TY  - JOUR
AU  - Milutinović, Nađa
AU  - Stević, Milan
AU  - Špirović Trifunović, Bojana
AU  - Brkić, Dragica
PY  - 2023
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6897
AB  - Mefentriflukonazol je nova aktivna supstanca sa fungicidnim delovanjem, koja pripada izopropanol azolima, novoj podgrupi u okviru hemijske grupe triazola. Inhibira biosintezu sterola i odlikuje se veoma selektivnim delovanjem. Sistemični je fungicid sa protektivnim, kurativnim i eradikativnim delovanjem i koristi se za suzbijanje značajnih patogena strnih žita (Septoria spp., Puccinia spp., Ramularia collo-cygni, Rhynchosporium secalis). Za razliku od većine triazola, povučenih iz primene u poslednje 2-3 godine, uglavnom zbog repro-toksičnog i karcinogenog delovanja, mefentriflukonazol ne deluje karcinogeno, genotoksično ni reprotoksično. Takođe, nije akutno toksičan, ne iritira kožu i oči i ne izaziva specifičnu toksičnost za ciljne organe posle jednokratne ili višekratne izloženosti. U dodiru sa kožom može izazvati senzibilizaciju i to je jedino toksikološko svojstvo na osnovu koga je klasifikovan i obeležen. Akutna i hronična dijetarna izloženost svih populacionih grupa ovoj aktivnoj supstanci je niska, sa velikom marginom bezbednosti. Mefentriflukonazol nije akutno oralno i kontakt-no toksičan za pčele i nije toksičan za kišne gliste. Za akvatične organizme, ribe, beskičmenjake i alge je veoma toksičan akutno i hronično, dok je za organizme sedimenta i akvatične makrofite toksičan. Povoljna toksikološka svojstva mefen-triflukonazola i dobra efikasnost preporučuju ovu aktivnu supstancu kao dobru zamenu za triazole povučene iz primene.
AB  - Mefentrifluconazole is a new fungicidal active substance from the isopropanol-azoles, a new sub-class of triazoles. It inhibits sterols biosynthesis and is a
very selective fungicide. It is a systemic fungicide with protective, curative, and
eradicative activity. Its spectrum includes important pathogens of cereals (Septoria spp., Puccinia spp., Ramularia collo-cygni, Rhynchosporium secalis). Unlike
most triazoles, withdrawn from use in the last 2-3 years, mainly due to reprotoxic
and carcinogenic effects, mefentrifluconazole is neither carcinogenic, nor genotoxic or reprotoxic. In adition, it is not acutely toxic, is not irritant to skin or
eyes and does not cause specific toxicity to target organs after single or repeated
exposure. In contact with the skin, it can cause sensitization, and this is the only
toxicological property on the basis of which it is classified and labeled. Acute and
chronic dietary exposure of all population groups to this active substance is low,
with a large margin of safety. Mefentrifluconazole is not acutely toxic to bees
and earthworms. It is very toxic acutely and chronically for aquatic organisms,
fish, invertebrates, and algae, while it is toxic for sediment organisms and aquatic macrophytes. The favourable toxicological properties of mefentrifluconazole,
and good efficacy in control of important pathogens, recommend this active substance as a good substitute for withdrawn triazoles.
PB  - Univerzitet u Novom Sadu - Poljoprivredni fakultet - Departman za fitomedicinu i zaštitu životne sredine, Novi Sad
T2  - Biljni lekar
T1  - Mefentriflukonazol - novi fungicid iz grupe triazola
EP  - 612
IS  - 4
SP  - 594
VL  - 51
DO  - 10.5937/BiljLek2304594M
ER  - 

@article{
author = "Milutinović, Nađa and Stević, Milan and Špirović Trifunović, Bojana and Brkić, Dragica",
year = "2023",
abstract = "Mefentriflukonazol je nova aktivna supstanca sa fungicidnim delovanjem, koja pripada izopropanol azolima, novoj podgrupi u okviru hemijske grupe triazola. Inhibira biosintezu sterola i odlikuje se veoma selektivnim delovanjem. Sistemični je fungicid sa protektivnim, kurativnim i eradikativnim delovanjem i koristi se za suzbijanje značajnih patogena strnih žita (Septoria spp., Puccinia spp., Ramularia collo-cygni, Rhynchosporium secalis). Za razliku od većine triazola, povučenih iz primene u poslednje 2-3 godine, uglavnom zbog repro-toksičnog i karcinogenog delovanja, mefentriflukonazol ne deluje karcinogeno, genotoksično ni reprotoksično. Takođe, nije akutno toksičan, ne iritira kožu i oči i ne izaziva specifičnu toksičnost za ciljne organe posle jednokratne ili višekratne izloženosti. U dodiru sa kožom može izazvati senzibilizaciju i to je jedino toksikološko svojstvo na osnovu koga je klasifikovan i obeležen. Akutna i hronična dijetarna izloženost svih populacionih grupa ovoj aktivnoj supstanci je niska, sa velikom marginom bezbednosti. Mefentriflukonazol nije akutno oralno i kontakt-no toksičan za pčele i nije toksičan za kišne gliste. Za akvatične organizme, ribe, beskičmenjake i alge je veoma toksičan akutno i hronično, dok je za organizme sedimenta i akvatične makrofite toksičan. Povoljna toksikološka svojstva mefen-triflukonazola i dobra efikasnost preporučuju ovu aktivnu supstancu kao dobru zamenu za triazole povučene iz primene., Mefentrifluconazole is a new fungicidal active substance from the isopropanol-azoles, a new sub-class of triazoles. It inhibits sterols biosynthesis and is a
very selective fungicide. It is a systemic fungicide with protective, curative, and
eradicative activity. Its spectrum includes important pathogens of cereals (Septoria spp., Puccinia spp., Ramularia collo-cygni, Rhynchosporium secalis). Unlike
most triazoles, withdrawn from use in the last 2-3 years, mainly due to reprotoxic
and carcinogenic effects, mefentrifluconazole is neither carcinogenic, nor genotoxic or reprotoxic. In adition, it is not acutely toxic, is not irritant to skin or
eyes and does not cause specific toxicity to target organs after single or repeated
exposure. In contact with the skin, it can cause sensitization, and this is the only
toxicological property on the basis of which it is classified and labeled. Acute and
chronic dietary exposure of all population groups to this active substance is low,
with a large margin of safety. Mefentrifluconazole is not acutely toxic to bees
and earthworms. It is very toxic acutely and chronically for aquatic organisms,
fish, invertebrates, and algae, while it is toxic for sediment organisms and aquatic macrophytes. The favourable toxicological properties of mefentrifluconazole,
and good efficacy in control of important pathogens, recommend this active substance as a good substitute for withdrawn triazoles.",
publisher = "Univerzitet u Novom Sadu - Poljoprivredni fakultet - Departman za fitomedicinu i zaštitu životne sredine, Novi Sad",
journal = "Biljni lekar",
title = "Mefentriflukonazol - novi fungicid iz grupe triazola",
pages = "612-594",
number = "4",
volume = "51",
doi = "10.5937/BiljLek2304594M"
}

Milutinović, N., Stević, M., Špirović Trifunović, B.,& Brkić, D.. (2023). Mefentriflukonazol - novi fungicid iz grupe triazola. in Biljni lekar
Univerzitet u Novom Sadu - Poljoprivredni fakultet - Departman za fitomedicinu i zaštitu životne sredine, Novi Sad., 51(4), 594-612.
https://doi.org/10.5937/BiljLek2304594M

Milutinović N, Stević M, Špirović Trifunović B, Brkić D. Mefentriflukonazol - novi fungicid iz grupe triazola. in Biljni lekar. 2023;51(4):594-612.
doi:10.5937/BiljLek2304594M .

