TY  - CONF
AU  - Brkić, Dragica
AU  - Gašić, Slavica
AU  - Radivojević, Ljiljana
AU  - Szakonyne-Pasics, I.
AU  - Karan, Vesela
AU  - Nešković, Neško
PY  - 2011
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2669
PB  - Elsevier Ireland Ltd, Clare
C3  - Toxicology Letters
T1  - Avalon (R) (bentazon plus dicamba) herbicide: Subchronic toxicity to rats
EP  - S229
SP  - S228
VL  - 205
DO  - 10.1016/j.toxlet.2011.05.782
ER  - 

@conference{
author = "Brkić, Dragica and Gašić, Slavica and Radivojević, Ljiljana and Szakonyne-Pasics, I. and Karan, Vesela and Nešković, Neško",
year = "2011",
publisher = "Elsevier Ireland Ltd, Clare",
journal = "Toxicology Letters",
title = "Avalon (R) (bentazon plus dicamba) herbicide: Subchronic toxicity to rats",
pages = "S229-S228",
volume = "205",
doi = "10.1016/j.toxlet.2011.05.782"
}

Brkić, D., Gašić, S., Radivojević, L., Szakonyne-Pasics, I., Karan, V.,& Nešković, N.. (2011). Avalon (R) (bentazon plus dicamba) herbicide: Subchronic toxicity to rats. in Toxicology Letters
Elsevier Ireland Ltd, Clare., 205, S228-S229.
https://doi.org/10.1016/j.toxlet.2011.05.782

Brkić D, Gašić S, Radivojević L, Szakonyne-Pasics I, Karan V, Nešković N. Avalon (R) (bentazon plus dicamba) herbicide: Subchronic toxicity to rats. in Toxicology Letters. 2011;205:S228-S229.
doi:10.1016/j.toxlet.2011.05.782 .

Brkić, Dragica, Gašić, Slavica, Radivojević, Ljiljana, Szakonyne-Pasics, I., Karan, Vesela, Nešković, Neško, "Avalon (R) (bentazon plus dicamba) herbicide: Subchronic toxicity to rats" in Toxicology Letters, 205 (2011):S228-S229,
https://doi.org/10.1016/j.toxlet.2011.05.782 . .

TY  - JOUR
AU  - Brkić, Dragica
AU  - Szakonyne-Pasics, Ilona
AU  - Gašić, Slavica
AU  - Karan, Vesela
AU  - Radivojević, Ljiljana
AU  - Nešković, Neško
PY  - 2011
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/2533
AB  - Hematological effects of the herbicide Avalon (GAL-57), a mixture of bentazon and dicamba, were tested on rats. Avalon was administered by gavage at three and four dose levels (250, 500, 1000 and 1250 mg/kg weight/day) for 28 and 90 days. Hematological parameters, number of erythrocytes, leukocytes and platelets, hemoglobin concentration, hematocrit and erythrocyte indexes (MCV, MCH and MCHC) were monitored. The results showed that the herbicide Avalon caused decrease in the values of hemoglobin, hematocrit and erythrocyte indexes (both males and females). The changes (mostly) correlated with the doses administered and, in most cases, a lower susceptibility of females than males was observed. The herbicide GAL-57 had no adverse effect on the number of leukocytes, erythrocytes and thrombocytes (both sexes, all doses tested). The results showed that the herbicide Avalon causes weak anemia to the animals tested. Reversibility was apparent during the recovery period of 28 days.
AB  - U radu su ispitivani hematološki efekti herbicida Avalon (GAL-57), koji je mešavina bentazona i dikambe kao aktivnih materija, na pacovima. Preparat je doziran oralnim putem (sondom u želudac) u više nivoa doza (250, 500, 1000 i 1250 mg/kg/telesne mase/dan) tokom 28 i 90 dana. Praćeni su sledeći pokazatelji: broj eritrocita, leukocita i trombocita, koncentracija hemoglobina, hematokrit i eritrocitni indeksi (prosečna zapremina eritrocita, srednja vrednost hemoglobina po eritrocitu i prosečna koncentracija hemoglobina u eritrocitima). Rezultati ovih ispitivanja su pokazali da herbicid Avalon kod oba pola izaziva smanjenje vrednosti hemoglobina, hematokrita i eritrocitnih indeksa, dok kod drugih ispitivanih pokazatelja (broj leukocita, eritrocita i trombocita) nisu registrovane promene u odnosu na kontrolu. Sve promene su, najčešće, u korelaciji sa primenjenim dozama a uočena je, u najvećem broju slučajeva, i nešto manja osetljivost ženki u odnosu na mužjake. Rezultati ispitivanja su, takođe, pokazali da Avalon izaziva blagu anemiju kod ispitivanih životinja s tim da je efekat reverzibilnog karaktera; nakon isteka perioda oporavka od 28 dana vrednosti za sve ispitivane parametre se vraćaju na normalu i ne razlikuju se značajnije u odnosu na kontrolu.
PB  - Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd
T2  - Pesticidi i fitomedicina
T1  - Hematological effects of herbicide Avalon® (bentazon+dicamba) in rats
T1  - Hematološki efekti herbicida Avalon® (bentazon+dikamba) za pacova
EP  - 407
IS  - 4
SP  - 401
VL  - 26
DO  - 10.2298/PIF1104401B
ER  - 

