TY  - JOUR
AU  - Kaisarević, Sonja
AU  - Tenji, Dina
AU  - Mihajlović, Varja
AU  - Micić, Bojana
AU  - Francija, Ester
AU  - Periz-Stanacev, Jelena
AU  - Krnić-Skiljo, Bojana
AU  - Brkić, Dragica
AU  - Teodorović, Ivana
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5073
AB  - Physiological responses of bacterial, fish, rat and human hepatoma cells to the technical cypermethrin (AS), cypermethrin-based plant protection product (PPP), and the major co-formulant (solvent) were compared. The endpoints included: bioluminescence, total protein content, activity of mitochondrial dehydrogenase and cytochrome P450 (CYP) enzymes CYP1A and CYP1B, and expression of several genes encoding different CYP enzyme isoforms. Toxicity of PPP was compared with the toxicity predicted using concentration addition model. Cypermethrin disturbs the activity of mitochondrial dehydrogenase. Induction of CYP1A1-, CYP1A2- and CYP1B1-associated activity was more pronounced in PPP than in cypermethrin treatment. The predominant biotransformation pathway of cypermethrin is related to Cyp3a1 induction. Deviations between observed and predicted toxicity of PPP indicate synergistic effects of cypermethrin and a solvent. In vitro cellular assays may serve as rapid pre-screening tool and provide for a good indication of mixture effects and prompt further in vivo testing of PPPs when really needed.
PB  - Elsevier, Amsterdam
T2  - Environmental Toxicology and Pharmacology
T1  - Comparative analyses of cellular physiological responses of non-target species to cypermethrin and its formulated product: Contribution to mode of action research
EP  - 39
SP  - 31
VL  - 65
DO  - 10.1016/j.etap.2018.11.007
ER  - 

@article{
author = "Kaisarević, Sonja and Tenji, Dina and Mihajlović, Varja and Micić, Bojana and Francija, Ester and Periz-Stanacev, Jelena and Krnić-Skiljo, Bojana and Brkić, Dragica and Teodorović, Ivana",
year = "2019",
abstract = "Physiological responses of bacterial, fish, rat and human hepatoma cells to the technical cypermethrin (AS), cypermethrin-based plant protection product (PPP), and the major co-formulant (solvent) were compared. The endpoints included: bioluminescence, total protein content, activity of mitochondrial dehydrogenase and cytochrome P450 (CYP) enzymes CYP1A and CYP1B, and expression of several genes encoding different CYP enzyme isoforms. Toxicity of PPP was compared with the toxicity predicted using concentration addition model. Cypermethrin disturbs the activity of mitochondrial dehydrogenase. Induction of CYP1A1-, CYP1A2- and CYP1B1-associated activity was more pronounced in PPP than in cypermethrin treatment. The predominant biotransformation pathway of cypermethrin is related to Cyp3a1 induction. Deviations between observed and predicted toxicity of PPP indicate synergistic effects of cypermethrin and a solvent. In vitro cellular assays may serve as rapid pre-screening tool and provide for a good indication of mixture effects and prompt further in vivo testing of PPPs when really needed.",
publisher = "Elsevier, Amsterdam",
journal = "Environmental Toxicology and Pharmacology",
title = "Comparative analyses of cellular physiological responses of non-target species to cypermethrin and its formulated product: Contribution to mode of action research",
pages = "39-31",
volume = "65",
doi = "10.1016/j.etap.2018.11.007"
}

Kaisarević, S., Tenji, D., Mihajlović, V., Micić, B., Francija, E., Periz-Stanacev, J., Krnić-Skiljo, B., Brkić, D.,& Teodorović, I.. (2019). Comparative analyses of cellular physiological responses of non-target species to cypermethrin and its formulated product: Contribution to mode of action research. in Environmental Toxicology and Pharmacology
Elsevier, Amsterdam., 65, 31-39.
https://doi.org/10.1016/j.etap.2018.11.007

Kaisarević S, Tenji D, Mihajlović V, Micić B, Francija E, Periz-Stanacev J, Krnić-Skiljo B, Brkić D, Teodorović I. Comparative analyses of cellular physiological responses of non-target species to cypermethrin and its formulated product: Contribution to mode of action research. in Environmental Toxicology and Pharmacology. 2019;65:31-39.
doi:10.1016/j.etap.2018.11.007 .

