TY  - JOUR
AU  - Todorović, Tamara R.
AU  - Vukasinović, Jelena
AU  - Portalone, Gustavo
AU  - Suleiman, Sherif
AU  - Gligorijević, Nevenka
AU  - Bjelogrlić, Snežana
AU  - Jovanović, Katarina
AU  - Radulović, Siniša
AU  - Andjelković, Katarina
AU  - Cassar, Analisse
AU  - Filipović, Nenad
AU  - Schembri-Wismayer, Pierre
PY  - 2017
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4388
AB  - Cobalt complexes with semi-and thiosemicarbazones of 8-quinolinecarboxaldehyde have been synthesized and characterized by X-ray diffraction analysis. These novel complexes and a previously synthesized cobalt complex with a selenium-based selenosemicarbazone ligand showed myeloid differentiation activity on all trans retinoic acid resistant HL-60 acute myeloid leukaemia cells. They also showed varying levels of cytotoxicity on five human tumor cell lines: cervix carcinoma cells (HeLa), lung adenocarcinoma cells (A549), colorectal adenocarcinoma cells (LS-174), breast carcinoma cells (MDA-MB-361), and chronic myeloid leukaemia (K562) as well as one normal human cell line: fetal lung fibroblast cells (MRC-5). Leukaemia differentiation was most strongly induced by a metal-free oxygen ligand and the selenium ligand, whilst the latter and the cobalt(II) complex with an oxygen ligand showed the strongest dose-dependent cytotoxic activity. In four out of five investigated tumor cell lines, it was of the same order of magnitude as cisplatin. These best compounds, however, had lower toxicity on non-transformed MRC-5 cells than cisplatin.
PB  - Royal Soc Chemistry, Cambridge
T2  - Medchemcomm
T1  - (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines
EP  - 111
IS  - 1
SP  - 103
VL  - 8
DO  - 10.1039/c6md00501b
ER  - 

@article{
author = "Todorović, Tamara R. and Vukasinović, Jelena and Portalone, Gustavo and Suleiman, Sherif and Gligorijević, Nevenka and Bjelogrlić, Snežana and Jovanović, Katarina and Radulović, Siniša and Andjelković, Katarina and Cassar, Analisse and Filipović, Nenad and Schembri-Wismayer, Pierre",
year = "2017",
abstract = "Cobalt complexes with semi-and thiosemicarbazones of 8-quinolinecarboxaldehyde have been synthesized and characterized by X-ray diffraction analysis. These novel complexes and a previously synthesized cobalt complex with a selenium-based selenosemicarbazone ligand showed myeloid differentiation activity on all trans retinoic acid resistant HL-60 acute myeloid leukaemia cells. They also showed varying levels of cytotoxicity on five human tumor cell lines: cervix carcinoma cells (HeLa), lung adenocarcinoma cells (A549), colorectal adenocarcinoma cells (LS-174), breast carcinoma cells (MDA-MB-361), and chronic myeloid leukaemia (K562) as well as one normal human cell line: fetal lung fibroblast cells (MRC-5). Leukaemia differentiation was most strongly induced by a metal-free oxygen ligand and the selenium ligand, whilst the latter and the cobalt(II) complex with an oxygen ligand showed the strongest dose-dependent cytotoxic activity. In four out of five investigated tumor cell lines, it was of the same order of magnitude as cisplatin. These best compounds, however, had lower toxicity on non-transformed MRC-5 cells than cisplatin.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Medchemcomm",
title = "(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines",
pages = "111-103",
number = "1",
volume = "8",
doi = "10.1039/c6md00501b"
}

Todorović, T. R., Vukasinović, J., Portalone, G., Suleiman, S., Gligorijević, N., Bjelogrlić, S., Jovanović, K., Radulović, S., Andjelković, K., Cassar, A., Filipović, N.,& Schembri-Wismayer, P.. (2017). (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines. in Medchemcomm
Royal Soc Chemistry, Cambridge., 8(1), 103-111.
https://doi.org/10.1039/c6md00501b

Todorović TR, Vukasinović J, Portalone G, Suleiman S, Gligorijević N, Bjelogrlić S, Jovanović K, Radulović S, Andjelković K, Cassar A, Filipović N, Schembri-Wismayer P. (Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines. in Medchemcomm. 2017;8(1):103-111.
doi:10.1039/c6md00501b .

