TY  - JOUR
AU  - Brkić, Dragica
AU  - Szakonyne-Pasics, Ilona
AU  - Gašić, Slavica
AU  - Teodorović, Ivana
AU  - Rašković, Božidar
AU  - Brkić, Nenad
AU  - Nesković, Nesko
PY  - 2015
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3821
AB  - Subacute and subchronic toxicity of the herbicide Avalon (R), a mixture of bentazone and dicamba, were tested on rats. Avalon (R) was administered at dose levels of 250, 500 and 1000 mg/kg body weight/day for 28 and 90 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were monitored together with biochemistry parameters. The results showed that the mixture caused increases in the activities of ALT, AST and ALP, elevated concentrations of sodium, albumin and albumin/globulin ratio in males. In females, ALT activity, cholesterol and phosphate levels were increased. The changes generally were dose related and, in most cases, females exhibited lower susceptibility than males. The effects of a mixture are, in the most cases, different from the effects of the individual substances. The effects of bentazone were not prevalent which would be expected taking the composition of the mixture into account.
PB  - Elsevier, Amsterdam
T2  - Environmental Toxicology and Pharmacology
T1  - Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats
EP  - 1066
IS  - 3
SP  - 1057
VL  - 39
DO  - 10.1016/j.etap.2015.03.004
ER  - 

@article{
author = "Brkić, Dragica and Szakonyne-Pasics, Ilona and Gašić, Slavica and Teodorović, Ivana and Rašković, Božidar and Brkić, Nenad and Nesković, Nesko",
year = "2015",
abstract = "Subacute and subchronic toxicity of the herbicide Avalon (R), a mixture of bentazone and dicamba, were tested on rats. Avalon (R) was administered at dose levels of 250, 500 and 1000 mg/kg body weight/day for 28 and 90 days. Alanine aminotransferase (ALT), aspartate aminotransferase (AST) and alkaline phosphatase (ALP) activities were monitored together with biochemistry parameters. The results showed that the mixture caused increases in the activities of ALT, AST and ALP, elevated concentrations of sodium, albumin and albumin/globulin ratio in males. In females, ALT activity, cholesterol and phosphate levels were increased. The changes generally were dose related and, in most cases, females exhibited lower susceptibility than males. The effects of a mixture are, in the most cases, different from the effects of the individual substances. The effects of bentazone were not prevalent which would be expected taking the composition of the mixture into account.",
publisher = "Elsevier, Amsterdam",
journal = "Environmental Toxicology and Pharmacology",
title = "Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats",
pages = "1066-1057",
number = "3",
volume = "39",
doi = "10.1016/j.etap.2015.03.004"
}

Brkić, D., Szakonyne-Pasics, I., Gašić, S., Teodorović, I., Rašković, B., Brkić, N.,& Nesković, N.. (2015). Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats. in Environmental Toxicology and Pharmacology
Elsevier, Amsterdam., 39(3), 1057-1066.
https://doi.org/10.1016/j.etap.2015.03.004

Brkić D, Szakonyne-Pasics I, Gašić S, Teodorović I, Rašković B, Brkić N, Nesković N. Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats. in Environmental Toxicology and Pharmacology. 2015;39(3):1057-1066.
doi:10.1016/j.etap.2015.03.004 .

Brkić, Dragica, Szakonyne-Pasics, Ilona, Gašić, Slavica, Teodorović, Ivana, Rašković, Božidar, Brkić, Nenad, Nesković, Nesko, "Subacute and subchronic toxicity of Avalon (R) mixture (bentazone plus dicamba) to rats" in Environmental Toxicology and Pharmacology, 39, no. 3 (2015):1057-1066,
https://doi.org/10.1016/j.etap.2015.03.004 . .

TY  - JOUR
AU  - Brkić, Dragica
AU  - Szakonyne-Pasics, Ilona
AU  - Gašić, Slavica
AU  - Karan, Vesela
AU  - Radivojević, Ljiljana
AU  - Nešković, Neško
PY  - 2011
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2533
AB  - Hematological effects of the herbicide Avalon (GAL-57), a mixture of bentazon and dicamba, were tested on rats. Avalon was administered by gavage at three and four dose levels (250, 500, 1000 and 1250 mg/kg weight/day) for 28 and 90 days. Hematological parameters, number of erythrocytes, leukocytes and platelets, hemoglobin concentration, hematocrit and erythrocyte indexes (MCV, MCH and MCHC) were monitored. The results showed that the herbicide Avalon caused decrease in the values of hemoglobin, hematocrit and erythrocyte indexes (both males and females). The changes (mostly) correlated with the doses administered and, in most cases, a lower susceptibility of females than males was observed. The herbicide GAL-57 had no adverse effect on the number of leukocytes, erythrocytes and thrombocytes (both sexes, all doses tested). The results showed that the herbicide Avalon causes weak anemia to the animals tested. Reversibility was apparent during the recovery period of 28 days.
AB  - U radu su ispitivani hematološki efekti herbicida Avalon (GAL-57), koji je mešavina bentazona i dikambe kao aktivnih materija, na pacovima. Preparat je doziran oralnim putem (sondom u želudac) u više nivoa doza (250, 500, 1000 i 1250 mg/kg/telesne mase/dan) tokom 28 i 90 dana. Praćeni su sledeći pokazatelji: broj eritrocita, leukocita i trombocita, koncentracija hemoglobina, hematokrit i eritrocitni indeksi (prosečna zapremina eritrocita, srednja vrednost hemoglobina po eritrocitu i prosečna koncentracija hemoglobina u eritrocitima). Rezultati ovih ispitivanja su pokazali da herbicid Avalon kod oba pola izaziva smanjenje vrednosti hemoglobina, hematokrita i eritrocitnih indeksa, dok kod drugih ispitivanih pokazatelja (broj leukocita, eritrocita i trombocita) nisu registrovane promene u odnosu na kontrolu. Sve promene su, najčešće, u korelaciji sa primenjenim dozama a uočena je, u najvećem broju slučajeva, i nešto manja osetljivost ženki u odnosu na mužjake. Rezultati ispitivanja su, takođe, pokazali da Avalon izaziva blagu anemiju kod ispitivanih životinja s tim da je efekat reverzibilnog karaktera; nakon isteka perioda oporavka od 28 dana vrednosti za sve ispitivane parametre se vraćaju na normalu i ne razlikuju se značajnije u odnosu na kontrolu.
PB  - Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd
T2  - Pesticidi i fitomedicina
T1  - Hematological effects of herbicide Avalon® (bentazon+dicamba) in rats
T1  - Hematološki efekti herbicida Avalon® (bentazon+dikamba) za pacova
EP  - 407
IS  - 4
SP  - 401
VL  - 26
DO  - 10.2298/PIF1104401B
ER  - 