@article{
author = "Brkić, Dragica and Szakonyne-Pasics, Ilona and Gašić, Slavica and Karan, Vesela and Radivojević, Ljiljana and Nešković, Neško",
year = "2011",
abstract = "Hematological effects of the herbicide Avalon (GAL-57), a mixture of bentazon and dicamba, were tested on rats. Avalon was administered by gavage at three and four dose levels (250, 500, 1000 and 1250 mg/kg weight/day) for 28 and 90 days. Hematological parameters, number of erythrocytes, leukocytes and platelets, hemoglobin concentration, hematocrit and erythrocyte indexes (MCV, MCH and MCHC) were monitored. The results showed that the herbicide Avalon caused decrease in the values of hemoglobin, hematocrit and erythrocyte indexes (both males and females). The changes (mostly) correlated with the doses administered and, in most cases, a lower susceptibility of females than males was observed. The herbicide GAL-57 had no adverse effect on the number of leukocytes, erythrocytes and thrombocytes (both sexes, all doses tested). The results showed that the herbicide Avalon causes weak anemia to the animals tested. Reversibility was apparent during the recovery period of 28 days., U radu su ispitivani hematološki efekti herbicida Avalon (GAL-57), koji je mešavina bentazona i dikambe kao aktivnih materija, na pacovima. Preparat je doziran oralnim putem (sondom u želudac) u više nivoa doza (250, 500, 1000 i 1250 mg/kg/telesne mase/dan) tokom 28 i 90 dana. Praćeni su sledeći pokazatelji: broj eritrocita, leukocita i trombocita, koncentracija hemoglobina, hematokrit i eritrocitni indeksi (prosečna zapremina eritrocita, srednja vrednost hemoglobina po eritrocitu i prosečna koncentracija hemoglobina u eritrocitima). Rezultati ovih ispitivanja su pokazali da herbicid Avalon kod oba pola izaziva smanjenje vrednosti hemoglobina, hematokrita i eritrocitnih indeksa, dok kod drugih ispitivanih pokazatelja (broj leukocita, eritrocita i trombocita) nisu registrovane promene u odnosu na kontrolu. Sve promene su, najčešće, u korelaciji sa primenjenim dozama a uočena je, u najvećem broju slučajeva, i nešto manja osetljivost ženki u odnosu na mužjake. Rezultati ispitivanja su, takođe, pokazali da Avalon izaziva blagu anemiju kod ispitivanih životinja s tim da je efekat reverzibilnog karaktera; nakon isteka perioda oporavka od 28 dana vrednosti za sve ispitivane parametre se vraćaju na normalu i ne razlikuju se značajnije u odnosu na kontrolu.",
publisher = "Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd",
journal = "Pesticidi i fitomedicina",
title = "Hematological effects of herbicide Avalon® (bentazon+dicamba) in rats, Hematološki efekti herbicida Avalon® (bentazon+dikamba) za pacova",
pages = "407-401",
number = "4",
volume = "26",
doi = "10.2298/PIF1104401B"
}

Brkić, D., Szakonyne-Pasics, I., Gašić, S., Karan, V., Radivojević, L.,& Nešković, N.. (2011). Hematological effects of herbicide Avalon® (bentazon+dicamba) in rats. in Pesticidi i fitomedicina
Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd., 26(4), 401-407.
https://doi.org/10.2298/PIF1104401B

Brkić D, Szakonyne-Pasics I, Gašić S, Karan V, Radivojević L, Nešković N. Hematological effects of herbicide Avalon® (bentazon+dicamba) in rats. in Pesticidi i fitomedicina. 2011;26(4):401-407.
doi:10.2298/PIF1104401B .

Brkić, Dragica, Szakonyne-Pasics, Ilona, Gašić, Slavica, Karan, Vesela, Radivojević, Ljiljana, Nešković, Neško, "Hematological effects of herbicide Avalon® (bentazon+dicamba) in rats" in Pesticidi i fitomedicina, 26, no. 4 (2011):401-407,
https://doi.org/10.2298/PIF1104401B . .

