Studies of enzyme interactions with toxic and pharmacologically active molecules

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Studies of enzyme interactions with toxic and pharmacologically active molecules (en)
Истраживања интеракција ензима са токсичним и фармаколошки активним молекулима (sr)
Istraživanja interakcija enzima sa toksičnim i farmakološki aktivnim molekulima (sr_RS)
Authors

Publications

Yield, quality and safety of yellow gentian roots produced under dry-farming conditions in various single basal fertilization and planting density models

Marković, Tatjana; Radanović, Dragoja; Nastasijević, Branislav; Antić-Mladenović, Svetlana; Vasić, Vesna; Matković, Ana

(Elsevier Science Bv, Amsterdam, 2019)

TY  - JOUR
AU  - Marković, Tatjana
AU  - Radanović, Dragoja
AU  - Nastasijević, Branislav
AU  - Antić-Mladenović, Svetlana
AU  - Vasić, Vesna
AU  - Matković, Ana
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5022
AB  - Yellow gentian (Gentiana lutea ssp. symphyandra (Murb.) Hayek) is a high-mountainous perennial spontaneously growing on meadows and open slopes of the Eastern part of the Alps and the Balkan Peninsula. While the excessive exploitation endangered its survival in the nature in many European countries, the orientation to its large-scale production enables its protection at natural stands and satisfaction of increasing market demands for its roots, a highly-valuable herbal drug (Gentianae radix). During the six-year field trial established with Yellow gentian nursery plants on black water-air permeable and biodegradable film, in dry farming conditions of Mountain Tara (Serbia), the influence of a sigle basal application of farm yard manure and mineral fertilizer, at different planting densities (11.1, 13.3 and 16 plants m(-2)) on produced yield (roots), has been investigated. Single dose fertilization positively influenced the yields but did not provide optimal supplies for cultivated crop in the second part of experiment. It depended on crop age, planting density but also the climatic conditions. In the second part of plant production period, particulary in denser establishemnts, additional fertilization should be applied. Providing the appropriate amounts of fertilizers, Yellow gentian can be successfully grown even in the densest planting model (16 plants m(-2)), which is quite important in respect to the economic feasibility of cultivation. Similar yields achieved in mineral and organic treatments (4.51 kg m(-2) and 4.85 kg m(-2) of fresh root, respectively), suggest the roots might be successfully produced in both, conventional and organic cultivation model. In attempt to estimate impact of fertilization treatments on chemical quality of produced raw material (Gentianae radix) the content of several pharmacological constituents (loganic acid, swertiamarin, gentiopicroside, sweroside, amarogentin and isogentisin) was evaluated; gentiopicroside and loganic acid were the most dominant ones, regadless the fertilization, whereas the content of isogentisin was significantly increased in both, organic and mineral fertilization model, and content of sweroside, only in mineral model. With regard to the safety of produced raw material, the contents of biogenic (Fe, Mn, Zn, Cu) and non-biogenic (Pb) trace elements were analyzed; all trace elements were within the safty limits except the Cd content which slightly exceeded the limit.
PB  - Elsevier Science Bv, Amsterdam
T2  - Industrial Crops and Products
T1  - Yield, quality and safety of yellow gentian roots produced under dry-farming conditions in various single basal fertilization and planting density models
EP  - 244
SP  - 236
VL  - 132
DO  - 10.1016/j.indcrop.2019.02.027
ER  - 
@article{
author = "Marković, Tatjana and Radanović, Dragoja and Nastasijević, Branislav and Antić-Mladenović, Svetlana and Vasić, Vesna and Matković, Ana",
year = "2019",
abstract = "Yellow gentian (Gentiana lutea ssp. symphyandra (Murb.) Hayek) is a high-mountainous perennial spontaneously growing on meadows and open slopes of the Eastern part of the Alps and the Balkan Peninsula. While the excessive exploitation endangered its survival in the nature in many European countries, the orientation to its large-scale production enables its protection at natural stands and satisfaction of increasing market demands for its roots, a highly-valuable herbal drug (Gentianae radix). During the six-year field trial established with Yellow gentian nursery plants on black water-air permeable and biodegradable film, in dry farming conditions of Mountain Tara (Serbia), the influence of a sigle basal application of farm yard manure and mineral fertilizer, at different planting densities (11.1, 13.3 and 16 plants m(-2)) on produced yield (roots), has been investigated. Single dose fertilization positively influenced the yields but did not provide optimal supplies for cultivated crop in the second part of experiment. It depended on crop age, planting density but also the climatic conditions. In the second part of plant production period, particulary in denser establishemnts, additional fertilization should be applied. Providing the appropriate amounts of fertilizers, Yellow gentian can be successfully grown even in the densest planting model (16 plants m(-2)), which is quite important in respect to the economic feasibility of cultivation. Similar yields achieved in mineral and organic treatments (4.51 kg m(-2) and 4.85 kg m(-2) of fresh root, respectively), suggest the roots might be successfully produced in both, conventional and organic cultivation model. In attempt to estimate impact of fertilization treatments on chemical quality of produced raw material (Gentianae radix) the content of several pharmacological constituents (loganic acid, swertiamarin, gentiopicroside, sweroside, amarogentin and isogentisin) was evaluated; gentiopicroside and loganic acid were the most dominant ones, regadless the fertilization, whereas the content of isogentisin was significantly increased in both, organic and mineral fertilization model, and content of sweroside, only in mineral model. With regard to the safety of produced raw material, the contents of biogenic (Fe, Mn, Zn, Cu) and non-biogenic (Pb) trace elements were analyzed; all trace elements were within the safty limits except the Cd content which slightly exceeded the limit.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Industrial Crops and Products",
title = "Yield, quality and safety of yellow gentian roots produced under dry-farming conditions in various single basal fertilization and planting density models",
pages = "244-236",
volume = "132",
doi = "10.1016/j.indcrop.2019.02.027"
}
Marković, T., Radanović, D., Nastasijević, B., Antić-Mladenović, S., Vasić, V.,& Matković, A.. (2019). Yield, quality and safety of yellow gentian roots produced under dry-farming conditions in various single basal fertilization and planting density models. in Industrial Crops and Products
Elsevier Science Bv, Amsterdam., 132, 236-244.
https://doi.org/10.1016/j.indcrop.2019.02.027
Marković T, Radanović D, Nastasijević B, Antić-Mladenović S, Vasić V, Matković A. Yield, quality and safety of yellow gentian roots produced under dry-farming conditions in various single basal fertilization and planting density models. in Industrial Crops and Products. 2019;132:236-244.
doi:10.1016/j.indcrop.2019.02.027 .
Marković, Tatjana, Radanović, Dragoja, Nastasijević, Branislav, Antić-Mladenović, Svetlana, Vasić, Vesna, Matković, Ana, "Yield, quality and safety of yellow gentian roots produced under dry-farming conditions in various single basal fertilization and planting density models" in Industrial Crops and Products, 132 (2019):236-244,
https://doi.org/10.1016/j.indcrop.2019.02.027 . .
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Adsorption of Organophosphate Pesticide Dimethoate on Gold Nanospheres and Nanorods

