TY  - JOUR
AU  - Popović-Djordjević, Jelena
AU  - Jevtić, Ivana I.
AU  - Grozdanić, Nada
AU  - Segan, Sandra
AU  - Zlatović, Mario
AU  - Ivanović, Milovan D.
AU  - Stanojković, Tatjana P.
PY  - 2017
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4378
AB  - The inhibitory activities of selected cyclic urea and carbamate derivatives (1-13) toward alpha-glucosidase (alpha-Gls) in in vitro assay were examined in this study. All examined compounds showed higher inhibitory activity (IC50) against alpha-Gls compared to standard antidiabetic drug acarbose. The most potent was benzyl (3,4,5-trimethoxyphenyl) carbamate (12) with IC50 = 49.85 +/- 0.10 mu M. In vitro cytotoxicity of the investigated compounds was tested on three human cancer cell lines HeLa, A549 and MDA-MB-453 using MTT assay. The best antitumour activity was achieved with compound 2 (trans-5-phenethyl-1-phenylhexahydro-1H-imidazo[4,5-c] pyridin-2(3H)-one) against MDA-MB-453 human breast cancer cell line (IC50 = 83.41 +/- 1.60 mu M). Cyclic ureas and carbamates showed promising anti-alpha-glucosidase activity and should be further tested as potential antidiabetic drugs. The PLS model of preliminary QSAR study indicated that, in planing the future synthesis of more potent compounds, the newly designed should have the substituents capable of polar interactions with receptor sites in various positions, while avoiding the increase of their lipophilicity.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - alpha-Glucosidase inhibitory activity and cytotoxic effects of some cyclic urea and carbamate derivatives
EP  - 303
IS  - 1
SP  - 298
VL  - 32
DO  - 10.1080/14756366.2016.1250754
ER  - 

@article{
author = "Popović-Djordjević, Jelena and Jevtić, Ivana I. and Grozdanić, Nada and Segan, Sandra and Zlatović, Mario and Ivanović, Milovan D. and Stanojković, Tatjana P.",
year = "2017",
abstract = "The inhibitory activities of selected cyclic urea and carbamate derivatives (1-13) toward alpha-glucosidase (alpha-Gls) in in vitro assay were examined in this study. All examined compounds showed higher inhibitory activity (IC50) against alpha-Gls compared to standard antidiabetic drug acarbose. The most potent was benzyl (3,4,5-trimethoxyphenyl) carbamate (12) with IC50 = 49.85 +/- 0.10 mu M. In vitro cytotoxicity of the investigated compounds was tested on three human cancer cell lines HeLa, A549 and MDA-MB-453 using MTT assay. The best antitumour activity was achieved with compound 2 (trans-5-phenethyl-1-phenylhexahydro-1H-imidazo[4,5-c] pyridin-2(3H)-one) against MDA-MB-453 human breast cancer cell line (IC50 = 83.41 +/- 1.60 mu M). Cyclic ureas and carbamates showed promising anti-alpha-glucosidase activity and should be further tested as potential antidiabetic drugs. The PLS model of preliminary QSAR study indicated that, in planing the future synthesis of more potent compounds, the newly designed should have the substituents capable of polar interactions with receptor sites in various positions, while avoiding the increase of their lipophilicity.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "alpha-Glucosidase inhibitory activity and cytotoxic effects of some cyclic urea and carbamate derivatives",
pages = "303-298",
number = "1",
volume = "32",
doi = "10.1080/14756366.2016.1250754"
}

Popović-Djordjević, J., Jevtić, I. I., Grozdanić, N., Segan, S., Zlatović, M., Ivanović, M. D.,& Stanojković, T. P.. (2017). alpha-Glucosidase inhibitory activity and cytotoxic effects of some cyclic urea and carbamate derivatives. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor & Francis Ltd, Abingdon., 32(1), 298-303.
https://doi.org/10.1080/14756366.2016.1250754

Popović-Djordjević J, Jevtić II, Grozdanić N, Segan S, Zlatović M, Ivanović MD, Stanojković TP. alpha-Glucosidase inhibitory activity and cytotoxic effects of some cyclic urea and carbamate derivatives. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2017;32(1):298-303.
doi:10.1080/14756366.2016.1250754 .

Popović-Djordjević, Jelena, Jevtić, Ivana I., Grozdanić, Nada, Segan, Sandra, Zlatović, Mario, Ivanović, Milovan D., Stanojković, Tatjana P., "alpha-Glucosidase inhibitory activity and cytotoxic effects of some cyclic urea and carbamate derivatives" in Journal of Enzyme Inhibition and Medicinal Chemistry, 32, no. 1 (2017):298-303,
https://doi.org/10.1080/14756366.2016.1250754 . .

