TY  - JOUR
AU  - Ebrahimi, Keramatollah
AU  - Sabljak, Predrag
AU  - Simić, Aleksandar
AU  - Skrobić, Ognjan
AU  - Velicović, Dejan
AU  - Sljukić, Vladimir
AU  - Novaković, Ivana
AU  - Dobricić, Valerija
AU  - Micev, Marjan
AU  - Pasko, Predrag
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5011
AB  - BACKGROUND: /Aim. KIT (KIT proto-oncogene receptor tyrosine kinase) and PDGFRA (platelet-derived growth factor receptor alpha) gene mutations represent major molecular forces inside the gastrointestinal stromal tumors (GIST). Aim of this study was to evaluate these mutations in the patients who underwent surgical resection of gastric GIST, but without imatinib mesylate treatment. Methods. Retrospective clinical study included patients who were operated on due to gastric GIST from November 2000 till November 2016. A molecular analysis of paraffin embedded tumor tissue was performed, and the patients with the presence of KIT and PDGFRA mutations were further evaluated, with regard to the pathological tumor stage, disease recurrence and overall survival. Results. Out of 45 patients in total, 43 patients had KIT and PDGFRA mutations, and 2 patients were classified as the wild type GIST. After curative resection, 11 patients were classified as a low risk GIST, 8 as an intermediate risk and 26 as a high risk GIST. The KIT mutations were present in 37 patients, most commonly as deletion in exon 11. The PDGFRA mutations were present in 6 patients. The presence of KIT mutation had a strong statistical correlation with the mitotic index (p = 0.021). After the ten-year follow-up, all patients with the PDGFRA mutations were alive, while those with the KIT mutations had a survival rate of 71% (p = 0.31). Conclusion. The presence of KIT exon 11 deletion in the patients with primarily resected gastric GIST is associated with the higher mitotic index and worse overall survival than those present with the PDGFRA mutations. This results suggest prognostic significance towards more aggressive behaviors.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Significance of KIT and PDGFRA mutations in gastric gastrointestinal stromal tumor imatinib-naive surgically treated patients
EP  - 1273
IS  - 12
SP  - 1268
VL  - 76
DO  - 10.2298/VSP180205048E
ER  - 

@article{
author = "Ebrahimi, Keramatollah and Sabljak, Predrag and Simić, Aleksandar and Skrobić, Ognjan and Velicović, Dejan and Sljukić, Vladimir and Novaković, Ivana and Dobricić, Valerija and Micev, Marjan and Pasko, Predrag",
year = "2019",
abstract = "BACKGROUND: /Aim. KIT (KIT proto-oncogene receptor tyrosine kinase) and PDGFRA (platelet-derived growth factor receptor alpha) gene mutations represent major molecular forces inside the gastrointestinal stromal tumors (GIST). Aim of this study was to evaluate these mutations in the patients who underwent surgical resection of gastric GIST, but without imatinib mesylate treatment. Methods. Retrospective clinical study included patients who were operated on due to gastric GIST from November 2000 till November 2016. A molecular analysis of paraffin embedded tumor tissue was performed, and the patients with the presence of KIT and PDGFRA mutations were further evaluated, with regard to the pathological tumor stage, disease recurrence and overall survival. Results. Out of 45 patients in total, 43 patients had KIT and PDGFRA mutations, and 2 patients were classified as the wild type GIST. After curative resection, 11 patients were classified as a low risk GIST, 8 as an intermediate risk and 26 as a high risk GIST. The KIT mutations were present in 37 patients, most commonly as deletion in exon 11. The PDGFRA mutations were present in 6 patients. The presence of KIT mutation had a strong statistical correlation with the mitotic index (p = 0.021). After the ten-year follow-up, all patients with the PDGFRA mutations were alive, while those with the KIT mutations had a survival rate of 71% (p = 0.31). Conclusion. The presence of KIT exon 11 deletion in the patients with primarily resected gastric GIST is associated with the higher mitotic index and worse overall survival than those present with the PDGFRA mutations. This results suggest prognostic significance towards more aggressive behaviors.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Significance of KIT and PDGFRA mutations in gastric gastrointestinal stromal tumor imatinib-naive surgically treated patients",
pages = "1273-1268",
number = "12",
volume = "76",
doi = "10.2298/VSP180205048E"
}

Ebrahimi, K., Sabljak, P., Simić, A., Skrobić, O., Velicović, D., Sljukić, V., Novaković, I., Dobricić, V., Micev, M.,& Pasko, P.. (2019). Significance of KIT and PDGFRA mutations in gastric gastrointestinal stromal tumor imatinib-naive surgically treated patients. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 76(12), 1268-1273.
https://doi.org/10.2298/VSP180205048E

Ebrahimi K, Sabljak P, Simić A, Skrobić O, Velicović D, Sljukić V, Novaković I, Dobricić V, Micev M, Pasko P. Significance of KIT and PDGFRA mutations in gastric gastrointestinal stromal tumor imatinib-naive surgically treated patients. in Vojnosanitetski pregled. 2019;76(12):1268-1273.
doi:10.2298/VSP180205048E .

