TY  - CONF
AU  - Apostolopoulou, Maria Eleftheria
AU  - Pećinar, Ilinka
AU  - Tsioutsiou, Efthymia Eleni
AU  - Vaios, Amountzias
AU  - Evanthia, Dina
AU  - Antigoni, Cheilari
AU  - Dajić Stevanović, Zora
AU  - Aligiannis, Nektarios
PY  - 2023
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6815
AB  - The Balkan Peninsula has a long tradition in folk medicine and a plethora of 
plant species are utilised in treating skin disorders [1]. Within the context of 
the EU project “EthnoHERBS”, the aim of this study was the phytochemical and 
biological investigation of Serbian plants that have been traditionally used in 
the treatment of skin ailments (hyperpigmentation, wound healing). Eighty two plant species, selected based on ethnobotanical studies, were extracted 
successively with dichloromethane, methanol and methanol:water (1:1) and 
their chemical profile was investigated through high-performance thin-layer 
chromatography (HPTLC) and high-performance liquid chromatography (HPLC DAD). The total phenolic (TPC) and total flavonoid content (TFC) were evaluat ed using the Folin-Ciocalteau and the aluminium chloride colorimetric method, 
respectively. The antioxidant capacity of extracts was determined through the 
DPPH assay (concentration of 200 µg/mL), and their anti-tyrosinase and an ti-collagenase activity was tested at a concentration of 300 µg/mL and 100 µg/
mL, respectively. Several secondary metabolites were detected in the extracts 
such as terpenes, flavonoids, tannins, etc. The highest antioxidant activity was 
found in the extracts of Mentha longifolia, Hypericum perforatum and Cotinus 
coggyria. The hydroalcoholic and the methanolic extracts of Cotinus coggyria
demonstrated the best anti-tyrosinase (IC50 = 36.27 μg/mL) and the best an ti-collagenase (IC50 = 18.13 μg/mL) activity, respectively. In conclusion, ex ploitation of traditional knowledge can provide valuable information for the 
development of natural products with beneficial skin effects
C3  - 71st International Congress and Annual Meeting of the Society for  Medicinal Plant and Natural Product Research (GA)
T1  - Exploration of Serbian biodiversity for the discovery of bioactive natural products with skin beneficial effects
SP  - 1369
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_6815
ER  - 

@conference{
author = "Apostolopoulou, Maria Eleftheria and Pećinar, Ilinka and Tsioutsiou, Efthymia Eleni and Vaios, Amountzias and Evanthia, Dina and Antigoni, Cheilari and Dajić Stevanović, Zora and Aligiannis, Nektarios",
year = "2023",
abstract = "The Balkan Peninsula has a long tradition in folk medicine and a plethora of 
plant species are utilised in treating skin disorders [1]. Within the context of 
the EU project “EthnoHERBS”, the aim of this study was the phytochemical and 
biological investigation of Serbian plants that have been traditionally used in 
the treatment of skin ailments (hyperpigmentation, wound healing). Eighty two plant species, selected based on ethnobotanical studies, were extracted 
successively with dichloromethane, methanol and methanol:water (1:1) and 
their chemical profile was investigated through high-performance thin-layer 
chromatography (HPTLC) and high-performance liquid chromatography (HPLC DAD). The total phenolic (TPC) and total flavonoid content (TFC) were evaluat ed using the Folin-Ciocalteau and the aluminium chloride colorimetric method, 
respectively. The antioxidant capacity of extracts was determined through the 
DPPH assay (concentration of 200 µg/mL), and their anti-tyrosinase and an ti-collagenase activity was tested at a concentration of 300 µg/mL and 100 µg/
mL, respectively. Several secondary metabolites were detected in the extracts 
such as terpenes, flavonoids, tannins, etc. The highest antioxidant activity was 
found in the extracts of Mentha longifolia, Hypericum perforatum and Cotinus 
coggyria. The hydroalcoholic and the methanolic extracts of Cotinus coggyria
demonstrated the best anti-tyrosinase (IC50 = 36.27 μg/mL) and the best an ti-collagenase (IC50 = 18.13 μg/mL) activity, respectively. In conclusion, ex ploitation of traditional knowledge can provide valuable information for the 
development of natural products with beneficial skin effects",
journal = "71st International Congress and Annual Meeting of the Society for  Medicinal Plant and Natural Product Research (GA)",
title = "Exploration of Serbian biodiversity for the discovery of bioactive natural products with skin beneficial effects",
pages = "1369",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_6815"
}

Apostolopoulou, M. E., Pećinar, I., Tsioutsiou, E. E., Vaios, A., Evanthia, D., Antigoni, C., Dajić Stevanović, Z.,& Aligiannis, N.. (2023). Exploration of Serbian biodiversity for the discovery of bioactive natural products with skin beneficial effects. in 71st International Congress and Annual Meeting of the Society for  Medicinal Plant and Natural Product Research (GA), 1369.
https://hdl.handle.net/21.15107/rcub_agrospace_6815

Apostolopoulou ME, Pećinar I, Tsioutsiou EE, Vaios A, Evanthia D, Antigoni C, Dajić Stevanović Z, Aligiannis N. Exploration of Serbian biodiversity for the discovery of bioactive natural products with skin beneficial effects. in 71st International Congress and Annual Meeting of the Society for  Medicinal Plant and Natural Product Research (GA). 2023;:1369.
https://hdl.handle.net/21.15107/rcub_agrospace_6815 .

Apostolopoulou, Maria Eleftheria, Pećinar, Ilinka, Tsioutsiou, Efthymia Eleni, Vaios, Amountzias, Evanthia, Dina, Antigoni, Cheilari, Dajić Stevanović, Zora, Aligiannis, Nektarios, "Exploration of Serbian biodiversity for the discovery of bioactive natural products with skin beneficial effects" in 71st International Congress and Annual Meeting of the Society for  Medicinal Plant and Natural Product Research (GA) (2023):1369,
https://hdl.handle.net/21.15107/rcub_agrospace_6815 .