TY  - JOUR
AU  - Veljković, Bojana
AU  - Djordjević, Nataša
AU  - Dolicanin, Zana
AU  - Licina, Braho
AU  - Topuzović, Marina
AU  - Stanković, Milan
AU  - Zlatić, Nenad
AU  - Dajić-Stevanović, Zora
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5130
AB  - In this study the leaves and fruits of wild raspberry (Rubus idaeus L.) populations from the central Balkan region were examined to determine the level of secondary metabolites and related antioxidant activity, as well as biological activity, upon existing ethnobotanical evidence, primarily linked to gastrointestinal disorders. The values obtained for total phenols ranged from 59.68 to 96.83 mg GA g(-1) and 24.29 to 38.71 mg GA g(-1) in leaf and fruit extracts, respectively. The highest values of tannins and anthocyanins were determined for leaf extracts from a population of east Serbia at a level of 1.27 mg mL(-1) and 9.00 mg mL(-1). Antioxidant activity was evaluated by measuring the scavenging capacity of the extracts on DPPH. Higher antioxidant activity was detected in the leaf extracts than in the fruit extracts. Leaf and fruit extract were the most effective against Escherichia coli (ATCC 8739). Anticancer activity was studied on a human colorectal cancer cell line HCT-116. Leaf extracts exhibited anticancer activity with IC50/24 h 162.38 mu g mL(-1) and IC50/48 h 95.69 mu g mL(-1). Wild raspberry leaf and fruit extracts contain numerous secondary metabolites providing marked antioxidant, antimicrobial and anticancer activity.
PB  - Academic Press
T2  - Notulae Botanicae Horti Agrobotanici Cluj-Napoca
T1  - Antioxidant and Anticancer Properties of Leaf and Fruit Extracts of the Wild Raspberry (Rubus idaeus L.)
EP  - 367
IS  - 2
SP  - 359
VL  - 47
DO  - 10.15835/nbha47111274
ER  - 

@article{
author = "Veljković, Bojana and Djordjević, Nataša and Dolicanin, Zana and Licina, Braho and Topuzović, Marina and Stanković, Milan and Zlatić, Nenad and Dajić-Stevanović, Zora",
year = "2019",
abstract = "In this study the leaves and fruits of wild raspberry (Rubus idaeus L.) populations from the central Balkan region were examined to determine the level of secondary metabolites and related antioxidant activity, as well as biological activity, upon existing ethnobotanical evidence, primarily linked to gastrointestinal disorders. The values obtained for total phenols ranged from 59.68 to 96.83 mg GA g(-1) and 24.29 to 38.71 mg GA g(-1) in leaf and fruit extracts, respectively. The highest values of tannins and anthocyanins were determined for leaf extracts from a population of east Serbia at a level of 1.27 mg mL(-1) and 9.00 mg mL(-1). Antioxidant activity was evaluated by measuring the scavenging capacity of the extracts on DPPH. Higher antioxidant activity was detected in the leaf extracts than in the fruit extracts. Leaf and fruit extract were the most effective against Escherichia coli (ATCC 8739). Anticancer activity was studied on a human colorectal cancer cell line HCT-116. Leaf extracts exhibited anticancer activity with IC50/24 h 162.38 mu g mL(-1) and IC50/48 h 95.69 mu g mL(-1). Wild raspberry leaf and fruit extracts contain numerous secondary metabolites providing marked antioxidant, antimicrobial and anticancer activity.",
publisher = "Academic Press",
journal = "Notulae Botanicae Horti Agrobotanici Cluj-Napoca",
title = "Antioxidant and Anticancer Properties of Leaf and Fruit Extracts of the Wild Raspberry (Rubus idaeus L.)",
pages = "367-359",
number = "2",
volume = "47",
doi = "10.15835/nbha47111274"
}

Veljković, B., Djordjević, N., Dolicanin, Z., Licina, B., Topuzović, M., Stanković, M., Zlatić, N.,& Dajić-Stevanović, Z.. (2019). Antioxidant and Anticancer Properties of Leaf and Fruit Extracts of the Wild Raspberry (Rubus idaeus L.). in Notulae Botanicae Horti Agrobotanici Cluj-Napoca
Academic Press., 47(2), 359-367.
https://doi.org/10.15835/nbha47111274

Veljković B, Djordjević N, Dolicanin Z, Licina B, Topuzović M, Stanković M, Zlatić N, Dajić-Stevanović Z. Antioxidant and Anticancer Properties of Leaf and Fruit Extracts of the Wild Raspberry (Rubus idaeus L.). in Notulae Botanicae Horti Agrobotanici Cluj-Napoca. 2019;47(2):359-367.
doi:10.15835/nbha47111274 .

Veljković, Bojana, Djordjević, Nataša, Dolicanin, Zana, Licina, Braho, Topuzović, Marina, Stanković, Milan, Zlatić, Nenad, Dajić-Stevanović, Zora, "Antioxidant and Anticancer Properties of Leaf and Fruit Extracts of the Wild Raspberry (Rubus idaeus L.)" in Notulae Botanicae Horti Agrobotanici Cluj-Napoca, 47, no. 2 (2019):359-367,
https://doi.org/10.15835/nbha47111274 . .