TY  - JOUR
AU  - Brkić, Dragica
AU  - Gašić, Slavica
AU  - Béres, Erzsébet
AU  - Pápai, Enikő
AU  - Karan, Vesela
AU  - Nešković, Neško
PY  - 2007
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1478
AB  - A micronucleus test was run to investigate mutagenic potential of the herbicide GAL-57, a formulated mixture of bentazone and dicamba. The test was applied to mice of both sexes (strain: CRL: NMRI BR) and the herbicide (product) was administered by gavage at 2000 mg/kg rate, twice within 24 hs. Cyclophosphamide (positive control) was administered at 60 mg/kg, while distilled water as a solvent was negative control. The animals were sacrificed 24 hrs after second treatment, their bone marrow cells isolated from femur, and effects evaluated. The data acquired showed that repeated treatment of mice with GAL-57 caused neither biological nor significant statistical increase in the number of micronuclei in treated animals. At the same time, the number of micronucleated polychromatic erythrocytes in the bone marrow of animals treated with cyclophosphamide (positive control) showed a significant statistical increase. The results suggest that the herbicide product tested did not show any mutagenic activity under the conditions of mouse micronucleus test.
AB  - Mutageni potencijal herbicida GAL-57, koji je formulisan kao mešavina bentazona i dikambe, ispitivan je primenom mikronukleus testa. Ispitivanja su rađena na miševima oba pola (soj: CRL: NMRI BR), a ispitivani herbicid (preparat) je doziran oralno (sondom u želudac) u dozi od 2000 mg/kg, dva puta u razmaku od 24 sata. Kao pozitivna kontrola korišćen je ciklofosfamid (60 mg/kg), a kao negativna rastvarač (destilovana voda). Životinje su žrtvovane 24 sata nakon drugog tretiranja, izolovane su ćelije koštane srži (iz femura) i ocenjivan je efekat supstancije. Dobijeni rezultati su pokazali da ponovljen tretman miševa herbicidom GAL-57 ne izaziva ni biološki ni statistički značajno povećanje broja mikronukleusa kod tretiranih životinja. Istovremeno, kod životinja tretiranih ciklofosfamidom (pozitivna kontrola) broj mikronukleusa u polihromatskim eritrocitima koštane srži miševa bio je statistički značajno povećan. Na osnovu ovih rezultata može se zaključiti da ispitivani herbicid (preparat), u uslovima mikronukleus testa, ne ispoljava mutagena svojstva.
PB  - Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd
T2  - Pesticidi i fitomedicina
T1  - Examination of mutagenic effects of GAL-57 herbicide (bentazone+dicamba) using mouse micronucleus test
T1  - Ispitivanja mutagenih svojstava herbicida GAL-57 (bentazon + dikamba) primenom mikronukleus testa
EP  - 260
IS  - 3
SP  - 255
VL  - 22
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_1478
ER  - 

@article{
author = "Brkić, Dragica and Gašić, Slavica and Béres, Erzsébet and Pápai, Enikő and Karan, Vesela and Nešković, Neško",
year = "2007",
abstract = "A micronucleus test was run to investigate mutagenic potential of the herbicide GAL-57, a formulated mixture of bentazone and dicamba. The test was applied to mice of both sexes (strain: CRL: NMRI BR) and the herbicide (product) was administered by gavage at 2000 mg/kg rate, twice within 24 hs. Cyclophosphamide (positive control) was administered at 60 mg/kg, while distilled water as a solvent was negative control. The animals were sacrificed 24 hrs after second treatment, their bone marrow cells isolated from femur, and effects evaluated. The data acquired showed that repeated treatment of mice with GAL-57 caused neither biological nor significant statistical increase in the number of micronuclei in treated animals. At the same time, the number of micronucleated polychromatic erythrocytes in the bone marrow of animals treated with cyclophosphamide (positive control) showed a significant statistical increase. The results suggest that the herbicide product tested did not show any mutagenic activity under the conditions of mouse micronucleus test., Mutageni potencijal herbicida GAL-57, koji je formulisan kao mešavina bentazona i dikambe, ispitivan je primenom mikronukleus testa. Ispitivanja su rađena na miševima oba pola (soj: CRL: NMRI BR), a ispitivani herbicid (preparat) je doziran oralno (sondom u želudac) u dozi od 2000 mg/kg, dva puta u razmaku od 24 sata. Kao pozitivna kontrola korišćen je ciklofosfamid (60 mg/kg), a kao negativna rastvarač (destilovana voda). Životinje su žrtvovane 24 sata nakon drugog tretiranja, izolovane su ćelije koštane srži (iz femura) i ocenjivan je efekat supstancije. Dobijeni rezultati su pokazali da ponovljen tretman miševa herbicidom GAL-57 ne izaziva ni biološki ni statistički značajno povećanje broja mikronukleusa kod tretiranih životinja. Istovremeno, kod životinja tretiranih ciklofosfamidom (pozitivna kontrola) broj mikronukleusa u polihromatskim eritrocitima koštane srži miševa bio je statistički značajno povećan. Na osnovu ovih rezultata može se zaključiti da ispitivani herbicid (preparat), u uslovima mikronukleus testa, ne ispoljava mutagena svojstva.",
publisher = "Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd",
journal = "Pesticidi i fitomedicina",
title = "Examination of mutagenic effects of GAL-57 herbicide (bentazone+dicamba) using mouse micronucleus test, Ispitivanja mutagenih svojstava herbicida GAL-57 (bentazon + dikamba) primenom mikronukleus testa",
pages = "260-255",
number = "3",
volume = "22",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_1478"
}

