TY  - JOUR
AU  - Jovanović, Svetlana P.
AU  - Syrgiannis, Zois
AU  - Budimir, Milica D.
AU  - Milivojević, Dušan D.
AU  - Jovanović, Dragana J.
AU  - Pavlović, Vladimir
AU  - Papan, Jelena M.
AU  - Bartenwerfer, Malte
AU  - Mojsin, Marija M.
AU  - Stevanović, Milena J.
AU  - Todorović-Marković, Biljana
PY  - 2020
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5390
AB  - Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HRTEM, SEM-EDS, FTIR, XRD, PL and UV-Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (O-1(2)) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce O-1(2) upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the production of the efficient photosensitizer. On the opposite, GQDs-TU are efficient . OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 mu g/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration.
PB  - Elsevier, Amsterdam
T2  - Materials Science & Engineering C-Materials for Biological Applications
T1  - Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea
VL  - 109
DO  - 10.1016/j.msec.2019.110539
ER  - 

@article{
author = "Jovanović, Svetlana P. and Syrgiannis, Zois and Budimir, Milica D. and Milivojević, Dušan D. and Jovanović, Dragana J. and Pavlović, Vladimir and Papan, Jelena M. and Bartenwerfer, Malte and Mojsin, Marija M. and Stevanović, Milena J. and Todorović-Marković, Biljana",
year = "2020",
abstract = "Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HRTEM, SEM-EDS, FTIR, XRD, PL and UV-Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (O-1(2)) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce O-1(2) upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the production of the efficient photosensitizer. On the opposite, GQDs-TU are efficient . OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 mu g/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration.",
publisher = "Elsevier, Amsterdam",
journal = "Materials Science & Engineering C-Materials for Biological Applications",
title = "Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea",
volume = "109",
doi = "10.1016/j.msec.2019.110539"
}

Jovanović, S. P., Syrgiannis, Z., Budimir, M. D., Milivojević, D. D., Jovanović, D. J., Pavlović, V., Papan, J. M., Bartenwerfer, M., Mojsin, M. M., Stevanović, M. J.,& Todorović-Marković, B.. (2020). Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea. in Materials Science & Engineering C-Materials for Biological Applications
Elsevier, Amsterdam., 109.
https://doi.org/10.1016/j.msec.2019.110539

Jovanović SP, Syrgiannis Z, Budimir MD, Milivojević DD, Jovanović DJ, Pavlović V, Papan JM, Bartenwerfer M, Mojsin MM, Stevanović MJ, Todorović-Marković B. Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea. in Materials Science & Engineering C-Materials for Biological Applications. 2020;109.
doi:10.1016/j.msec.2019.110539 .

Jovanović, Svetlana P., Syrgiannis, Zois, Budimir, Milica D., Milivojević, Dušan D., Jovanović, Dragana J., Pavlović, Vladimir, Papan, Jelena M., Bartenwerfer, Malte, Mojsin, Marija M., Stevanović, Milena J., Todorović-Marković, Biljana, "Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea" in Materials Science & Engineering C-Materials for Biological Applications, 109 (2020),
https://doi.org/10.1016/j.msec.2019.110539 . .