TY  - CONF
AU  - Avdović, Edina
AU  - Milenković, Dejan
AU  - Djorović, Jelena
AU  - Vuković, Nenad
AU  - Dolicanin, Zana
AU  - Trifunović, Srećko
AU  - Marković, Zoran
AU  - Jeremić, Svetlana
PY  - 2018
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5654
AB  - The structure of the newly synthesized coumarin derivative, 3-(1-(3-hydroxypropylamino)-ethylidene)-chroman-2,4-dione, was investigated theoretically. The density functional theory calculations, with B3LYP functional (and with empirical dispersion corrections D3BJ) in combination with the 6–311+G(d,p) basis set, are performed in order to optimized the molecular structure of the investigated coumarin derivative. Molecular docking analysis was carried out in order to identify the potency of inhibition of the title molecule against human C-reactive protein. The inhibition activity was obtained for ten conformations of ligand inside protein.
AB  - Struktura novo sintetisanog derivata kumarina, 3- (1- (3-hidroksipropilamino) -etiliden) -hroman-2,4-diona, ispitana je primenom teorijskih metoda. Za optimizaciju strukture ispitivanog kumarinskog derivata korišćena je teorija funkcionalne gustine: B3LYP funkcional ( sa empirijskim ispravkama disperzije D3BJ) u kombinaciji sa 6-311+G(d, p) bazisnim setom. Urađen je molekulski doking, kao i analiza dobijenih rezultata kako bi se utvrdio potencijal inhibicije molekula ispitivanog jedinjenja prema humanom C-reaktivnom proteinu. Aktivnost inhibicije izračunata je za deset potencijalnih konformacija liganda unutar proteina.
C3  - 23. Savetovanje o biotehnologiji sa međunarodnim učešćem, Čačak, 09.-10. 03. 2018.
T1  - Ligand-Protein Interaction Of 3-(1-(3-Hydroxypropylamino)Etylidene)Chroman-2,4-Dione With Human C Reactive Protein
T1  - Ligand-protein interakcije 3-(1-(3-hidroksipropilamino)etiliden)hroman-2,4-diona sa humanim C reaktivnim proteinom
UR  - https://hdl.handle.net/21.15107/rcub_agrospace_5654
ER  - 

@conference{
author = "Avdović, Edina and Milenković, Dejan and Djorović, Jelena and Vuković, Nenad and Dolicanin, Zana and Trifunović, Srećko and Marković, Zoran and Jeremić, Svetlana",
year = "2018",
abstract = "The structure of the newly synthesized coumarin derivative, 3-(1-(3-hydroxypropylamino)-ethylidene)-chroman-2,4-dione, was investigated theoretically. The density functional theory calculations, with B3LYP functional (and with empirical dispersion corrections D3BJ) in combination with the 6–311+G(d,p) basis set, are performed in order to optimized the molecular structure of the investigated coumarin derivative. Molecular docking analysis was carried out in order to identify the potency of inhibition of the title molecule against human C-reactive protein. The inhibition activity was obtained for ten conformations of ligand inside protein., Struktura novo sintetisanog derivata kumarina, 3- (1- (3-hidroksipropilamino) -etiliden) -hroman-2,4-diona, ispitana je primenom teorijskih metoda. Za optimizaciju strukture ispitivanog kumarinskog derivata korišćena je teorija funkcionalne gustine: B3LYP funkcional ( sa empirijskim ispravkama disperzije D3BJ) u kombinaciji sa 6-311+G(d, p) bazisnim setom. Urađen je molekulski doking, kao i analiza dobijenih rezultata kako bi se utvrdio potencijal inhibicije molekula ispitivanog jedinjenja prema humanom C-reaktivnom proteinu. Aktivnost inhibicije izračunata je za deset potencijalnih konformacija liganda unutar proteina.",
journal = "23. Savetovanje o biotehnologiji sa međunarodnim učešćem, Čačak, 09.-10. 03. 2018.",
title = "Ligand-Protein Interaction Of 3-(1-(3-Hydroxypropylamino)Etylidene)Chroman-2,4-Dione With Human C Reactive Protein, Ligand-protein interakcije 3-(1-(3-hidroksipropilamino)etiliden)hroman-2,4-diona sa humanim C reaktivnim proteinom",
url = "https://hdl.handle.net/21.15107/rcub_agrospace_5654"
}

Avdović, E., Milenković, D., Djorović, J., Vuković, N., Dolicanin, Z., Trifunović, S., Marković, Z.,& Jeremić, S.. (2018). Ligand-Protein Interaction Of 3-(1-(3-Hydroxypropylamino)Etylidene)Chroman-2,4-Dione With Human C Reactive Protein. in 23. Savetovanje o biotehnologiji sa međunarodnim učešćem, Čačak, 09.-10. 03. 2018..
https://hdl.handle.net/21.15107/rcub_agrospace_5654

Avdović E, Milenković D, Djorović J, Vuković N, Dolicanin Z, Trifunović S, Marković Z, Jeremić S. Ligand-Protein Interaction Of 3-(1-(3-Hydroxypropylamino)Etylidene)Chroman-2,4-Dione With Human C Reactive Protein. in 23. Savetovanje o biotehnologiji sa međunarodnim učešćem, Čačak, 09.-10. 03. 2018.. 2018;.
https://hdl.handle.net/21.15107/rcub_agrospace_5654 .

Avdović, Edina, Milenković, Dejan, Djorović, Jelena, Vuković, Nenad, Dolicanin, Zana, Trifunović, Srećko, Marković, Zoran, Jeremić, Svetlana, "Ligand-Protein Interaction Of 3-(1-(3-Hydroxypropylamino)Etylidene)Chroman-2,4-Dione With Human C Reactive Protein" in 23. Savetovanje o biotehnologiji sa međunarodnim učešćem, Čačak, 09.-10. 03. 2018. (2018),
https://hdl.handle.net/21.15107/rcub_agrospace_5654 .