Milutinović, Nađa, Stević, Milan, Špirović Trifunović, Bojana, Brkić, Dragica, "Mefentriflukonazol - novi fungicid iz grupe triazola" in Biljni lekar, 51, no. 4 (2023):594-612,
https://doi.org/10.5937/BiljLek2304594M . .

TY  - JOUR
AU  - Milincić, Danijel D.
AU  - Vojinović, Uroš
AU  - Kostić, Aleksandar
AU  - Pešić, Mirjana
AU  - Špirović-Trifunović, Bojana
AU  - Brkić, Dragica
AU  - Stević, Milan
AU  - Kojić, Milan
AU  - Stanisavljević, Nemanja S.
PY  - 2020
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5371
AB  - The aim of this study was to investigate the bioaccessibility of pesticide residues in blueberries (com-mercial and sample from controlled field trial) from Serbia, involving the presence of a complex food matrix and to assess the potential risk to human health. The presence of nine active substances (azox-ystrobin, boscalid, fludioxonil, cyprodinil, pyrimethanil, pyridaben, pyriproxyfen, acetamiprid and thia-metoxam) in initial blueberry samples was determined in concentration range from 5.15 mu g/kg for thiametoxam to 187 mu g/kg for azoxystrobin. Clothianidin, metabolite of thiametoxam, was not detected in any blueberry sample. However, after in vitro digestion, the content of initially detected pesticides residues was significantly decreased or it was below limit of quantification resulting in the total bio-accessibility of about 15%. Azoxystrobin, pyrimethanil and fludioxonil was quantified in digestive juice at concentrations which were about 81%, 37% and 10% less than the inital concentration, respectively. The presence of food matrix during digestion of blueberries even more severely reduced concentration of pesticide residues (total bioaccessibility was about 7%) compared to digestion without the food matrix. Only azoxystrobin was quantified after digestion with food matrix in concentration of 27 mu g/kg in sample from controlled field trial and detected in two commercial samples but below the limit of quantification. Furthermore, chronic risk assessment indicated that risk is acceptable for the health of different human subpopulation groups. The current study on pesticides residues, most commonly applied on blueberries, provides for the first time an insight into their bioaccessibility under conditions that mimic physiological environment of human digestive tract.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Chemosphere
T1  - In vitro assessment of pesticide residues bioaccessibility in conventionally grown blueberries as affected by complex food matrix
VL  - 252
DO  - 10.1016/j.chemosphere.2020.126568
ER  - 

@article{
author = "Milincić, Danijel D. and Vojinović, Uroš and Kostić, Aleksandar and Pešić, Mirjana and Špirović-Trifunović, Bojana and Brkić, Dragica and Stević, Milan and Kojić, Milan and Stanisavljević, Nemanja S.",
year = "2020",
abstract = "The aim of this study was to investigate the bioaccessibility of pesticide residues in blueberries (com-mercial and sample from controlled field trial) from Serbia, involving the presence of a complex food matrix and to assess the potential risk to human health. The presence of nine active substances (azox-ystrobin, boscalid, fludioxonil, cyprodinil, pyrimethanil, pyridaben, pyriproxyfen, acetamiprid and thia-metoxam) in initial blueberry samples was determined in concentration range from 5.15 mu g/kg for thiametoxam to 187 mu g/kg for azoxystrobin. Clothianidin, metabolite of thiametoxam, was not detected in any blueberry sample. However, after in vitro digestion, the content of initially detected pesticides residues was significantly decreased or it was below limit of quantification resulting in the total bio-accessibility of about 15%. Azoxystrobin, pyrimethanil and fludioxonil was quantified in digestive juice at concentrations which were about 81%, 37% and 10% less than the inital concentration, respectively. The presence of food matrix during digestion of blueberries even more severely reduced concentration of pesticide residues (total bioaccessibility was about 7%) compared to digestion without the food matrix. Only azoxystrobin was quantified after digestion with food matrix in concentration of 27 mu g/kg in sample from controlled field trial and detected in two commercial samples but below the limit of quantification. Furthermore, chronic risk assessment indicated that risk is acceptable for the health of different human subpopulation groups. The current study on pesticides residues, most commonly applied on blueberries, provides for the first time an insight into their bioaccessibility under conditions that mimic physiological environment of human digestive tract.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Chemosphere",
title = "In vitro assessment of pesticide residues bioaccessibility in conventionally grown blueberries as affected by complex food matrix",
volume = "252",
doi = "10.1016/j.chemosphere.2020.126568"
}

Milincić, D. D., Vojinović, U., Kostić, A., Pešić, M., Špirović-Trifunović, B., Brkić, D., Stević, M., Kojić, M.,& Stanisavljević, N. S.. (2020). In vitro assessment of pesticide residues bioaccessibility in conventionally grown blueberries as affected by complex food matrix. in Chemosphere
Pergamon-Elsevier Science Ltd, Oxford., 252.
https://doi.org/10.1016/j.chemosphere.2020.126568

Milincić DD, Vojinović U, Kostić A, Pešić M, Špirović-Trifunović B, Brkić D, Stević M, Kojić M, Stanisavljević NS. In vitro assessment of pesticide residues bioaccessibility in conventionally grown blueberries as affected by complex food matrix. in Chemosphere. 2020;252.
doi:10.1016/j.chemosphere.2020.126568 .

Milincić, Danijel D., Vojinović, Uroš, Kostić, Aleksandar, Pešić, Mirjana, Špirović-Trifunović, Bojana, Brkić, Dragica, Stević, Milan, Kojić, Milan, Stanisavljević, Nemanja S., "In vitro assessment of pesticide residues bioaccessibility in conventionally grown blueberries as affected by complex food matrix" in Chemosphere, 252 (2020),
https://doi.org/10.1016/j.chemosphere.2020.126568 . .

TY  - JOUR
AU  - Kaisarević, Sonja
AU  - Tenji, Dina
AU  - Mihajlović, Varja
AU  - Micić, Bojana
AU  - Francija, Ester
AU  - Periz-Stanacev, Jelena
AU  - Krnić-Skiljo, Bojana
AU  - Brkić, Dragica
AU  - Teodorović, Ivana
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5073
AB  - Physiological responses of bacterial, fish, rat and human hepatoma cells to the technical cypermethrin (AS), cypermethrin-based plant protection product (PPP), and the major co-formulant (solvent) were compared. The endpoints included: bioluminescence, total protein content, activity of mitochondrial dehydrogenase and cytochrome P450 (CYP) enzymes CYP1A and CYP1B, and expression of several genes encoding different CYP enzyme isoforms. Toxicity of PPP was compared with the toxicity predicted using concentration addition model. Cypermethrin disturbs the activity of mitochondrial dehydrogenase. Induction of CYP1A1-, CYP1A2- and CYP1B1-associated activity was more pronounced in PPP than in cypermethrin treatment. The predominant biotransformation pathway of cypermethrin is related to Cyp3a1 induction. Deviations between observed and predicted toxicity of PPP indicate synergistic effects of cypermethrin and a solvent. In vitro cellular assays may serve as rapid pre-screening tool and provide for a good indication of mixture effects and prompt further in vivo testing of PPPs when really needed.
PB  - Elsevier, Amsterdam
T2  - Environmental Toxicology and Pharmacology
T1  - Comparative analyses of cellular physiological responses of non-target species to cypermethrin and its formulated product: Contribution to mode of action research
EP  - 39
SP  - 31
VL  - 65
DO  - 10.1016/j.etap.2018.11.007
ER  - 