Brkić, D., Gašić, S., Béres, E., Pápai, E., Karan, V.,& Nešković, N.. (2007). Examination of mutagenic effects of GAL-57 herbicide (bentazone+dicamba) using mouse micronucleus test. in Pesticidi i fitomedicina
Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd., 22(3), 255-260.
https://hdl.handle.net/21.15107/rcub_agrospace_1478

Brkić D, Gašić S, Béres E, Pápai E, Karan V, Nešković N. Examination of mutagenic effects of GAL-57 herbicide (bentazone+dicamba) using mouse micronucleus test. in Pesticidi i fitomedicina. 2007;22(3):255-260.
https://hdl.handle.net/21.15107/rcub_agrospace_1478 .

Brkić, Dragica, Gašić, Slavica, Béres, Erzsébet, Pápai, Enikő, Karan, Vesela, Nešković, Neško, "Examination of mutagenic effects of GAL-57 herbicide (bentazone+dicamba) using mouse micronucleus test" in Pesticidi i fitomedicina, 22, no. 3 (2007):255-260,
https://hdl.handle.net/21.15107/rcub_agrospace_1478 .

TY  - JOUR
AU  - Brkić, Dragica
AU  - Gašić, Slavica
AU  - Vértesi, Adél
AU  - Karan, Vesela
AU  - Nešković, Neško
PY  - 2006
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1190
AB  - Genotoxicity of the herbicide GAL-57, containing two active ingredients, bentazon and dicamba, was investigated using the Ames test. Salmonella typhimurium (tester strains TA98 and TA100) and Escherichia coli (strain WP2uvrA) were used. Nine product concentrations were tested at a range of 19.53-5000 μg/plate and each concentration, as well as the controls, in triplicate. Testing was done with and without metabolic activation (liver microsomal fraction, S-9 mix). The results of our investigation revealed no biological or statistically significant increase in mutagenic factors, and this offered a basis for our conclusion that the herbicide GAL-57 has no genotoxic properties (with or without metabolic activation) under experimental conditions in the Ames test.
AB  - Genotoksična svojstva herbicida GAL-57, koji u svom sastavu ima dve aktivne materije, bentazon i dikambu, ispitivana su primenom Ames-ovog testa. Korišćene su bakterije Salmonella typhimurium (sojevi TA98 i TA100) i Escherichia coli (WP2uvrA soj). Ispitivano je devet koncentracija preparata u opsegu 19.53-5000 μg/ploča pri čemu je svaka koncentracija, kao i kontrole, testirana po tri puta. Ispitivanje je obavljeno sa i bez metaboličke aktivacije (mikrozomska frakcija jetre, S-9 mix). Rezultati ispitivanja su pokazali da nema ni biološki ni statistički značajnog povećanja faktora mutacije na osnovu čega se zaključuje da herbicid GAL-57, u eksperimentalnim uslovima Ames-ovog testa, ne poseduje genotoksična svojstva (sa i bez metaboličke aktivacije).
PB  - Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd
T2  - Pesticidi i fitomedicina
T1  - Genotoxicity of GAL-57 herbicide in Salmonella typhimurium and Escherichia coli
T1  - Ispitivanja genotoksičnosti herbicida GAL-57 na Salmonella typhimurium i Escherichia coli
EP  - 323
IS  - 4
SP  - 317
VL  - 21
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_1190
ER  - 

@article{
author = "Brkić, Dragica and Gašić, Slavica and Vértesi, Adél and Karan, Vesela and Nešković, Neško",
year = "2006",
abstract = "Genotoxicity of the herbicide GAL-57, containing two active ingredients, bentazon and dicamba, was investigated using the Ames test. Salmonella typhimurium (tester strains TA98 and TA100) and Escherichia coli (strain WP2uvrA) were used. Nine product concentrations were tested at a range of 19.53-5000 μg/plate and each concentration, as well as the controls, in triplicate. Testing was done with and without metabolic activation (liver microsomal fraction, S-9 mix). The results of our investigation revealed no biological or statistically significant increase in mutagenic factors, and this offered a basis for our conclusion that the herbicide GAL-57 has no genotoxic properties (with or without metabolic activation) under experimental conditions in the Ames test., Genotoksična svojstva herbicida GAL-57, koji u svom sastavu ima dve aktivne materije, bentazon i dikambu, ispitivana su primenom Ames-ovog testa. Korišćene su bakterije Salmonella typhimurium (sojevi TA98 i TA100) i Escherichia coli (WP2uvrA soj). Ispitivano je devet koncentracija preparata u opsegu 19.53-5000 μg/ploča pri čemu je svaka koncentracija, kao i kontrole, testirana po tri puta. Ispitivanje je obavljeno sa i bez metaboličke aktivacije (mikrozomska frakcija jetre, S-9 mix). Rezultati ispitivanja su pokazali da nema ni biološki ni statistički značajnog povećanja faktora mutacije na osnovu čega se zaključuje da herbicid GAL-57, u eksperimentalnim uslovima Ames-ovog testa, ne poseduje genotoksična svojstva (sa i bez metaboličke aktivacije).",
publisher = "Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd",
journal = "Pesticidi i fitomedicina",
title = "Genotoxicity of GAL-57 herbicide in Salmonella typhimurium and Escherichia coli, Ispitivanja genotoksičnosti herbicida GAL-57 na Salmonella typhimurium i Escherichia coli",
pages = "323-317",
number = "4",
volume = "21",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_1190"
}

