TY  - JOUR
AU  - Nakov, Dimitar
AU  - Hristov, Slavča
AU  - Stanković, Branislav
AU  - Pol, Francois
AU  - Dimitrov, Ivan
AU  - Ilieski, Vlatko
AU  - Mormede, Pierre
AU  - Nerve, Julie
AU  - Terenina, Elena
AU  - Lieubeau, Blandine
AU  - Papanastasiou, Dimitrios K.
AU  - Bartzanas, Thomas
AU  - Norton, Tomas
AU  - Piette, Deborah
AU  - Tullo, Emanuela
AU  - van Dixhoorn, D.E.
PY  - 2019
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/5053
AB  - Features of intensive farming can seriously threaten pig homeostasis, well-being and productivity. Disease tolerance of an organism is the adaptive ability in preserving homeostasis and at the same time limiting the detrimental impact that infection can inflict on its health and performance without affecting pathogen burden per se. While disease resistance (DRs ) can be assessed measuring appropriately the pathogen burden within the host, the tolerance cannot be quantified easily. Indeed, it requires the assessment of the changes in performance as well as the changes in pathogen burden. In this paper, special attention is given to criteria required to standardize methodologies for assessing disease tolerance (DT) in respect of infectious diseases in pigs. The concept is applied to different areas of expertise and specific examples are given. The basic physiological mechanisms of DT are reviewed. Disease tolerance pathways, genetics of the tolerance-related traits, stress and disease tolerance, and role of metabolic stress in DT are described. In addition, methodologies based on monitoring of growth and reproductive performance, welfare, emotional affective states, sickness behavior for assessment of disease tolerance, and methodologies based on the relationship between environmental challenges and disease tolerance are considered. Automated Precision Livestock Farming technologies available for monitoring performance, health and welfare-related measures in pig farms, and their limitations regarding DT in pigs are also presented. Since defining standardized methodologies for assessing DT is a serious challenge for biologists, animal scientists and veterinarians, this work should contribute to improvement of health, welfare and production in pigs.
PB  - Frontiers Media Sa, Lausanne
T2  - Frontiers in Veterinary Science
T1  - Methodologies for Assessing Disease Tolerance in Pigs
VL  - 5
DO  - 10.3389/fvets.2018.00329
ER  - 

@article{
author = "Nakov, Dimitar and Hristov, Slavča and Stanković, Branislav and Pol, Francois and Dimitrov, Ivan and Ilieski, Vlatko and Mormede, Pierre and Nerve, Julie and Terenina, Elena and Lieubeau, Blandine and Papanastasiou, Dimitrios K. and Bartzanas, Thomas and Norton, Tomas and Piette, Deborah and Tullo, Emanuela and van Dixhoorn, D.E.",
year = "2019",
abstract = "Features of intensive farming can seriously threaten pig homeostasis, well-being and productivity. Disease tolerance of an organism is the adaptive ability in preserving homeostasis and at the same time limiting the detrimental impact that infection can inflict on its health and performance without affecting pathogen burden per se. While disease resistance (DRs ) can be assessed measuring appropriately the pathogen burden within the host, the tolerance cannot be quantified easily. Indeed, it requires the assessment of the changes in performance as well as the changes in pathogen burden. In this paper, special attention is given to criteria required to standardize methodologies for assessing disease tolerance (DT) in respect of infectious diseases in pigs. The concept is applied to different areas of expertise and specific examples are given. The basic physiological mechanisms of DT are reviewed. Disease tolerance pathways, genetics of the tolerance-related traits, stress and disease tolerance, and role of metabolic stress in DT are described. In addition, methodologies based on monitoring of growth and reproductive performance, welfare, emotional affective states, sickness behavior for assessment of disease tolerance, and methodologies based on the relationship between environmental challenges and disease tolerance are considered. Automated Precision Livestock Farming technologies available for monitoring performance, health and welfare-related measures in pig farms, and their limitations regarding DT in pigs are also presented. Since defining standardized methodologies for assessing DT is a serious challenge for biologists, animal scientists and veterinarians, this work should contribute to improvement of health, welfare and production in pigs.",
publisher = "Frontiers Media Sa, Lausanne",
journal = "Frontiers in Veterinary Science",
title = "Methodologies for Assessing Disease Tolerance in Pigs",
volume = "5",
doi = "10.3389/fvets.2018.00329"
}

Nakov, D., Hristov, S., Stanković, B., Pol, F., Dimitrov, I., Ilieski, V., Mormede, P., Nerve, J., Terenina, E., Lieubeau, B., Papanastasiou, D. K., Bartzanas, T., Norton, T., Piette, D., Tullo, E.,& van Dixhoorn, D.E.. (2019). Methodologies for Assessing Disease Tolerance in Pigs. in Frontiers in Veterinary Science
Frontiers Media Sa, Lausanne., 5.
https://doi.org/10.3389/fvets.2018.00329

Nakov D, Hristov S, Stanković B, Pol F, Dimitrov I, Ilieski V, Mormede P, Nerve J, Terenina E, Lieubeau B, Papanastasiou DK, Bartzanas T, Norton T, Piette D, Tullo E, van Dixhoorn D. Methodologies for Assessing Disease Tolerance in Pigs. in Frontiers in Veterinary Science. 2019;5.
doi:10.3389/fvets.2018.00329 .

Nakov, Dimitar, Hristov, Slavča, Stanković, Branislav, Pol, Francois, Dimitrov, Ivan, Ilieski, Vlatko, Mormede, Pierre, Nerve, Julie, Terenina, Elena, Lieubeau, Blandine, Papanastasiou, Dimitrios K., Bartzanas, Thomas, Norton, Tomas, Piette, Deborah, Tullo, Emanuela, van Dixhoorn, D.E., "Methodologies for Assessing Disease Tolerance in Pigs" in Frontiers in Veterinary Science, 5 (2019),
https://doi.org/10.3389/fvets.2018.00329 . .