TY  - JOUR
AU  - Trifunović-Macedoljan, Jelena
AU  - Pantelić, Nebojša
AU  - Jadranin, Milka
AU  - Juranić, Ivan O.
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4995
AB  - The biosynthetic pathway of biogenic amines is very active during the growth of many tumour cells. Non-Hodgkin lymphoma represents a very heterogeneous group of malignancies. The concentration level of some biogenic amines (putrescine, histamine, spermidine, epinephrine, and spermine) was investigated to elucidate whether they could be observed as markers for the patients with non-Hodgkin's lymphoma. In this study, the method of acidic extraction of five biogenic amines from human serum, dansyl chloride pre-column derivatization, and LC/DAD analysis were used to determine the content of biogenic amines in biological fluids. The results indicate that statistically significant differences exist in putrescine, spermidine and histamine contents in non-Hodgkin's patients versus healthy controls. The concentrations of putrescine, spermidine and epinephrine were elevated, and histamine was lower compared to controls. Based on their content, serum biogenic amines could be considered as potential tumour markers.
PB  - Editura Acad Romane, Bucuresti
T2  - Revue Roumaine de Chimie
T1  - Biogenic amines content in the serum of patients with non-hodgkin's lymphoma
EP  - 686
IS  - 8
SP  - 681
VL  - 64
DO  - 10.3224/rrch.2019.64.8.05
ER  - 

@article{
author = "Trifunović-Macedoljan, Jelena and Pantelić, Nebojša and Jadranin, Milka and Juranić, Ivan O.",
year = "2019",
abstract = "The biosynthetic pathway of biogenic amines is very active during the growth of many tumour cells. Non-Hodgkin lymphoma represents a very heterogeneous group of malignancies. The concentration level of some biogenic amines (putrescine, histamine, spermidine, epinephrine, and spermine) was investigated to elucidate whether they could be observed as markers for the patients with non-Hodgkin's lymphoma. In this study, the method of acidic extraction of five biogenic amines from human serum, dansyl chloride pre-column derivatization, and LC/DAD analysis were used to determine the content of biogenic amines in biological fluids. The results indicate that statistically significant differences exist in putrescine, spermidine and histamine contents in non-Hodgkin's patients versus healthy controls. The concentrations of putrescine, spermidine and epinephrine were elevated, and histamine was lower compared to controls. Based on their content, serum biogenic amines could be considered as potential tumour markers.",
publisher = "Editura Acad Romane, Bucuresti",
journal = "Revue Roumaine de Chimie",
title = "Biogenic amines content in the serum of patients with non-hodgkin's lymphoma",
pages = "686-681",
number = "8",
volume = "64",
doi = "10.3224/rrch.2019.64.8.05"
}

Trifunović-Macedoljan, J., Pantelić, N., Jadranin, M.,& Juranić, I. O.. (2019). Biogenic amines content in the serum of patients with non-hodgkin's lymphoma. in Revue Roumaine de Chimie
Editura Acad Romane, Bucuresti., 64(8), 681-686.
https://doi.org/10.3224/rrch.2019.64.8.05

Trifunović-Macedoljan J, Pantelić N, Jadranin M, Juranić IO. Biogenic amines content in the serum of patients with non-hodgkin's lymphoma. in Revue Roumaine de Chimie. 2019;64(8):681-686.
doi:10.3224/rrch.2019.64.8.05 .

Trifunović-Macedoljan, Jelena, Pantelić, Nebojša, Jadranin, Milka, Juranić, Ivan O., "Biogenic amines content in the serum of patients with non-hodgkin's lymphoma" in Revue Roumaine de Chimie, 64, no. 8 (2019):681-686,
https://doi.org/10.3224/rrch.2019.64.8.05 . .