@article{
author = "Kaisarević, Sonja and Tenji, Dina and Mihajlović, Varja and Micić, Bojana and Francija, Ester and Periz-Stanacev, Jelena and Krnić-Skiljo, Bojana and Brkić, Dragica and Teodorović, Ivana",
year = "2019",
abstract = "Physiological responses of bacterial, fish, rat and human hepatoma cells to the technical cypermethrin (AS), cypermethrin-based plant protection product (PPP), and the major co-formulant (solvent) were compared. The endpoints included: bioluminescence, total protein content, activity of mitochondrial dehydrogenase and cytochrome P450 (CYP) enzymes CYP1A and CYP1B, and expression of several genes encoding different CYP enzyme isoforms. Toxicity of PPP was compared with the toxicity predicted using concentration addition model. Cypermethrin disturbs the activity of mitochondrial dehydrogenase. Induction of CYP1A1-, CYP1A2- and CYP1B1-associated activity was more pronounced in PPP than in cypermethrin treatment. The predominant biotransformation pathway of cypermethrin is related to Cyp3a1 induction. Deviations between observed and predicted toxicity of PPP indicate synergistic effects of cypermethrin and a solvent. In vitro cellular assays may serve as rapid pre-screening tool and provide for a good indication of mixture effects and prompt further in vivo testing of PPPs when really needed.",
publisher = "Elsevier, Amsterdam",
journal = "Environmental Toxicology and Pharmacology",
title = "Comparative analyses of cellular physiological responses of non-target species to cypermethrin and its formulated product: Contribution to mode of action research",
pages = "39-31",
volume = "65",
doi = "10.1016/j.etap.2018.11.007"
}

Kaisarević, S., Tenji, D., Mihajlović, V., Micić, B., Francija, E., Periz-Stanacev, J., Krnić-Skiljo, B., Brkić, D.,& Teodorović, I.. (2019). Comparative analyses of cellular physiological responses of non-target species to cypermethrin and its formulated product: Contribution to mode of action research. in Environmental Toxicology and Pharmacology
Elsevier, Amsterdam., 65, 31-39.
https://doi.org/10.1016/j.etap.2018.11.007

Kaisarević S, Tenji D, Mihajlović V, Micić B, Francija E, Periz-Stanacev J, Krnić-Skiljo B, Brkić D, Teodorović I. Comparative analyses of cellular physiological responses of non-target species to cypermethrin and its formulated product: Contribution to mode of action research. in Environmental Toxicology and Pharmacology. 2019;65:31-39.
doi:10.1016/j.etap.2018.11.007 .

Kaisarević, Sonja, Tenji, Dina, Mihajlović, Varja, Micić, Bojana, Francija, Ester, Periz-Stanacev, Jelena, Krnić-Skiljo, Bojana, Brkić, Dragica, Teodorović, Ivana, "Comparative analyses of cellular physiological responses of non-target species to cypermethrin and its formulated product: Contribution to mode of action research" in Environmental Toxicology and Pharmacology, 65 (2019):31-39,
https://doi.org/10.1016/j.etap.2018.11.007 . .

TY  - JOUR
AU  - Jokić, Goran
AU  - Blazić, Tanja
AU  - Marković, Tatjana
AU  - Dedović, Suzana
AU  - Brkić, Dragica
AU  - Vuska, Marina
PY  - 2018
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4708
AB  - Several herbal products have already been confirmed to have impact on rodent diet or behaviour. Some of them, rich in terpenes, have shown repellent effects. In that context, we evaluated the repellent activity of fresh and flat baits containing two different concentrations (0.03125% and 0.0625%) of commercial Melaleuca alternifolia and Cymbopogon martinii essential oils (EO) of determined chemical composition (GC-FID and GC/MS) against house mice (Mus musculus). The repellent effects of all tested baits varied depending on mice gender, bait freshness, and content of EO in baits. Baits with the higher concentrations of M. alternifolia and C. martinii EOs had the lowest preference indexes on the 1st day of exposure of both males and females to fresh EO baits [-0.77 and -0.88 (males) and -0.62 and -0.98 (females)], respectively. Baits with the lower content of M. alternifolia EO had an index value of -0.71. Long-term repellent effects can be achieved by using the higher concentration of either of the two tested EOs, while short-term effects can be expected from the lower concentrations.
PB  - Pergamon-Elsevier Science Ltd, Oxford
T2  - Journal of Stored Products Research
T1  - Wild Mus musculus response on two different essential oils with high repellent potential
EP  - 111
SP  - 106
VL  - 79
DO  - 10.1016/j.jspr.2018.10.001
ER  - 

@article{
author = "Jokić, Goran and Blazić, Tanja and Marković, Tatjana and Dedović, Suzana and Brkić, Dragica and Vuska, Marina",
year = "2018",
abstract = "Several herbal products have already been confirmed to have impact on rodent diet or behaviour. Some of them, rich in terpenes, have shown repellent effects. In that context, we evaluated the repellent activity of fresh and flat baits containing two different concentrations (0.03125% and 0.0625%) of commercial Melaleuca alternifolia and Cymbopogon martinii essential oils (EO) of determined chemical composition (GC-FID and GC/MS) against house mice (Mus musculus). The repellent effects of all tested baits varied depending on mice gender, bait freshness, and content of EO in baits. Baits with the higher concentrations of M. alternifolia and C. martinii EOs had the lowest preference indexes on the 1st day of exposure of both males and females to fresh EO baits [-0.77 and -0.88 (males) and -0.62 and -0.98 (females)], respectively. Baits with the lower content of M. alternifolia EO had an index value of -0.71. Long-term repellent effects can be achieved by using the higher concentration of either of the two tested EOs, while short-term effects can be expected from the lower concentrations.",
publisher = "Pergamon-Elsevier Science Ltd, Oxford",
journal = "Journal of Stored Products Research",
title = "Wild Mus musculus response on two different essential oils with high repellent potential",
pages = "111-106",
volume = "79",
doi = "10.1016/j.jspr.2018.10.001"
}

Jokić, G., Blazić, T., Marković, T., Dedović, S., Brkić, D.,& Vuska, M.. (2018). Wild Mus musculus response on two different essential oils with high repellent potential. in Journal of Stored Products Research
Pergamon-Elsevier Science Ltd, Oxford., 79, 106-111.
https://doi.org/10.1016/j.jspr.2018.10.001

Jokić G, Blazić T, Marković T, Dedović S, Brkić D, Vuska M. Wild Mus musculus response on two different essential oils with high repellent potential. in Journal of Stored Products Research. 2018;79:106-111.
doi:10.1016/j.jspr.2018.10.001 .

Jokić, Goran, Blazić, Tanja, Marković, Tatjana, Dedović, Suzana, Brkić, Dragica, Vuska, Marina, "Wild Mus musculus response on two different essential oils with high repellent potential" in Journal of Stored Products Research, 79 (2018):106-111,
https://doi.org/10.1016/j.jspr.2018.10.001 . .

TY  - JOUR
AU  - Vucinić, Slavica
AU  - Antonijević, Biljana
AU  - Tsatsakis, Aristidis M.
AU  - Vassilopoulou, Loukia
AU  - Docea, Anca Oana
AU  - Nosyrev, Alexander E.
AU  - Izotov, Boris N.
AU  - Thiermann, Horst
AU  - Drakoulis, Nikolaos
AU  - Brkić, Dragica
PY  - 2017
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4411
AB  - Exposure to organophosphorus nerve agents, the most deadly chemical warfare agents, is possible in a variety of situations, such as destruction of chemical warfare agents, terrorist attacks, armed conflicts or accidents in research laboratories and storage facilities. Hundreds of thousands of tons of chemical munitions were disposed of at the sea in the post World War II period, with European, Russian, Japanese and US coasts being the most affected. Sulfur mustard, Lewisite and nerve agents appear to be the most frequently chemical warfare agents disposed of at the sea. Addressing the overall environmental risk, it has been one of the priorities of the world community since that time. Aside from confirming exposure to nerve agents in the alleged use for forensic purposes, the detection and identification of biological markers of exposure are also needed for the diagnosis and treatment of poisoning, in addition to occupational health monitoring for specific profiles of workers. When estimating detrimental effects of acute or potential chronic sub-lethal doses of organophosphorus nerve agents, released accidentally or intentionally into the environment, it is necessary to understand the wide spectra of physical, chemical and toxicological properties of these agents, and predict their ultimate fate in environmental systems.
PB  - Elsevier, Amsterdam
T2  - Environmental Toxicology and Pharmacology
T1  - Environmental exposure to organophosphorus nerve agents
EP  - 171
SP  - 163
VL  - 56
DO  - 10.1016/j.etap.2017.09.004
ER  - 

