TY  - JOUR
AU  - Boltić, Zorana
AU  - Petkovska, Menka
AU  - Obradović, Bojana M.
AU  - Nedović, Viktor
AU  - Bugarski, Branko
PY  - 2003
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/541
AB  - Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the antibiotic diffusion coefficients were estimated. In addition, the mass transfer resistance of the membrane was shown to be insignificant confirming the suitability of the applied experimental system. Since liposomes are known as systems with slower drug release, then, when it comes to their incorporation in the final form of a preparation for further experiments in vivo, the system of choice would be liposomes with an encapsulated antibiotic drug. The established experimental system could be extended to other liposome formulations with respect to the release rate of the active components.
AB  - Rezultati su pokazali značajan efekat produženog oslobađanja odabranog antibiotika iz lipidnih vezikula u membranskom sistemu sa cilindričnim modulom (namenski dizajniran u cilju mimike sistema primene topičnog preparata na koži) u poređenju sa rastvorom leka iste inicijalne koncentracije koji je podvrgnut istim eksperimentalnim uslovima. Dva modela nestacionarne, jednodimenzione difuzije primenjena su za predviđanje brzine oslobađanja leka iz lipidnih vezikula u cilindričnom membranskom modulu. Oba modela su pokazala dobro slaganje sa eksperimentalnim rezultatima i predskazala približno pedeset puta sporije otpuštanje iz lipidnih vezikula u poređenju sa čistim rastvorom leka. Osim toga, rezultati matematičkog modelovanja su pokazali da celulozno-acetatna membrana ima zanemarljiv uticaj na ukupnu brzinu oslobađanja leka. Ovakav rezultat potvrdio je pogodnost primenjenog eksperimentalnog sistema za ispitivanje kinetike otpuštanja odabranog antibiotika iz lipidnih vezikula.Kako se pokazalo da je otpuštanje leka iz disperzije lipidnih vezikula sporije u poređenju sa čistim rastvorom antibiotika, ovakav sistem nosača sa inkapsuliranim antibiotskim agensom ima prednost kada je u pitanju njegovo ugrađivanje u finalni oblik topičnog preparata za dalja ispitivanja in vivo. Odabrani eksperimentalni sistem se može primeniti i na druge formulacije na bazi lipidnih vezikula, za ispitivanje kinetike otpuštanja inkapsuliranih aktivnih supstanci. Na taj način bi se mogla uspostaviti relevantna metoda za in vitro karakterizaciju i poređenje različitih sistema nosača aktivnih komponenti.
PB  - Savez hemijskih inženjera, Beograd
T2  - Hemijska industrija
T1  - In vitro evaluation of the controlled release of antibiotics from liposomes
T1  - In vitro ispitivanje kontrolisanog otpuštanja antibiotika iz liposoma
EP  - 595
IS  - 12
SP  - 589
VL  - 57
DO  - 10.2298/HEMIND0312589B
ER  - 

