TY  - JOUR
AU  - Milutinović, Violeta
AU  - Petrović, Predrag
AU  - Petković, Miloš
AU  - Klaus, Anita
AU  - Ušjak, Ljuboš
AU  - Niketić, Marjan
AU  - Petrović, Silvana
PY  - 2023
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6482
AB  - The composition and anticholinesterase activity of the dried MeOH extracts of Hieracium scheppigianum and H. naegelianum underground parts (rhizomes and roots), as well as the anticholinesterase activity of the dried, previously chemically characterised MeOH extracts of the flowering aerial parts of these two and 26 other Hieracium species in the strict sense (s. str.), were investigated. Furthermore, the anticholinesterase activity of 12 selected secondary metabolites of these extracts was evaluated. Using semi-preparative LC-MS, five caffeoylquinic acids and the sesquiterpene lactone crepiside E were isolated from H. scheppigianum underground parts extract. All these compounds were also identified in the underground parts extract of H. naegelianum. Quantitative LC-MS analysis showed that the analysed underground parts extracts were rich in both caffeoylquinic acids (139.77 and 156.62 mg/g of extract, respectively) and crepiside E (126.88 and 116.58 mg/g). In the Ellman method, the tested extracts showed an interesting anti-AChE and/or anti-BChE activity (IC50=0.56–1.58 mg/mL), which can be explained, at least partially, by the presence of some of their constituents. Among the metabolites tested, the best activity was revealed for the flavonoids apigenin, luteolin and diosmetin, and the sesquiterpene lactone 8-epiixerisamine A (IC50=68.09–299.37 μM). © 2023 Wiley-VHCA AG, Zurich, Switzerland.
T2  - Chemistry and Biodiversity
T2  - Chemistry and Biodiversity
T1  - Investigation of Anticholinesterase Activity of Chemically Characterised Hieracium s. str. Methanol Extracts and Their Selected Metabolites
DO  - 10.1002/cbdv.202301044
ER  - 

@article{
author = "Milutinović, Violeta and Petrović, Predrag and Petković, Miloš and Klaus, Anita and Ušjak, Ljuboš and Niketić, Marjan and Petrović, Silvana",
year = "2023",
abstract = "The composition and anticholinesterase activity of the dried MeOH extracts of Hieracium scheppigianum and H. naegelianum underground parts (rhizomes and roots), as well as the anticholinesterase activity of the dried, previously chemically characterised MeOH extracts of the flowering aerial parts of these two and 26 other Hieracium species in the strict sense (s. str.), were investigated. Furthermore, the anticholinesterase activity of 12 selected secondary metabolites of these extracts was evaluated. Using semi-preparative LC-MS, five caffeoylquinic acids and the sesquiterpene lactone crepiside E were isolated from H. scheppigianum underground parts extract. All these compounds were also identified in the underground parts extract of H. naegelianum. Quantitative LC-MS analysis showed that the analysed underground parts extracts were rich in both caffeoylquinic acids (139.77 and 156.62 mg/g of extract, respectively) and crepiside E (126.88 and 116.58 mg/g). In the Ellman method, the tested extracts showed an interesting anti-AChE and/or anti-BChE activity (IC50=0.56–1.58 mg/mL), which can be explained, at least partially, by the presence of some of their constituents. Among the metabolites tested, the best activity was revealed for the flavonoids apigenin, luteolin and diosmetin, and the sesquiterpene lactone 8-epiixerisamine A (IC50=68.09–299.37 μM). © 2023 Wiley-VHCA AG, Zurich, Switzerland.",
journal = "Chemistry and Biodiversity, Chemistry and Biodiversity",
title = "Investigation of Anticholinesterase Activity of Chemically Characterised Hieracium s. str. Methanol Extracts and Their Selected Metabolites",
doi = "10.1002/cbdv.202301044"
}

Milutinović, V., Petrović, P., Petković, M., Klaus, A., Ušjak, L., Niketić, M.,& Petrović, S.. (2023). Investigation of Anticholinesterase Activity of Chemically Characterised Hieracium s. str. Methanol Extracts and Their Selected Metabolites. in Chemistry and Biodiversity.
https://doi.org/10.1002/cbdv.202301044

Milutinović V, Petrović P, Petković M, Klaus A, Ušjak L, Niketić M, Petrović S. Investigation of Anticholinesterase Activity of Chemically Characterised Hieracium s. str. Methanol Extracts and Their Selected Metabolites. in Chemistry and Biodiversity. 2023;.
doi:10.1002/cbdv.202301044 .

Milutinović, Violeta, Petrović, Predrag, Petković, Miloš, Klaus, Anita, Ušjak, Ljuboš, Niketić, Marjan, Petrović, Silvana, "Investigation of Anticholinesterase Activity of Chemically Characterised Hieracium s. str. Methanol Extracts and Their Selected Metabolites" in Chemistry and Biodiversity (2023),
https://doi.org/10.1002/cbdv.202301044 . .

