TY  - JOUR
AU  - Pruesse, Ulf
AU  - Bilancetti, Luca
AU  - Bucko, Marek
AU  - Bugarski, Branko
AU  - Bukowski, Jozef
AU  - Gemeiner, Peter
AU  - Lewinska, Dorota
AU  - Manojlović, Verica
AU  - Massart, Benjamin
AU  - Nastruzzi, Claudio
AU  - Nedović, Viktor
AU  - Poncelet, Denis
AU  - Siebenhaar, Swen
AU  - Tobler, Lucien
AU  - Tosi, Azzurra
AU  - Vikartovska, Alica
AU  - Vorlop, Klaus-Dieter
PY  - 2008
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1813
AB  - This paper describes the results of the round robin experiment "Bead production technologies" carried out during the COST 840 action "Bioencapsulation Innovation and Technologies" within the 5th Framework Program of the European Community. In this round robin experiment, calcium alginate hydrogel beads with the diameter of (800 +/- 100) mu m were produced by the most common bead production technologies using 0.5-4 mass % sodium alginate solutions as starting material. Dynamic viscosity of the alginate solutions ranged from less than 50 mPa s up to more than 10000 mPa s. With the coaxial air-flow and electrostatic enhanced dropping technologies as well as with the JetCutter technology in the soft-landing mode, beads were produced from all alginate solutions, whereas the vibration technology was not capable to process the high-viscosity 3 % and 4 % alginate solutions. Spherical beads were generated by the electrostatic and the JetCutter technologies. Slightly deformed beads were obtained from high-viscosity alginate solutions using the coaxial airflow and from the 0.5 % and 2 % alginate solutions using the vibration technology. The rate of bead production using the JetCutter was about 10 times higher than with the vibration technology and more than 10000 times higher than with the coaxial air-flow and electrostatic technology.
PB  - Springer International Publishing Ag, Cham
T2  - Chemical Papers
T1  - Comparison of different technologies for alginate beads production
EP  - 374
IS  - 4
SP  - 364
VL  - 62
DO  - 10.2478/s11696-008-0035-x
ER  - 

@article{
author = "Pruesse, Ulf and Bilancetti, Luca and Bucko, Marek and Bugarski, Branko and Bukowski, Jozef and Gemeiner, Peter and Lewinska, Dorota and Manojlović, Verica and Massart, Benjamin and Nastruzzi, Claudio and Nedović, Viktor and Poncelet, Denis and Siebenhaar, Swen and Tobler, Lucien and Tosi, Azzurra and Vikartovska, Alica and Vorlop, Klaus-Dieter",
year = "2008",
abstract = "This paper describes the results of the round robin experiment "Bead production technologies" carried out during the COST 840 action "Bioencapsulation Innovation and Technologies" within the 5th Framework Program of the European Community. In this round robin experiment, calcium alginate hydrogel beads with the diameter of (800 +/- 100) mu m were produced by the most common bead production technologies using 0.5-4 mass % sodium alginate solutions as starting material. Dynamic viscosity of the alginate solutions ranged from less than 50 mPa s up to more than 10000 mPa s. With the coaxial air-flow and electrostatic enhanced dropping technologies as well as with the JetCutter technology in the soft-landing mode, beads were produced from all alginate solutions, whereas the vibration technology was not capable to process the high-viscosity 3 % and 4 % alginate solutions. Spherical beads were generated by the electrostatic and the JetCutter technologies. Slightly deformed beads were obtained from high-viscosity alginate solutions using the coaxial airflow and from the 0.5 % and 2 % alginate solutions using the vibration technology. The rate of bead production using the JetCutter was about 10 times higher than with the vibration technology and more than 10000 times higher than with the coaxial air-flow and electrostatic technology.",
publisher = "Springer International Publishing Ag, Cham",
journal = "Chemical Papers",
title = "Comparison of different technologies for alginate beads production",
pages = "374-364",
number = "4",
volume = "62",
doi = "10.2478/s11696-008-0035-x"
}

