TY  - JOUR
AU  - Ebrahimi, Keramatollah
AU  - Sabljak, Predrag
AU  - Simić, Aleksandar
AU  - Skrobić, Ognjan
AU  - Velicović, Dejan
AU  - Sljukić, Vladimir
AU  - Novaković, Ivana
AU  - Dobricić, Valerija
AU  - Micev, Marjan
AU  - Pasko, Predrag
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5011
AB  - BACKGROUND: /Aim. KIT (KIT proto-oncogene receptor tyrosine kinase) and PDGFRA (platelet-derived growth factor receptor alpha) gene mutations represent major molecular forces inside the gastrointestinal stromal tumors (GIST). Aim of this study was to evaluate these mutations in the patients who underwent surgical resection of gastric GIST, but without imatinib mesylate treatment. Methods. Retrospective clinical study included patients who were operated on due to gastric GIST from November 2000 till November 2016. A molecular analysis of paraffin embedded tumor tissue was performed, and the patients with the presence of KIT and PDGFRA mutations were further evaluated, with regard to the pathological tumor stage, disease recurrence and overall survival. Results. Out of 45 patients in total, 43 patients had KIT and PDGFRA mutations, and 2 patients were classified as the wild type GIST. After curative resection, 11 patients were classified as a low risk GIST, 8 as an intermediate risk and 26 as a high risk GIST. The KIT mutations were present in 37 patients, most commonly as deletion in exon 11. The PDGFRA mutations were present in 6 patients. The presence of KIT mutation had a strong statistical correlation with the mitotic index (p = 0.021). After the ten-year follow-up, all patients with the PDGFRA mutations were alive, while those with the KIT mutations had a survival rate of 71% (p = 0.31). Conclusion. The presence of KIT exon 11 deletion in the patients with primarily resected gastric GIST is associated with the higher mitotic index and worse overall survival than those present with the PDGFRA mutations. This results suggest prognostic significance towards more aggressive behaviors.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Significance of KIT and PDGFRA mutations in gastric gastrointestinal stromal tumor imatinib-naive surgically treated patients
EP  - 1273
IS  - 12
SP  - 1268
VL  - 76
DO  - 10.2298/VSP180205048E
ER  - 

@article{
author = "Ebrahimi, Keramatollah and Sabljak, Predrag and Simić, Aleksandar and Skrobić, Ognjan and Velicović, Dejan and Sljukić, Vladimir and Novaković, Ivana and Dobricić, Valerija and Micev, Marjan and Pasko, Predrag",
year = "2019",
abstract = "BACKGROUND: /Aim. KIT (KIT proto-oncogene receptor tyrosine kinase) and PDGFRA (platelet-derived growth factor receptor alpha) gene mutations represent major molecular forces inside the gastrointestinal stromal tumors (GIST). Aim of this study was to evaluate these mutations in the patients who underwent surgical resection of gastric GIST, but without imatinib mesylate treatment. Methods. Retrospective clinical study included patients who were operated on due to gastric GIST from November 2000 till November 2016. A molecular analysis of paraffin embedded tumor tissue was performed, and the patients with the presence of KIT and PDGFRA mutations were further evaluated, with regard to the pathological tumor stage, disease recurrence and overall survival. Results. Out of 45 patients in total, 43 patients had KIT and PDGFRA mutations, and 2 patients were classified as the wild type GIST. After curative resection, 11 patients were classified as a low risk GIST, 8 as an intermediate risk and 26 as a high risk GIST. The KIT mutations were present in 37 patients, most commonly as deletion in exon 11. The PDGFRA mutations were present in 6 patients. The presence of KIT mutation had a strong statistical correlation with the mitotic index (p = 0.021). After the ten-year follow-up, all patients with the PDGFRA mutations were alive, while those with the KIT mutations had a survival rate of 71% (p = 0.31). Conclusion. The presence of KIT exon 11 deletion in the patients with primarily resected gastric GIST is associated with the higher mitotic index and worse overall survival than those present with the PDGFRA mutations. This results suggest prognostic significance towards more aggressive behaviors.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Significance of KIT and PDGFRA mutations in gastric gastrointestinal stromal tumor imatinib-naive surgically treated patients",
pages = "1273-1268",
number = "12",
volume = "76",
doi = "10.2298/VSP180205048E"
}

Ebrahimi, K., Sabljak, P., Simić, A., Skrobić, O., Velicović, D., Sljukić, V., Novaković, I., Dobricić, V., Micev, M.,& Pasko, P.. (2019). Significance of KIT and PDGFRA mutations in gastric gastrointestinal stromal tumor imatinib-naive surgically treated patients. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(12), 1268-1273.
https://doi.org/10.2298/VSP180205048E

Ebrahimi K, Sabljak P, Simić A, Skrobić O, Velicović D, Sljukić V, Novaković I, Dobricić V, Micev M, Pasko P. Significance of KIT and PDGFRA mutations in gastric gastrointestinal stromal tumor imatinib-naive surgically treated patients. in Vojnosanitetski pregled. 2019;76(12):1268-1273.
doi:10.2298/VSP180205048E .