TY  - JOUR
AU  - Trifunović-Macedoljan, Jelena
AU  - Pantelić, Nebojša
AU  - Damjanović, Ana
AU  - Rasković, Sanvila
AU  - Nikolić-Durović, Marina
AU  - Pudar, Georgina
AU  - Jadranin, Milka
AU  - Juranić, Ivan O.
AU  - Juranić, Zorica
PY  - 2016
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4037
AB  - Biogenic amines are integral part of nearly every cell. In the present study, the method of acidic extraction of histamine (His), of polyamines putrescine (Put), spermidine (Spd) and catecholamines epinephrine (Epi) and norepinephrine (NE) from human serum, precolumn derivatization with dansyl chloride, and LC/DAD analysis of the biogenic amines was used with the aim of monitoring differences of their levels in patients with diabetes mellitus, chronic urticaria, and Hashimoto's thyroiditis, compared to healthy subjects, and to observe them as possible markers for immune mediated diseases. The retention times were used for the determination of serum biogenic amines. Statistically significant differences were found in the levels of putrescine and histamine in diabetes mellitus patients, of the levels of putrescine, histamine, spermidine and epinephrine in chronic urticaria patients and of the levels of putrescine and spermidine levels in Hashimoto's thyroiditis patients, compared to those of healthy controls. Norepinephrine was found only in the serum of patients with chronic urticaria. The values of recovery, evaluated in controls, varied between 85.7 and 106.7 %. The statistically significant changes in putrescine, histamine, spermidine and epinephrine levels in patients compared with those in healthy people reflects the existence of biochemical disturbances in the mentioned immune-mediated diseases.
PB  - Srpsko hemijsko društvo, Beograd
T2  - JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
T1  - LC/DAD determination of biogenic amines in serum of patients with diabetes mellitus, chronic urticaria or Hashimoto's thyroiditis
EP  - 498
IS  - 5
SP  - 487
VL  - 81
DO  - 10.2298/JSC150910020T
ER  - 

@article{
author = "Trifunović-Macedoljan, Jelena and Pantelić, Nebojša and Damjanović, Ana and Rasković, Sanvila and Nikolić-Durović, Marina and Pudar, Georgina and Jadranin, Milka and Juranić, Ivan O. and Juranić, Zorica",
year = "2016",
abstract = "Biogenic amines are integral part of nearly every cell. In the present study, the method of acidic extraction of histamine (His), of polyamines putrescine (Put), spermidine (Spd) and catecholamines epinephrine (Epi) and norepinephrine (NE) from human serum, precolumn derivatization with dansyl chloride, and LC/DAD analysis of the biogenic amines was used with the aim of monitoring differences of their levels in patients with diabetes mellitus, chronic urticaria, and Hashimoto's thyroiditis, compared to healthy subjects, and to observe them as possible markers for immune mediated diseases. The retention times were used for the determination of serum biogenic amines. Statistically significant differences were found in the levels of putrescine and histamine in diabetes mellitus patients, of the levels of putrescine, histamine, spermidine and epinephrine in chronic urticaria patients and of the levels of putrescine and spermidine levels in Hashimoto's thyroiditis patients, compared to those of healthy controls. Norepinephrine was found only in the serum of patients with chronic urticaria. The values of recovery, evaluated in controls, varied between 85.7 and 106.7 %. The statistically significant changes in putrescine, histamine, spermidine and epinephrine levels in patients compared with those in healthy people reflects the existence of biochemical disturbances in the mentioned immune-mediated diseases.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "JOURNAL OF THE SERBIAN CHEMICAL SOCIETY",
title = "LC/DAD determination of biogenic amines in serum of patients with diabetes mellitus, chronic urticaria or Hashimoto's thyroiditis",
pages = "498-487",
number = "5",
volume = "81",
doi = "10.2298/JSC150910020T"
}

Trifunović-Macedoljan, J., Pantelić, N., Damjanović, A., Rasković, S., Nikolić-Durović, M., Pudar, G., Jadranin, M., Juranić, I. O.,& Juranić, Z.. (2016). LC/DAD determination of biogenic amines in serum of patients with diabetes mellitus, chronic urticaria or Hashimoto's thyroiditis. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
Srpsko hemijsko društvo, Beograd., 81(5), 487-498.
https://doi.org/10.2298/JSC150910020T

Trifunović-Macedoljan J, Pantelić N, Damjanović A, Rasković S, Nikolić-Durović M, Pudar G, Jadranin M, Juranić IO, Juranić Z. LC/DAD determination of biogenic amines in serum of patients with diabetes mellitus, chronic urticaria or Hashimoto's thyroiditis. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY. 2016;81(5):487-498.
doi:10.2298/JSC150910020T .

Trifunović-Macedoljan, Jelena, Pantelić, Nebojša, Damjanović, Ana, Rasković, Sanvila, Nikolić-Durović, Marina, Pudar, Georgina, Jadranin, Milka, Juranić, Ivan O., Juranić, Zorica, "LC/DAD determination of biogenic amines in serum of patients with diabetes mellitus, chronic urticaria or Hashimoto's thyroiditis" in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 81, no. 5 (2016):487-498,
https://doi.org/10.2298/JSC150910020T . .