Brkić, D., Gašić, S., Vértesi, A., Karan, V.,& Nešković, N.. (2006). Genotoxicity of GAL-57 herbicide in Salmonella typhimurium and Escherichia coli. in Pesticidi i fitomedicina
Institut za pesticide i zaštitu životne sredine, Beograd i Društvo za zaštitu bilja Srbije, Beograd., 21(4), 317-323.
https://hdl.handle.net/21.15107/rcub_agrospace_1190

Brkić D, Gašić S, Vértesi A, Karan V, Nešković N. Genotoxicity of GAL-57 herbicide in Salmonella typhimurium and Escherichia coli. in Pesticidi i fitomedicina. 2006;21(4):317-323.
https://hdl.handle.net/21.15107/rcub_agrospace_1190 .

Brkić, Dragica, Gašić, Slavica, Vértesi, Adél, Karan, Vesela, Nešković, Neško, "Genotoxicity of GAL-57 herbicide in Salmonella typhimurium and Escherichia coli" in Pesticidi i fitomedicina, 21, no. 4 (2006):317-323,
https://hdl.handle.net/21.15107/rcub_agrospace_1190 .

TY  - JOUR
AU  - Poleksić, Vesna
AU  - Karan, Vesela
PY  - 1999
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/159
AB  - Acute and subacute toxicity of the herbicide trifluralin on fish was investigated in laboratory toxicity tests with carp, Median lethal concentrations were determined in acute tests. The 96-h LC50 value was 0.045 (0.036-0.051) mg/L. Fish were exposed to subacute concentrations of the herbicide (0.005, 0,01, and 0.02 mg/L trifluralin) in the 14-day toxicity tests and the effects on the relative growth rate, some biochemical parameters [alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanin aminotransferase (ALT) activities in serum, gills, liver, and kidney], gills, liver, and kidney structure were studied. A decrease in relative growth rate was found. An increase of functional enzyme activities in blood serum and the organs examined, particularly in the highest concentration of trifluralin indicated changes in the vital organs, was confirmed by histological analysis. The most severe changes (although mostly reversible) were found in the gills and kidney of the fish examined.
PB  - Academic Press Inc Elsevier Science, San Diego
T2  - Ecotoxicology and Environmental Safety
T1  - Effects of trifluralin on carp: Biochemical and histological evaluation
EP  - 221
IS  - 2
SP  - 213
VL  - 43
DO  - 10.1006/eesa.1999.1790
ER  - 

@article{
author = "Poleksić, Vesna and Karan, Vesela",
year = "1999",
abstract = "Acute and subacute toxicity of the herbicide trifluralin on fish was investigated in laboratory toxicity tests with carp, Median lethal concentrations were determined in acute tests. The 96-h LC50 value was 0.045 (0.036-0.051) mg/L. Fish were exposed to subacute concentrations of the herbicide (0.005, 0,01, and 0.02 mg/L trifluralin) in the 14-day toxicity tests and the effects on the relative growth rate, some biochemical parameters [alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanin aminotransferase (ALT) activities in serum, gills, liver, and kidney], gills, liver, and kidney structure were studied. A decrease in relative growth rate was found. An increase of functional enzyme activities in blood serum and the organs examined, particularly in the highest concentration of trifluralin indicated changes in the vital organs, was confirmed by histological analysis. The most severe changes (although mostly reversible) were found in the gills and kidney of the fish examined.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Ecotoxicology and Environmental Safety",
title = "Effects of trifluralin on carp: Biochemical and histological evaluation",
pages = "221-213",
number = "2",
volume = "43",
doi = "10.1006/eesa.1999.1790"
}

Poleksić, V.,& Karan, V.. (1999). Effects of trifluralin on carp: Biochemical and histological evaluation. in Ecotoxicology and Environmental Safety
Academic Press Inc Elsevier Science, San Diego., 43(2), 213-221.
https://doi.org/10.1006/eesa.1999.1790

Poleksić V, Karan V. Effects of trifluralin on carp: Biochemical and histological evaluation. in Ecotoxicology and Environmental Safety. 1999;43(2):213-221.
doi:10.1006/eesa.1999.1790 .