@article{
author = "Boltić, Zorana and Petkovska, Menka and Obradović, Bojana M. and Nedović, Viktor and Bugarski, Branko",
year = "2003",
abstract = "Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the antibiotic diffusion coefficients were estimated. In addition, the mass transfer resistance of the membrane was shown to be insignificant confirming the suitability of the applied experimental system. Since liposomes are known as systems with slower drug release, then, when it comes to their incorporation in the final form of a preparation for further experiments in vivo, the system of choice would be liposomes with an encapsulated antibiotic drug. The established experimental system could be extended to other liposome formulations with respect to the release rate of the active components., Rezultati su pokazali značajan efekat produženog oslobađanja odabranog antibiotika iz lipidnih vezikula u membranskom sistemu sa cilindričnim modulom (namenski dizajniran u cilju mimike sistema primene topičnog preparata na koži) u poređenju sa rastvorom leka iste inicijalne koncentracije koji je podvrgnut istim eksperimentalnim uslovima. Dva modela nestacionarne, jednodimenzione difuzije primenjena su za predviđanje brzine oslobađanja leka iz lipidnih vezikula u cilindričnom membranskom modulu. Oba modela su pokazala dobro slaganje sa eksperimentalnim rezultatima i predskazala približno pedeset puta sporije otpuštanje iz lipidnih vezikula u poređenju sa čistim rastvorom leka. Osim toga, rezultati matematičkog modelovanja su pokazali da celulozno-acetatna membrana ima zanemarljiv uticaj na ukupnu brzinu oslobađanja leka. Ovakav rezultat potvrdio je pogodnost primenjenog eksperimentalnog sistema za ispitivanje kinetike otpuštanja odabranog antibiotika iz lipidnih vezikula.Kako se pokazalo da je otpuštanje leka iz disperzije lipidnih vezikula sporije u poređenju sa čistim rastvorom antibiotika, ovakav sistem nosača sa inkapsuliranim antibiotskim agensom ima prednost kada je u pitanju njegovo ugrađivanje u finalni oblik topičnog preparata za dalja ispitivanja in vivo. Odabrani eksperimentalni sistem se može primeniti i na druge formulacije na bazi lipidnih vezikula, za ispitivanje kinetike otpuštanja inkapsuliranih aktivnih supstanci. Na taj način bi se mogla uspostaviti relevantna metoda za in vitro karakterizaciju i poređenje različitih sistema nosača aktivnih komponenti.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Hemijska industrija",
title = "In vitro evaluation of the controlled release of antibiotics from liposomes, In vitro ispitivanje kontrolisanog otpuštanja antibiotika iz liposoma",
pages = "595-589",
number = "12",
volume = "57",
doi = "10.2298/HEMIND0312589B"
}

Boltić, Z., Petkovska, M., Obradović, B. M., Nedović, V.,& Bugarski, B.. (2003). In vitro evaluation of the controlled release of antibiotics from liposomes. in Hemijska industrija
Savez hemijskih inženjera, Beograd., 57(12), 589-595.
https://doi.org/10.2298/HEMIND0312589B

Boltić Z, Petkovska M, Obradović BM, Nedović V, Bugarski B. In vitro evaluation of the controlled release of antibiotics from liposomes. in Hemijska industrija. 2003;57(12):589-595.
doi:10.2298/HEMIND0312589B .

Boltić, Zorana, Petkovska, Menka, Obradović, Bojana M., Nedović, Viktor, Bugarski, Branko, "In vitro evaluation of the controlled release of antibiotics from liposomes" in Hemijska industrija, 57, no. 12 (2003):589-595,
https://doi.org/10.2298/HEMIND0312589B . .

TY  - JOUR
AU  - Boltić, Z.
AU  - Petkovska, Menka
AU  - Obradović, B.
AU  - Nedović, Viktor
AU  - Bugarski, Branko
PY  - 2003
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/523
AB  - Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the antibiotic diffusion coefficients were estimated. In addition, the mass transfer resistance of the membrane was shown to be insignificant confirming the suitability of the applied experimental system. Since liposomes are known as systems with slower drug release, then, when it comes to their incorporation in the final form of a preparation for further experiments in vivo, the system of choice would be liposomes with an encapsulated antibiotic drug. Tfie established experimental system could be extended to other liposome formulations with respect to the release rate of the active components.
PB  - Savez hemijskih inženjera, Beograd
T2  - Chemical Industry and Chemical Engineering Quarterly / CICEQ
T1  - In vitro evaluation of the controlled release of antibiotics from liposomes
T1  - In vitro ispitivanje kontrolisanog otpuštanja antibiotika iz liposoma
EP  - 595
IS  - 4
SP  - 589
VL  - 9
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_523
ER  - 

