TY  - JOUR
AU  - Jovanović, Svetlana P.
AU  - Syrgiannis, Zois
AU  - Budimir, Milica D.
AU  - Milivojević, Dušan D.
AU  - Jovanović, Dragana J.
AU  - Pavlović, Vladimir
AU  - Papan, Jelena M.
AU  - Bartenwerfer, Malte
AU  - Mojsin, Marija M.
AU  - Stevanović, Milena J.
AU  - Todorović-Marković, Biljana
PY  - 2020
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5390
AB  - Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HRTEM, SEM-EDS, FTIR, XRD, PL and UV-Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (O-1(2)) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce O-1(2) upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the production of the efficient photosensitizer. On the opposite, GQDs-TU are efficient . OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 mu g/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration.
PB  - Elsevier, Amsterdam
T2  - Materials Science & Engineering C-Materials for Biological Applications
T1  - Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea
VL  - 109
DO  - 10.1016/j.msec.2019.110539
ER  - 

@article{
author = "Jovanović, Svetlana P. and Syrgiannis, Zois and Budimir, Milica D. and Milivojević, Dušan D. and Jovanović, Dragana J. and Pavlović, Vladimir and Papan, Jelena M. and Bartenwerfer, Malte and Mojsin, Marija M. and Stevanović, Milena J. and Todorović-Marković, Biljana",
year = "2020",
abstract = "Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HRTEM, SEM-EDS, FTIR, XRD, PL and UV-Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (O-1(2)) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce O-1(2) upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the production of the efficient photosensitizer. On the opposite, GQDs-TU are efficient . OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 mu g/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration.",
publisher = "Elsevier, Amsterdam",
journal = "Materials Science & Engineering C-Materials for Biological Applications",
title = "Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea",
volume = "109",
doi = "10.1016/j.msec.2019.110539"
}

Jovanović, S. P., Syrgiannis, Z., Budimir, M. D., Milivojević, D. D., Jovanović, D. J., Pavlović, V., Papan, J. M., Bartenwerfer, M., Mojsin, M. M., Stevanović, M. J.,& Todorović-Marković, B.. (2020). Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea. in Materials Science & Engineering C-Materials for Biological Applications
Elsevier, Amsterdam., 109.
https://doi.org/10.1016/j.msec.2019.110539

Jovanović SP, Syrgiannis Z, Budimir MD, Milivojević DD, Jovanović DJ, Pavlović V, Papan JM, Bartenwerfer M, Mojsin MM, Stevanović MJ, Todorović-Marković B. Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea. in Materials Science & Engineering C-Materials for Biological Applications. 2020;109.
doi:10.1016/j.msec.2019.110539 .

Jovanović, Svetlana P., Syrgiannis, Zois, Budimir, Milica D., Milivojević, Dušan D., Jovanović, Dragana J., Pavlović, Vladimir, Papan, Jelena M., Bartenwerfer, Malte, Mojsin, Marija M., Stevanović, Milena J., Todorović-Marković, Biljana, "Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea" in Materials Science & Engineering C-Materials for Biological Applications, 109 (2020),
https://doi.org/10.1016/j.msec.2019.110539 . .

TY  - JOUR
AU  - Marković, Zoran M.
AU  - Jovanović, Svetlana P.
AU  - Masković, Pavle Z.
AU  - Mojsin, Marija M.
AU  - Stevanović, Milena J.
AU  - Danko, Martin
AU  - Micusik, Matej
AU  - Jovanović, Dragana J.
AU  - Kleinova, Angela
AU  - Spitalsky, Zdeno
AU  - Pavlović, Vladimir
AU  - Todorović-Marković, Biljana
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5003
AB  - Photoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of four graphene based nanomaterials (graphene oxide-GO, graphene quantum dots-GQDs, carbon quantum dots-CQDs and N-doped carbon quantum dots-N-CQDs) depending on the presence/absence of visible light source. Structural and optical properties of these materials and their potentials for reactive oxygen species generation/quenching are investigated by applying different microscopy and spectroscopy techniques (transmission electron microscopy, FTIR, UV-Vis, photoluminescence, electron paramagnetic resonance). Results show that all types of quantum dots has pro-oxidant and antioxidant potentials whereas GO demonstrated only moderate antioxidant effect. The best free radical scavenger is CQDs sample in the absence of light. CQDs are the best singlet oxygen generator under blue light irradiation as well. To check photo-cytotoxicity of these materials, photo-cytotoxic concentrations of the GO, GQDs, CQDs and N-CQDs were determined for three cellular lines: human rhabdomyosarcoma (RD), cell line derived from human cervix carcinoma Hep2c (HeLa) and fibroblast cell line from murine (L2OB). Cytotoxicity test has indicated that all samples are much less photocytotoxic than cis-diamminedichloroplatinum (cis-DPP). The production method and doping of quantum dots affect the photodynamic activity of tested samples very much.
PB  - Elsevier Science Sa, Lausanne
T2  - Journal of Photochemistry and Photobiology B-Biology
T1  - Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines
VL  - 200
DO  - 10.1016/j.jphotobiol.2019.111647
ER  - 

