TY  - JOUR
AU  - Torović, Ljilja
AU  - Bursić, Vojislava
AU  - Vuković, Gorica
PY  - 2023
UR  - http://www.ncbi.nlm.nih.gov/pubmed/37662793
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/6420
AB  - Following the implementation of the European regulation limiting the presence of tropane alkaloids in certain foods, a survey was conducted in Serbia on 103 maize products (grits, polenta and semolina) to determine atropine and scopolamine content using liquid chromatography with tandem-mass spectrometry analysis (LC-MS/MS). The probability of exceeding the Acute Reference Dose (ARfD; 0.016 μg/kg bw/day) of the sum of atropine and scopolamine by consuming these products was tested. Overall, across age categories - children, younger and older adolescents, and adults, the group ARfD was exceeded by 21.4%, 17.5%, 11.7% and 11.7% of the samples, with maximum exposure reaching as much as 19-, 13-, 9- and 9-fold the group ARfD, respectively. Nevertheless, polenta could be the most favorable dietary option (17.9% of positive samples, 7.7% resulting in excessive exposure in children, reaching a maximum of 1.4-fold the group ARfD). According to the reported findings, adverse health effects of tropane alkaloids cannot be ruled out. The Margin of Exposure, founded on a clinically significant acute effects dose established by FAO/WHO, ranged from 1194 to 2381 (mean) and from 28 to 56 (95th percentile) across age categories. These estimates should certainly draw the attention of food authorities and nutritionist, particularly in the case of highly sensitive populations with contraindications and high consumers of corn products, such as coeliac patients.
T2  - Heliyon
T2  - HeliyonHeliyon
T1  - Health concerns associated to tropane alkaloids in maize food products in Serbia
IS  - 9
SP  - e19404
VL  - 9
DO  - 10.1016/j.heliyon.2023.e19404
ER  - 

@article{
author = "Torović, Ljilja and Bursić, Vojislava and Vuković, Gorica",
year = "2023",
abstract = "Following the implementation of the European regulation limiting the presence of tropane alkaloids in certain foods, a survey was conducted in Serbia on 103 maize products (grits, polenta and semolina) to determine atropine and scopolamine content using liquid chromatography with tandem-mass spectrometry analysis (LC-MS/MS). The probability of exceeding the Acute Reference Dose (ARfD; 0.016 μg/kg bw/day) of the sum of atropine and scopolamine by consuming these products was tested. Overall, across age categories - children, younger and older adolescents, and adults, the group ARfD was exceeded by 21.4%, 17.5%, 11.7% and 11.7% of the samples, with maximum exposure reaching as much as 19-, 13-, 9- and 9-fold the group ARfD, respectively. Nevertheless, polenta could be the most favorable dietary option (17.9% of positive samples, 7.7% resulting in excessive exposure in children, reaching a maximum of 1.4-fold the group ARfD). According to the reported findings, adverse health effects of tropane alkaloids cannot be ruled out. The Margin of Exposure, founded on a clinically significant acute effects dose established by FAO/WHO, ranged from 1194 to 2381 (mean) and from 28 to 56 (95th percentile) across age categories. These estimates should certainly draw the attention of food authorities and nutritionist, particularly in the case of highly sensitive populations with contraindications and high consumers of corn products, such as coeliac patients.",
journal = "Heliyon, HeliyonHeliyon",
title = "Health concerns associated to tropane alkaloids in maize food products in Serbia",
number = "9",
pages = "e19404",
volume = "9",
doi = "10.1016/j.heliyon.2023.e19404"
}

Torović, L., Bursić, V.,& Vuković, G.. (2023). Health concerns associated to tropane alkaloids in maize food products in Serbia. in Heliyon, 9(9), e19404.
https://doi.org/10.1016/j.heliyon.2023.e19404

Torović L, Bursić V, Vuković G. Health concerns associated to tropane alkaloids in maize food products in Serbia. in Heliyon. 2023;9(9):e19404.
doi:10.1016/j.heliyon.2023.e19404 .

Torović, Ljilja, Bursić, Vojislava, Vuković, Gorica, "Health concerns associated to tropane alkaloids in maize food products in Serbia" in Heliyon, 9, no. 9 (2023):e19404,
https://doi.org/10.1016/j.heliyon.2023.e19404 . .