TY  - JOUR
AU  - Veljović, Sonja
AU  - Veljović, Mile
AU  - Nikićević, Ninoslav
AU  - Despotović, Saša
AU  - Radulović, Siniša
AU  - Nikšić, Miomir
AU  - Filipović, Lana
PY  - 2017
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4355
AB  - The content of phenolic compounds (TPC) and glucans, as well as the effectiveness of antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts were determined and compared. The content of glucans (total, alpha- and beta-) strongly depended on the extraction time and particle size, but only interaction of these parameters influenced the TPC. Gallic acid, quercetin, trans-cinnamic acid, kaempferol, hesperetin and naringenin were detected in extracts by HPLC-DAD. The most abundant phenols were hesperetin (1.875-3.222 mu g/g) and naringenin (1.235-2.856 mu g/g). The ethanol extracts exhibited noteworthy antioxidant activity, but the significant amount of phenolic compounds was strongly linked to polysaccharides, and hence reduced their antioxidant capacity. The results of the antiproliferative activity in vitro showed that the analyzed extracts were the most effective against HeLa cells. Significant correlations were observed between the antiproliferative effect and the TPC/glucan content of extracts.
PB  - Springer India, New Delhi
T2  - Journal of Food Science and Technology-Mysore
T1  - Chemical composition, antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts
EP  - 1320
IS  - 5
SP  - 1312
VL  - 54
DO  - 10.1007/s13197-017-2559-y
ER  - 

@article{
author = "Veljović, Sonja and Veljović, Mile and Nikićević, Ninoslav and Despotović, Saša and Radulović, Siniša and Nikšić, Miomir and Filipović, Lana",
year = "2017",
abstract = "The content of phenolic compounds (TPC) and glucans, as well as the effectiveness of antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts were determined and compared. The content of glucans (total, alpha- and beta-) strongly depended on the extraction time and particle size, but only interaction of these parameters influenced the TPC. Gallic acid, quercetin, trans-cinnamic acid, kaempferol, hesperetin and naringenin were detected in extracts by HPLC-DAD. The most abundant phenols were hesperetin (1.875-3.222 mu g/g) and naringenin (1.235-2.856 mu g/g). The ethanol extracts exhibited noteworthy antioxidant activity, but the significant amount of phenolic compounds was strongly linked to polysaccharides, and hence reduced their antioxidant capacity. The results of the antiproliferative activity in vitro showed that the analyzed extracts were the most effective against HeLa cells. Significant correlations were observed between the antiproliferative effect and the TPC/glucan content of extracts.",
publisher = "Springer India, New Delhi",
journal = "Journal of Food Science and Technology-Mysore",
title = "Chemical composition, antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts",
pages = "1320-1312",
number = "5",
volume = "54",
doi = "10.1007/s13197-017-2559-y"
}

Veljović, S., Veljović, M., Nikićević, N., Despotović, S., Radulović, S., Nikšić, M.,& Filipović, L.. (2017). Chemical composition, antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts. in Journal of Food Science and Technology-Mysore
Springer India, New Delhi., 54(5), 1312-1320.
https://doi.org/10.1007/s13197-017-2559-y

Veljović S, Veljović M, Nikićević N, Despotović S, Radulović S, Nikšić M, Filipović L. Chemical composition, antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts. in Journal of Food Science and Technology-Mysore. 2017;54(5):1312-1320.
doi:10.1007/s13197-017-2559-y .

Veljović, Sonja, Veljović, Mile, Nikićević, Ninoslav, Despotović, Saša, Radulović, Siniša, Nikšić, Miomir, Filipović, Lana, "Chemical composition, antiproliferative and antioxidant activity of differently processed Ganoderma lucidum ethanol extracts" in Journal of Food Science and Technology-Mysore, 54, no. 5 (2017):1312-1320,
https://doi.org/10.1007/s13197-017-2559-y . .

