TY  - JOUR
AU  - Petrović, Marija
AU  - Jovanović, Marina
AU  - Lević, Steva
AU  - Nedović, Viktor
AU  - Mitić‑Ćulafić, Dragana
AU  - Živković Semren, Tanja
AU  - Veljović, Sonja
PY  - 2021
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5954
AB  - Herbal residues from the production and processing of medicinal plants are usually discarded as waste material. Plantago major is an edible plant, traditionally used for medicinal purposes, having wide application in the pharmaceutical and cosmetics industry, usually in the form of liquid extracts and tinctures. In this work, extracts of P. major leaves waste remaining after industrial tincture production and dried leaves used initially for tincture production were investigated and compared. Methods: The chemical composition was obtained by FTIR analysis, whereas polyphenolic profile was assessed by HPLC. Antioxidant activity, sun protection factor (SPF), cytotoxic activity against colon carcinoma (HCT116) and melanoma (Hs294T) human cell lines as well as antistaphylococcal activity against S. aureus ATCC strains and one clinical isolate were also evaluated. Results: FTIR analysis revealed wider chemical diversity in waste samples than in initial plant material. Among detected phenolics, chlorogenic acid, luteolin, and rutin were the most abundant in all extracts, whereas luteolin was even higher in the waste. Waste extracts had a significantly lower sun protection factor (SPF) when compared to initial dried leaves. On the contrary, cytotoxic activity of waste extracts against tested human cell lines were more efficient when compared to initial dried leaves, which can be attributed to the higher luteolin content in tincture residues. Both waste and initial dried leaves extracts exhibited antibacterial activity against all tested S. aureus strains at higher tested concentrations. Conclusion: P. major waste remaining after industrial tincture production represents high-value material with great valorization potential. Graphic abstract: [Figure not available: see fulltext.]
PB  - Springer Science and Business Media B.V.
T2  - Waste and Biomass Valorization
T1  - Valorization potential of Plantago major L. solid waste remaining  after industrial tincture production: Insight into the chemical  composition and bioactive properties
DO  - 10.1007/s12649-021-01608-6
ER  - 

@article{
author = "Petrović, Marija and Jovanović, Marina and Lević, Steva and Nedović, Viktor and Mitić‑Ćulafić, Dragana and Živković Semren, Tanja and Veljović, Sonja",
year = "2021",
abstract = "Herbal residues from the production and processing of medicinal plants are usually discarded as waste material. Plantago major is an edible plant, traditionally used for medicinal purposes, having wide application in the pharmaceutical and cosmetics industry, usually in the form of liquid extracts and tinctures. In this work, extracts of P. major leaves waste remaining after industrial tincture production and dried leaves used initially for tincture production were investigated and compared. Methods: The chemical composition was obtained by FTIR analysis, whereas polyphenolic profile was assessed by HPLC. Antioxidant activity, sun protection factor (SPF), cytotoxic activity against colon carcinoma (HCT116) and melanoma (Hs294T) human cell lines as well as antistaphylococcal activity against S. aureus ATCC strains and one clinical isolate were also evaluated. Results: FTIR analysis revealed wider chemical diversity in waste samples than in initial plant material. Among detected phenolics, chlorogenic acid, luteolin, and rutin were the most abundant in all extracts, whereas luteolin was even higher in the waste. Waste extracts had a significantly lower sun protection factor (SPF) when compared to initial dried leaves. On the contrary, cytotoxic activity of waste extracts against tested human cell lines were more efficient when compared to initial dried leaves, which can be attributed to the higher luteolin content in tincture residues. Both waste and initial dried leaves extracts exhibited antibacterial activity against all tested S. aureus strains at higher tested concentrations. Conclusion: P. major waste remaining after industrial tincture production represents high-value material with great valorization potential. Graphic abstract: [Figure not available: see fulltext.]",
publisher = "Springer Science and Business Media B.V.",
journal = "Waste and Biomass Valorization",
title = "Valorization potential of Plantago major L. solid waste remaining  after industrial tincture production: Insight into the chemical  composition and bioactive properties",
doi = "10.1007/s12649-021-01608-6"
}

Petrović, M., Jovanović, M., Lević, S., Nedović, V., Mitić‑Ćulafić, D., Živković Semren, T.,& Veljović, S.. (2021). Valorization potential of Plantago major L. solid waste remaining  after industrial tincture production: Insight into the chemical  composition and bioactive properties. in Waste and Biomass Valorization
Springer Science and Business Media B.V...
https://doi.org/10.1007/s12649-021-01608-6

Petrović M, Jovanović M, Lević S, Nedović V, Mitić‑Ćulafić D, Živković Semren T, Veljović S. Valorization potential of Plantago major L. solid waste remaining  after industrial tincture production: Insight into the chemical  composition and bioactive properties. in Waste and Biomass Valorization. 2021;.
doi:10.1007/s12649-021-01608-6 .

Petrović, Marija, Jovanović, Marina, Lević, Steva, Nedović, Viktor, Mitić‑Ćulafić, Dragana, Živković Semren, Tanja, Veljović, Sonja, "Valorization potential of Plantago major L. solid waste remaining  after industrial tincture production: Insight into the chemical  composition and bioactive properties" in Waste and Biomass Valorization (2021),
https://doi.org/10.1007/s12649-021-01608-6 . .