@article{
author = "Vucinić, Slavica and Antonijević, Biljana and Tsatsakis, Aristidis M. and Vassilopoulou, Loukia and Docea, Anca Oana and Nosyrev, Alexander E. and Izotov, Boris N. and Thiermann, Horst and Drakoulis, Nikolaos and Brkić, Dragica",
year = "2017",
abstract = "Exposure to organophosphorus nerve agents, the most deadly chemical warfare agents, is possible in a variety of situations, such as destruction of chemical warfare agents, terrorist attacks, armed conflicts or accidents in research laboratories and storage facilities. Hundreds of thousands of tons of chemical munitions were disposed of at the sea in the post World War II period, with European, Russian, Japanese and US coasts being the most affected. Sulfur mustard, Lewisite and nerve agents appear to be the most frequently chemical warfare agents disposed of at the sea. Addressing the overall environmental risk, it has been one of the priorities of the world community since that time. Aside from confirming exposure to nerve agents in the alleged use for forensic purposes, the detection and identification of biological markers of exposure are also needed for the diagnosis and treatment of poisoning, in addition to occupational health monitoring for specific profiles of workers. When estimating detrimental effects of acute or potential chronic sub-lethal doses of organophosphorus nerve agents, released accidentally or intentionally into the environment, it is necessary to understand the wide spectra of physical, chemical and toxicological properties of these agents, and predict their ultimate fate in environmental systems.",
publisher = "Elsevier, Amsterdam",
journal = "Environmental Toxicology and Pharmacology",
title = "Environmental exposure to organophosphorus nerve agents",
pages = "171-163",
volume = "56",
doi = "10.1016/j.etap.2017.09.004"
}

Vucinić, S., Antonijević, B., Tsatsakis, A. M., Vassilopoulou, L., Docea, A. O., Nosyrev, A. E., Izotov, B. N., Thiermann, H., Drakoulis, N.,& Brkić, D.. (2017). Environmental exposure to organophosphorus nerve agents. in Environmental Toxicology and Pharmacology
Elsevier, Amsterdam., 56, 163-171.
https://doi.org/10.1016/j.etap.2017.09.004

Vucinić S, Antonijević B, Tsatsakis AM, Vassilopoulou L, Docea AO, Nosyrev AE, Izotov BN, Thiermann H, Drakoulis N, Brkić D. Environmental exposure to organophosphorus nerve agents. in Environmental Toxicology and Pharmacology. 2017;56:163-171.
doi:10.1016/j.etap.2017.09.004 .

Vucinić, Slavica, Antonijević, Biljana, Tsatsakis, Aristidis M., Vassilopoulou, Loukia, Docea, Anca Oana, Nosyrev, Alexander E., Izotov, Boris N., Thiermann, Horst, Drakoulis, Nikolaos, Brkić, Dragica, "Environmental exposure to organophosphorus nerve agents" in Environmental Toxicology and Pharmacology, 56 (2017):163-171,
https://doi.org/10.1016/j.etap.2017.09.004 . .

TY  - JOUR
AU  - Brkić, Dragica
AU  - Szakonyne-Pasics, Ilona
AU  - Gašić, Slavica
AU  - Teodorović, Ivana
AU  - Rašković, Božidar
AU  - Brkić, Nenad
AU  - Nesković, Nesko
PY  - 2015
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3821
AB  - Subacute and subchronic toxicity of the herbicide Avalon (R), a mixture of bentazone and dicamba, were tested on rats. Avalon (R) was administered at dose levels of 250, 500 and 1000 mg/kg body weight/day for 28 and 90 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were monitored together with biochemistry parameters. The results showed that the mixture caused increases in the activities of ALT, AST and ALP, elevated concentrations of sodium, albumin and albumin/globulin ratio in males. In females, ALT activity, cholesterol and phosphate levels were increased. The changes generally were dose related and, in most cases, females exhibited lower susceptibility than males. The effects of a mixture are, in the most cases, different from the effects of the individual substances. The effects of bentazone were not prevalent which would be expected taking the composition of the mixture into account.
PB  - Elsevier, Amsterdam
T2  - Environmental Toxicology and Pharmacology
T1  - Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats
EP  - 1066
IS  - 3
SP  - 1057
VL  - 39
DO  - 10.1016/j.etap.2015.03.004
ER  - 

@article{
author = "Brkić, Dragica and Szakonyne-Pasics, Ilona and Gašić, Slavica and Teodorović, Ivana and Rašković, Božidar and Brkić, Nenad and Nesković, Nesko",
year = "2015",
abstract = "Subacute and subchronic toxicity of the herbicide Avalon (R), a mixture of bentazone and dicamba, were tested on rats. Avalon (R) was administered at dose levels of 250, 500 and 1000 mg/kg body weight/day for 28 and 90 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were monitored together with biochemistry parameters. The results showed that the mixture caused increases in the activities of ALT, AST and ALP, elevated concentrations of sodium, albumin and albumin/globulin ratio in males. In females, ALT activity, cholesterol and phosphate levels were increased. The changes generally were dose related and, in most cases, females exhibited lower susceptibility than males. The effects of a mixture are, in the most cases, different from the effects of the individual substances. The effects of bentazone were not prevalent which would be expected taking the composition of the mixture into account.",
publisher = "Elsevier, Amsterdam",
journal = "Environmental Toxicology and Pharmacology",
title = "Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats",
pages = "1066-1057",
number = "3",
volume = "39",
doi = "10.1016/j.etap.2015.03.004"
}

Brkić, D., Szakonyne-Pasics, I., Gašić, S., Teodorović, I., Rašković, B., Brkić, N.,& Nesković, N.. (2015). Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats. in Environmental Toxicology and Pharmacology
Elsevier, Amsterdam., 39(3), 1057-1066.
https://doi.org/10.1016/j.etap.2015.03.004

Brkić D, Szakonyne-Pasics I, Gašić S, Teodorović I, Rašković B, Brkić N, Nesković N. Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats. in Environmental Toxicology and Pharmacology. 2015;39(3):1057-1066.
doi:10.1016/j.etap.2015.03.004 .

Brkić, Dragica, Szakonyne-Pasics, Ilona, Gašić, Slavica, Teodorović, Ivana, Rašković, Božidar, Brkić, Nenad, Nesković, Nesko, "Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats" in Environmental Toxicology and Pharmacology, 39, no. 3 (2015):1057-1066,
https://doi.org/10.1016/j.etap.2015.03.004 . .