TY  - JOUR
AU  - Zmejkovski, Bojana B.
AU  - Pantelić, Nebojša
AU  - Filipović, Lana
AU  - Arandelović, Sandra
AU  - Radulović, Siniša
AU  - Sabo, Tibor J.
AU  - Kaludjerović, Goran N.
PY  - 2017
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4473
AB  - Aims: Platinum(II) and platinum(IV) complexes [PtCln{(S,S)-(i-Am)(2)eddip}] (n = 2, 4: 1, 2, respectively; (S,S)-(i-Am)(2)eddip = O,O'-diisoamyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate) were synthesized and characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Method: Quantum chemical calculations were used to predict formed isomers of 1 and 2. Furthermore, reduction of 2 with ascorbic acid was followed by time-dependant C-13 NMR spectroscopy in order to enable assignation of the formed isomers for complex 1. In vitro cytotoxic activity was determined for 1 and 2 on a panel of five human tumor cell lines derived from cervix adenocarcinoma (HeLa), alveolar basal adenocarcinoma (A549), breast adenocarcinoma (MDA-453), colorectal cancer (LS 174), erythromyeloblastoid leukemia (K562), as well as one non-malignant human lung fibroblast cell line (MRC-5), using MTT assay. Result: Both complexes exhibited high (2 against K562: IC50 = 5.4 mu M), more active than cisplatin, to moderate activity (1). Both complexes caused considerable decrease of cell number in K562 cells in G1, S and G2 phases, concordantly increasing subpopulation in sub-G1 fraction. Morphological analysis of K562 cell death induced by platinum(II/IV) complexes indicate apoptosis.
PB  - Bentham Science Publ Ltd, Sharjah
T2  - Anti-Cancer Agents in Medicinal Chemistry
T1  - In Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N'-di-2-propanoic Acid
EP  - 1143
IS  - 8
SP  - 1136
VL  - 17
DO  - 10.2174/1871520616666161207155634
ER  - 

@article{
author = "Zmejkovski, Bojana B. and Pantelić, Nebojša and Filipović, Lana and Arandelović, Sandra and Radulović, Siniša and Sabo, Tibor J. and Kaludjerović, Goran N.",
year = "2017",
abstract = "Aims: Platinum(II) and platinum(IV) complexes [PtCln{(S,S)-(i-Am)(2)eddip}] (n = 2, 4: 1, 2, respectively; (S,S)-(i-Am)(2)eddip = O,O'-diisoamyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate) were synthesized and characterized by elemental analysis, IR, H-1 and C-13 NMR spectroscopy and mass spectrometry. Method: Quantum chemical calculations were used to predict formed isomers of 1 and 2. Furthermore, reduction of 2 with ascorbic acid was followed by time-dependant C-13 NMR spectroscopy in order to enable assignation of the formed isomers for complex 1. In vitro cytotoxic activity was determined for 1 and 2 on a panel of five human tumor cell lines derived from cervix adenocarcinoma (HeLa), alveolar basal adenocarcinoma (A549), breast adenocarcinoma (MDA-453), colorectal cancer (LS 174), erythromyeloblastoid leukemia (K562), as well as one non-malignant human lung fibroblast cell line (MRC-5), using MTT assay. Result: Both complexes exhibited high (2 against K562: IC50 = 5.4 mu M), more active than cisplatin, to moderate activity (1). Both complexes caused considerable decrease of cell number in K562 cells in G1, S and G2 phases, concordantly increasing subpopulation in sub-G1 fraction. Morphological analysis of K562 cell death induced by platinum(II/IV) complexes indicate apoptosis.",
publisher = "Bentham Science Publ Ltd, Sharjah",
journal = "Anti-Cancer Agents in Medicinal Chemistry",
title = "In Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N'-di-2-propanoic Acid",
pages = "1143-1136",
number = "8",
volume = "17",
doi = "10.2174/1871520616666161207155634"
}

Zmejkovski, B. B., Pantelić, N., Filipović, L., Arandelović, S., Radulović, S., Sabo, T. J.,& Kaludjerović, G. N.. (2017). In Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N'-di-2-propanoic Acid. in Anti-Cancer Agents in Medicinal Chemistry
Bentham Science Publ Ltd, Sharjah., 17(8), 1136-1143.
https://doi.org/10.2174/1871520616666161207155634

Zmejkovski BB, Pantelić N, Filipović L, Arandelović S, Radulović S, Sabo TJ, Kaludjerović GN. In Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N'-di-2-propanoic Acid. in Anti-Cancer Agents in Medicinal Chemistry. 2017;17(8):1136-1143.
doi:10.2174/1871520616666161207155634 .

Zmejkovski, Bojana B., Pantelić, Nebojša, Filipović, Lana, Arandelović, Sandra, Radulović, Siniša, Sabo, Tibor J., Kaludjerović, Goran N., "In Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N'-di-2-propanoic Acid" in Anti-Cancer Agents in Medicinal Chemistry, 17, no. 8 (2017):1136-1143,
https://doi.org/10.2174/1871520616666161207155634 . .