TY  - JOUR
AU  - Filipović, Nenad
AU  - Bjelogrlić, Snežana
AU  - Portalone, Gustavo
AU  - Pelliccia, Sveva
AU  - Silvestri, Romano
AU  - Klisurić, Olivera
AU  - Sencanski, Milan
AU  - Stanković, Dalibor
AU  - Todorović, Tamara R.
AU  - Muller, Christian D.
PY  - 2016
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4028
AB  - 8-Quinolinecarboxaldehyde selenosemicarbazone (H8qasesc) and its octahedral Co(III) complex were characterized by single crystal X-ray diffraction analysis, spectroscopy methods and cyclic voltammetry. The antineoplastic activity of the ligand and the complex has been assessed on an acute monocytic leukemia cell line (THP-1) and AsPC-1 cancer stem cell (CSC) line derived from a patient suffering from pancreatic adenocarcinoma, with cisplatin (CDDP) as a reference compound. Evaluation involved determination of pro-apoptotic activity, changes in cell cycle distribution, the role of caspase activation in the process of cell death, and the ability of the investigated compounds to challenge reprogramming of the CSC phenotype. Compared to CDDP, treatment with H8qasesc induced a higher apoptotic response in both investigated cell lines. Apoptosis triggered by H8qasesc was highly caspase-dependent but did not include activation of either caspase-8 or -9. According to cell cycle changes H8qasesc delayed the transition of cells during DNA replication but in a manner different from that of CDDP. The ligand did not show nuclease activity on pUC19 plasmid, while docking studies disclosed that it does not have intercalating properties. Treatment of THP-1 cells with the Co(III) complex resulted in a strong toxic response, whereas cell death in the treated AsPC-1 line was not achieved for 24 h. Additionally, the complex concentration-dependently digested plasmid DNA which might be the cause of its cytotoxic activity. Finally, H8qasesc successfully initiated reprogramming of the CSC phenotype in the AsPC-1 cell line.
PB  - Royal Soc Chemistry, Cambridge
T2  - Medchemcomm
T1  - Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(III) complex in human cancer cell lines
EP  - 1616
IS  - 8
SP  - 1604
VL  - 7
DO  - 10.1039/c6md00199h
ER  - 

@article{
author = "Filipović, Nenad and Bjelogrlić, Snežana and Portalone, Gustavo and Pelliccia, Sveva and Silvestri, Romano and Klisurić, Olivera and Sencanski, Milan and Stanković, Dalibor and Todorović, Tamara R. and Muller, Christian D.",
year = "2016",
abstract = "8-Quinolinecarboxaldehyde selenosemicarbazone (H8qasesc) and its octahedral Co(III) complex were characterized by single crystal X-ray diffraction analysis, spectroscopy methods and cyclic voltammetry. The antineoplastic activity of the ligand and the complex has been assessed on an acute monocytic leukemia cell line (THP-1) and AsPC-1 cancer stem cell (CSC) line derived from a patient suffering from pancreatic adenocarcinoma, with cisplatin (CDDP) as a reference compound. Evaluation involved determination of pro-apoptotic activity, changes in cell cycle distribution, the role of caspase activation in the process of cell death, and the ability of the investigated compounds to challenge reprogramming of the CSC phenotype. Compared to CDDP, treatment with H8qasesc induced a higher apoptotic response in both investigated cell lines. Apoptosis triggered by H8qasesc was highly caspase-dependent but did not include activation of either caspase-8 or -9. According to cell cycle changes H8qasesc delayed the transition of cells during DNA replication but in a manner different from that of CDDP. The ligand did not show nuclease activity on pUC19 plasmid, while docking studies disclosed that it does not have intercalating properties. Treatment of THP-1 cells with the Co(III) complex resulted in a strong toxic response, whereas cell death in the treated AsPC-1 line was not achieved for 24 h. Additionally, the complex concentration-dependently digested plasmid DNA which might be the cause of its cytotoxic activity. Finally, H8qasesc successfully initiated reprogramming of the CSC phenotype in the AsPC-1 cell line.",
publisher = "Royal Soc Chemistry, Cambridge",
journal = "Medchemcomm",
title = "Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(III) complex in human cancer cell lines",
pages = "1616-1604",
number = "8",
volume = "7",
doi = "10.1039/c6md00199h"
}

Filipović, N., Bjelogrlić, S., Portalone, G., Pelliccia, S., Silvestri, R., Klisurić, O., Sencanski, M., Stanković, D., Todorović, T. R.,& Muller, C. D.. (2016). Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(III) complex in human cancer cell lines. in Medchemcomm
Royal Soc Chemistry, Cambridge., 7(8), 1604-1616.
https://doi.org/10.1039/c6md00199h

Filipović N, Bjelogrlić S, Portalone G, Pelliccia S, Silvestri R, Klisurić O, Sencanski M, Stanković D, Todorović TR, Muller CD. Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(III) complex in human cancer cell lines. in Medchemcomm. 2016;7(8):1604-1616.
doi:10.1039/c6md00199h .

Filipović, Nenad, Bjelogrlić, Snežana, Portalone, Gustavo, Pelliccia, Sveva, Silvestri, Romano, Klisurić, Olivera, Sencanski, Milan, Stanković, Dalibor, Todorović, Tamara R., Muller, Christian D., "Pro-apoptotic and pro-differentiation induction by 8-quinolinecarboxaldehyde selenosemicarbazone and its Co(III) complex in human cancer cell lines" in Medchemcomm, 7, no. 8 (2016):1604-1616,
https://doi.org/10.1039/c6md00199h . .