@article{
author = "Boltić, Z. and Petkovska, Menka and Obradović, B. and Nedović, Viktor and Bugarski, Branko",
year = "2003",
abstract = "Results of this study have shown significantly prolonged release of selected antibiotic from liposome dispersion as compared to free antibiotic solution of the same initial concentration. Two models of non-steady one-dimensional diffusion were successfully applied to the experimental data and the antibiotic diffusion coefficients were estimated. In addition, the mass transfer resistance of the membrane was shown to be insignificant confirming the suitability of the applied experimental system. Since liposomes are known as systems with slower drug release, then, when it comes to their incorporation in the final form of a preparation for further experiments in vivo, the system of choice would be liposomes with an encapsulated antibiotic drug. Tfie established experimental system could be extended to other liposome formulations with respect to the release rate of the active components.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Chemical Industry and Chemical Engineering Quarterly / CICEQ",
title = "In vitro evaluation of the controlled release of antibiotics from liposomes, In vitro ispitivanje kontrolisanog otpuštanja antibiotika iz liposoma",
pages = "595-589",
number = "4",
volume = "9",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_523"
}

Boltić, Z., Petkovska, M., Obradović, B., Nedović, V.,& Bugarski, B.. (2003). In vitro evaluation of the controlled release of antibiotics from liposomes. in Chemical Industry and Chemical Engineering Quarterly / CICEQ
Savez hemijskih inženjera, Beograd., 9(4), 589-595.
https://hdl.handle.net/21.15107/rcub_agrospace_523

Boltić Z, Petkovska M, Obradović B, Nedović V, Bugarski B. In vitro evaluation of the controlled release of antibiotics from liposomes. in Chemical Industry and Chemical Engineering Quarterly / CICEQ. 2003;9(4):589-595.
https://hdl.handle.net/21.15107/rcub_agrospace_523 .

Boltić, Z., Petkovska, Menka, Obradović, B., Nedović, Viktor, Bugarski, Branko, "In vitro evaluation of the controlled release of antibiotics from liposomes" in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 9, no. 4 (2003):589-595,
https://hdl.handle.net/21.15107/rcub_agrospace_523 .

TY  - JOUR
AU  - Leskošek, Ida
AU  - Nedović, Viktor
AU  - Petkovska, Menka
PY  - 1997
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/121
AB  - The industrial application of dialysis for the de-alcoholization of beer is based on a diafiltration method, because a small positive transmembrane pressure an the beer side of the membrane is necessary to prevent ingress of water by osmosis and resulting dilution of the beer. This pressure difference introduces the new driving and convective mass transfer mechanism, which takes place simultaneously with the diffusive mechanism (specific for dialysis). The question is the influence which it has on the overall mass transfer phenomenon and selectivity of the alcohol/extract separation. An experimental investigation of beer diafiltration using two different membranes (cellulose based Cuprophane and polysulfone) was performed at different transmembrane pressure differences and flow rates. On the basis of the experimentally measured inlet and outlet concentrations the convective components of the alcohol and extract mass fluxes as well as the overall separation factor were determined. This data was analysed and compared. The results indicate that convective mass transfer stimulated extract transfer and losses and thus diminished the efficiency of selective alcohol/extract separation in beer dialysis.
PB  - Inst Brewing, London
T2  - Journal of the Institute of Brewing
T1  - Effect of convective mass transfer on beer diafiltration
EP  - 282
IS  - 5
SP  - 279
VL  - 103
DO  - 10.1002/j.2050-0416.1997.tb00956.x
ER  - 