Ebrahimi, Keramatollah, Sabljak, Predrag, Simić, Aleksandar, Skrobić, Ognjan, Velicović, Dejan, Sljukić, Vladimir, Novaković, Ivana, Dobricić, Valerija, Micev, Marjan, Pasko, Predrag, "Significance of KIT and PDGFRA mutations in gastric gastrointestinal stromal tumor imatinib-naive surgically treated patients" in Vojnosanitetski pregled, 76, no. 12 (2019):1268-1273,
https://doi.org/10.2298/VSP180205048E . .

TY  - JOUR
AU  - Rajković, Miloš
AU  - Novaković, Ivana D.
AU  - Petrović, Aleksandar
PY  - 2007
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1373
AB  - The amount of titration acid in must is in the largest number of cases with in the range 5.0-8.0 g/dm3. Wines, as a rule, contain less acids than must, and according to Regulations, titratable acidity is in the range of 4.0-8.0 g/dm3 expressed in tartaric acid, because a part of tartaric acid is deposited in the form of salts (tartar or argol) during alcohol fermentation. For wines that contain less than 4 g/dm3 of titratable acids there arises a suspicion about their origin, that is, that during the preparation some illegal acts were done. Because of that, the aim of this paper is to determine titratable acidity in white wine, using standard methods of determination, which are compared with the results received by potentiometric titration using ion-selective electrode. According to the received results it can be seen that wine titration with indicator gives sufficient reliable values of wine titration acidity. However, as potentiometric titration at pH value 7.00 is more reliable and objective method, the values of titratable acids content in wine, expressed through tartaric acid, are given according to this result. The analysis of differential potentiometric curves shows that these curves can give us an answer to the question of the presence of a larger amount of other nonorganic substances, which have already existed in wine. However, none of the used methods gives absolutely reliable answer what substances are present in analysed samples.
AB  - Količina titracionih kiselina u širi se, u najvećem broju slučajeva, kreće između 5 i 8 g/dm3. Vina, po pravilu, sadrže nešto manje kiselina nego šira, a prema Pravilniku, titraciona kiselost se kreće između 4,0 i 8,0 g/dm3 izraženo u vinskoj kiselini, jer se deo vinske kiseline istaloži u obliku soli (streša) u toku alkoholne fermentacije. Za vina koja sadrže ispod 4 g/dm3 titracionih kiselina postoji sumnja u njihovo poreklo, tj. da su prilikom njihovog spravljanja vršene nedozvoljene radnje. Zbog toga je cilj rada bio da se izvrši određivanje titracione kiselosti u belom vinu, standardnim metodama određivanja koje su upoređene sa rezultatima dobijenim potenciometrijskom titracijom uz jon-selektivnu elektrodu. Na osnovu dobijenih rezultata uočava se da titracija vina uz indikator daje dovoljno pouzdane vrednosti titracione kiselosti vina. Međutim, pošto je potenciometrijska titracija, pri pH vrednosti 7,00, pouzdanija i objektivnija metoda, vrednosti za sadržaj titracionih kiselina u vinu, izraženih preko vinske kiseline, date su upravo na osnovu ovog rezultata. Analiza diferencijalnih potenciometrijskih krivih, ukazuje da ove krive mogu pružiti odgovor na pitanje o prisustvu veće količine drugih neorganskih supstanci, koje se već nalaze u vinu. Međutim, ni jedna od ispitivanih metoda ne daje dovoljno pouzdan odgovor koje supstance su prisutne u analiziranim uzorcima, već odgovor na ovo pitanje može pružiti jedino metoda jonske hromatografije.
PB  - Univerzitet u Beogradu - Poljoprivredni fakultet, Beograd
T2  - Journal of Agricultural Sciences (Belgrade)
T1  - Determination of titratable acidity in white wine
T1  - Određivanje titracione kiselosti u belom vinu
EP  - 184
IS  - 2
SP  - 169
VL  - 52
DO  - 10.2298/JAS0702169R
ER  - 

