TY  - CONF
AU  - Filipović, Nenad
AU  - Stevanović, Magdalena
AU  - Pavlović, Vladimir B.
AU  - Uskoković, Dragan
PY  - 2013
UR  - http://dais.sanu.ac.rs/123456789/431
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5680
AB  - Drug delivery systems of nano- and micro-size represent a new generation of therapeutics that hold promise to become excellent tool in treatment of various diseases and disorders, which are resistant to currently available drugs. This study was performed in order to develop the selenium nanoparticles coated with poly(ε-caprolactone) (PCL), as a potential anticancer agent. Selenium nanoparticles (SeNp) were first synthesized by chemical reduction of sodium selenite, using ascorbic acid as reductant and bovine serum albumin as stabilizer. Obtained SeNPs, with average diameter of ~80 nm, were then incorporated within PCL applying emulsification and freeze drying methods. The final microparticles of PCL/SeNp were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Efficiency of encapsulation of SeNp within PCL particles was determined with inductively coupled plasma atomic emission spectroscopy (ICP-AES) analyses.
PB  - Belgrade : Institute of Technical Sciences of SASA
C3  - Program and the Book of Abstracts / Twelfth Young Researchers' Conference Materials Sciences and Engineering December 11-13, 2013, Belgrade, Serbia
T1  - Preparation and characterization of selenium nanoparticles incorporated within poly(ε-caprolactone)
EP  - 4
SP  - 4
UR  - https://hdl.handle.net/21.15107/rcub_dais_431
ER  - 

@conference{
author = "Filipović, Nenad and Stevanović, Magdalena and Pavlović, Vladimir B. and Uskoković, Dragan",
year = "2013",
abstract = "Drug delivery systems of nano- and micro-size represent a new generation of therapeutics that hold promise to become excellent tool in treatment of various diseases and disorders, which are resistant to currently available drugs. This study was performed in order to develop the selenium nanoparticles coated with poly(ε-caprolactone) (PCL), as a potential anticancer agent. Selenium nanoparticles (SeNp) were first synthesized by chemical reduction of sodium selenite, using ascorbic acid as reductant and bovine serum albumin as stabilizer. Obtained SeNPs, with average diameter of ~80 nm, were then incorporated within PCL applying emulsification and freeze drying methods. The final microparticles of PCL/SeNp were characterized by Fourier transform infrared spectroscopy (FTIR) and scanning electron microscopy (SEM). Efficiency of encapsulation of SeNp within PCL particles was determined with inductively coupled plasma atomic emission spectroscopy (ICP-AES) analyses.",
publisher = "Belgrade : Institute of Technical Sciences of SASA",
journal = "Program and the Book of Abstracts / Twelfth Young Researchers' Conference Materials Sciences and Engineering December 11-13, 2013, Belgrade, Serbia",
title = "Preparation and characterization of selenium nanoparticles incorporated within poly(ε-caprolactone)",
pages = "4-4",
url = "https://hdl.handle.net/21.15107/rcub_dais_431"
}

Filipović, N., Stevanović, M., Pavlović, V. B.,& Uskoković, D.. (2013). Preparation and characterization of selenium nanoparticles incorporated within poly(ε-caprolactone). in Program and the Book of Abstracts / Twelfth Young Researchers' Conference Materials Sciences and Engineering December 11-13, 2013, Belgrade, Serbia
Belgrade : Institute of Technical Sciences of SASA., 4-4.
https://hdl.handle.net/21.15107/rcub_dais_431

Filipović N, Stevanović M, Pavlović VB, Uskoković D. Preparation and characterization of selenium nanoparticles incorporated within poly(ε-caprolactone). in Program and the Book of Abstracts / Twelfth Young Researchers' Conference Materials Sciences and Engineering December 11-13, 2013, Belgrade, Serbia. 2013;:4-4.
https://hdl.handle.net/21.15107/rcub_dais_431 .

Filipović, Nenad, Stevanović, Magdalena, Pavlović, Vladimir B., Uskoković, Dragan, "Preparation and characterization of selenium nanoparticles incorporated within poly(ε-caprolactone)" in Program and the Book of Abstracts / Twelfth Young Researchers' Conference Materials Sciences and Engineering December 11-13, 2013, Belgrade, Serbia (2013):4-4,
https://hdl.handle.net/21.15107/rcub_dais_431 .