TY  - CHAP
AU  - Vučinić, S.
AU  - Antonijević, B.
AU  - Brkić, Dragica
PY  - 2014
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3471
AB  - Besides being a potential risk to humans and other living organisms, organophosphorus (OP) compounds also poses a risk to the environment. Production and placing pesticides on the market are under national and international legislative framework, although in many developing countries the regulation is still inadequate or not properly enforced. Occupational exposure to OPs includes any job which involves either direct or indirect contact with OP compounds, while public exposure to OPs may occur through contaminated food or from hand-to-mouth contact with contaminated surfaces, inhalation and dermal contact. The aim of this chapter is to present a comprehensive review of control and regulation measures, risk assessment methods, types and modality of occupational and environmental exposure to OPs, and ecotoxicology of these compounds. Review of the literature on OP exposure in electronic bibliographic databases, textbooks, and Internet sources was done. The acute high-dose effects of OPs are well known and include neurological dysfunction due to the inhibition of acetylcholinesterase (AChE), while effects of low-level exposure are still a matter of controversy. Advances in analytical methods help scientists to find new biomarkers of exposure and tools for biological monitoring and regulations of occupational exposure.
PB  - Springer-Verlag London Ltd
T2  - Basic and Clinical Toxicology of Organophosphorus Compounds
T1  - Occupational and environmental aspects of organophosphorus compounds
EP  - 244
SP  - 213
DO  - 10.1007/978-1-4471-5625-3_8
ER  - 

@inbook{
author = "Vučinić, S. and Antonijević, B. and Brkić, Dragica",
year = "2014",
abstract = "Besides being a potential risk to humans and other living organisms, organophosphorus (OP) compounds also poses a risk to the environment. Production and placing pesticides on the market are under national and international legislative framework, although in many developing countries the regulation is still inadequate or not properly enforced. Occupational exposure to OPs includes any job which involves either direct or indirect contact with OP compounds, while public exposure to OPs may occur through contaminated food or from hand-to-mouth contact with contaminated surfaces, inhalation and dermal contact. The aim of this chapter is to present a comprehensive review of control and regulation measures, risk assessment methods, types and modality of occupational and environmental exposure to OPs, and ecotoxicology of these compounds. Review of the literature on OP exposure in electronic bibliographic databases, textbooks, and Internet sources was done. The acute high-dose effects of OPs are well known and include neurological dysfunction due to the inhibition of acetylcholinesterase (AChE), while effects of low-level exposure are still a matter of controversy. Advances in analytical methods help scientists to find new biomarkers of exposure and tools for biological monitoring and regulations of occupational exposure.",
publisher = "Springer-Verlag London Ltd",
journal = "Basic and Clinical Toxicology of Organophosphorus Compounds",
booktitle = "Occupational and environmental aspects of organophosphorus compounds",
pages = "244-213",
doi = "10.1007/978-1-4471-5625-3_8"
}

Vučinić, S., Antonijević, B.,& Brkić, D.. (2014). Occupational and environmental aspects of organophosphorus compounds. in Basic and Clinical Toxicology of Organophosphorus Compounds
Springer-Verlag London Ltd., 213-244.
https://doi.org/10.1007/978-1-4471-5625-3_8

Vučinić S, Antonijević B, Brkić D. Occupational and environmental aspects of organophosphorus compounds. in Basic and Clinical Toxicology of Organophosphorus Compounds. 2014;:213-244.
doi:10.1007/978-1-4471-5625-3_8 .

Vučinić, S., Antonijević, B., Brkić, Dragica, "Occupational and environmental aspects of organophosphorus compounds" in Basic and Clinical Toxicology of Organophosphorus Compounds (2014):213-244,
https://doi.org/10.1007/978-1-4471-5625-3_8 . .

TY  - CONF
AU  - Brkić, Dragica
AU  - Gašić, Slavica
AU  - Radivojević, Ljiljana
AU  - Szakonyne-Pasics, I.
AU  - Karan, Vesela
AU  - Nešković, Neško
PY  - 2011
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2669
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Avalon (R) (bentazon plus dicamba) herbicide: Subchronic toxicity to rats
EP  - S229
SP  - S228
VL  - 205
DO  - 10.1016/j.toxlet.2011.05.782
ER  - 

@conference{
author = "Brkić, Dragica and Gašić, Slavica and Radivojević, Ljiljana and Szakonyne-Pasics, I. and Karan, Vesela and Nešković, Neško",
year = "2011",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Avalon (R) (bentazon plus dicamba) herbicide: Subchronic toxicity to rats",
pages = "S229-S228",
volume = "205",
doi = "10.1016/j.toxlet.2011.05.782"
}

Brkić, D., Gašić, S., Radivojević, L., Szakonyne-Pasics, I., Karan, V.,& Nešković, N.. (2011). Avalon (R) (bentazon plus dicamba) herbicide: Subchronic toxicity to rats. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 205, S228-S229.
https://doi.org/10.1016/j.toxlet.2011.05.782

Brkić D, Gašić S, Radivojević L, Szakonyne-Pasics I, Karan V, Nešković N. Avalon (R) (bentazon plus dicamba) herbicide: Subchronic toxicity to rats. in Toxicology Letters. 2011;205:S228-S229.
doi:10.1016/j.toxlet.2011.05.782 .

Brkić, Dragica, Gašić, Slavica, Radivojević, Ljiljana, Szakonyne-Pasics, I., Karan, Vesela, Nešković, Neško, "Avalon (R) (bentazon plus dicamba) herbicide: Subchronic toxicity to rats" in Toxicology Letters, 205 (2011):S228-S229,
https://doi.org/10.1016/j.toxlet.2011.05.782 . .

TY  - JOUR
AU  - Brkić, Dragica
AU  - Szakonyne-Pasics, Ilona
AU  - Gašić, Slavica
AU  - Karan, Vesela
AU  - Radivojević, Ljiljana
AU  - Nešković, Neško
PY  - 2011
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2533
AB  - Hematological effects of the herbicide Avalon (GAL-57), a mixture of bentazon and dicamba, were tested on rats. Avalon was administered by gavage at three and four dose levels (250, 500, 1000 and 1250 mg/kg weight/day) for 28 and 90 days. Hematological parameters, number of erythrocytes, leukocytes and platelets, hemoglobin concentration, hematocrit and erythrocyte indexes (MCV, MCH and MCHC) were monitored. The results showed that the herbicide Avalon caused decrease in the values of hemoglobin, hematocrit and erythrocyte indexes (both males and females). The changes (mostly) correlated with the doses administered and, in most cases, a lower susceptibility of females than males was observed. The herbicide GAL-57 had no adverse effect on the number of leukocytes, erythrocytes and thrombocytes (both sexes, all doses tested). The results showed that the herbicide Avalon causes weak anemia to the animals tested. Reversibility was apparent during the recovery period of 28 days.
AB  - U radu su ispitivani hematološki efekti herbicida Avalon (GAL-57), koji je mešavina bentazona i dikambe kao aktivnih materija, na pacovima. Preparat je doziran oralnim putem (sondom u želudac) u više nivoa doza (250, 500, 1000 i 1250 mg/kg/telesne mase/dan) tokom 28 i 90 dana. Praćeni su sledeći pokazatelji: broj eritrocita, leukocita i trombocita, koncentracija hemoglobina, hematokrit i eritrocitni indeksi (prosečna zapremina eritrocita, srednja vrednost hemoglobina po eritrocitu i prosečna koncentracija hemoglobina u eritrocitima). Rezultati ovih ispitivanja su pokazali da herbicid Avalon kod oba pola izaziva smanjenje vrednosti hemoglobina, hematokrita i eritrocitnih indeksa, dok kod drugih ispitivanih pokazatelja (broj leukocita, eritrocita i trombocita) nisu registrovane promene u odnosu na kontrolu. Sve promene su, najčešće, u korelaciji sa primenjenim dozama a uočena je, u najvećem broju slučajeva, i nešto manja osetljivost ženki u odnosu na mužjake. Rezultati ispitivanja su, takođe, pokazali da Avalon izaziva blagu anemiju kod ispitivanih životinja s tim da je efekat reverzibilnog karaktera; nakon isteka perioda oporavka od 28 dana vrednosti za sve ispitivane parametre se vraćaju na normalu i ne razlikuju se značajnije u odnosu na kontrolu.
PB  - Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd
T2  - Pesticidi i fitomedicina
T1  - Hematological effects of herbicide Avalon® (bentazon+dicamba) in rats
T1  - Hematološki efekti herbicida Avalon® (bentazon+dikamba) za pacova
EP  - 407
IS  - 4
SP  - 401
VL  - 26
DO  - 10.2298/PIF1104401B
ER  - 