Poleksić, Vesna, Karan, Vesela, "Effects of trifluralin on carp: Biochemical and histological evaluation" in Ecotoxicology and Environmental Safety, 43, no. 2 (1999):213-221,
https://doi.org/10.1006/eesa.1999.1790 . .

TY  - CONF
AU  - Karan, Vesela
AU  - Vitorović, S
AU  - Tutundzić, V
AU  - Poleksić, Vesna
PY  - 1998
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/144
AB  - Copper sulfate is one of the most widely used algicides for the control of phytoplankton in lakes, reservoirs, and ponds. It is also used for aquatic weed control. To study the toxic effects of copper on carp (Cyprinus carpio L.), toxicity tests were carried out. Fish recovery in copper-free water was followed. After a 14-day period of exposure to five concentrations of copper sulfate (0.25-4.0 mg/L CUSO4, values ranging from approximately 5 to 70% of the 96-h LC-50) and a recovery period of the same duration, activities of the functional enzymes alkaline phosphatase (AP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the blood serum and gills were determined. Because the gills are the known target organ for copper, changes in gill structure were investigated as well. In all exposure groups for all the enzymes studied, an increase in activity was noted after 14 days. The increase in AP activity was the most pronounced in both gills and serum of carp exposed to the highest concentration tested (4 mg/L). After a "recovery" period, compared with the end of treatment, a decrease in enzyme activities was recorded, indicating eventual recovery from the Cu-induced stress (the only exception being the ALT activity in gills in the highest CuSO4 concentration). The results of biochemical analysis were confirmed by histopathology. Lesions such as epithelial hyperplasia, curling of secondary lamellae, and changes in chloride cells were observed on the gills, and their severity increased with increased toxicant concentration. Most of the changes were reversible, as exhibited by gill histopathology after the recovery period.
PB  - Academic Press Inc Elsevier Science, San Diego
C3  - Ecotoxicology and Environmental Safety
T1  - Functional enzymes activity and gill histology of carp after copper sulfate exposure and recovery
EP  - 55
IS  - 1-2
SP  - 49
VL  - 40
DO  - 10.1006/eesa.1998.1641
ER  - 

@conference{
author = "Karan, Vesela and Vitorović, S and Tutundzić, V and Poleksić, Vesna",
year = "1998",
abstract = "Copper sulfate is one of the most widely used algicides for the control of phytoplankton in lakes, reservoirs, and ponds. It is also used for aquatic weed control. To study the toxic effects of copper on carp (Cyprinus carpio L.), toxicity tests were carried out. Fish recovery in copper-free water was followed. After a 14-day period of exposure to five concentrations of copper sulfate (0.25-4.0 mg/L CUSO4, values ranging from approximately 5 to 70% of the 96-h LC-50) and a recovery period of the same duration, activities of the functional enzymes alkaline phosphatase (AP), aspartate aminotransferase (AST), and alanine aminotransferase (ALT) in the blood serum and gills were determined. Because the gills are the known target organ for copper, changes in gill structure were investigated as well. In all exposure groups for all the enzymes studied, an increase in activity was noted after 14 days. The increase in AP activity was the most pronounced in both gills and serum of carp exposed to the highest concentration tested (4 mg/L). After a "recovery" period, compared with the end of treatment, a decrease in enzyme activities was recorded, indicating eventual recovery from the Cu-induced stress (the only exception being the ALT activity in gills in the highest CuSO4 concentration). The results of biochemical analysis were confirmed by histopathology. Lesions such as epithelial hyperplasia, curling of secondary lamellae, and changes in chloride cells were observed on the gills, and their severity increased with increased toxicant concentration. Most of the changes were reversible, as exhibited by gill histopathology after the recovery period.",
publisher = "Academic Press Inc Elsevier Science, San Diego",
journal = "Ecotoxicology and Environmental Safety",
title = "Functional enzymes activity and gill histology of carp after copper sulfate exposure and recovery",
pages = "55-49",
number = "1-2",
volume = "40",
doi = "10.1006/eesa.1998.1641"
}

Karan, V., Vitorović, S., Tutundzić, V.,& Poleksić, V.. (1998). Functional enzymes activity and gill histology of carp after copper sulfate exposure and recovery. in Ecotoxicology and Environmental Safety
Academic Press Inc Elsevier Science, San Diego., 40(1-2), 49-55.
https://doi.org/10.1006/eesa.1998.1641

Karan V, Vitorović S, Tutundzić V, Poleksić V. Functional enzymes activity and gill histology of carp after copper sulfate exposure and recovery. in Ecotoxicology and Environmental Safety. 1998;40(1-2):49-55.
doi:10.1006/eesa.1998.1641 .

Karan, Vesela, Vitorović, S, Tutundzić, V, Poleksić, Vesna, "Functional enzymes activity and gill histology of carp after copper sulfate exposure and recovery" in Ecotoxicology and Environmental Safety, 40, no. 1-2 (1998):49-55,
https://doi.org/10.1006/eesa.1998.1641 . .