Pruesse, U., Bilancetti, L., Bucko, M., Bugarski, B., Bukowski, J., Gemeiner, P., Lewinska, D., Manojlović, V., Massart, B., Nastruzzi, C., Nedović, V., Poncelet, D., Siebenhaar, S., Tobler, L., Tosi, A., Vikartovska, A.,& Vorlop, K.. (2008). Comparison of different technologies for alginate beads production. in Chemical Papers
Springer International Publishing Ag, Cham., 62(4), 364-374.
https://doi.org/10.2478/s11696-008-0035-x

Pruesse U, Bilancetti L, Bucko M, Bugarski B, Bukowski J, Gemeiner P, Lewinska D, Manojlović V, Massart B, Nastruzzi C, Nedović V, Poncelet D, Siebenhaar S, Tobler L, Tosi A, Vikartovska A, Vorlop K. Comparison of different technologies for alginate beads production. in Chemical Papers. 2008;62(4):364-374.
doi:10.2478/s11696-008-0035-x .

Pruesse, Ulf, Bilancetti, Luca, Bucko, Marek, Bugarski, Branko, Bukowski, Jozef, Gemeiner, Peter, Lewinska, Dorota, Manojlović, Verica, Massart, Benjamin, Nastruzzi, Claudio, Nedović, Viktor, Poncelet, Denis, Siebenhaar, Swen, Tobler, Lucien, Tosi, Azzurra, Vikartovska, Alica, Vorlop, Klaus-Dieter, "Comparison of different technologies for alginate beads production" in Chemical Papers, 62, no. 4 (2008):364-374,
https://doi.org/10.2478/s11696-008-0035-x . .

TY  - JOUR
AU  - Nedović, Viktor
AU  - Manojlović, Verica
AU  - Pruesse, Ulf
AU  - Bugarski, Branko
AU  - Djonlagić, Jasna
AU  - Vorlop, Klaus D.
PY  - 2006
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/1224
AB  - The aim of this study was to optimize the electrostatic extrusion process for producing small, spherical and uniform microbeads with different fluid viscosities by varying the operating parameters in very wide ranges. Alginate was used as a model polymer. Since the rheological behavior of the solution is one of the parameters that affects the flow dynamics during extrusion, viscosity measurements of solutions with different alginate content were performed. The results obtained in this study show that an electrostatic droplet generator can be used for the production of spherical microbeads of narrow size distribution from low- and medium- viscous fluids (0.5, 1, and 2% of alginate). The average microbead diameter for low-viscous solutions was less than 100 micrometers. It was possible to obtain beads smaller than 500 micrometers that were very uniform (standard deviations less than 2.5%) and of spherical (the shape distortion was less than 1%) from medium-viscous alginate solution (2%). By reducing the polymer flowrate to less than 1 ml/h, even smaller microbeads were produced with diameters of about 300 micrometers. The particular contribution of this paper is in exceeding limitations regarding the use of high-viscous polymer solutions. Optimization of the operating conditions that included the use of a very small needle (0.15 mm), enlargement of the electrode distance to more than 20 cm and a severe reduction in the polymer flow rate to lower than 5 ml/h (for 3% alginate) or 1 ml/h (for 4% alginate) enabled the production of small, entirely spherical and uniform microbeads with an average microbead diameter lower than 500 and 700 micrometers in the case of 3 and 4% of alginate, respectively.
