TY  - JOUR
AU  - Popović-Djordjević, Jelena
AU  - Klaus, Anita
AU  - Zizak, Zeljko S.
AU  - Matić, Ivana Z.
AU  - Drakulić, Branko J.
PY  - 2016
UR  - http://aspace.agrif.bg.ac.rs/handle/123456789/4155
AB  - Antiproliferative and antibacterial activities of nine glutarimide derivatives (1-9) were reported. Cytotoxicity of compounds was tested toward three human cancer cell lines, HeLa, K562 and MDA-MB-453 by MTT assay. Compound 7 (2-benzyl-2-azaspiro[5.11] heptadecane-1,3,7-trione), containing 12-membered ketone ring, was found to be the most potent toward all tested cell lines (IC50 = 9-27 mu M). Preliminary screening of antibacterial activity by a disk diffusion method showed that Gram-positive bacteria were more susceptible to the tested compounds than Gram-negative bacteria. Minimum inhibitory concentration (MIC) determined by a broth microdilution method confirmed that compounds 1, 2, 4, 6-8 and 9 inhibited the growth of all tested Gram-positive and some of the Gram-negative bacteria. The best antibacterial potential was achieved with compound 9 (ethyl 4-(1-benzyl-2,6-dioxopiperidin-3-yl) butanoate) against Bacillus cereus (MIC 0.625 mg/mL; 1.97 x 10(-3) mol/L). Distinction between more and less active/inactive compounds was assessed from the pharmacophoric patterns obtained by molecular interaction fields.
PB  - Taylor & Francis Ltd, Abingdon
T2  - Journal of Enzyme Inhibition and Medicinal Chemistry
T1  - Antiproliferative and antibacterial activity of some glutarimide derivatives
EP  - 923
IS  - 6
SP  - 915
VL  - 31
DO  - 10.3109/14756366.2015.1070844
ER  - 

@article{
author = "Popović-Djordjević, Jelena and Klaus, Anita and Zizak, Zeljko S. and Matić, Ivana Z. and Drakulić, Branko J.",
year = "2016",
abstract = "Antiproliferative and antibacterial activities of nine glutarimide derivatives (1-9) were reported. Cytotoxicity of compounds was tested toward three human cancer cell lines, HeLa, K562 and MDA-MB-453 by MTT assay. Compound 7 (2-benzyl-2-azaspiro[5.11] heptadecane-1,3,7-trione), containing 12-membered ketone ring, was found to be the most potent toward all tested cell lines (IC50 = 9-27 mu M). Preliminary screening of antibacterial activity by a disk diffusion method showed that Gram-positive bacteria were more susceptible to the tested compounds than Gram-negative bacteria. Minimum inhibitory concentration (MIC) determined by a broth microdilution method confirmed that compounds 1, 2, 4, 6-8 and 9 inhibited the growth of all tested Gram-positive and some of the Gram-negative bacteria. The best antibacterial potential was achieved with compound 9 (ethyl 4-(1-benzyl-2,6-dioxopiperidin-3-yl) butanoate) against Bacillus cereus (MIC 0.625 mg/mL; 1.97 x 10(-3) mol/L). Distinction between more and less active/inactive compounds was assessed from the pharmacophoric patterns obtained by molecular interaction fields.",
publisher = "Taylor & Francis Ltd, Abingdon",
journal = "Journal of Enzyme Inhibition and Medicinal Chemistry",
title = "Antiproliferative and antibacterial activity of some glutarimide derivatives",
pages = "923-915",
number = "6",
volume = "31",
doi = "10.3109/14756366.2015.1070844"
}

Popović-Djordjević, J., Klaus, A., Zizak, Z. S., Matić, I. Z.,& Drakulić, B. J.. (2016). Antiproliferative and antibacterial activity of some glutarimide derivatives. in Journal of Enzyme Inhibition and Medicinal Chemistry
Taylor & Francis Ltd, Abingdon., 31(6), 915-923.
https://doi.org/10.3109/14756366.2015.1070844

Popović-Djordjević J, Klaus A, Zizak ZS, Matić IZ, Drakulić BJ. Antiproliferative and antibacterial activity of some glutarimide derivatives. in Journal of Enzyme Inhibition and Medicinal Chemistry. 2016;31(6):915-923.
doi:10.3109/14756366.2015.1070844 .

Popović-Djordjević, Jelena, Klaus, Anita, Zizak, Zeljko S., Matić, Ivana Z., Drakulić, Branko J., "Antiproliferative and antibacterial activity of some glutarimide derivatives" in Journal of Enzyme Inhibition and Medicinal Chemistry, 31, no. 6 (2016):915-923,
https://doi.org/10.3109/14756366.2015.1070844 . .