Ebrahimi, Keramatollah, Sabljak, Predrag, Simić, Aleksandar, Skrobić, Ognjan, Velicović, Dejan, Sljukić, Vladimir, Novaković, Ivana, Dobricić, Valerija, Micev, Marjan, Pasko, Predrag, "Significance of KIT and PDGFRA mutations in gastric gastrointestinal stromal tumor imatinib-naive surgically treated patients" in Vojnosanitetski pregled, 76, no. 12 (2019):1268-1273,
https://doi.org/10.2298/VSP180205048E . .

TY  - JOUR
AU  - Radovanović, Nebojša
AU  - Simić, Aleksandar
AU  - Skrobić, Ognjan
AU  - Kotarac, Milutin
AU  - Ivanović, Nenad
PY  - 2014
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3473
AB  - BACKGROUND: /Aim. The incidence of peptic ulcer-induced gastric outlet obstruction is constantly declining. The aim of this study was to present our results in the treatment of gastric outlet obstruction with highly selective vagotomy and gastrojejunostomy. Methods. This retrospective clinical study included 13 patients with peptic ulcer induced gastric outlet obstruction operated with highly selective vagotomy and gastrojejunostomy. A 3-year follow-up was conducted including clinical interview and upper gastrointestinal endoscopy on 1 and 3 years after the surgery. Results. The most common preoperative symptom was vomiting (in 92.3% of patients). The mean preoperative body mass index was 16.3 +/- 3.1 kg/m(2), with 9 patients classified preoperatively as underweight. There were no intraoperative complications, nor mortality. At a 3-year follow-up there was no ulcer recurrence. Delayed gastric emptying was present in 1, bile reflux in 2, and erosive gastritis in 1 patient. Two patients suffered from mild "dumping" syndrome. Conclusion. Higly selective vagotomy combined with gastrojejunostomy is a safe and easily feasible surgical solution of gastric outlet obstruction induced by peptic ulcer. Good functional results and low rate of complications can be expected at a long-term follow-up.
PB  - Vojnomedicinska akademija - Institut za naučne informacije, Beograd
T2  - Vojnosanitetski pregled
T1  - Highly selective vagotomy and gastrojejunostomy in the treatment of peptic ulcer induced gastric outlet obstruction
EP  - 1017
IS  - 11
SP  - 1013
VL  - 71
DO  - 10.2298/VSP1411013R
ER  - 

@article{
author = "Radovanović, Nebojša and Simić, Aleksandar and Skrobić, Ognjan and Kotarac, Milutin and Ivanović, Nenad",
year = "2014",
abstract = "BACKGROUND: /Aim. The incidence of peptic ulcer-induced gastric outlet obstruction is constantly declining. The aim of this study was to present our results in the treatment of gastric outlet obstruction with highly selective vagotomy and gastrojejunostomy. Methods. This retrospective clinical study included 13 patients with peptic ulcer induced gastric outlet obstruction operated with highly selective vagotomy and gastrojejunostomy. A 3-year follow-up was conducted including clinical interview and upper gastrointestinal endoscopy on 1 and 3 years after the surgery. Results. The most common preoperative symptom was vomiting (in 92.3% of patients). The mean preoperative body mass index was 16.3 +/- 3.1 kg/m(2), with 9 patients classified preoperatively as underweight. There were no intraoperative complications, nor mortality. At a 3-year follow-up there was no ulcer recurrence. Delayed gastric emptying was present in 1, bile reflux in 2, and erosive gastritis in 1 patient. Two patients suffered from mild "dumping" syndrome. Conclusion. Higly selective vagotomy combined with gastrojejunostomy is a safe and easily feasible surgical solution of gastric outlet obstruction induced by peptic ulcer. Good functional results and low rate of complications can be expected at a long-term follow-up.",
publisher = "Vojnomedicinska akademija - Institut za naučne informacije, Beograd",
journal = "Vojnosanitetski pregled",
title = "Highly selective vagotomy and gastrojejunostomy in the treatment of peptic ulcer induced gastric outlet obstruction",
pages = "1017-1013",
number = "11",
volume = "71",
doi = "10.2298/VSP1411013R"
}

Radovanović, N., Simić, A., Skrobić, O., Kotarac, M.,& Ivanović, N.. (2014). Highly selective vagotomy and gastrojejunostomy in the treatment of peptic ulcer induced gastric outlet obstruction. in Vojnosanitetski pregled
Vojnomedicinska akademija - Institut za naučne informacije, Beograd., 71(11), 1013-1017.
https://doi.org/10.2298/VSP1411013R

Radovanović N, Simić A, Skrobić O, Kotarac M, Ivanović N. Highly selective vagotomy and gastrojejunostomy in the treatment of peptic ulcer induced gastric outlet obstruction. in Vojnosanitetski pregled. 2014;71(11):1013-1017.
doi:10.2298/VSP1411013R .

Radovanović, Nebojša, Simić, Aleksandar, Skrobić, Ognjan, Kotarac, Milutin, Ivanović, Nenad, "Highly selective vagotomy and gastrojejunostomy in the treatment of peptic ulcer induced gastric outlet obstruction" in Vojnosanitetski pregled, 71, no. 11 (2014):1013-1017,
https://doi.org/10.2298/VSP1411013R . .