TY  - JOUR
AU  - Popović-Djordjević, Jelena
AU  - Došen-Mićović, Ljiljana I.
AU  - Juranić, Ivan O.
AU  - Drakulić, Branko J.
PY  - 2010
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2335
AB  - Alignment-free, three dimensional structure-activity relationships (3D QSAR) of the antiproliferative potency of twenty-two glutarimide-containing compounds, taken from National Cancer Institute Developmental therapeutics Program database, toward eight representative human tumour cell lines are reported. The descriptors used in the QSAR study were derived from GRID molecular interaction fields. The obtained models readily detect structural motifs positively or negatively correlated with the potency of the studied compounds toward each cell line. In this way, the pharmacophoric pattern required for high potency of compounds is reported. This pattern can serve as guidance for the design and syntheses of novel congeners, planned to be tested toward human tumour cell lines.
AB  - U tekstu je opisan odnos strukture i antiproliferativne aktivnosti 22 glutarimidna derivata prema osam reprezentativnih linija humanih tumora. Podaci o strukturi jedinjenja i njihovoj aktivnosti su preuzeti iz baze podataka Nacionalnog Instituta za rak, SAD. Deskriptori, nezavisni od poravnavanja molekula (GRIND-2), korišćeni u proučavanju odnosa strukture i aktivnosti su dobijeni upotrebom programa GRID. Modeli jasno prikazuju strukturne elemente jedinjenja koji se pozitivno ili negativno korelišu sa biološkom aktivnošću. Farmakoforna slika dobijena iz modela će biti korišćena za planiranje novih analoga koji sadrže glutarimidni prsten i za koje se očekuje da će pokazati značajnu antiproliferativnu aktivnost.
PB  - Srpsko hemijsko društvo, Beograd
T2  - JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
T1  - Antiproliferative activity of NCI-DTP glutarimide derivatives: An alignment independent 3D QSAR study
T1  - Antiproliferativna aktivnost glutarimidnih derivata iz baze podataka Nacionalnog instituta za rak, SAD - 3D odnos strukture i aktivnosti nezavisan od poravnavanja molekula
EP  - 1179
IS  - 9
SP  - 1167
VL  - 75
DO  - 10.2298/JSC091202076P
ER  - 

@article{
author = "Popović-Djordjević, Jelena and Došen-Mićović, Ljiljana I. and Juranić, Ivan O. and Drakulić, Branko J.",
year = "2010",
abstract = "Alignment-free, three dimensional structure-activity relationships (3D QSAR) of the antiproliferative potency of twenty-two glutarimide-containing compounds, taken from National Cancer Institute Developmental therapeutics Program database, toward eight representative human tumour cell lines are reported. The descriptors used in the QSAR study were derived from GRID molecular interaction fields. The obtained models readily detect structural motifs positively or negatively correlated with the potency of the studied compounds toward each cell line. In this way, the pharmacophoric pattern required for high potency of compounds is reported. This pattern can serve as guidance for the design and syntheses of novel congeners, planned to be tested toward human tumour cell lines., U tekstu je opisan odnos strukture i antiproliferativne aktivnosti 22 glutarimidna derivata prema osam reprezentativnih linija humanih tumora. Podaci o strukturi jedinjenja i njihovoj aktivnosti su preuzeti iz baze podataka Nacionalnog Instituta za rak, SAD. Deskriptori, nezavisni od poravnavanja molekula (GRIND-2), korišćeni u proučavanju odnosa strukture i aktivnosti su dobijeni upotrebom programa GRID. Modeli jasno prikazuju strukturne elemente jedinjenja koji se pozitivno ili negativno korelišu sa biološkom aktivnošću. Farmakoforna slika dobijena iz modela će biti korišćena za planiranje novih analoga koji sadrže glutarimidni prsten i za koje se očekuje da će pokazati značajnu antiproliferativnu aktivnost.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "JOURNAL OF THE SERBIAN CHEMICAL SOCIETY",
title = "Antiproliferative activity of NCI-DTP glutarimide derivatives: An alignment independent 3D QSAR study, Antiproliferativna aktivnost glutarimidnih derivata iz baze podataka Nacionalnog instituta za rak, SAD - 3D odnos strukture i aktivnosti nezavisan od poravnavanja molekula",
pages = "1179-1167",
number = "9",
volume = "75",
doi = "10.2298/JSC091202076P"
}

