Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites
Samo za registrovane korisnike
2022
Autori
Šuljagić, MarijaMilenković, Milica
Uskoković, Vuk
Mirković, Miljana
Vrbica, Boško
Pavlović, Vladimir
Živković-Radovanović, Vukosava
Stanković, Dalibor
Andjelković, Ljubica
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
The emerging threat of bacterial resistance to antibiotics prompts the urgent search for biomaterials for the treatment of infectious disease. Here we report on the synthesis and characterization of a multiphasic nanocomposite comprising magnetic iron oxide and silver nanoparticles. The method of synthesis involved the combustion of a metalorganic complex and reduction of the silver ions that were exchanged and/or adsorbed on the surface of iron oxide. Different physical and chemical treatments coupled to the reduction process, including ultrasound and Lugol's iodine solution, respectively, homogenized the distribution of the silver nanoparticles on the iron oxide phase. Remarkably, using ascorbic acid as a reductant enhanced the magnetic properties of the material as a result of the reduction of the magnetic matrix alongside the silver cations. The treatment with ultrasound detached large amounts of silver from the iron oxide phase and resulted in the lowest amount of silver incorpora...ted in the nanocomposite. Despite that, this treatment led to the highest antibacterial activity against both Gram-positive and Gram-negative strains, indicating that the homogeneity of the distribution of silver on the iron oxide matrix is a more important determinant of the antibacterial performance than the amount of silver incorporated in the material. At the same time, the treatment with Lugol's iodine equally increased the distribution homogeneity, but induced excessive ion exchange and crystal lattice substitutions, thereby adversely affecting the antibacterial performance. This has indicated that the mode of binding silver to iron oxide can compensate for the positive effects of homogeneous distribution with respect to the antibacterial performance.
Ključne reči:
Bactericidal effect / Iron oxide/Ag nanocomposites / Ultrasound treatmentIzvor:
Materials Today Communications, 2022, 32, 104157-Finansiranje / projekti:
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200026 (Univerzitet u Beogradu, Institut za hemiju, tehnologiju i metalurgiju - IHTM) (RS-MESTD-inst-2020-200026)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200168 (Univerzitet u Beogradu, Hemijski fakultet) (RS-MESTD-inst-2020-200168)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200116 (Univerzitet u Beogradu, Poljoprivredni fakultet) (RS-MESTD-inst-2020-200116)
- Ministarstvo nauke, tehnološkog razvoja i inovacija Republike Srbije, institucionalno finansiranje - 200017 (Univerzitet u Beogradu, Institut za nuklearne nauke Vinča, Beograd-Vinča) (RS-MESTD-inst-2020-200017)
URI
https://www.sciencedirect.com/science/article/pii/S235249282201008Xhttp://aspace.agrif.bg.ac.rs/handle/123456789/6160
Institucija/grupa
Poljoprivredni fakultetTY - JOUR AU - Šuljagić, Marija AU - Milenković, Milica AU - Uskoković, Vuk AU - Mirković, Miljana AU - Vrbica, Boško AU - Pavlović, Vladimir AU - Živković-Radovanović, Vukosava AU - Stanković, Dalibor AU - Andjelković, Ljubica PY - 2022 UR - https://www.sciencedirect.com/science/article/pii/S235249282201008X UR - http://aspace.agrif.bg.ac.rs/handle/123456789/6160 AB - The emerging threat of bacterial resistance to antibiotics prompts the urgent search for biomaterials for the treatment of infectious disease. Here we report on the synthesis and characterization of a multiphasic nanocomposite comprising magnetic iron oxide and silver nanoparticles. The method of synthesis involved the combustion of a metalorganic complex and reduction of the silver ions that were exchanged and/or adsorbed on the surface of iron oxide. Different physical and chemical treatments coupled to the reduction process, including ultrasound and Lugol's iodine solution, respectively, homogenized the distribution of the silver nanoparticles on the iron oxide phase. Remarkably, using ascorbic acid as a reductant enhanced the magnetic properties of the material as a result of the reduction of the magnetic matrix alongside the silver cations. The treatment with ultrasound detached