TY  - JOUR
AU  - Filipović, Nenad
AU  - Stevanović, Magdalena
AU  - Radulović, Aleksandra
AU  - Pavlović, Vladimir
AU  - Uskoković, Dragan
PY  - 2013
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/3298
AB  - Poly(epsilon-caprolactone) (PCL) particles were prepared by physicochemical method with solvent/non-solvent systems. The synthetic polymer polyvinylpyrrolidone (PVP) and natural polymer poly(alpha,gamma,L-glutamic acid) (PGA), were used as stabilizers and their influence on size and morphology of the particles was examined. The results were compared with those obtained without the use of stabilizers. This study evaluated, for the first time, PGA as stabilizer of PCL particles and demonstrated that PGA is more efficient stabilizer of PCL particles than most commonly used PVP. The particles obtained by using PGA as stabilizer were spherical, with smooth surfaces and dimensions below 1 mu m. The drying conditions were also varied in order to examine their influence on the formation of PCL particles. The samples were characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, particle size distribution (DLS) and zeta potential measurements.
PB  - Elsevier Sci Ltd, Oxford
T2  - Composites Part B-Engineering
T1  - Facile synthesis of poly(epsilon-caprolactone) micro and nanospheres using different types of polyelectrolytes as stabilizers under ambient and elevated temperature
EP  - 1479
IS  - 1
SP  - 1471
VL  - 45
DO  - 10.1016/j.compositesb.2012.07.008
ER  - 

@article{
author = "Filipović, Nenad and Stevanović, Magdalena and Radulović, Aleksandra and Pavlović, Vladimir and Uskoković, Dragan",
year = "2013",
abstract = "Poly(epsilon-caprolactone) (PCL) particles were prepared by physicochemical method with solvent/non-solvent systems. The synthetic polymer polyvinylpyrrolidone (PVP) and natural polymer poly(alpha,gamma,L-glutamic acid) (PGA), were used as stabilizers and their influence on size and morphology of the particles was examined. The results were compared with those obtained without the use of stabilizers. This study evaluated, for the first time, PGA as stabilizer of PCL particles and demonstrated that PGA is more efficient stabilizer of PCL particles than most commonly used PVP. The particles obtained by using PGA as stabilizer were spherical, with smooth surfaces and dimensions below 1 mu m. The drying conditions were also varied in order to examine their influence on the formation of PCL particles. The samples were characterized by Fourier-transform infrared spectroscopy, scanning electron microscopy, particle size distribution (DLS) and zeta potential measurements.",
publisher = "Elsevier Sci Ltd, Oxford",
journal = "Composites Part B-Engineering",
title = "Facile synthesis of poly(epsilon-caprolactone) micro and nanospheres using different types of polyelectrolytes as stabilizers under ambient and elevated temperature",
pages = "1479-1471",
number = "1",
volume = "45",
doi = "10.1016/j.compositesb.2012.07.008"
}

Filipović, N., Stevanović, M., Radulović, A., Pavlović, V.,& Uskoković, D.. (2013). Facile synthesis of poly(epsilon-caprolactone) micro and nanospheres using different types of polyelectrolytes as stabilizers under ambient and elevated temperature. in Composites Part B-Engineering
Elsevier Sci Ltd, Oxford., 45(1), 1471-1479.
https://doi.org/10.1016/j.compositesb.2012.07.008

Filipović N, Stevanović M, Radulović A, Pavlović V, Uskoković D. Facile synthesis of poly(epsilon-caprolactone) micro and nanospheres using different types of polyelectrolytes as stabilizers under ambient and elevated temperature. in Composites Part B-Engineering. 2013;45(1):1471-1479.
doi:10.1016/j.compositesb.2012.07.008 .

Filipović, Nenad, Stevanović, Magdalena, Radulović, Aleksandra, Pavlović, Vladimir, Uskoković, Dragan, "Facile synthesis of poly(epsilon-caprolactone) micro and nanospheres using different types of polyelectrolytes as stabilizers under ambient and elevated temperature" in Composites Part B-Engineering, 45, no. 1 (2013):1471-1479,
https://doi.org/10.1016/j.compositesb.2012.07.008 . .