@article{
author = "Leskošek, Ida and Nedović, Viktor and Petkovska, Menka",
year = "1997",
abstract = "The industrial application of dialysis for the de-alcoholization of beer is based on a diafiltration method, because a small positive transmembrane pressure an the beer side of the membrane is necessary to prevent ingress of water by osmosis and resulting dilution of the beer. This pressure difference introduces the new driving and convective mass transfer mechanism, which takes place simultaneously with the diffusive mechanism (specific for dialysis). The question is the influence which it has on the overall mass transfer phenomenon and selectivity of the alcohol/extract separation. An experimental investigation of beer diafiltration using two different membranes (cellulose based Cuprophane and polysulfone) was performed at different transmembrane pressure differences and flow rates. On the basis of the experimentally measured inlet and outlet concentrations the convective components of the alcohol and extract mass fluxes as well as the overall separation factor were determined. This data was analysed and compared. The results indicate that convective mass transfer stimulated extract transfer and losses and thus diminished the efficiency of selective alcohol/extract separation in beer dialysis.",
publisher = "Inst Brewing, London",
journal = "Journal of the Institute of Brewing",
title = "Effect of convective mass transfer on beer diafiltration",
pages = "282-279",
number = "5",
volume = "103",
doi = "10.1002/j.2050-0416.1997.tb00956.x"
}

Leskošek, I., Nedović, V.,& Petkovska, M.. (1997). Effect of convective mass transfer on beer diafiltration. in Journal of the Institute of Brewing
Inst Brewing, London., 103(5), 279-282.
https://doi.org/10.1002/j.2050-0416.1997.tb00956.x

Leskošek I, Nedović V, Petkovska M. Effect of convective mass transfer on beer diafiltration. in Journal of the Institute of Brewing. 1997;103(5):279-282.
doi:10.1002/j.2050-0416.1997.tb00956.x .

Leskošek, Ida, Nedović, Viktor, Petkovska, Menka, "Effect of convective mass transfer on beer diafiltration" in Journal of the Institute of Brewing, 103, no. 5 (1997):279-282,
https://doi.org/10.1002/j.2050-0416.1997.tb00956.x . .

TY  - JOUR
AU  - Petkovska, Menka
AU  - Leskošek, Ida
AU  - Nedović, Viktor
PY  - 1997
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/122
AB  - An experimental investigation of beer dialysis with transmembrane pressure (diafiltration) was performed using two different hollow-fibre membranes: cuprophane (regenerated cellulose) and polysulfone for different flow rates and transmembrane pressure differences (TMP). In this process two simultaneous mass transfer mechanisms take place-diffusion and convection. On the basis of the experimentally measured inlet and outlet concentrations, the diffusive and convective components of the alcohol and extract fluxes were determined. It was found that the contribution of convective transport introduced by the TMP depends on the membrane type, beer flow rate and solute molecule size. The diffusive component is of primary importance for the elimination of alcohol molecules, while the convective component plays an important role in the transport of large molecules and extract loss.
PB  - Elsevier, Amsterdam
T2  - Food and Bioproducts Processing
T1  - Analysis of mass transfer in beer diafiltration with cellulose-based and polysulfone membranes
EP  - 252
IS  - C4
SP  - 247
VL  - 75
DO  - 10.1205/096030897531658
ER  - 

@article{
author = "Petkovska, Menka and Leskošek, Ida and Nedović, Viktor",
year = "1997",
abstract = "An experimental investigation of beer dialysis with transmembrane pressure (diafiltration) was performed using two different hollow-fibre membranes: cuprophane (regenerated cellulose) and polysulfone for different flow rates and transmembrane pressure differences (TMP). In this process two simultaneous mass transfer mechanisms take place-diffusion and convection. On the basis of the experimentally measured inlet and outlet concentrations, the diffusive and convective components of the alcohol and extract fluxes were determined. It was found that the contribution of convective transport introduced by the TMP depends on the membrane type, beer flow rate and solute molecule size. The diffusive component is of primary importance for the elimination of alcohol molecules, while the convective component plays an important role in the transport of large molecules and extract loss.",
publisher = "Elsevier, Amsterdam",
journal = "Food and Bioproducts Processing",
title = "Analysis of mass transfer in beer diafiltration with cellulose-based and polysulfone membranes",
pages = "252-247",
number = "C4",
volume = "75",
doi = "10.1205/096030897531658"
}

