TY  - JOUR
AU  - Rac, Vladislav
AU  - Lević, Steva
AU  - Balanc, Bojana
AU  - Graells, Beatriz Olalde
AU  - Bijelić, Goran
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4932
AB  - The use of polyvinyl alcohol (PVA) cryogel as a model hydrogel for iontophoretic transdermal investigations is proposed. Due to the excellent combination of its properties, it could be used for evaluating iontophoretic transdermal delivery of variety of drugs, regardless of pK(a), pH or presence of auxiliary ions. Applicability of PVA Cryogel for drug delivery purposes was compared to those of polyacrylic acid/polyvinyl alcohol (PAA/PVA) and polyacrylic acid/polyvinylpyrrolidone (PAA/PVP) adhesive interpenetrating networks. Swelling properties of PVA Cryogel were shown to be almost independent on pH and NaCl concentration, while swelling of PAA-based gels was significantly affected. Addition of PVA and PVP to PAA decreased swelling degrees and increased adhesivity and compression moduli. Iontophoretic experiments were performed using a donor gel/skin/receptor gel configuration; current density and delivery duration were varied. Dexamethasone sodium phosphate was used as model drug molecule. PVA Cryogel was used for investigating the influence of NaCl concentration, which can alter the amount of current carried by the drug ions and, therefore, the delivery rate. By using PVA Cryogel it was possible to easily determine the amount of drug permeated through the skin into the receptor gel, the amount retained by the skin and the amount remained in the donor hydrogel. Decreasing NaCl concentration in PVA Cryogel resulted in higher total amounts of drug delivered and significantly enhanced drug permeation through the lower layers of the skin into the receptor hydrogel.
PB  - Elsevier, Amsterdam
T2  - Colloids and Surfaces B-Biointerfaces
T1  - PVA Cryogel as model hydrogel for iontophoretic transdermal drug delivery investigations. Comparison with PAA/PVA and PAA/PVP interpenetrating networks
EP  - 448
SP  - 441
VL  - 180
DO  - 10.1016/j.colsurfb.2019.05.017
ER  - 

@article{
author = "Rac, Vladislav and Lević, Steva and Balanc, Bojana and Graells, Beatriz Olalde and Bijelić, Goran",
year = "2019",
abstract = "The use of polyvinyl alcohol (PVA) cryogel as a model hydrogel for iontophoretic transdermal investigations is proposed. Due to the excellent combination of its properties, it could be used for evaluating iontophoretic transdermal delivery of variety of drugs, regardless of pK(a), pH or presence of auxiliary ions. Applicability of PVA Cryogel for drug delivery purposes was compared to those of polyacrylic acid/polyvinyl alcohol (PAA/PVA) and polyacrylic acid/polyvinylpyrrolidone (PAA/PVP) adhesive interpenetrating networks. Swelling properties of PVA Cryogel were shown to be almost independent on pH and NaCl concentration, while swelling of PAA-based gels was significantly affected. Addition of PVA and PVP to PAA decreased swelling degrees and increased adhesivity and compression moduli. Iontophoretic experiments were performed using a donor gel/skin/receptor gel configuration; current density and delivery duration were varied. Dexamethasone sodium phosphate was used as model drug molecule. PVA Cryogel was used for investigating the influence of NaCl concentration, which can alter the amount of current carried by the drug ions and, therefore, the delivery rate. By using PVA Cryogel it was possible to easily determine the amount of drug permeated through the skin into the receptor gel, the amount retained by the skin and the amount remained in the donor hydrogel. Decreasing NaCl concentration in PVA Cryogel resulted in higher total amounts of drug delivered and significantly enhanced drug permeation through the lower layers of the skin into the receptor hydrogel.",
publisher = "Elsevier, Amsterdam",
journal = "Colloids and Surfaces B-Biointerfaces",
title = "PVA Cryogel as model hydrogel for iontophoretic transdermal drug delivery investigations. Comparison with PAA/PVA and PAA/PVP interpenetrating networks",
pages = "448-441",
volume = "180",
doi = "10.1016/j.colsurfb.2019.05.017"
}

Rac, V., Lević, S., Balanc, B., Graells, B. O.,& Bijelić, G.. (2019). PVA Cryogel as model hydrogel for iontophoretic transdermal drug delivery investigations. Comparison with PAA/PVA and PAA/PVP interpenetrating networks. in Colloids and Surfaces B-Biointerfaces
Elsevier, Amsterdam., 180, 441-448.
https://doi.org/10.1016/j.colsurfb.2019.05.017

Rac V, Lević S, Balanc B, Graells BO, Bijelić G. PVA Cryogel as model hydrogel for iontophoretic transdermal drug delivery investigations. Comparison with PAA/PVA and PAA/PVP interpenetrating networks. in Colloids and Surfaces B-Biointerfaces. 2019;180:441-448.
doi:10.1016/j.colsurfb.2019.05.017 .