TY  - JOUR
AU  - Tomović, Gordana M.
AU  - Mihailović, Nevena
AU  - Tumi, Ahmed F.
AU  - Gajić, Boško
AU  - Misljenović, Tomica D.
AU  - Niketić, Marjan
PY  - 2013
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3117
AB  - Serpentine soils from 16 sample points in Serbia as well as the roots and shoots of eight Brassicaceae family species: Aethionema saxatile, Alyssum montanum, Alyssum repens, Cardamine plumieri, Erysimum linariifolium, Erysimum carniolicum, Isatis tinctoria, Rorippa lippizensis, were analyzed with regard to their concentrations of P, K, Fe, Ca, Mg, Ni, Zn, Mn, Cu, Cr, Cd, and Pb. Most of the soil samples were typical of ultramafic sites with low concentrations of P, K and Ca and high concentrations of Mg, Fe, Ni and Zn. Ca/Mg ratio was  lt 1 in most soil samples and Brassicaceae plants. Only in A. montanum, A. repens, E. linariifolium and R. lippizensis was the Ca/Mg ratio >1. The levels of P, K, Fe and Zn were high, Mn and Cu occurred in low amounts, whereas Cr, Cd, Co and Pb were only traceable. In the roots and shoots of A. montanum and A. repens the measured concentrations of Ni were 657 mg kg(-1) and 676 mg kg(-1) respectively, which is the first instance that such high concentrations of Ni were detected in these two species.
PB  - Polish Acad Sciences, Inst Environmental Engineering, Zabrze
T2  - Archives of Environmental Protection
T1  - Trace metals in soils and several brassicaceae plant species from serpentine sites of Serbia
EP  - 49
IS  - 4
SP  - 29
VL  - 39
DO  - 10.2478/aep-2013-0039
ER  - 

@article{
author = "Tomović, Gordana M. and Mihailović, Nevena and Tumi, Ahmed F. and Gajić, Boško and Misljenović, Tomica D. and Niketić, Marjan",
year = "2013",
abstract = "Serpentine soils from 16 sample points in Serbia as well as the roots and shoots of eight Brassicaceae family species: Aethionema saxatile, Alyssum montanum, Alyssum repens, Cardamine plumieri, Erysimum linariifolium, Erysimum carniolicum, Isatis tinctoria, Rorippa lippizensis, were analyzed with regard to their concentrations of P, K, Fe, Ca, Mg, Ni, Zn, Mn, Cu, Cr, Cd, and Pb. Most of the soil samples were typical of ultramafic sites with low concentrations of P, K and Ca and high concentrations of Mg, Fe, Ni and Zn. Ca/Mg ratio was  lt 1 in most soil samples and Brassicaceae plants. Only in A. montanum, A. repens, E. linariifolium and R. lippizensis was the Ca/Mg ratio >1. The levels of P, K, Fe and Zn were high, Mn and Cu occurred in low amounts, whereas Cr, Cd, Co and Pb were only traceable. In the roots and shoots of A. montanum and A. repens the measured concentrations of Ni were 657 mg kg(-1) and 676 mg kg(-1) respectively, which is the first instance that such high concentrations of Ni were detected in these two species.",
publisher = "Polish Acad Sciences, Inst Environmental Engineering, Zabrze",
journal = "Archives of Environmental Protection",
title = "Trace metals in soils and several brassicaceae plant species from serpentine sites of Serbia",
pages = "49-29",
number = "4",
volume = "39",
doi = "10.2478/aep-2013-0039"
}

Tomović, G. M., Mihailović, N., Tumi, A. F., Gajić, B., Misljenović, T. D.,& Niketić, M.. (2013). Trace metals in soils and several brassicaceae plant species from serpentine sites of Serbia. in Archives of Environmental Protection
Polish Acad Sciences, Inst Environmental Engineering, Zabrze., 39(4), 29-49.
https://doi.org/10.2478/aep-2013-0039

Tomović GM, Mihailović N, Tumi AF, Gajić B, Misljenović TD, Niketić M. Trace metals in soils and several brassicaceae plant species from serpentine sites of Serbia. in Archives of Environmental Protection. 2013;39(4):29-49.
doi:10.2478/aep-2013-0039 .

Tomović, Gordana M., Mihailović, Nevena, Tumi, Ahmed F., Gajić, Boško, Misljenović, Tomica D., Niketić, Marjan, "Trace metals in soils and several brassicaceae plant species from serpentine sites of Serbia" in Archives of Environmental Protection, 39, no. 4 (2013):29-49,
https://doi.org/10.2478/aep-2013-0039 . .