TY  - JOUR
AU  - Stanojević, Marija
AU  - Trifković, Jelena
AU  - Fotirić-Akšić, Milica
AU  - Rakonjac, Vera
AU  - Nikolić, Dragan
AU  - Segan, Sandra
AU  - Milojković-Opsenica, Dušanka M.
PY  - 2015
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3752
AB  - Large amounts of fruit seeds, especially peach, are discarded annually in juice or conserve producing industries which is a potential waste of valuable resource and serious disposal problem. Regarding the fact that peach seeds can be obtained as a byproduct from processing companies their exploitation should be greater and, consequently more information of cultivars' kernels and their composition is required. A total of 25 samples of kernels from various peach germplasm (including commercial cultivars, perspective hybrids and vineyard peach accessions) differing in origin and ripening time were characterized by evaluation of their sugar composition. Twenty characteristic carbohydrates and sugar alcohols were determined and quantified using high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC/PAD). Sucrose, glucose and fructose are the most important sugars in peach kernels similar to other representatives of the Rosaceae family. Also, high amounts of sugars in seeds of promising hybrids implies that through conventional breeding programs peach kernels with high sugar content can be obtained. In addition, by the means of several pattern recognition methods the variables that discriminate peach kernels arising from diverse germplasm and different stage of maturity were identified and successful models for further prediction were developed. Sugars such as ribose, trehalose, arabinose, galactitol, fructose, maltose, sorbitol, sucrose, iso-maltotriose were marked as most important for such discrimination.
PB  - Springer, Dordrecht
T2  - Plant Foods for Human Nutrition
T1  - Sugar Profile of Kernels as a Marker of Origin and Ripening Time of Peach (Prunus persicae L.)
EP  - 440
IS  - 4
SP  - 433
VL  - 70
DO  - 10.1007/s11130-015-0515-4
ER  - 

@article{
author = "Stanojević, Marija and Trifković, Jelena and Fotirić-Akšić, Milica and Rakonjac, Vera and Nikolić, Dragan and Segan, Sandra and Milojković-Opsenica, Dušanka M.",
year = "2015",
abstract = "Large amounts of fruit seeds, especially peach, are discarded annually in juice or conserve producing industries which is a potential waste of valuable resource and serious disposal problem. Regarding the fact that peach seeds can be obtained as a byproduct from processing companies their exploitation should be greater and, consequently more information of cultivars' kernels and their composition is required. A total of 25 samples of kernels from various peach germplasm (including commercial cultivars, perspective hybrids and vineyard peach accessions) differing in origin and ripening time were characterized by evaluation of their sugar composition. Twenty characteristic carbohydrates and sugar alcohols were determined and quantified using high-performance anion-exchange chromatography with pulsed amperometric detection (HPAEC/PAD). Sucrose, glucose and fructose are the most important sugars in peach kernels similar to other representatives of the Rosaceae family. Also, high amounts of sugars in seeds of promising hybrids implies that through conventional breeding programs peach kernels with high sugar content can be obtained. In addition, by the means of several pattern recognition methods the variables that discriminate peach kernels arising from diverse germplasm and different stage of maturity were identified and successful models for further prediction were developed. Sugars such as ribose, trehalose, arabinose, galactitol, fructose, maltose, sorbitol, sucrose, iso-maltotriose were marked as most important for such discrimination.",
publisher = "Springer, Dordrecht",
journal = "Plant Foods for Human Nutrition",
title = "Sugar Profile of Kernels as a Marker of Origin and Ripening Time of Peach (Prunus persicae L.)",
pages = "440-433",
number = "4",
volume = "70",
doi = "10.1007/s11130-015-0515-4"
}

Stanojević, M., Trifković, J., Fotirić-Akšić, M., Rakonjac, V., Nikolić, D., Segan, S.,& Milojković-Opsenica, D. M.. (2015). Sugar Profile of Kernels as a Marker of Origin and Ripening Time of Peach (Prunus persicae L.). in Plant Foods for Human Nutrition
Springer, Dordrecht., 70(4), 433-440.
https://doi.org/10.1007/s11130-015-0515-4

Stanojević M, Trifković J, Fotirić-Akšić M, Rakonjac V, Nikolić D, Segan S, Milojković-Opsenica DM. Sugar Profile of Kernels as a Marker of Origin and Ripening Time of Peach (Prunus persicae L.). in Plant Foods for Human Nutrition. 2015;70(4):433-440.
doi:10.1007/s11130-015-0515-4 .

Stanojević, Marija, Trifković, Jelena, Fotirić-Akšić, Milica, Rakonjac, Vera, Nikolić, Dragan, Segan, Sandra, Milojković-Opsenica, Dušanka M., "Sugar Profile of Kernels as a Marker of Origin and Ripening Time of Peach (Prunus persicae L.)" in Plant Foods for Human Nutrition, 70, no. 4 (2015):433-440,
https://doi.org/10.1007/s11130-015-0515-4 . .