TY  - JOUR
AU  - Nešković, Neško
AU  - Poleksić, Vesna
AU  - Elezović, I.
AU  - Karan, Vesela
AU  - Budimir, M
PY  - 1996
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/94
T2  - Bulletin of Environmental Contamination and Toxicology
T1  - Biochemical and histopathological effects of glyphosate on carp, Cyprinus carpio L.
EP  - 302
IS  - 2
SP  - 295
VL  - 56
DO  - 10.1007/s001289900044
ER  - 

@article{
author = "Nešković, Neško and Poleksić, Vesna and Elezović, I. and Karan, Vesela and Budimir, M",
year = "1996",
journal = "Bulletin of Environmental Contamination and Toxicology",
title = "Biochemical and histopathological effects of glyphosate on carp, Cyprinus carpio L.",
pages = "302-295",
number = "2",
volume = "56",
doi = "10.1007/s001289900044"
}

Nešković, N., Poleksić, V., Elezović, I., Karan, V.,& Budimir, M.. (1996). Biochemical and histopathological effects of glyphosate on carp, Cyprinus carpio L.. in Bulletin of Environmental Contamination and Toxicology, 56(2), 295-302.
https://doi.org/10.1007/s001289900044

Nešković N, Poleksić V, Elezović I, Karan V, Budimir M. Biochemical and histopathological effects of glyphosate on carp, Cyprinus carpio L.. in Bulletin of Environmental Contamination and Toxicology. 1996;56(2):295-302.
doi:10.1007/s001289900044 .

Nešković, Neško, Poleksić, Vesna, Elezović, I., Karan, Vesela, Budimir, M, "Biochemical and histopathological effects of glyphosate on carp, Cyprinus carpio L." in Bulletin of Environmental Contamination and Toxicology, 56, no. 2 (1996):295-302,
https://doi.org/10.1007/s001289900044 . .

TY  - JOUR
AU  - Nešković, Neško
AU  - Karan, Vesela
AU  - Elezović, I.
AU  - Poleksić, Vesna
AU  - Budimir, M.
PY  - 1994
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/77
AB  - Acute and subacute 2,4-D toxicity to carp (Cyprinus carpio L.) were investigated. Acute toxicity (LC-50) was investigated in semi-static test during a 24, 48 and 96- hours exposition. Subacute toxicity was investigated by exposing to different 2,4,-D concentrations (150, 200, and 250 mg/L) for 14 days. Biochemical and morphological changes in certain organs and tissues were investigated. LC- 50 values at 24 hours exposure was 310.0 mg/L, 295.0 mg/L for 48 hours, and 270.0 mg/L for 96 hours exposure. Subacute toxicity tests show that 2,4-D induce changes in the enzyme activities (AP, GOT, GPT) and morphological changes in the gills, liver and kidneys, but changes are of limited biological importance.Acute and subacute 2,4-D toxicity to carp (Cyprinus carpio L.) were investigated. Acute toxicity (LC-50) was investigated in semi-static test during a 24, 48, and 96- hours exposition. Subacute toxicity was investigated by exposing fish to different 2,4,-D concentrations (150, 200, and 250 mg/L) for 14 days. Biochemical and morphological changes in certain organs and tissues were investigated. LC-50 values at 24 hours exposure was 310.0 mg/L, 295.0 mg/L for 48 hours, and 270.0 mg/L for 96 hours exposure. Subacute toxicity tests show that 2,4-D induce changes in the enzyme activities (AP, GOT, GPT) and morphological changes in the gills, liver and kidneys, but changes are of limited biological importance.
T2  - Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural
T1  - Toxic effects of 2,4-D herbicide on fish
EP  - 279
IS  - 2
SP  - 265
VL  - 29
DO  - 10.1080/03601239409372879
ER  - 

@article{
author = "Nešković, Neško and Karan, Vesela and Elezović, I. and Poleksić, Vesna and Budimir, M.",
year = "1994",
abstract = "Acute and subacute 2,4-D toxicity to carp (Cyprinus carpio L.) were investigated. Acute toxicity (LC-50) was investigated in semi-static test during a 24, 48 and 96- hours exposition. Subacute toxicity was investigated by exposing to different 2,4,-D concentrations (150, 200, and 250 mg/L) for 14 days. Biochemical and morphological changes in certain organs and tissues were investigated. LC- 50 values at 24 hours exposure was 310.0 mg/L, 295.0 mg/L for 48 hours, and 270.0 mg/L for 96 hours exposure. Subacute toxicity tests show that 2,4-D induce changes in the enzyme activities (AP, GOT, GPT) and morphological changes in the gills, liver and kidneys, but changes are of limited biological importance.Acute and subacute 2,4-D toxicity to carp (Cyprinus carpio L.) were investigated. Acute toxicity (LC-50) was investigated in semi-static test during a 24, 48, and 96- hours exposition. Subacute toxicity was investigated by exposing fish to different 2,4,-D concentrations (150, 200, and 250 mg/L) for 14 days. Biochemical and morphological changes in certain organs and tissues were investigated. LC-50 values at 24 hours exposure was 310.0 mg/L, 295.0 mg/L for 48 hours, and 270.0 mg/L for 96 hours exposure. Subacute toxicity tests show that 2,4-D induce changes in the enzyme activities (AP, GOT, GPT) and morphological changes in the gills, liver and kidneys, but changes are of limited biological importance.",
journal = "Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural",
title = "Toxic effects of 2,4-D herbicide on fish",
pages = "279-265",
number = "2",
volume = "29",
doi = "10.1080/03601239409372879"
}