Momić, Tatjana; Lazarević-Pasti, Tamara; Bogdanović, Una; Vodnik, Vesna; Mraković, Ana; Rakocević, Zlatko; Pavlović, Vladimir; Vasić, Vesna

(Hindawi Ltd, London, 2016)

TY  - JOUR
AU  - Momić, Tatjana
AU  - Lazarević-Pasti, Tamara
AU  - Bogdanović, Una
AU  - Vodnik, Vesna
AU  - Mraković, Ana
AU  - Rakocević, Zlatko
AU  - Pavlović, Vladimir
AU  - Vasić, Vesna
PY  - 2016
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4038
AB  - Organophosphorus pesticide dimethoate was adsorbed onto gold nanospheres and nanorods in aqueous solution using batch technique. Adsorption of dimethoate onto gold nanoparticles was confirmed by UV-Vis spectrophotometry, TEM, AFM, and FTIR analysis. The adsorption of nanospheres resulted in aggregation which was not the case with nanorods. Nanoparticles adsorption features were characterized using Langmuir and Freundlich isotherm models. The Langmuir adsorption isotherm was found to have the best fit to the experimental data for both types of nanoparticles. Adsorption capacity detected for nanospheres is 456 mg/g and for nanorods is 57.1 mg/g. Also, nanoparticles were successfully used for dimethoate removal from spiked drinking water while nanospheres were shown to be more efficient than nanorods.
PB  - Hindawi Ltd, London
T2  - Journal of Nanomaterials
T1  - Adsorption of Organophosphate Pesticide Dimethoate on Gold Nanospheres and Nanorods
VL  - 2016
DO  - 10.1155/2016/8910271
ER  - 
@article{
author = "Momić, Tatjana and Lazarević-Pasti, Tamara and Bogdanović, Una and Vodnik, Vesna and Mraković, Ana and Rakocević, Zlatko and Pavlović, Vladimir and Vasić, Vesna",
year = "2016",
abstract = "Organophosphorus pesticide dimethoate was adsorbed onto gold nanospheres and nanorods in aqueous solution using batch technique. Adsorption of dimethoate onto gold nanoparticles was confirmed by UV-Vis spectrophotometry, TEM, AFM, and FTIR analysis. The adsorption of nanospheres resulted in aggregation which was not the case with nanorods. Nanoparticles adsorption features were characterized using Langmuir and Freundlich isotherm models. The Langmuir adsorption isotherm was found to have the best fit to the experimental data for both types of nanoparticles. Adsorption capacity detected for nanospheres is 456 mg/g and for nanorods is 57.1 mg/g. Also, nanoparticles were successfully used for dimethoate removal from spiked drinking water while nanospheres were shown to be more efficient than nanorods.",
publisher = "Hindawi Ltd, London",
journal = "Journal of Nanomaterials",
title = "Adsorption of Organophosphate Pesticide Dimethoate on Gold Nanospheres and Nanorods",
volume = "2016",
doi = "10.1155/2016/8910271"
}
Momić, T., Lazarević-Pasti, T., Bogdanović, U., Vodnik, V., Mraković, A., Rakocević, Z., Pavlović, V.,& Vasić, V.. (2016). Adsorption of Organophosphate Pesticide Dimethoate on Gold Nanospheres and Nanorods. in Journal of Nanomaterials
Hindawi Ltd, London., 2016.
https://doi.org/10.1155/2016/8910271
Momić T, Lazarević-Pasti T, Bogdanović U, Vodnik V, Mraković A, Rakocević Z, Pavlović V, Vasić V. Adsorption of Organophosphate Pesticide Dimethoate on Gold Nanospheres and Nanorods. in Journal of Nanomaterials. 2016;2016.
doi:10.1155/2016/8910271 .
Momić, Tatjana, Lazarević-Pasti, Tamara, Bogdanović, Una, Vodnik, Vesna, Mraković, Ana, Rakocević, Zlatko, Pavlović, Vladimir, Vasić, Vesna, "Adsorption of Organophosphate Pesticide Dimethoate on Gold Nanospheres and Nanorods" in Journal of Nanomaterials, 2016 (2016),
https://doi.org/10.1155/2016/8910271 . .
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