@article{
author = "Brkić, Dragica and Szakonyne-Pasics, Ilona and Gašić, Slavica and Karan, Vesela and Radivojević, Ljiljana and Nešković, Neško",
year = "2011",
abstract = "Hematological effects of the herbicide Avalon (GAL-57), a mixture of bentazon and dicamba, were tested on rats. Avalon was administered by gavage at three and four dose levels (250, 500, 1000 and 1250 mg/kg weight/day) for 28 and 90 days. Hematological parameters, number of erythrocytes, leukocytes and platelets, hemoglobin concentration, hematocrit and erythrocyte indexes (MCV, MCH and MCHC) were monitored. The results showed that the herbicide Avalon caused decrease in the values of hemoglobin, hematocrit and erythrocyte indexes (both males and females). The changes (mostly) correlated with the doses administered and, in most cases, a lower susceptibility of females than males was observed. The herbicide GAL-57 had no adverse effect on the number of leukocytes, erythrocytes and thrombocytes (both sexes, all doses tested). The results showed that the herbicide Avalon causes weak anemia to the animals tested. Reversibility was apparent during the recovery period of 28 days., U radu su ispitivani hematološki efekti herbicida Avalon (GAL-57), koji je mešavina bentazona i dikambe kao aktivnih materija, na pacovima. Preparat je doziran oralnim putem (sondom u želudac) u više nivoa doza (250, 500, 1000 i 1250 mg/kg/telesne mase/dan) tokom 28 i 90 dana. Praćeni su sledeći pokazatelji: broj eritrocita, leukocita i trombocita, koncentracija hemoglobina, hematokrit i eritrocitni indeksi (prosečna zapremina eritrocita, srednja vrednost hemoglobina po eritrocitu i prosečna koncentracija hemoglobina u eritrocitima). Rezultati ovih ispitivanja su pokazali da herbicid Avalon kod oba pola izaziva smanjenje vrednosti hemoglobina, hematokrita i eritrocitnih indeksa, dok kod drugih ispitivanih pokazatelja (broj leukocita, eritrocita i trombocita) nisu registrovane promene u odnosu na kontrolu. Sve promene su, najčešće, u korelaciji sa primenjenim dozama a uočena je, u najvećem broju slučajeva, i nešto manja osetljivost ženki u odnosu na mužjake. Rezultati ispitivanja su, takođe, pokazali da Avalon izaziva blagu anemiju kod ispitivanih životinja s tim da je efekat reverzibilnog karaktera; nakon isteka perioda oporavka od 28 dana vrednosti za sve ispitivane parametre se vraćaju na normalu i ne razlikuju se značajnije u odnosu na kontrolu.",
publisher = "Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd",
journal = "Pesticidi i fitomedicina",
title = "Hematological effects of herbicide Avalon® (bentazon+dicamba) in rats, Hematološki efekti herbicida Avalon® (bentazon+dikamba) za pacova",
pages = "407-401",
number = "4",
volume = "26",
doi = "10.2298/PIF1104401B"
}

Brkić, D., Szakonyne-Pasics, I., Gašić, S., Karan, V., Radivojević, L.,& Nešković, N.. (2011). Hematological effects of herbicide Avalon® (bentazon+dicamba) in rats. in Pesticidi i fitomedicina
Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd., 26(4), 401-407.
https://doi.org/10.2298/PIF1104401B

Brkić D, Szakonyne-Pasics I, Gašić S, Karan V, Radivojević L, Nešković N. Hematological effects of herbicide Avalon® (bentazon+dicamba) in rats. in Pesticidi i fitomedicina. 2011;26(4):401-407.
doi:10.2298/PIF1104401B .

Brkić, Dragica, Szakonyne-Pasics, Ilona, Gašić, Slavica, Karan, Vesela, Radivojević, Ljiljana, Nešković, Neško, "Hematological effects of herbicide Avalon® (bentazon+dicamba) in rats" in Pesticidi i fitomedicina, 26, no. 4 (2011):401-407,
https://doi.org/10.2298/PIF1104401B . .

TY  - JOUR
AU  - Kostić, Miroslav
AU  - Popović, Zorica
AU  - Brkić, Dragica
AU  - Milanović, Slobodan
AU  - Sivčev, Ivan
AU  - Stanković, Sladjan
PY  - 2008
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1835
AB  - Ethanol solutions of essential oil of Ocimum basilicum and its main component, linalool (both isomer forms), all in three concentrations, as well as botanical standard Bioneem (0.5%), were tested for their toxicity and antifeedant activity against the second instar gypsy moth larvae in the laboratory bioassay. The essential oil of O. basilicum was subjected to gas chromatography analysis, and totally 37 compounds were detected, of which linalool was predominantly present. All tested solutions showed low to moderate larvicidal effect in both residual toxicity test and in chronic larval mortality bioassay. Chronic mortality tests showed that obtained mortality was a consequence of starving rather than ingestion of treated leaves. However, antifeedant index achieved by application of tested solutions in feeding choice assay was remarkable. Foliar application of all tested compounds deterred feeding by L2 in the same percent as Bioneem. Antifeedant index was relatively high at all tested treatments (85-94%); moreover, the larval desensitization to repelling volatiles has not occurred after five days of observation. Low toxic and high antifeedant properties make these plant-derived compounds suitable for incorporation in integrated pest management programs, especially in urban environments.
PB  - Elsevier Sci Ltd, Oxford
T2  - Bioresource Technology
T1  - Larvicidal and antifeedant activity of some plant-derived compounds to Lymantria dispar L. (Lepidoptera : Limantriidae)
EP  - 7901
IS  - 16
SP  - 7897
VL  - 99
DO  - 10.1016/j.biortech.2008.02.010
ER  - 

@article{
author = "Kostić, Miroslav and Popović, Zorica and Brkić, Dragica and Milanović, Slobodan and Sivčev, Ivan and Stanković, Sladjan",
year = "2008",
abstract = "Ethanol solutions of essential oil of Ocimum basilicum and its main component, linalool (both isomer forms), all in three concentrations, as well as botanical standard Bioneem (0.5%), were tested for their toxicity and antifeedant activity against the second instar gypsy moth larvae in the laboratory bioassay. The essential oil of O. basilicum was subjected to gas chromatography analysis, and totally 37 compounds were detected, of which linalool was predominantly present. All tested solutions showed low to moderate larvicidal effect in both residual toxicity test and in chronic larval mortality bioassay. Chronic mortality tests showed that obtained mortality was a consequence of starving rather than ingestion of treated leaves. However, antifeedant index achieved by application of tested solutions in feeding choice assay was remarkable. Foliar application of all tested compounds deterred feeding by L2 in the same percent as Bioneem. Antifeedant index was relatively high at all tested treatments (85-94%); moreover, the larval desensitization to repelling volatiles has not occurred after five days of observation. Low toxic and high antifeedant properties make these plant-derived compounds suitable for incorporation in integrated pest management programs, especially in urban environments.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Bioresource Technology",
title = "Larvicidal and antifeedant activity of some plant-derived compounds to Lymantria dispar L. (Lepidoptera : Limantriidae)",
pages = "7901-7897",
number = "16",
volume = "99",
doi = "10.1016/j.biortech.2008.02.010"
}

Kostić, M., Popović, Z., Brkić, D., Milanović, S., Sivčev, I.,& Stanković, S.. (2008). Larvicidal and antifeedant activity of some plant-derived compounds to Lymantria dispar L. (Lepidoptera : Limantriidae). in Bioresource Technology
Elsevier Sci Ltd, Oxford., 99(16), 7897-7901.
https://doi.org/10.1016/j.biortech.2008.02.010

Kostić M, Popović Z, Brkić D, Milanović S, Sivčev I, Stanković S. Larvicidal and antifeedant activity of some plant-derived compounds to Lymantria dispar L. (Lepidoptera : Limantriidae). in Bioresource Technology. 2008;99(16):7897-7901.
doi:10.1016/j.biortech.2008.02.010 .