Nešković, N., Karan, V., Elezović, I., Poleksić, V.,& Budimir, M.. (1994). Toxic effects of 2,4-D herbicide on fish. in Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural, 29(2), 265-279.
https://doi.org/10.1080/03601239409372879

Nešković N, Karan V, Elezović I, Poleksić V, Budimir M. Toxic effects of 2,4-D herbicide on fish. in Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural. 1994;29(2):265-279.
doi:10.1080/03601239409372879 .

Nešković, Neško, Karan, Vesela, Elezović, I., Poleksić, Vesna, Budimir, M., "Toxic effects of 2,4-D herbicide on fish" in Journal of Environmental Science and Health - Part B Pesticides, Food Contaminants, and Agricultural, 29, no. 2 (1994):265-279,
https://doi.org/10.1080/03601239409372879 . .

TY  - JOUR
AU  - Nešković, Neško
AU  - Elezović, I.
AU  - Karan, Vesela
AU  - Poleksić, Vesna
AU  - Budimir, M.
PY  - 1993
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/74
AB  - Investigations of acute and subacute atrazine toxicity in carp (Cyprinus carpio L.) were carried out. Acute toxicity was investigated in a semi-static test during a 96-hr exposition. The estimated LC-50 value was 18.8 mg/l. Subacute toxicity was investigated by exposing fish (carp) to different atrazine concentrations (1.5, 3.0, and 6.0 mg/l) for 14 days. Biochemical and histopathological changes in certain organs and tissues were investigated. The results show that atrazine leads to changes of varying intensity depending on the parameter tested, the organs and tissues examined, as well as the atrazine concentration. Biochemical changes were most prominent in the alkaline phosphatase, glutamic-oxaloacetic transaminase, and glutamic-pyruvic tranaminase activities whereas the most severe histopathological changes were observed in the gills.
T2  - Ecotoxicology and Environmental Safety
T1  - Acute and subacute toxicity of atrazine to carp (Cyprinus carpio L.)
EP  - 182
IS  - 2
SP  - 173
VL  - 25
DO  - 10.1006/eesa.1993.1016
ER  - 

@article{
author = "Nešković, Neško and Elezović, I. and Karan, Vesela and Poleksić, Vesna and Budimir, M.",
year = "1993",
abstract = "Investigations of acute and subacute atrazine toxicity in carp (Cyprinus carpio L.) were carried out. Acute toxicity was investigated in a semi-static test during a 96-hr exposition. The estimated LC-50 value was 18.8 mg/l. Subacute toxicity was investigated by exposing fish (carp) to different atrazine concentrations (1.5, 3.0, and 6.0 mg/l) for 14 days. Biochemical and histopathological changes in certain organs and tissues were investigated. The results show that atrazine leads to changes of varying intensity depending on the parameter tested, the organs and tissues examined, as well as the atrazine concentration. Biochemical changes were most prominent in the alkaline phosphatase, glutamic-oxaloacetic transaminase, and glutamic-pyruvic tranaminase activities whereas the most severe histopathological changes were observed in the gills.",
journal = "Ecotoxicology and Environmental Safety",
title = "Acute and subacute toxicity of atrazine to carp (Cyprinus carpio L.)",
pages = "182-173",
number = "2",
volume = "25",
doi = "10.1006/eesa.1993.1016"
}

Nešković, N., Elezović, I., Karan, V., Poleksić, V.,& Budimir, M.. (1993). Acute and subacute toxicity of atrazine to carp (Cyprinus carpio L.). in Ecotoxicology and Environmental Safety, 25(2), 173-182.
https://doi.org/10.1006/eesa.1993.1016

Nešković N, Elezović I, Karan V, Poleksić V, Budimir M. Acute and subacute toxicity of atrazine to carp (Cyprinus carpio L.). in Ecotoxicology and Environmental Safety. 1993;25(2):173-182.
doi:10.1006/eesa.1993.1016 .

Nešković, Neško, Elezović, I., Karan, Vesela, Poleksić, Vesna, Budimir, M., "Acute and subacute toxicity of atrazine to carp (Cyprinus carpio L.)" in Ecotoxicology and Environmental Safety, 25, no. 2 (1993):173-182,
https://doi.org/10.1006/eesa.1993.1016 . .