TY  - JOUR
AU  - Su, Guo-Zhu
AU  - Wang, Shang-Yi
AU  - Yang, Xiu-Ying
AU  - Stevanović, Zora Dajić
AU  - Li, Na
AU  - Tanić, Nikola
AU  - Arsenijević, Nebojša
AU  - Yu, Shi-Shan
AU  - Li, Yong
PY  - 2022
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6191
AB  - Five undescribed dihydroflavonoid glycoside derivatives, namely albvisosides A‒E, together with two known compounds were isolated from the roots and stem leaves of Viscum album L. var. album. (European mistletoe). Their structures were determined by HRESIMS, 1D and 2D NMR, and ECD analysis. Albvisoside B exhibits significant inhibitory effect on hepatic lipid accumulation in HepG2 cells at very low concentrations (EC50: 0.7 nM). Using proteome integral solubility alteration assay, the direct targets or downstream effectors of albvisoside B were elucidated. As a result, 97 proteins were identified based on ligand-induced alterations in the protein thermal stability. Bioinformatics analysis indicated that albvisoside B primarily ameliorated oleic acid-induced lipid accumulation by regulating the selenoamino acids metabolism signaling pathway. RPL3, ADAM17, and RPL14 were likely to be involved in mediating the lipid-lowering effect of albvisoside B. © 2022 Elsevier Ltd
T2  - Phytochemistry
T2  - Phytochemistry
T1  - Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification
VL  - 204
DO  - 10.1016/j.phytochem.2022.113458
ER  - 

@article{
author = "Su, Guo-Zhu and Wang, Shang-Yi and Yang, Xiu-Ying and Stevanović, Zora Dajić and Li, Na and Tanić, Nikola and Arsenijević, Nebojša and Yu, Shi-Shan and Li, Yong",
year = "2022",
abstract = "Five undescribed dihydroflavonoid glycoside derivatives, namely albvisosides A‒E, together with two known compounds were isolated from the roots and stem leaves of Viscum album L. var. album. (European mistletoe). Their structures were determined by HRESIMS, 1D and 2D NMR, and ECD analysis. Albvisoside B exhibits significant inhibitory effect on hepatic lipid accumulation in HepG2 cells at very low concentrations (EC50: 0.7 nM). Using proteome integral solubility alteration assay, the direct targets or downstream effectors of albvisoside B were elucidated. As a result, 97 proteins were identified based on ligand-induced alterations in the protein thermal stability. Bioinformatics analysis indicated that albvisoside B primarily ameliorated oleic acid-induced lipid accumulation by regulating the selenoamino acids metabolism signaling pathway. RPL3, ADAM17, and RPL14 were likely to be involved in mediating the lipid-lowering effect of albvisoside B. © 2022 Elsevier Ltd",
journal = "Phytochemistry, Phytochemistry",
title = "Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification",
volume = "204",
doi = "10.1016/j.phytochem.2022.113458"
}

Su, G., Wang, S., Yang, X., Stevanović, Z. D., Li, N., Tanić, N., Arsenijević, N., Yu, S.,& Li, Y.. (2022). Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification. in Phytochemistry, 204.
https://doi.org/10.1016/j.phytochem.2022.113458

Su G, Wang S, Yang X, Stevanović ZD, Li N, Tanić N, Arsenijević N, Yu S, Li Y. Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification. in Phytochemistry. 2022;204.
doi:10.1016/j.phytochem.2022.113458 .

Su, Guo-Zhu, Wang, Shang-Yi, Yang, Xiu-Ying, Stevanović, Zora Dajić, Li, Na, Tanić, Nikola, Arsenijević, Nebojša, Yu, Shi-Shan, Li, Yong, "Dihydroflavonoid glycosides from Viscum album and their inhibitory effects on hepatic lipid accumulation and target identification" in Phytochemistry, 204 (2022),
https://doi.org/10.1016/j.phytochem.2022.113458 . .