TY  - JOUR
AU  - Tumi, Ahmed F.
AU  - Mihailović, Nevena
AU  - Gajić, Boško
AU  - Niketić, Marjan
AU  - Tomović, Gordana
PY  - 2012
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2792
AB  - Ultramafic areas exist in large blocks or as small outcrops separated from other geological substrates in Serbia and host a certain number of facultative serpentinophytes. Among them is Alyssum murale Waldst & Kit. s.l., widespread species distributed in SE Europe and SW Asia and well known example of Ni hyperaccumulators. The aims of the present study were to investigate the level of concentration of Ni (and some elements such as Fe, Mn, Zn, Cu, Ni, Cr, Pb, Co, and Cd) at several serpentine soils in Serbia and to determine the level of accumulation of these elements in roots, shoots, and leaves, with a focus on Ni. The maximum available concentrations of metals in soil dry matter (DM) were 950 mg.kg(-1) Fe, 3,110 mg.kg(-1) Ca, 4,600 mg.kg(-1) Mg, 443 mg.kg(-1) Ni, 803 mg.kg(-1) Mn, 26 mg.kg(-1) Zn, 4 mg.kg(-1) Cu, 43 mg.kg(-1) Cr, 82 mg.kg(-1) Co, 1 mg.kg(-1) Cd, and 17 mg.kg(-1) Pb. The Ca/Mg ratio in serpentine soils varied from 0.08 to 6.22. In A. murale plants, the maximum concentrations of Ni were up to 2,926 mg.kg(-1) in roots, 6,793 mg.kg(-1) in shoots, and 13,160 mg.kg(-1) in leaves. Ca/Mg ratio in plant tissues were up to 2.25 (roots), 9.25 (shoots), and 15.23 (leaves). Cu content in the roots and shoots was high (up to 1,044 mg.kg(-1) Cu and 849 mg.kg(-1) Cu). This survey suggests that some A. murale populations from serpentine soils of Serbia emerge as strong Ni hyperaccumulators and can be used for phytoextraction purposes.
T2  - Polish Journal of Environmental Studies
T1  - Comparative Study of Hyperaccumulation of Nickel by Alyssum murale s.l. Populations from the Ultramafics of Serbia
EP  - 1866
IS  - 6
SP  - 1855
VL  - 21
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_2792
ER  - 

@article{
author = "Tumi, Ahmed F. and Mihailović, Nevena and Gajić, Boško and Niketić, Marjan and Tomović, Gordana",
year = "2012",
abstract = "Ultramafic areas exist in large blocks or as small outcrops separated from other geological substrates in Serbia and host a certain number of facultative serpentinophytes. Among them is Alyssum murale Waldst & Kit. s.l., widespread species distributed in SE Europe and SW Asia and well known example of Ni hyperaccumulators. The aims of the present study were to investigate the level of concentration of Ni (and some elements such as Fe, Mn, Zn, Cu, Ni, Cr, Pb, Co, and Cd) at several serpentine soils in Serbia and to determine the level of accumulation of these elements in roots, shoots, and leaves, with a focus on Ni. The maximum available concentrations of metals in soil dry matter (DM) were 950 mg.kg(-1) Fe, 3,110 mg.kg(-1) Ca, 4,600 mg.kg(-1) Mg, 443 mg.kg(-1) Ni, 803 mg.kg(-1) Mn, 26 mg.kg(-1) Zn, 4 mg.kg(-1) Cu, 43 mg.kg(-1) Cr, 82 mg.kg(-1) Co, 1 mg.kg(-1) Cd, and 17 mg.kg(-1) Pb. The Ca/Mg ratio in serpentine soils varied from 0.08 to 6.22. In A. murale plants, the maximum concentrations of Ni were up to 2,926 mg.kg(-1) in roots, 6,793 mg.kg(-1) in shoots, and 13,160 mg.kg(-1) in leaves. Ca/Mg ratio in plant tissues were up to 2.25 (roots), 9.25 (shoots), and 15.23 (leaves). Cu content in the roots and shoots was high (up to 1,044 mg.kg(-1) Cu and 849 mg.kg(-1) Cu). This survey suggests that some A. murale populations from serpentine soils of Serbia emerge as strong Ni hyperaccumulators and can be used for phytoextraction purposes.",
journal = "Polish Journal of Environmental Studies",
title = "Comparative Study of Hyperaccumulation of Nickel by Alyssum murale s.l. Populations from the Ultramafics of Serbia",
pages = "1866-1855",
number = "6",
volume = "21",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_2792"
}

Tumi, A. F., Mihailović, N., Gajić, B., Niketić, M.,& Tomović, G.. (2012). Comparative Study of Hyperaccumulation of Nickel by Alyssum murale s.l. Populations from the Ultramafics of Serbia. in Polish Journal of Environmental Studies, 21(6), 1855-1866.
https://hdl.handle.net/21.15107/rcub_agrospace_2792

Tumi AF, Mihailović N, Gajić B, Niketić M, Tomović G. Comparative Study of Hyperaccumulation of Nickel by Alyssum murale s.l. Populations from the Ultramafics of Serbia. in Polish Journal of Environmental Studies. 2012;21(6):1855-1866.
https://hdl.handle.net/21.15107/rcub_agrospace_2792 .

Tumi, Ahmed F., Mihailović, Nevena, Gajić, Boško, Niketić, Marjan, Tomović, Gordana, "Comparative Study of Hyperaccumulation of Nickel by Alyssum murale s.l. Populations from the Ultramafics of Serbia" in Polish Journal of Environmental Studies, 21, no. 6 (2012):1855-1866,
https://hdl.handle.net/21.15107/rcub_agrospace_2792 .