Kostić, Miroslav, Popović, Zorica, Brkić, Dragica, Milanović, Slobodan, Sivčev, Ivan, Stanković, Sladjan, "Larvicidal and antifeedant activity of some plant-derived compounds to Lymantria dispar L. (Lepidoptera : Limantriidae)" in Bioresource Technology, 99, no. 16 (2008):7897-7901,
https://doi.org/10.1016/j.biortech.2008.02.010 . .

TY  - JOUR
AU  - Brkić, Dragica
AU  - Vitorović, Slavoljub Lj.
AU  - Gašić, Slavica
AU  - Nešković, Neško
PY  - 2008
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1793
AB  - Carbofuran toxicity on rats was studied during subchronic exposure. Female and male rats were administered carbofuran in drinking water in concentrations of 25, 100 and 400ppm for a period of 90 days. Clinical symptoms, water consumption, body weight gain, organ weight, pathological and histopathological changes in the liver and kidneys were observed and biochemical and haematological examinations were carried out. The results obtained show that carbofuran administered to rats caused a significant decrease in water consumption as well as in brain, serum and erythrocyte cholinesterase activities. Statistically significant increases in relation to the control were found in the serum enzyme activities. The haematological data showed that carbofuran had no significant effect on Hb concentration and total RBC, but total WBC showed a significant statistical decrease. The histopathological changes in liver and kidneys were observed. However, cell regeneration in the liver and kidneys was found in all test groups.
PB  - Elsevier Science Bv, Amsterdam
T2  - Environmental Toxicology and Pharmacology
T1  - Carbofuran in water: Subchronic toxicity to rats
EP  - 341
IS  - 3
SP  - 334
VL  - 25
DO  - 10.1016/j.etap.2007.11.002
ER  - 

@article{
author = "Brkić, Dragica and Vitorović, Slavoljub Lj. and Gašić, Slavica and Nešković, Neško",
year = "2008",
abstract = "Carbofuran toxicity on rats was studied during subchronic exposure. Female and male rats were administered carbofuran in drinking water in concentrations of 25, 100 and 400ppm for a period of 90 days. Clinical symptoms, water consumption, body weight gain, organ weight, pathological and histopathological changes in the liver and kidneys were observed and biochemical and haematological examinations were carried out. The results obtained show that carbofuran administered to rats caused a significant decrease in water consumption as well as in brain, serum and erythrocyte cholinesterase activities. Statistically significant increases in relation to the control were found in the serum enzyme activities. The haematological data showed that carbofuran had no significant effect on Hb concentration and total RBC, but total WBC showed a significant statistical decrease. The histopathological changes in liver and kidneys were observed. However, cell regeneration in the liver and kidneys was found in all test groups.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "Environmental Toxicology and Pharmacology",
title = "Carbofuran in water: Subchronic toxicity to rats",
pages = "341-334",
number = "3",
volume = "25",
doi = "10.1016/j.etap.2007.11.002"
}

Brkić, D., Vitorović, S. Lj., Gašić, S.,& Nešković, N.. (2008). Carbofuran in water: Subchronic toxicity to rats. in Environmental Toxicology and Pharmacology
Elsevier Science Bv, Amsterdam., 25(3), 334-341.
https://doi.org/10.1016/j.etap.2007.11.002

Brkić D, Vitorović SL, Gašić S, Nešković N. Carbofuran in water: Subchronic toxicity to rats. in Environmental Toxicology and Pharmacology. 2008;25(3):334-341.
doi:10.1016/j.etap.2007.11.002 .

Brkić, Dragica, Vitorović, Slavoljub Lj., Gašić, Slavica, Nešković, Neško, "Carbofuran in water: Subchronic toxicity to rats" in Environmental Toxicology and Pharmacology, 25, no. 3 (2008):334-341,
https://doi.org/10.1016/j.etap.2007.11.002 . .

TY  - JOUR
AU  - Brkić, Dragica
AU  - Gašić, Slavica
AU  - Béres, Erzsébet
AU  - Pápai, Enikő
AU  - Karan, Vesela
AU  - Nešković, Neško
PY  - 2007
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1478
AB  - A micronucleus test was run to investigate mutagenic potential of the herbicide GAL-57, a formulated mixture of bentazone and dicamba. The test was applied to mice of both sexes (strain: CRL: NMRI BR) and the herbicide (product) was administered by gavage at 2000 mg/kg rate, twice within 24 hs. Cyclophosphamide (positive control) was administered at 60 mg/kg, while distilled water as a solvent was negative control. The animals were sacrificed 24 hrs after second treatment, their bone marrow cells isolated from femur, and effects evaluated. The data acquired showed that repeated treatment of mice with GAL-57 caused neither biological nor significant statistical increase in the number of micronuclei in treated animals. At the same time, the number of micronucleated polychromatic erythrocytes in the bone marrow of animals treated with cyclophosphamide (positive control) showed a significant statistical increase. The results suggest that the herbicide product tested did not show any mutagenic activity under the conditions of mouse micronucleus test.
AB  - Mutageni potencijal herbicida GAL-57, koji je formulisan kao mešavina bentazona i dikambe, ispitivan je primenom mikronukleus testa. Ispitivanja su rađena na miševima oba pola (soj: CRL: NMRI BR), a ispitivani herbicid (preparat) je doziran oralno (sondom u želudac) u dozi od 2000 mg/kg, dva puta u razmaku od 24 sata. Kao pozitivna kontrola korišćen je ciklofosfamid (60 mg/kg), a kao negativna rastvarač (destilovana voda). Životinje su žrtvovane 24 sata nakon drugog tretiranja, izolovane su ćelije koštane srži (iz femura) i ocenjivan je efekat supstancije. Dobijeni rezultati su pokazali da ponovljen tretman miševa herbicidom GAL-57 ne izaziva ni biološki ni statistički značajno povećanje broja mikronukleusa kod tretiranih životinja. Istovremeno, kod životinja tretiranih ciklofosfamidom (pozitivna kontrola) broj mikronukleusa u polihromatskim eritrocitima koštane srži miševa bio je statistički značajno povećan. Na osnovu ovih rezultata može se zaključiti da ispitivani herbicid (preparat), u uslovima mikronukleus testa, ne ispoljava mutagena svojstva.
PB  - Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd
T2  - Pesticidi i fitomedicina
T1  - Examination of mutagenic effects of GAL-57 herbicide (bentazone+dicamba) using mouse micronucleus test
T1  - Ispitivanja mutagenih svojstava herbicida GAL-57 (bentazon + dikamba) primenom mikronukleus testa
EP  - 260
IS  - 3
SP  - 255
VL  - 22
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_1478
ER  - 