AB  - Elektrostatička ekstruzija je novija ekstruziona metoda koja se zasniva na primeni električne sile koja deluje na površini meniskusa tečnosti na vrhu igle, usled čega dolazi do generisanja velikog broja kapljica. U prethodnim istraživanjima je utvrđeno da je veličina čestica funkcija više parametara kao što su električni potencijal, prečnik kapilare, rastojanje između elektroda, protok i fizičko-hemijske osobine polimera (površinski napon viskoznost, koncentracija). Takođe, utvrđeno je i da postoje određena ograničenja koja se odnose na ekstruziju veoma viskoznih rastvora. Ovaj rad je posvećen optimizaciji metode radi dobijanja što sitnijih i uniformnijih čestica. S obzirom da je viskoznost rastvora jedan od parametara koji utiče na dinamiku isticanja polimera kroz kapilaru, najpre su izvršena merenja viskoznosti rastvora alginata različitih koncentracija. Utvrđeno je da povećanje koncentracije rastvora sa 2 do 4% dovodi do povećanja viskoznosti sa oko 2000 na 17000 mPas na 21 °C. Dobijeni rezultati su pokazali da je elektrostička ekstruzija vrlo povoljna za dobijanje sferičnih čestica uskog opsega raspodele veličina koristeći nisko- i srednje-viskozne rastvore polimera (0,5, 1 i 2% alginata). Sa nisko-viskoznim rastvorom alginata, pod određenim uslovima, dobijene su čestice čiji je srednji prečnik čak manji i od 100 μn. Sa srednje viskoznim alginatnim rastvorom dobijene su čestice prečnika ispod 500 μm, koje su bile vrlo uniformne (srednje kvadratno odstupanje manje od 2,5%) i sferične (deformacija oblika manja od 1%), a smanjenjem protoka rastvora, moguće je dobiti čestice i manje od 300 μm. Poseban doprinos rada je u prevazilaženju ograničenja koja se odnose na ekstruziju veoma viskoznih rastvora. Optimizacija procesnih parametara koja je podrazumevala primenu vrlo tanke igle (0,15 mm), povećanje rastojanja između elektroda iznad 20 cm i smanjenje protoka ispod 5 ml/h (za 3% alginat), odn. 1 ml/h (za 4% alginat), omogućila je dobijanje malih, potpuno sferičnih i uniformnih mikročestica čiji je srednji prečnik bio ispod 500 i 700 μm za 3 i 4% alginatni rastvor, respektivno.
PB  - Savez hemijskih inženjera, Beograd
T2  - Chemical Industry and Chemical Engineering Quarterly / CICEQ
T1  - Optimization of the electrostatic droplet generation process for controlled microbead production: Single nozzle system
T1  - Optimizacija elektrostatičkog generisanja čestica u cilju kontrolisanja njihovih mikronskih veličina - sistem sa jednom mlaznicom
EP  - 57
IS  - 1
SP  - 53
VL  - 12
DO  - 10.2298/CICEQ0601053N
ER  - 