@article{
author = "Brkić, Dragica and Szakonyne-Pasics, Ilona and Gašić, Slavica and Karan, Vesela and Radivojević, Ljiljana and Nešković, Neško",
year = "2011",
abstract = "Hematological effects of the herbicide Avalon (GAL-57), a mixture of bentazon and dicamba, were tested on rats. Avalon was administered by gavage at three and four dose levels (250, 500, 1000 and 1250 mg/kg weight/day) for 28 and 90 days. Hematological parameters, number of erythrocytes, leukocytes and platelets, hemoglobin concentration, hematocrit and erythrocyte indexes (MCV, MCH and MCHC) were monitored. The results showed that the herbicide Avalon caused decrease in the values of hemoglobin, hematocrit and erythrocyte indexes (both males and females). The changes (mostly) correlated with the doses administered and, in most cases, a lower susceptibility of females than males was observed. The herbicide GAL-57 had no adverse effect on the number of leukocytes, erythrocytes and thrombocytes (both sexes, all doses tested). The results showed that the herbicide Avalon causes weak anemia to the animals tested. Reversibility was apparent during the recovery period of 28 days., U radu su ispitivani hematološki efekti herbicida Avalon (GAL-57), koji je mešavina bentazona i dikambe kao aktivnih materija, na pacovima. Preparat je doziran oralnim putem (sondom u želudac) u više nivoa doza (250, 500, 1000 i 1250 mg/kg/telesne mase/dan) tokom 28 i 90 dana. Praćeni su sledeći pokazatelji: broj eritrocita, leukocita i trombocita, koncentracija hemoglobina, hematokrit i eritrocitni indeksi (prosečna zapremina eritrocita, srednja vrednost hemoglobina po eritrocitu i prosečna koncentracija hemoglobina u eritrocitima). Rezultati ovih ispitivanja su pokazali da herbicid Avalon kod oba pola izaziva smanjenje vrednosti hemoglobina, hematokrita i eritrocitnih indeksa, dok kod drugih ispitivanih pokazatelja (broj leukocita, eritrocita i trombocita) nisu registrovane promene u odnosu na kontrolu. Sve promene su, najčešće, u korelaciji sa primenjenim dozama a uočena je, u najvećem broju slučajeva, i nešto manja osetljivost ženki u odnosu na mužjake. Rezultati ispitivanja su, takođe, pokazali da Avalon izaziva blagu anemiju kod ispitivanih životinja s tim da je efekat reverzibilnog karaktera; nakon isteka perioda oporavka od 28 dana vrednosti za sve ispitivane parametre se vraćaju na normalu i ne razlikuju se značajnije u odnosu na kontrolu.",
publisher = "Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd",
journal = "Pesticidi i fitomedicina",
title = "Hematological effects of herbicide Avalon® (bentazon+dicamba) in rats, Hematološki efekti herbicida Avalon® (bentazon+dikamba) za pacova",
pages = "407-401",
number = "4",
volume = "26",
doi = "10.2298/PIF1104401B"
}

Brkić, D., Szakonyne-Pasics, I., Gašić, S., Karan, V., Radivojević, L.,& Nešković, N.. (2011). Hematological effects of herbicide Avalon® (bentazon+dicamba) in rats. in Pesticidi i fitomedicina
Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd., 26(4), 401-407.
https://doi.org/10.2298/PIF1104401B

Brkić D, Szakonyne-Pasics I, Gašić S, Karan V, Radivojević L, Nešković N. Hematological effects of herbicide Avalon® (bentazon+dicamba) in rats. in Pesticidi i fitomedicina. 2011;26(4):401-407.
doi:10.2298/PIF1104401B .

Brkić, Dragica, Szakonyne-Pasics, Ilona, Gašić, Slavica, Karan, Vesela, Radivojević, Ljiljana, Nešković, Neško, "Hematological effects of herbicide Avalon® (bentazon+dicamba) in rats" in Pesticidi i fitomedicina, 26, no. 4 (2011):401-407,
https://doi.org/10.2298/PIF1104401B . .