Rac, Vladislav, Lević, Steva, Balanc, Bojana, Graells, Beatriz Olalde, Bijelić, Goran, "PVA Cryogel as model hydrogel for iontophoretic transdermal drug delivery investigations. Comparison with PAA/PVA and PAA/PVP interpenetrating networks" in Colloids and Surfaces B-Biointerfaces, 180 (2019):441-448,
https://doi.org/10.1016/j.colsurfb.2019.05.017 . .

TY  - CONF
AU  - Filipović, Nenad
AU  - Saveljić, Igor
AU  - Rac, Vladislav
AU  - Graells, Beatriz Olalde
AU  - Bijelić, Goran
PY  - 2017
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4451
AB  - The concept of iontophoresis is often applied to increase the transdermal transport of drugs and other bioactive agents into the skin or other tissues. It is a non-invasive drug delivery method which involves electromigration and electroosmosis in addition to diffusion and is shown to be a viable alternative to conventional administration routs such as oral, hypodermic and intravenous injection. In this study we investigated, experimentally and numerically, in vitro drug delivery of dexamethasone sodium phosphate to porcine skin. Different current densities, delivery durations and drug loads were investigated experimentally and introduced as boundary conditions for numerical simulations. Nernst-Planck equation was used for calculation of active substance flux through equivalent model of homogeneous hydrogel and skin layers. The obtained numerical results were in good agreement with experimental observations. A comprehensive in-silico platform, which includes appropriate numerical tools for fitting, could contribute to iontophoretic drug-delivery devices design and correct dosage and drug clearance profiles as well as to perform much faster in-silico experiments to better determine parameters and performance criteria of iontophoretic drug delivery.
PB  - Elsevier Science Bv, Amsterdam
C3  - International Journal of Pharmaceutics
T1  - Computational and experimental model of transdermal iontophorethic drug delivery system
EP  - 388
IS  - 2
SP  - 383
VL  - 533
DO  - 10.1016/j.ijpharm.2017.05.066
ER  - 

@conference{
author = "Filipović, Nenad and Saveljić, Igor and Rac, Vladislav and Graells, Beatriz Olalde and Bijelić, Goran",
year = "2017",
abstract = "The concept of iontophoresis is often applied to increase the transdermal transport of drugs and other bioactive agents into the skin or other tissues. It is a non-invasive drug delivery method which involves electromigration and electroosmosis in addition to diffusion and is shown to be a viable alternative to conventional administration routs such as oral, hypodermic and intravenous injection. In this study we investigated, experimentally and numerically, in vitro drug delivery of dexamethasone sodium phosphate to porcine skin. Different current densities, delivery durations and drug loads were investigated experimentally and introduced as boundary conditions for numerical simulations. Nernst-Planck equation was used for calculation of active substance flux through equivalent model of homogeneous hydrogel and skin layers. The obtained numerical results were in good agreement with experimental observations. A comprehensive in-silico platform, which includes appropriate numerical tools for fitting, could contribute to iontophoretic drug-delivery devices design and correct dosage and drug clearance profiles as well as to perform much faster in-silico experiments to better determine parameters and performance criteria of iontophoretic drug delivery.",
publisher = "Elsevier Science Bv, Amsterdam",
journal = "International Journal of Pharmaceutics",
title = "Computational and experimental model of transdermal iontophorethic drug delivery system",
pages = "388-383",
number = "2",
volume = "533",
doi = "10.1016/j.ijpharm.2017.05.066"
}

Filipović, N., Saveljić, I., Rac, V., Graells, B. O.,& Bijelić, G.. (2017). Computational and experimental model of transdermal iontophorethic drug delivery system. in International Journal of Pharmaceutics
Elsevier Science Bv, Amsterdam., 533(2), 383-388.
https://doi.org/10.1016/j.ijpharm.2017.05.066

Filipović N, Saveljić I, Rac V, Graells BO, Bijelić G. Computational and experimental model of transdermal iontophorethic drug delivery system. in International Journal of Pharmaceutics. 2017;533(2):383-388.
doi:10.1016/j.ijpharm.2017.05.066 .

Filipović, Nenad, Saveljić, Igor, Rac, Vladislav, Graells, Beatriz Olalde, Bijelić, Goran, "Computational and experimental model of transdermal iontophorethic drug delivery system" in International Journal of Pharmaceutics, 533, no. 2 (2017):383-388,
https://doi.org/10.1016/j.ijpharm.2017.05.066 . .