@article{
author = "Rajković, Miloš and Novaković, Ivana D. and Petrović, Aleksandar",
year = "2007",
abstract = "The amount of titration acid in must is in the largest number of cases with in the range 5.0-8.0 g/dm3. Wines, as a rule, contain less acids than must, and according to Regulations, titratable acidity is in the range of 4.0-8.0 g/dm3 expressed in tartaric acid, because a part of tartaric acid is deposited in the form of salts (tartar or argol) during alcohol fermentation. For wines that contain less than 4 g/dm3 of titratable acids there arises a suspicion about their origin, that is, that during the preparation some illegal acts were done. Because of that, the aim of this paper is to determine titratable acidity in white wine, using standard methods of determination, which are compared with the results received by potentiometric titration using ion-selective electrode. According to the received results it can be seen that wine titration with indicator gives sufficient reliable values of wine titration acidity. However, as potentiometric titration at pH value 7.00 is more reliable and objective method, the values of titratable acids content in wine, expressed through tartaric acid, are given according to this result. The analysis of differential potentiometric curves shows that these curves can give us an answer to the question of the presence of a larger amount of other nonorganic substances, which have already existed in wine. However, none of the used methods gives absolutely reliable answer what substances are present in analysed samples., Količina titracionih kiselina u širi se, u najvećem broju slučajeva, kreće između 5 i 8 g/dm3. Vina, po pravilu, sadrže nešto manje kiselina nego šira, a prema Pravilniku, titraciona kiselost se kreće između 4,0 i 8,0 g/dm3 izraženo u vinskoj kiselini, jer se deo vinske kiseline istaloži u obliku soli (streša) u toku alkoholne fermentacije. Za vina koja sadrže ispod 4 g/dm3 titracionih kiselina postoji sumnja u njihovo poreklo, tj. da su prilikom njihovog spravljanja vršene nedozvoljene radnje. Zbog toga je cilj rada bio da se izvrši određivanje titracione kiselosti u belom vinu, standardnim metodama određivanja koje su upoređene sa rezultatima dobijenim potenciometrijskom titracijom uz jon-selektivnu elektrodu. Na osnovu dobijenih rezultata uočava se da titracija vina uz indikator daje dovoljno pouzdane vrednosti titracione kiselosti vina. Međutim, pošto je potenciometrijska titracija, pri pH vrednosti 7,00, pouzdanija i objektivnija metoda, vrednosti za sadržaj titracionih kiselina u vinu, izraženih preko vinske kiseline, date su upravo na osnovu ovog rezultata. Analiza diferencijalnih potenciometrijskih krivih, ukazuje da ove krive mogu pružiti odgovor na pitanje o prisustvu veće količine drugih neorganskih supstanci, koje se već nalaze u vinu. Međutim, ni jedna od ispitivanih metoda ne daje dovoljno pouzdan odgovor koje supstance su prisutne u analiziranim uzorcima, već odgovor na ovo pitanje može pružiti jedino metoda jonske hromatografije.",
publisher = "Univerzitet u Beogradu - Poljoprivredni fakultet, Beograd",
journal = "Journal of Agricultural Sciences (Belgrade)",
title = "Determination of titratable acidity in white wine, Određivanje titracione kiselosti u belom vinu",
pages = "184-169",
number = "2",
volume = "52",
doi = "10.2298/JAS0702169R"
}

Rajković, M., Novaković, I. D.,& Petrović, A.. (2007). Determination of titratable acidity in white wine. in Journal of Agricultural Sciences (Belgrade)
Univerzitet u Beogradu - Poljoprivredni fakultet, Beograd., 52(2), 169-184.
https://doi.org/10.2298/JAS0702169R

Rajković M, Novaković ID, Petrović A. Determination of titratable acidity in white wine. in Journal of Agricultural Sciences (Belgrade). 2007;52(2):169-184.
doi:10.2298/JAS0702169R .

Rajković, Miloš, Novaković, Ivana D., Petrović, Aleksandar, "Determination of titratable acidity in white wine" in Journal of Agricultural Sciences (Belgrade), 52, no. 2 (2007):169-184,
https://doi.org/10.2298/JAS0702169R . .