TY  - CONF
AU  - Stupar, Petar
AU  - Stevanović, Magdalena
AU  - Filipović, Nenad
AU  - Pavlović, Vladimir B.
AU  - Nunić, Jana
AU  - Cundrič, Sandra
AU  - Filipič, Metka
AU  - Uskoković, Dragan
PY  - 2012
UR  - http://dais.sanu.ac.rs/123456789/531
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5689
AB  - A common limitation of using polymeric micro and nanoparticles in long-term conservation is due to their poor physical and chemical stability. Freeze-drying is one of the most convenient methods that enable further reconstitution of micro and nanoparticles for therapeutical use. Nevertheless, this process generates various stresses during freezing and desiccation steps. The aim of this study was to evaluate different cryoprotectants (protective excipients that are usually added to increase stability upon storage and protect the particles from freezing stress): sugars (glucose and sucrose) and polymers (PVA and PGA), on the outcome of freeze-dried poly(ε-caprolactone) micro and nanospheres. The best freeze-drying results in terms of morphological characteristics, analyzed with SEM, were achieved with glucose at concentration of 1%. The FTIR analysis confirmed that the molecular structure of PCL particles remained the same after the addition cryoprotectants.
PB  - Belgrade : Materials Research Society of Serbia; Institute of Technical Sciences of SASA; Vinča Institute of Nuclear Sciences, University of Belgrade
C3  - Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts
T1  - Effects of different cryoprotectants on morphology of lyophilized poly(ε-caprolactone) micro and nanospheres
EP  - 104
SP  - 104
UR  - https://hdl.handle.net/21.15107/rcub_dais_531
ER  - 

@conference{
author = "Stupar, Petar and Stevanović, Magdalena and Filipović, Nenad and Pavlović, Vladimir B. and Nunić, Jana and Cundrič, Sandra and Filipič, Metka and Uskoković, Dragan",
year = "2012",
abstract = "A common limitation of using polymeric micro and nanoparticles in long-term conservation is due to their poor physical and chemical stability. Freeze-drying is one of the most convenient methods that enable further reconstitution of micro and nanoparticles for therapeutical use. Nevertheless, this process generates various stresses during freezing and desiccation steps. The aim of this study was to evaluate different cryoprotectants (protective excipients that are usually added to increase stability upon storage and protect the particles from freezing stress): sugars (glucose and sucrose) and polymers (PVA and PGA), on the outcome of freeze-dried poly(ε-caprolactone) micro and nanospheres. The best freeze-drying results in terms of morphological characteristics, analyzed with SEM, were achieved with glucose at concentration of 1%. The FTIR analysis confirmed that the molecular structure of PCL particles remained the same after the addition cryoprotectants.",
publisher = "Belgrade : Materials Research Society of Serbia; Institute of Technical Sciences of SASA; Vinča Institute of Nuclear Sciences, University of Belgrade",
journal = "Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts",
title = "Effects of different cryoprotectants on morphology of lyophilized poly(ε-caprolactone) micro and nanospheres",
pages = "104-104",
url = "https://hdl.handle.net/21.15107/rcub_dais_531"
}

Stupar, P., Stevanović, M., Filipović, N., Pavlović, V. B., Nunić, J., Cundrič, S., Filipič, M.,& Uskoković, D.. (2012). Effects of different cryoprotectants on morphology of lyophilized poly(ε-caprolactone) micro and nanospheres. in Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts
Belgrade : Materials Research Society of Serbia; Institute of Technical Sciences of SASA; Vinča Institute of Nuclear Sciences, University of Belgrade., 104-104.
https://hdl.handle.net/21.15107/rcub_dais_531

Stupar P, Stevanović M, Filipović N, Pavlović VB, Nunić J, Cundrič S, Filipič M, Uskoković D. Effects of different cryoprotectants on morphology of lyophilized poly(ε-caprolactone) micro and nanospheres. in Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts. 2012;:104-104.
https://hdl.handle.net/21.15107/rcub_dais_531 .

Stupar, Petar, Stevanović, Magdalena, Filipović, Nenad, Pavlović, Vladimir B., Nunić, Jana, Cundrič, Sandra, Filipič, Metka, Uskoković, Dragan, "Effects of different cryoprotectants on morphology of lyophilized poly(ε-caprolactone) micro and nanospheres" in Joint Event of the 11th Young Researchers’ Conference: Materials Science and Engineering and the 1st European Early Stage Researches’ Conference on Hydrogen Storage: Program and the Book of Abstracts (2012):104-104,
https://hdl.handle.net/21.15107/rcub_dais_531 .