@article{
author = "Nedović, Viktor and Manojlović, Verica and Pruesse, Ulf and Bugarski, Branko and Djonlagić, Jasna and Vorlop, Klaus D.",
year = "2006",
abstract = "The aim of this study was to optimize the electrostatic extrusion process for producing small, spherical and uniform microbeads with different fluid viscosities by varying the operating parameters in very wide ranges. Alginate was used as a model polymer. Since the rheological behavior of the solution is one of the parameters that affects the flow dynamics during extrusion, viscosity measurements of solutions with different alginate content were performed. The results obtained in this study show that an electrostatic droplet generator can be used for the production of spherical microbeads of narrow size distribution from low- and medium- viscous fluids (0.5, 1, and 2% of alginate). The average microbead diameter for low-viscous solutions was less than 100 micrometers. It was possible to obtain beads smaller than 500 micrometers that were very uniform (standard deviations less than 2.5%) and of spherical (the shape distortion was less than 1%) from medium-viscous alginate solution (2%). By reducing the polymer flowrate to less than 1 ml/h, even smaller microbeads were produced with diameters of about 300 micrometers. The particular contribution of this paper is in exceeding limitations regarding the use of high-viscous polymer solutions. Optimization of the operating conditions that included the use of a very small needle (0.15 mm), enlargement of the electrode distance to more than 20 cm and a severe reduction in the polymer flow rate to lower than 5 ml/h (for 3% alginate) or 1 ml/h (for 4% alginate) enabled the production of small, entirely spherical and uniform microbeads with an average microbead diameter lower than 500 and 700 micrometers in the case of 3 and 4% of alginate, respectively., Elektrostatička ekstruzija je novija ekstruziona metoda koja se zasniva na primeni električne sile koja deluje na površini meniskusa tečnosti na vrhu igle, usled čega dolazi do generisanja velikog broja kapljica. U prethodnim istraživanjima je utvrđeno da je veličina čestica funkcija više parametara kao što su električni potencijal, prečnik kapilare, rastojanje između elektroda, protok i fizičko-hemijske osobine polimera (površinski napon viskoznost, koncentracija). Takođe, utvrđeno je i da postoje određena ograničenja koja se odnose na ekstruziju veoma viskoznih rastvora. Ovaj rad je posvećen optimizaciji metode radi dobijanja što sitnijih i uniformnijih čestica. S obzirom da je viskoznost rastvora jedan od parametara koji utiče na dinamiku isticanja polimera kroz kapilaru, najpre su izvršena merenja viskoznosti rastvora alginata različitih koncentracija. Utvrđeno je da povećanje koncentracije rastvora sa 2 do 4% dovodi do povećanja viskoznosti sa oko 2000 na 17000 mPas na 21 °C. Dobijeni rezultati su pokazali da je elektrostička ekstruzija vrlo povoljna za dobijanje sferičnih čestica uskog opsega raspodele veličina koristeći nisko- i srednje-viskozne rastvore polimera (0,5, 1 i 2% alginata). Sa nisko-viskoznim rastvorom alginata, pod određenim uslovima, dobijene su čestice čiji je srednji prečnik čak manji i od 100 μn. Sa srednje viskoznim alginatnim rastvorom dobijene su čestice prečnika ispod 500 μm, koje su bile vrlo uniformne (srednje kvadratno odstupanje manje od 2,5%) i sferične (deformacija oblika manja od 1%), a smanjenjem protoka rastvora, moguće je dobiti čestice i manje od 300 μm. Poseban doprinos rada je u prevazilaženju ograničenja koja se odnose na ekstruziju veoma viskoznih rastvora. Optimizacija procesnih parametara koja je podrazumevala primenu vrlo tanke igle (0,15 mm), povećanje rastojanja između elektroda iznad 20 cm i smanjenje protoka ispod 5 ml/h (za 3% alginat), odn. 1 ml/h (za 4% alginat), omogućila je dobijanje malih, potpuno sferičnih i uniformnih mikročestica čiji je srednji prečnik bio ispod 500 i 700 μm za 3 i 4% alginatni rastvor, respektivno.",
publisher = "Savez hemijskih inženjera, Beograd",
journal = "Chemical Industry and Chemical Engineering Quarterly / CICEQ",
title = "Optimization of the electrostatic droplet generation process for controlled microbead production: Single nozzle system, Optimizacija elektrostatičkog generisanja čestica u cilju kontrolisanja njihovih mikronskih veličina - sistem sa jednom mlaznicom",
pages = "57-53",
number = "1",
volume = "12",
doi = "10.2298/CICEQ0601053N"
}

Nedović, V., Manojlović, V., Pruesse, U., Bugarski, B., Djonlagić, J.,& Vorlop, K. D.. (2006). Optimization of the electrostatic droplet generation process for controlled microbead production: Single nozzle system. in Chemical Industry and Chemical Engineering Quarterly / CICEQ
Savez hemijskih inženjera, Beograd., 12(1), 53-57.
https://doi.org/10.2298/CICEQ0601053N

Nedović V, Manojlović V, Pruesse U, Bugarski B, Djonlagić J, Vorlop KD. Optimization of the electrostatic droplet generation process for controlled microbead production: Single nozzle system. in Chemical Industry and Chemical Engineering Quarterly / CICEQ. 2006;12(1):53-57.
doi:10.2298/CICEQ0601053N .

Nedović, Viktor, Manojlović, Verica, Pruesse, Ulf, Bugarski, Branko, Djonlagić, Jasna, Vorlop, Klaus D., "Optimization of the electrostatic droplet generation process for controlled microbead production: Single nozzle system" in Chemical Industry and Chemical Engineering Quarterly / CICEQ, 12, no. 1 (2006):53-57,
https://doi.org/10.2298/CICEQ0601053N . .