TY  - JOUR
AU  - Rajković, Miloš
AU  - Novaković, Ivana D.
PY  - 2007
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1380
AB  - Potentiometric analysis of fluoride content (as F- ion) in solutions by using fluoride ion-selective electrode is simple, reliable and cheap. Very small concentrations of fluoride-ions (to 10-6 mol/dm3) can be determined by fluoride selective electrode, with regulation of ion strength of a solution and control of concentration of hydroxide ions and interfering ions of metals. The influence of pH and complexing ions of metals can be successfully regulated by the TISAB solution and by preserving pH value in the range from 5.00 to 7.00. The content of fluorides in the samples can be determined by the method of direct potentiometer, and in the case of very low concentration by standard addition method. In this paper it was analyzed the determination of fluoride ions concentration in bottled mineral waters and water from Belgrade plumbing in two Belgrade districts (Palilula and Novi Beograd) and in tea, by using the fluoride selective electrode. It was determined that the content of fluoride ions in bottled mineral water significantly differs from values given on declaration, and that content of fluoride ions varies over a period of time. The content of fluoride ions in water from plumbing in two Belgrade districts at the time of analysis was significantly increased and exceeded values given in Regulation for drinking water quality. The received results from the analysis of fluorides in teas show that fluorides exist in teas in different concentrations. There are also differences between the same kinds of tea, which is noted with mint (Mentha piperitae folium), as a consequence of differences between soils where it was planted. As taking of fluorides, according to World Health Organisation recommendation (WHO), is limited in the range from 2 to 4 mg per day, it is necessary to give the content of fluorides on all products that are used in human consumption.
AB  - Potenciometrijsko određivanje sadržaja fluorida (kao F-jon) u rastvorima upotrebom fluoridne jon-selektivne elektrode je jednostavno, pouzdano i jeftino. Fluorid-selektivnom elektrodom mogu se odrediti veoma niske koncentracije fluorid-jona (do 10-6 mol/dm3), uz regulisanje jonske jačine rastvora i kontrolisanje koncentracije hidroksid-jona i interferirajućih jona metala. Uticaj pH i kompleksirajućih jona metala može se uspešno regulisati rastvorom TISABa i održavanjem pH vrednosti u oblasti od 5,00 do 7,00. Sadržaj fluorida u uzorcima može se odrediti metodom direktne potenciometrije, a u slučaju veoma niskih koncentracije, metodom standardnog dodatka. U radu je vršeno određivanje koncentracije F--jona u flaširanim mineralnim vodama ('Vujić voda', 'Rosa', 'Duboka', 'Voda-voda', 'Aqua viva', 'Knjaz Miloš') i vodi iz beogradskog vodovoda sa dve beogradske opštine (Palilula i Novi Beograd) i u čajevima (Divlja nana (Mentha piperitae folium), Čaj od žalfije (Salviae officinalis), Čaj od kantariona (Hypericum perforatum), 'Domaća nana' (Mentha piperita L.), Čaj od kamilice (Chamomillae flos)), upotrebom fluorid-selektivne elektrode. Uočeno je da sadržaj fluorid-jona u flaširanim mineralnim vodama znatno odstupa od vrednosti koje su date na deklaraciji, ali i da sadržaj fluorid-jona varira tokom vremena. Sadržaj fluorid-jona u vodi iz vodovoda sa dve beogradske opštine, u vreme analiziranja je znatno povećan i premašuje vrednosti propisane Pravilnikom o kvalitetu vode za piće. Dobijeni rezultati ispitivanja fluorida u čajevima ukazuju da se fluoridi nalaze u čajevima u različitim koncentracijama. Do razlike dolazi i među istim vrstama čaja, što je zabeleženo kod nane (Mentha piperitae folium), što je posledica pre svega zemljišta na kojem je nana uzgajana. Kako je, saglasno preporukama Svetske zdravstvene organizacije (SZO), unošenje fluorida limitirano u opsegu 2 do 4 mg dnevno, na svim proizvodima koji se koriste u humanoj upotrebi potrebno je navesti i sadržaj fluorida.
PB  - Univerzitet u Beogradu - Poljoprivredni fakultet, Beograd
T2  - Journal of Agricultural Sciences (Belgrade)
T1  - Determination of fluoride content in drinking water and tea infusions using fluoride ion selective electrode
T1  - Određivanje sadržaja fluorida u vodi za piće i čajevima fluorid-selektivnom elektrodom
EP  - 168
IS  - 2
SP  - 155
VL  - 52
DO  - 10.2298/JAS0702155R
ER  - 

