The synthesis of various functionalized or spirobicyclic glutarimides by a novel tandem process has been disclosed. The reaction involves a base-catalyzed Michael addition of active methylene compounds to secondary conjugated amides, followed by intramolecular N-acylation of the carboxamido group. It provides a relatively general and simple access to useful synthetic intermediaries and potentially active pharmacological compounds. In addition, a novel group of spirobicyclic systems has been synthesized.
Keywords:
synthesis / functionalized or spirobicyclic glutarimides / tandem process
TY - JOUR
AU - Popović-Djordjević, Jelena
AU - Ivanović, MD
AU - Kiricojević, Vesna D.
PY - 2005
UR - http://aspace.agrif.bg.ac.rs/handle/123456789/1022
AB - The synthesis of various functionalized or spirobicyclic glutarimides by a novel tandem process has been disclosed. The reaction involves a base-catalyzed Michael addition of active methylene compounds to secondary conjugated amides, followed by intramolecular N-acylation of the carboxamido group. It provides a relatively general and simple access to useful synthetic intermediaries and potentially active pharmacological compounds. In addition, a novel group of spirobicyclic systems has been synthesized.
PB - Pergamon-Elsevier Science Ltd, Oxford
T2 - Tetrahedron Letters
T1 - A novel tandem process leading to functionalized glutarimides
EP - 2614
IS - 15
SP - 2611
VL - 46
DO - 10.1016/j.tetlet.2005.02.087
ER -
@article{
author = "Popović-Djordjević, Jelena and Ivanović, MD and Kiricojević, Vesna D.",
year = "2005",
abstract = "The synthesis of various functionalized or spirobicyclic glutarimides by a novel tandem process has been disclosed. The reaction involves a base-catalyzed Michael addition of active methylene compounds to secondary conjugated amides, followed by intramolecular N-acylation of the carboxamido group. It provides a relatively general and simple access to useful synthetic intermediaries and potentially active pharmacological compounds. In addition, a novel group of spirobicyclic systems has been synthesized.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Tetrahedron Letters",
title = "A novel tandem process leading to functionalized glutarimides",
pages = "2614-2611",
number = "15",
volume = "46",
doi = "10.1016/j.tetlet.2005.02.087"
}
Popović-Djordjević, J., Ivanović, M.,& Kiricojević, V. D.. (2005). A novel tandem process leading to functionalized glutarimides. in Tetrahedron Letters
Pergamon-Elsevier Science Ltd, Oxford., 46(15), 2611-2614.
https://doi.org/10.1016/j.tetlet.2005.02.087
Popović-Djordjević J, Ivanović M, Kiricojević VD. A novel tandem process leading to functionalized glutarimides. in Tetrahedron Letters. 2005;46(15):2611-2614.
doi:10.1016/j.tetlet.2005.02.087 .
Popović-Djordjević, Jelena, Ivanović, MD, Kiricojević, Vesna D., "A novel tandem process leading to functionalized glutarimides" in Tetrahedron Letters, 46, no. 15 (2005):2611-2614,
https://doi.org/10.1016/j.tetlet.2005.02.087 . .
