 25, 100 and 400ppm for a period of 90 days. Clinical symptoms, water consumption, body weight gain, organ weight, pathological and histopathological changes in the liver and kidneys were observed and biochemical and haematological examinations were carried out. The results obtained show that carbofuran administered to rats caused a significant decrease in water consumption as well as in brain, serum and erythrocyte cholinesterase activities. Statistically significant increases in relation to the control were found in the serum enzyme activities. The haematological data showed that carbofuran had no significant effect on Hb concentration and total RBC, but total WBC showed a significant statistical decrease. The histopathological changes in liver and kidneys were observed. However, cell regeneration in the liver and kidneys was found in all test groups.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Environmental Toxicology and Pharmacology",
title = "Carbofuran in water: Subchronic toxicity to rats",
pages = "341-334",
number = "3",
volume = "25",
doi = "10.1016/j.etap.2007.11.002"
}
Brkić, D., Vitorović, S. Lj., Gašić, S.,& Nešković, N.. (2008). Carbofuran in water: Subchronic toxicity to rats. in Environmental Toxicology and Pharmacology
Elsevier Science Bv, Amsterdam., 25(3), 334-341.
https://doi.org/10.1016/j.etap.2007.11.002
Brkić D, Vitorović SL, Gašić S, Nešković N. Carbofuran in water: Subchronic toxicity to rats. in Environmental Toxicology and Pharmacology. 2008;25(3):334-341.
doi:10.1016/j.etap.2007.11.002 .
Brkić, Dragica, Vitorović, Slavoljub Lj., Gašić, Slavica, Nešković, Neško, "Carbofuran in water: Subchronic toxicity to rats" in Environmental Toxicology and Pharmacology, 25, no. 3 (2008):334-341,
https://doi.org/10.1016/j.etap.2007.11.002 . .