@article{
author = "Rajković, Miloš and Novaković, Ivana D.",
year = "2007",
abstract = "Potentiometric analysis of fluoride content (as F- ion) in solutions by using fluoride ion-selective electrode is simple, reliable and cheap. Very small concentrations of fluoride-ions (to 10-6 mol/dm3) can be determined by fluoride selective electrode, with regulation of ion strength of a solution and control of concentration of hydroxide ions and interfering ions of metals. The influence of pH and complexing ions of metals can be successfully regulated by the TISAB solution and by preserving pH value in the range from 5.00 to 7.00. The content of fluorides in the samples can be determined by the method of direct potentiometer, and in the case of very low concentration by standard addition method. In this paper it was analyzed the determination of fluoride ions concentration in bottled mineral waters and water from Belgrade plumbing in two Belgrade districts (Palilula and Novi Beograd) and in tea, by using the fluoride selective electrode. It was determined that the content of fluoride ions in bottled mineral water significantly differs from values given on declaration, and that content of fluoride ions varies over a period of time. The content of fluoride ions in water from plumbing in two Belgrade districts at the time of analysis was significantly increased and exceeded values given in Regulation for drinking water quality. The received results from the analysis of fluorides in teas show that fluorides exist in teas in different concentrations. There are also differences between the same kinds of tea, which is noted with mint (Mentha piperitae folium), as a consequence of differences between soils where it was planted. As taking of fluorides, according to World Health Organisation recommendation (WHO), is limited in the range from 2 to 4 mg per day, it is necessary to give the content of fluorides on all products that are used in human consumption., Potenciometrijsko određivanje sadržaja fluorida (kao F-jon) u rastvorima upotrebom fluoridne jon-selektivne elektrode je jednostavno, pouzdano i jeftino. Fluorid-selektivnom elektrodom mogu se odrediti veoma niske koncentracije fluorid-jona (do 10-6 mol/dm3), uz regulisanje jonske jačine rastvora i kontrolisanje koncentracije hidroksid-jona i interferirajućih jona metala. Uticaj pH i kompleksirajućih jona metala može se uspešno regulisati rastvorom TISABa i održavanjem pH vrednosti u oblasti od 5,00 do 7,00. Sadržaj fluorida u uzorcima može se odrediti metodom direktne potenciometrije, a u slučaju veoma niskih koncentracije, metodom standardnog dodatka. U radu je vršeno određivanje koncentracije F--jona u flaširanim mineralnim vodama ('Vujić voda', 'Rosa', 'Duboka', 'Voda-voda', 'Aqua viva', 'Knjaz Miloš') i vodi iz beogradskog vodovoda sa dve beogradske opštine (Palilula i Novi Beograd) i u čajevima (Divlja nana (Mentha piperitae folium), Čaj od žalfije (Salviae officinalis), Čaj od kantariona (Hypericum perforatum), 'Domaća nana' (Mentha piperita L.), Čaj od kamilice (Chamomillae flos)), upotrebom fluorid-selektivne elektrode. Uočeno je da sadržaj fluorid-jona u flaširanim mineralnim vodama znatno odstupa od vrednosti koje su date na deklaraciji, ali i da sadržaj fluorid-jona varira tokom vremena. Sadržaj fluorid-jona u vodi iz vodovoda sa dve beogradske opštine, u vreme analiziranja je znatno povećan i premašuje vrednosti propisane Pravilnikom o kvalitetu vode za piće. Dobijeni rezultati ispitivanja fluorida u čajevima ukazuju da se fluoridi nalaze u čajevima u različitim koncentracijama. Do razlike dolazi i među istim vrstama čaja, što je zabeleženo kod nane (Mentha piperitae folium), što je posledica pre svega zemljišta na kojem je nana uzgajana. Kako je, saglasno preporukama Svetske zdravstvene organizacije (SZO), unošenje fluorida limitirano u opsegu 2 do 4 mg dnevno, na svim proizvodima koji se koriste u humanoj upotrebi potrebno je navesti i sadržaj fluorida.",
publisher = "Univerzitet u Beogradu - Poljoprivredni fakultet, Beograd",
journal = "Journal of Agricultural Sciences (Belgrade)",
title = "Determination of fluoride content in drinking water and tea infusions using fluoride ion selective electrode, Određivanje sadržaja fluorida u vodi za piće i čajevima fluorid-selektivnom elektrodom",
pages = "168-155",
number = "2",
volume = "52",
doi = "10.2298/JAS0702155R"
}

Rajković, M.,& Novaković, I. D.. (2007). Determination of fluoride content in drinking water and tea infusions using fluoride ion selective electrode. in Journal of Agricultural Sciences (Belgrade)
Univerzitet u Beogradu - Poljoprivredni fakultet, Beograd., 52(2), 155-168.
https://doi.org/10.2298/JAS0702155R

Rajković M, Novaković ID. Determination of fluoride content in drinking water and tea infusions using fluoride ion selective electrode. in Journal of Agricultural Sciences (Belgrade). 2007;52(2):155-168.
doi:10.2298/JAS0702155R .

Rajković, Miloš, Novaković, Ivana D., "Determination of fluoride content in drinking water and tea infusions using fluoride ion selective electrode" in Journal of Agricultural Sciences (Belgrade), 52, no. 2 (2007):155-168,
https://doi.org/10.2298/JAS0702155R . .