@article{
author = "Brkić, Dragica and Gašić, Slavica and Béres, Erzsébet and Pápai, Enikő and Karan, Vesela and Nešković, Neško",
year = "2007",
abstract = "A micronucleus test was run to investigate mutagenic potential of the herbicide GAL-57, a formulated mixture of bentazone and dicamba. The test was applied to mice of both sexes (strain: CRL: NMRI BR) and the herbicide (product) was administered by gavage at 2000 mg/kg rate, twice within 24 hs. Cyclophosphamide (positive control) was administered at 60 mg/kg, while distilled water as a solvent was negative control. The animals were sacrificed 24 hrs after second treatment, their bone marrow cells isolated from femur, and effects evaluated. The data acquired showed that repeated treatment of mice with GAL-57 caused neither biological nor significant statistical increase in the number of micronuclei in treated animals. At the same time, the number of micronucleated polychromatic erythrocytes in the bone marrow of animals treated with cyclophosphamide (positive control) showed a significant statistical increase. The results suggest that the herbicide product tested did not show any mutagenic activity under the conditions of mouse micronucleus test., Mutageni potencijal herbicida GAL-57, koji je formulisan kao mešavina bentazona i dikambe, ispitivan je primenom mikronukleus testa. Ispitivanja su rađena na miševima oba pola (soj: CRL: NMRI BR), a ispitivani herbicid (preparat) je doziran oralno (sondom u želudac) u dozi od 2000 mg/kg, dva puta u razmaku od 24 sata. Kao pozitivna kontrola korišćen je ciklofosfamid (60 mg/kg), a kao negativna rastvarač (destilovana voda). Životinje su žrtvovane 24 sata nakon drugog tretiranja, izolovane su ćelije koštane srži (iz femura) i ocenjivan je efekat supstancije. Dobijeni rezultati su pokazali da ponovljen tretman miševa herbicidom GAL-57 ne izaziva ni biološki ni statistički značajno povećanje broja mikronukleusa kod tretiranih životinja. Istovremeno, kod životinja tretiranih ciklofosfamidom (pozitivna kontrola) broj mikronukleusa u polihromatskim eritrocitima koštane srži miševa bio je statistički značajno povećan. Na osnovu ovih rezultata može se zaključiti da ispitivani herbicid (preparat), u uslovima mikronukleus testa, ne ispoljava mutagena svojstva.",
publisher = "Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd",
journal = "Pesticidi i fitomedicina",
title = "Examination of mutagenic effects of GAL-57 herbicide (bentazone+dicamba) using mouse micronucleus test, Ispitivanja mutagenih svojstava herbicida GAL-57 (bentazon + dikamba) primenom mikronukleus testa",
pages = "260-255",
number = "3",
volume = "22",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_1478"
}

Brkić, D., Gašić, S., Béres, E., Pápai, E., Karan, V.,& Nešković, N.. (2007). Examination of mutagenic effects of GAL-57 herbicide (bentazone+dicamba) using mouse micronucleus test. in Pesticidi i fitomedicina
Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd., 22(3), 255-260.
https://hdl.handle.net/21.15107/rcub_agrospace_1478

Brkić D, Gašić S, Béres E, Pápai E, Karan V, Nešković N. Examination of mutagenic effects of GAL-57 herbicide (bentazone+dicamba) using mouse micronucleus test. in Pesticidi i fitomedicina. 2007;22(3):255-260.
https://hdl.handle.net/21.15107/rcub_agrospace_1478 .

Brkić, Dragica, Gašić, Slavica, Béres, Erzsébet, Pápai, Enikő, Karan, Vesela, Nešković, Neško, "Examination of mutagenic effects of GAL-57 herbicide (bentazone+dicamba) using mouse micronucleus test" in Pesticidi i fitomedicina, 22, no. 3 (2007):255-260,
https://hdl.handle.net/21.15107/rcub_agrospace_1478 .

TY  - JOUR
AU  - Brkić, Dragica
AU  - Gašić, Slavica
AU  - Vértesi, Adél
AU  - Karan, Vesela
AU  - Nešković, Neško
PY  - 2006
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1190
AB  - Genotoxicity of the herbicide GAL-57, containing two active ingredients, bentazon and dicamba, was investigated using the Ames test. Salmonella typhimurium (tester strains TA98 and TA100) and Escherichia coli (strain WP2uvrA) were used. Nine product concentrations were tested at a range of 19.53-5000 μg/plate and each concentration, as well as the controls, in triplicate. Testing was done with and without metabolic activation (liver microsomal fraction, S-9 mix). The results of our investigation revealed no biological or statistically significant increase in mutagenic factors, and this offered a basis for our conclusion that the herbicide GAL-57 has no genotoxic properties (with or without metabolic activation) under experimental conditions in the Ames test.
AB  - Genotoksična svojstva herbicida GAL-57, koji u svom sastavu ima dve aktivne materije, bentazon i dikambu, ispitivana su primenom Ames-ovog testa. Korišćene su bakterije Salmonella typhimurium (sojevi TA98 i TA100) i Escherichia coli (WP2uvrA soj). Ispitivano je devet koncentracija preparata u opsegu 19.53-5000 μg/ploča pri čemu je svaka koncentracija, kao i kontrole, testirana po tri puta. Ispitivanje je obavljeno sa i bez metaboličke aktivacije (mikrozomska frakcija jetre, S-9 mix). Rezultati ispitivanja su pokazali da nema ni biološki ni statistički značajnog povećanja faktora mutacije na osnovu čega se zaključuje da herbicid GAL-57, u eksperimentalnim uslovima Ames-ovog testa, ne poseduje genotoksična svojstva (sa i bez metaboličke aktivacije).
PB  - Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd
T2  - Pesticidi i fitomedicina
T1  - Genotoxicity of GAL-57 herbicide in Salmonella typhimurium and Escherichia coli
T1  - Ispitivanja genotoksičnosti herbicida GAL-57 na Salmonella typhimurium i Escherichia coli
EP  - 323
IS  - 4
SP  - 317
VL  - 21
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_1190
ER  - 

@article{
author = "Brkić, Dragica and Gašić, Slavica and Vértesi, Adél and Karan, Vesela and Nešković, Neško",
year = "2006",
abstract = "Genotoxicity of the herbicide GAL-57, containing two active ingredients, bentazon and dicamba, was investigated using the Ames test. Salmonella typhimurium (tester strains TA98 and TA100) and Escherichia coli (strain WP2uvrA) were used. Nine product concentrations were tested at a range of 19.53-5000 μg/plate and each concentration, as well as the controls, in triplicate. Testing was done with and without metabolic activation (liver microsomal fraction, S-9 mix). The results of our investigation revealed no biological or statistically significant increase in mutagenic factors, and this offered a basis for our conclusion that the herbicide GAL-57 has no genotoxic properties (with or without metabolic activation) under experimental conditions in the Ames test., Genotoksična svojstva herbicida GAL-57, koji u svom sastavu ima dve aktivne materije, bentazon i dikambu, ispitivana su primenom Ames-ovog testa. Korišćene su bakterije Salmonella typhimurium (sojevi TA98 i TA100) i Escherichia coli (WP2uvrA soj). Ispitivano je devet koncentracija preparata u opsegu 19.53-5000 μg/ploča pri čemu je svaka koncentracija, kao i kontrole, testirana po tri puta. Ispitivanje je obavljeno sa i bez metaboličke aktivacije (mikrozomska frakcija jetre, S-9 mix). Rezultati ispitivanja su pokazali da nema ni biološki ni statistički značajnog povećanja faktora mutacije na osnovu čega se zaključuje da herbicid GAL-57, u eksperimentalnim uslovima Ames-ovog testa, ne poseduje genotoksična svojstva (sa i bez metaboličke aktivacije).",
publisher = "Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd",
journal = "Pesticidi i fitomedicina",
title = "Genotoxicity of GAL-57 herbicide in Salmonella typhimurium and Escherichia coli, Ispitivanja genotoksičnosti herbicida GAL-57 na Salmonella typhimurium i Escherichia coli",
pages = "323-317",
number = "4",
volume = "21",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_1190"
}

Brkić, D., Gašić, S., Vértesi, A., Karan, V.,& Nešković, N.. (2006). Genotoxicity of GAL-57 herbicide in Salmonella typhimurium and Escherichia coli. in Pesticidi i fitomedicina
Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd., 21(4), 317-323.
https://hdl.handle.net/21.15107/rcub_agrospace_1190

Brkić D, Gašić S, Vértesi A, Karan V, Nešković N. Genotoxicity of GAL-57 herbicide in Salmonella typhimurium and Escherichia coli. in Pesticidi i fitomedicina. 2006;21(4):317-323.
https://hdl.handle.net/21.15107/rcub_agrospace_1190 .

Brkić, Dragica, Gašić, Slavica, Vértesi, Adél, Karan, Vesela, Nešković, Neško, "Genotoxicity of GAL-57 herbicide in Salmonella typhimurium and Escherichia coli" in Pesticidi i fitomedicina, 21, no. 4 (2006):317-323,
https://hdl.handle.net/21.15107/rcub_agrospace_1190 .