Kaisarević, Sonja, Tenji, Dina, Mihajlović, Varja, Micić, Bojana, Francija, Ester, Periz-Stanacev, Jelena, Krnić-Skiljo, Bojana, Brkić, Dragica, Teodorović, Ivana, "Comparative analyses of cellular physiological responses of non-target species to cypermethrin and its formulated product: Contribution to mode of action research" in Environmental Toxicology and Pharmacology, 65 (2019):31-39,
https://doi.org/10.1016/j.etap.2018.11.007 . .

TY  - JOUR
AU  - Brkić, Dragica
AU  - Szakonyne-Pasics, Ilona
AU  - Gašić, Slavica
AU  - Teodorović, Ivana
AU  - Rašković, Božidar
AU  - Brkić, Nenad
AU  - Nesković, Nesko
PY  - 2015
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3821
AB  - Subacute and subchronic toxicity of the herbicide Avalon (R), a mixture of bentazone and dicamba, were tested on rats. Avalon (R) was administered at dose levels of 250, 500 and 1000 mg/kg body weight/day for 28 and 90 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were monitored together with biochemistry parameters. The results showed that the mixture caused increases in the activities of ALT, AST and ALP, elevated concentrations of sodium, albumin and albumin/globulin ratio in males. In females, ALT activity, cholesterol and phosphate levels were increased. The changes generally were dose related and, in most cases, females exhibited lower susceptibility than males. The effects of a mixture are, in the most cases, different from the effects of the individual substances. The effects of bentazone were not prevalent which would be expected taking the composition of the mixture into account.
PB  - Elsevier, Amsterdam
T2  - Environmental Toxicology and Pharmacology
T1  - Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats
EP  - 1066
IS  - 3
SP  - 1057
VL  - 39
DO  - 10.1016/j.etap.2015.03.004
ER  - 

@article{
author = "Brkić, Dragica and Szakonyne-Pasics, Ilona and Gašić, Slavica and Teodorović, Ivana and Rašković, Božidar and Brkić, Nenad and Nesković, Nesko",
year = "2015",
abstract = "Subacute and subchronic toxicity of the herbicide Avalon (R), a mixture of bentazone and dicamba, were tested on rats. Avalon (R) was administered at dose levels of 250, 500 and 1000 mg/kg body weight/day for 28 and 90 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were monitored together with biochemistry parameters. The results showed that the mixture caused increases in the activities of ALT, AST and ALP, elevated concentrations of sodium, albumin and albumin/globulin ratio in males. In females, ALT activity, cholesterol and phosphate levels were increased. The changes generally were dose related and, in most cases, females exhibited lower susceptibility than males. The effects of a mixture are, in the most cases, different from the effects of the individual substances. The effects of bentazone were not prevalent which would be expected taking the composition of the mixture into account.",
publisher = "Elsevier, Amsterdam",
journal = "Environmental Toxicology and Pharmacology",
title = "Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats",
pages = "1066-1057",
number = "3",
volume = "39",
doi = "10.1016/j.etap.2015.03.004"
}

Brkić, D., Szakonyne-Pasics, I., Gašić, S., Teodorović, I., Rašković, B., Brkić, N.,& Nesković, N.. (2015). Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats. in Environmental Toxicology and Pharmacology
Elsevier, Amsterdam., 39(3), 1057-1066.
https://doi.org/10.1016/j.etap.2015.03.004

Brkić D, Szakonyne-Pasics I, Gašić S, Teodorović I, Rašković B, Brkić N, Nesković N. Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats. in Environmental Toxicology and Pharmacology. 2015;39(3):1057-1066.
doi:10.1016/j.etap.2015.03.004 .

Brkić, Dragica, Szakonyne-Pasics, Ilona, Gašić, Slavica, Teodorović, Ivana, Rašković, Božidar, Brkić, Nenad, Nesković, Nesko, "Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats" in Environmental Toxicology and Pharmacology, 39, no. 3 (2015):1057-1066,
https://doi.org/10.1016/j.etap.2015.03.004 . .