Popović-Djordjević, J., Došen-Mićović, L. I., Juranić, I. O.,& Drakulić, B. J.. (2010). Antiproliferative activity of NCI-DTP glutarimide derivatives: An alignment independent 3D QSAR study. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY
Srpsko hemijsko društvo, Beograd., 75(9), 1167-1179.
https://doi.org/10.2298/JSC091202076P

Popović-Djordjević J, Došen-Mićović LI, Juranić IO, Drakulić BJ. Antiproliferative activity of NCI-DTP glutarimide derivatives: An alignment independent 3D QSAR study. in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY. 2010;75(9):1167-1179.
doi:10.2298/JSC091202076P .

Popović-Djordjević, Jelena, Došen-Mićović, Ljiljana I., Juranić, Ivan O., Drakulić, Branko J., "Antiproliferative activity of NCI-DTP glutarimide derivatives: An alignment independent 3D QSAR study" in JOURNAL OF THE SERBIAN CHEMICAL SOCIETY, 75, no. 9 (2010):1167-1179,
https://doi.org/10.2298/JSC091202076P . .

TY  - JOUR
AU  - Vitnik, Vesna
AU  - Ivanović, M.D.
AU  - Vitnik, Željko J.
AU  - Popović-Djordjević, Jelena
AU  - Zizak, Z.S.
AU  - Juranić, Zorica
AU  - Juranić, Ivan O.
PY  - 2009
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2112
AB  - Phase-transfer-catalyzed (PTC) reactions of ketones with bromoform and aqueous lithium hydroxide in alcoholic solvent result in the formation of alpha,beta-unsaturated carboxylic acids. The reaction was performed at room temperature for 24h. The corresponding conjugated acids were obtained from cyclic or aromatic ketones, whereas bromo acids were obtained from 4-oxo-piperidine-1-carboxylic acid ethyl ester (13) and 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (14).
PB  - Taylor & Francis Inc, Philadelphia
T2  - Synthetic Communications
T1  - One-Step Conversion of Ketones to Conjugated Acids Using Bromoform
EP  - 1471
IS  - 8
SP  - 1457
VL  - 39
DO  - 10.1080/00397910802531955
ER  - 

@article{
author = "Vitnik, Vesna and Ivanović, M.D. and Vitnik, Željko J. and Popović-Djordjević, Jelena and Zizak, Z.S. and Juranić, Zorica and Juranić, Ivan O.",
year = "2009",
abstract = "Phase-transfer-catalyzed (PTC) reactions of ketones with bromoform and aqueous lithium hydroxide in alcoholic solvent result in the formation of alpha,beta-unsaturated carboxylic acids. The reaction was performed at room temperature for 24h. The corresponding conjugated acids were obtained from cyclic or aromatic ketones, whereas bromo acids were obtained from 4-oxo-piperidine-1-carboxylic acid ethyl ester (13) and 4-oxo-piperidine-1-carboxylic acid tert-butyl ester (14).",
publisher = "Taylor & Francis Inc, Philadelphia",
journal = "Synthetic Communications",
title = "One-Step Conversion of Ketones to Conjugated Acids Using Bromoform",
pages = "1471-1457",
number = "8",
volume = "39",
doi = "10.1080/00397910802531955"
}

Vitnik, V., Ivanović, M.D., Vitnik, Ž. J., Popović-Djordjević, J., Zizak, Z.S., Juranić, Z.,& Juranić, I. O.. (2009). One-Step Conversion of Ketones to Conjugated Acids Using Bromoform. in Synthetic Communications
Taylor & Francis Inc, Philadelphia., 39(8), 1457-1471.
https://doi.org/10.1080/00397910802531955

Vitnik V, Ivanović M, Vitnik ŽJ, Popović-Djordjević J, Zizak Z, Juranić Z, Juranić IO. One-Step Conversion of Ketones to Conjugated Acids Using Bromoform. in Synthetic Communications. 2009;39(8):1457-1471.
doi:10.1080/00397910802531955 .

Vitnik, Vesna, Ivanović, M.D., Vitnik, Željko J., Popović-Djordjević, Jelena, Zizak, Z.S., Juranić, Zorica, Juranić, Ivan O., "One-Step Conversion of Ketones to Conjugated Acids Using Bromoform" in Synthetic Communications, 39, no. 8 (2009):1457-1471,
https://doi.org/10.1080/00397910802531955 . .