TY  - CONF
AU  - Filipović, Nenad
AU  - Stevanović, Magdalena
AU  - Pavlović, Vladimir B.
AU  - Radulović, Aleksandra
AU  - Stojanović, Zoran S.
AU  - Uskoković, Dragan
PY  - 2011
UR  - http://dais.sanu.ac.rs/123456789/692
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5705
AB  - Poly-ε-caprolactone (PCL) is a semicrystalline, biodegradable and biocompatible polymer. Its advantages, as high permeability to small drug molecules, failure to generate an acidic environment during degradation (as compared to polylactides and polyglycolides) and a slow degradation rate, make this aliphatic polyester suitable for extended long-term delivery over a period of more than one year. In this study PCL particles were prepared by physicochemical method with solvent/nonsolvent systems. The synthetic polymer polyvinylpyrrolidone (PVP) and natural polymer poly (α, γ, L-glutamic acid) (PGA), were used as stabilizers and their influence on size and morphology of the particles was examined. The results were compared with those obtained without the use of stabilizers. Characterization of obtained particles was performed by Fourier transform infrared spectroscopy. The morphology and size distribution were determined using SEM and particle analyzer.
PB  - Belgrade : Institute of Technical Sciences of the Serbian Academy of Sciences and Arts
C3  - Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia
T1  - Synthesis and the effect of processing parameters on characteristics of poly-ε-caprolactone micro- and nanospheres
EP  - 2
SP  - 2
UR  - https://hdl.handle.net/21.15107/rcub_dais_692
ER  - 

@conference{
author = "Filipović, Nenad and Stevanović, Magdalena and Pavlović, Vladimir B. and Radulović, Aleksandra and Stojanović, Zoran S. and Uskoković, Dragan",
year = "2011",
abstract = "Poly-ε-caprolactone (PCL) is a semicrystalline, biodegradable and biocompatible polymer. Its advantages, as high permeability to small drug molecules, failure to generate an acidic environment during degradation (as compared to polylactides and polyglycolides) and a slow degradation rate, make this aliphatic polyester suitable for extended long-term delivery over a period of more than one year. In this study PCL particles were prepared by physicochemical method with solvent/nonsolvent systems. The synthetic polymer polyvinylpyrrolidone (PVP) and natural polymer poly (α, γ, L-glutamic acid) (PGA), were used as stabilizers and their influence on size and morphology of the particles was examined. The results were compared with those obtained without the use of stabilizers. Characterization of obtained particles was performed by Fourier transform infrared spectroscopy. The morphology and size distribution were determined using SEM and particle analyzer.",
publisher = "Belgrade : Institute of Technical Sciences of the Serbian Academy of Sciences and Arts",
journal = "Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia",
title = "Synthesis and the effect of processing parameters on characteristics of poly-ε-caprolactone micro- and nanospheres",
pages = "2-2",
url = "https://hdl.handle.net/21.15107/rcub_dais_692"
}

Filipović, N., Stevanović, M., Pavlović, V. B., Radulović, A., Stojanović, Z. S.,& Uskoković, D.. (2011). Synthesis and the effect of processing parameters on characteristics of poly-ε-caprolactone micro- and nanospheres. in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia
Belgrade : Institute of Technical Sciences of the Serbian Academy of Sciences and Arts., 2-2.
https://hdl.handle.net/21.15107/rcub_dais_692

Filipović N, Stevanović M, Pavlović VB, Radulović A, Stojanović ZS, Uskoković D. Synthesis and the effect of processing parameters on characteristics of poly-ε-caprolactone micro- and nanospheres. in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia. 2011;:2-2.
https://hdl.handle.net/21.15107/rcub_dais_692 .

Filipović, Nenad, Stevanović, Magdalena, Pavlović, Vladimir B., Radulović, Aleksandra, Stojanović, Zoran S., Uskoković, Dragan, "Synthesis and the effect of processing parameters on characteristics of poly-ε-caprolactone micro- and nanospheres" in Program and the Book of Abstracts / Tenth Young Researchers' Conference Materials Science and Engineering, December 21-23, 2011, Belgrade, Serbia (2011):2-2,
https://hdl.handle.net/21.15107/rcub_dais_692 .