Todorović, Tamara R., Vukasinović, Jelena, Portalone, Gustavo, Suleiman, Sherif, Gligorijević, Nevenka, Bjelogrlić, Snežana, Jovanović, Katarina, Radulović, Siniša, Andjelković, Katarina, Cassar, Analisse, Filipović, Nenad, Schembri-Wismayer, Pierre, "(Chalcogen)semicarbazones and their cobalt complexes differentiate HL-60 myeloid leukaemia cells and are cytotoxic towards tumor cell lines" in Medchemcomm, 8, no. 1 (2017):103-111,
https://doi.org/10.1039/c6md00501b . .

TY  - JOUR
AU  - Djordjević, Ivana S.
AU  - Vukasinović, Jelena
AU  - Todorović, Tamara R.
AU  - Filipović, Nenad
AU  - Rodić, Marko V.
AU  - Lolić, Aleksandar
AU  - Portalone, Gustavo
AU  - Zlatović, Mario
AU  - Grubisić, Sonja
PY  - 2017
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4462
AB  - Cobalt(III) complexes derived from thio-and selenosemicarbazone ligands have been studied to elucidate the nature and consequences of S to Se substitution on their possible biological activity. Solid state structures of cobalt(III) complexes with bis-tridentate coordinated 2-quinolinecarboxaldehyde thio-and selenosemicarbazone were determined by single crystal X-ray diffraction analysis. The complexes were also characterized by spectroscopic methods and cyclic voltammetry. Electronic properties of the complexes were studied using DFT and TD-DFT methods. Finally, evident in vitro antioxidant activity of the complexes was demonstrated.
PB  - Srpsko hemijsko društvo, Beograd
T2  - JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
T1  - Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study
EP  - 839
IS  - 7-8
SP  - 825
VL  - 82
DO  - 10.2298/JSC170412062D
ER  - 

@article{
author = "Djordjević, Ivana S. and Vukasinović, Jelena and Todorović, Tamara R. and Filipović, Nenad and Rodić, Marko V. and Lolić, Aleksandar and Portalone, Gustavo and Zlatović, Mario and Grubisić, Sonja",
year = "2017",
abstract = "Cobalt(III) complexes derived from thio-and selenosemicarbazone ligands have been studied to elucidate the nature and consequences of S to Se substitution on their possible biological activity. Solid state structures of cobalt(III) complexes with bis-tridentate coordinated 2-quinolinecarboxaldehyde thio-and selenosemicarbazone were determined by single crystal X-ray diffraction analysis. The complexes were also characterized by spectroscopic methods and cyclic voltammetry. Electronic properties of the complexes were studied using DFT and TD-DFT methods. Finally, evident in vitro antioxidant activity of the complexes was demonstrated.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "JOURNAL OF THE SERBIAN CHEMICAL SOCIETY",
title = "Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study",
pages = "839-825",
number = "7-8",
volume = "82",
doi = "10.2298/JSC170412062D"
}

Djordjević, I. S., Vukasinović, J., Todorović, T. R., Filipović, N., Rodić, M. V., Lolić, A., Portalone, G., Zlatović, M.,& Grubisić, S.. (2017). Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
Srpsko hemijsko društvo, Beograd., 82(7-8), 825-839.
https://doi.org/10.2298/JSC170412062D

Djordjević IS, Vukasinović J, Todorović TR, Filipović N, Rodić MV, Lolić A, Portalone G, Zlatović M, Grubisić S. Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY. 2017;82(7-8):825-839.
doi:10.2298/JSC170412062D .

Djordjević, Ivana S., Vukasinović, Jelena, Todorović, Tamara R., Filipović, Nenad, Rodić, Marko V., Lolić, Aleksandar, Portalone, Gustavo, Zlatović, Mario, Grubisić, Sonja, "Synthesis, structures and electronic properties of Co(III) complexes with 2-quinolinecarboxaldehyde thio- and selenosemicarbazone: A combined experimental and theoretical study" in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 82, no. 7-8 (2017):825-839,
https://doi.org/10.2298/JSC170412062D . .