large amounts of silver from the iron oxide phase and resulted in the lowest amount of silver incorporated in the nanocomposite. Despite that, this treatment led to the highest antibacterial activity against both Gram-positive and Gram-negative strains, indicating that the homogeneity of the distribution of silver on the iron oxide matrix is a more important determinant of the antibacterial performance than the amount of silver incorporated in the material. At the same time, the treatment with Lugol's iodine equally increased the distribution homogeneity, but induced excessive ion exchange and crystal lattice substitutions, thereby adversely affecting the antibacterial performance. This has indicated that the mode of binding silver to iron oxide can compensate for the positive effects of homogeneous distribution with respect to the antibacterial performance. T2 - Materials Today Communications T2 - Materials Today CommunicationsMaterials Today Communications T1 - Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites SP - 104157 VL - 32 DO - 10.1016/j.mtcomm.2022.104157 ER -
@article{ author = "Šuljagić, Marija and Milenković, Milica and Uskoković, Vuk and Mirković, Miljana and Vrbica, Boško and Pavlović, Vladimir and Živković-Radovanović, Vukosava and Stanković, Dalibor and Andjelković, Ljubica", year = "2022", abstract = "The emerging threat of bacterial resistance to antibiotics prompts the urgent search for biomaterials for the treatment of infectious disease. Here we report on the synthesis and characterization of a multiphasic nanocomposite comprising magnetic iron oxide and silver nanoparticles. The method of synthesis involved the combustion of a metalorganic complex and reduction of the silver ions that were exchanged and/or adsorbed on the surface of iron oxide. Different physical and chemical treatments coupled to the reduction process, including ultrasound and Lugol's iodine solution, respectively, homogenized the distribution of the silver nanoparticles on the iron oxide phase. Remarkably, using ascorbic acid as a reductant enhanced the magnetic properties of the material as a result of the reduction of the magnetic matrix alongside the silver cations. The treatment with ultrasound detached large amounts of silver from the iron oxide phase and resulted in the lowest amount of silver incorporated in the nanocomposite. Despite that, this treatment led to the highest antibacterial activity against both Gram-positive and Gram-negative strains, indicating that the homogeneity of the distribution of silver on the iron oxide matrix is a more important determinant of the antibacterial performance than the amount of silver incorporated in the material. At the same time, the treatment with Lugol's iodine equally increased the distribution homogeneity, but induced excessive ion exchange and crystal lattice substitutions, thereby adversely affecting the antibacterial performance. This has indicated that the mode of binding silver to iron oxide can compensate for the positive effects of homogeneous distribution with respect to the antibacterial performance.", journal = "Materials Today Communications, Materials Today CommunicationsMaterials Today Communications", title = "Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites", pages = "104157", volume = "32", doi = "10.1016/j.mtcomm.2022.104157" }
Šuljagić, M., Milenković, M., Uskoković, V., Mirković, M., Vrbica, B., Pavlović, V., Živković-Radovanović, V., Stanković, D.,& Andjelković, L.. (2022). Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites. in Materials Today Communications, 32, 104157. https://doi.org/10.1016/j.mtcomm.2022.104157
Šuljagić M, Milenković M, Uskoković V, Mirković M, Vrbica B, Pavlović V, Živković-Radovanović V, Stanković D, Andjelković L. Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites. in Materials Today Communications. 2022;32:104157. doi:10.1016/j.mtcomm.2022.104157 .
Šuljagić, Marija, Milenković, Milica, Uskoković, Vuk, Mirković, Miljana, Vrbica, Boško, Pavlović, Vladimir, Živković-Radovanović, Vukosava, Stanković, Dalibor, Andjelković, Ljubica, "Silver distribution and binding mode as key determinants of the antimicrobial performance of iron oxide/silver nanocomposites" in Materials Today Communications, 32 (2022):104157, https://doi.org/10.1016/j.mtcomm.2022.104157 . .