@conference{
author = "Apostolopoulou, Maria Eleftheria and Pećinar, Ilinka and Tsioutsiou, Efthymia Eleni and Vaios, Amountzias and Evanthia, Dina and Antigoni, Cheilari and Dajić Stevanović, Zora and Aligiannis, Nektarios",
year = "2023",
abstract = "The Balkan Peninsula has a long tradition in folk medicine and a plethora of
plant species are utilised in treating skin disorders [1]. Within the context of
the EU project “EthnoHERBS”, the aim of this study was the phytochemical and
biological investigation of Serbian plants that have been traditionally used in
the treatment of skin ailments (hyperpigmentation, wound healing). Eighty two plant species, selected based on ethnobotanical studies, were extracted
successively with dichloromethane, methanol and methanol:water (1:1) and
their chemical profile was investigated through high-performance thin-layer
chromatography (HPTLC) and high-performance liquid chromatography (HPLC DAD). The total phenolic (TPC) and total flavonoid content (TFC) were evaluat ed using the Folin-Ciocalteau and the aluminium chloride colorimetric method,
respectively. The antioxidant capacity of extracts was determined through the
DPPH assay (concentration of 200 µg/mL), and their anti-tyrosinase and an ti-collagenase activity was tested at a concentration of 300 µg/mL and 100 µg/
mL, respectively. Several secondary metabolites were detected in the extracts
such as terpenes, flavonoids, tannins, etc. The highest antioxidant activity was
found in the extracts of Mentha longifolia, Hypericum perforatum and Cotinus
coggyria. The hydroalcoholic and the methanolic extracts of Cotinus coggyria
demonstrated the best anti-tyrosinase (IC50 = 36.27 μg/mL) and the best an ti-collagenase (IC50 = 18.13 μg/mL) activity, respectively. In conclusion, ex ploitation of traditional knowledge can provide valuable information for the
development of natural products with beneficial skin effects",
journal = "71st International Congress and Annual Meeting of the Society for Medicinal Plant and Natural Product Research (GA)",
title = "Exploration of Serbian biodiversity for the discovery of bioactive natural products with skin beneficial effects",
pages = "1369",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_6815"
}