@article{
author = "Marković, Zoran M. and Jovanović, Svetlana P. and Masković, Pavle Z. and Mojsin, Marija M. and Stevanović, Milena J. and Danko, Martin and Micusik, Matej and Jovanović, Dragana J. and Kleinova, Angela and Spitalsky, Zdeno and Pavlović, Vladimir and Todorović-Marković, Biljana",
year = "2019",
abstract = "Photoactive materials called photosensitizers can be used for treatment of different types of cancer in combination with light source. In this paper, we have investigated pro-oxidant and antioxidant potentials of four graphene based nanomaterials (graphene oxide-GO, graphene quantum dots-GQDs, carbon quantum dots-CQDs and N-doped carbon quantum dots-N-CQDs) depending on the presence/absence of visible light source. Structural and optical properties of these materials and their potentials for reactive oxygen species generation/quenching are investigated by applying different microscopy and spectroscopy techniques (transmission electron microscopy, FTIR, UV-Vis, photoluminescence, electron paramagnetic resonance). Results show that all types of quantum dots has pro-oxidant and antioxidant potentials whereas GO demonstrated only moderate antioxidant effect. The best free radical scavenger is CQDs sample in the absence of light. CQDs are the best singlet oxygen generator under blue light irradiation as well. To check photo-cytotoxicity of these materials, photo-cytotoxic concentrations of the GO, GQDs, CQDs and N-CQDs were determined for three cellular lines: human rhabdomyosarcoma (RD), cell line derived from human cervix carcinoma Hep2c (HeLa) and fibroblast cell line from murine (L2OB). Cytotoxicity test has indicated that all samples are much less photocytotoxic than cis-diamminedichloroplatinum (cis-DPP). The production method and doping of quantum dots affect the photodynamic activity of tested samples very much.",
publisher = "Elsevier Science Sa, Lausanne",
journal = "Journal of Photochemistry and Photobiology B-Biology",
title = "Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines",
volume = "200",
doi = "10.1016/j.jphotobiol.2019.111647"
}

Marković, Z. M., Jovanović, S. P., Masković, P. Z., Mojsin, M. M., Stevanović, M. J., Danko, M., Micusik, M., Jovanović, D. J., Kleinova, A., Spitalsky, Z., Pavlović, V.,& Todorović-Marković, B.. (2019). Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines. in Journal of Photochemistry and Photobiology B-Biology
Elsevier Science Sa, Lausanne., 200.
https://doi.org/10.1016/j.jphotobiol.2019.111647

Marković ZM, Jovanović SP, Masković PZ, Mojsin MM, Stevanović MJ, Danko M, Micusik M, Jovanović DJ, Kleinova A, Spitalsky Z, Pavlović V, Todorović-Marković B. Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines. in Journal of Photochemistry and Photobiology B-Biology. 2019;200.
doi:10.1016/j.jphotobiol.2019.111647 .

Marković, Zoran M., Jovanović, Svetlana P., Masković, Pavle Z., Mojsin, Marija M., Stevanović, Milena J., Danko, Martin, Micusik, Matej, Jovanović, Dragana J., Kleinova, Angela, Spitalsky, Zdeno, Pavlović, Vladimir, Todorović-Marković, Biljana, "Graphene oxide size and structure pro-oxidant and antioxidant activity and photoinduced cytotoxicity relation on three cancer cell lines" in Journal of Photochemistry and Photobiology B-Biology, 200 (2019),
https://doi.org/10.1016/j.jphotobiol.2019.111647 . .