Petkovska, M., Leskošek, I.,& Nedović, V.. (1997). Analysis of mass transfer in beer diafiltration with cellulose-based and polysulfone membranes. in Food and Bioproducts Processing
Elsevier, Amsterdam., 75(C4), 247-252.
https://doi.org/10.1205/096030897531658

Petkovska M, Leskošek I, Nedović V. Analysis of mass transfer in beer diafiltration with cellulose-based and polysulfone membranes. in Food and Bioproducts Processing. 1997;75(C4):247-252.
doi:10.1205/096030897531658 .

Petkovska, Menka, Leskošek, Ida, Nedović, Viktor, "Analysis of mass transfer in beer diafiltration with cellulose-based and polysulfone membranes" in Food and Bioproducts Processing, 75, no. C4 (1997):247-252,
https://doi.org/10.1205/096030897531658 . .

TY  - JOUR
AU  - Petkovska, Menka
AU  - Leskošek-Čukalović, Ida
AU  - Vukosavljević, Predrag
AU  - Krstić, D.
PY  - 1996
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/96
AB  - Experimental investigation of selective alcohol removal from beer by dialysis and dialysis with transmembrane pressure (diafiltration), using two different hollow-fiber membranes: Cuprophan (regenerated cellulose) and polysulfone, was performed. The values of the main mass transfer parameters: hydraulic permeability, clearance, normalized mass flux, extraction ratio and selectivity were determined, and the influence of the flow-rates and the applied transmembrane pressure difference was analyzed. Based on these prameters, comparison of the two membranes was performed.
PB  - Srpsko hemijsko društvo, Beograd
T2  - Journal of the Serbian Chemical Society
T1  - Analysis of mass transfer in beer dialysis and diafiltration with two different membranes
EP  - 342
IS  - 4-5
SP  - 331
VL  - 61
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_96
ER  - 

@article{
author = "Petkovska, Menka and Leskošek-Čukalović, Ida and Vukosavljević, Predrag and Krstić, D.",
year = "1996",
abstract = "Experimental investigation of selective alcohol removal from beer by dialysis and dialysis with transmembrane pressure (diafiltration), using two different hollow-fiber membranes: Cuprophan (regenerated cellulose) and polysulfone, was performed. The values of the main mass transfer parameters: hydraulic permeability, clearance, normalized mass flux, extraction ratio and selectivity were determined, and the influence of the flow-rates and the applied transmembrane pressure difference was analyzed. Based on these prameters, comparison of the two membranes was performed.",
publisher = "Srpsko hemijsko društvo, Beograd",
journal = "Journal of the Serbian Chemical Society",
title = "Analysis of mass transfer in beer dialysis and diafiltration with two different membranes",
pages = "342-331",
number = "4-5",
volume = "61",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_96"
}

Petkovska, M., Leskošek-Čukalović, I., Vukosavljević, P.,& Krstić, D.. (1996). Analysis of mass transfer in beer dialysis and diafiltration with two different membranes. in Journal of the Serbian Chemical Society
Srpsko hemijsko društvo, Beograd., 61(4-5), 331-342.
https://hdl.handle.net/21.15107/rcub_agrospace_96

Petkovska M, Leskošek-Čukalović I, Vukosavljević P, Krstić D. Analysis of mass transfer in beer dialysis and diafiltration with two different membranes. in Journal of the Serbian Chemical Society. 1996;61(4-5):331-342.
https://hdl.handle.net/21.15107/rcub_agrospace_96 .

Petkovska, Menka, Leskošek-Čukalović, Ida, Vukosavljević, Predrag, Krstić, D., "Analysis of mass transfer in beer dialysis and diafiltration with two different membranes" in Journal of the Serbian Chemical Society, 61, no. 4-5 (1996):331-342,
https://hdl.handle.net/21.15107/rcub_agrospace_96 .