Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea
Samo za registrovane korisnike
2020
Autori
Jovanović, Svetlana P.Syrgiannis, Zois
Budimir, Milica D.
Milivojević, Dušan D.
Jovanović, Dragana J.
Pavlović, Vladimir
Papan, Jelena M.
Bartenwerfer, Malte
Mojsin, Marija M.
Stevanović, Milena J.
Todorović-Marković, Biljana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HRTEM, SEM-EDS, FTIR, XRD, PL and UV-Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (O-1(2)) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce O-1(2) upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the prod...uction of the efficient photosensitizer. On the opposite, GQDs-TU are efficient . OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 mu g/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration.
Ključne reči:
Graphene quantum dots / Photodynamic therapy / Singlet oxygen / Cytotoxicity / AntioxidantIzvor:
Materials Science & Engineering C-Materials for Biological Applications, 2020, 109Izdavač:
- Elsevier, Amsterdam
Finansiranje / projekti:
- Tanki slojevi jednoslojnih ugljeničnih nanotuba i grafena za primenu u elektronici (RS-MESTD-Basic Research (BR or ON)-172003)
- Proučavanje signalnih puteva i epigenetičkih mehanizama uključenih u kontrolu ekspresije humanih SOX gena: dalje rasvetljavanje njihove uloge u određivanju sudbine i diferencijaciji ćelija (RS-MESTD-Basic Research (BR or ON)-173051)
DOI: 10.1016/j.msec.2019.110539
ISSN: 0928-4931
PubMed: 32229000
WoS: 000527394600048
Scopus: 2-s2.0-85076495597
Institucija/grupa
Poljoprivredni fakultetTY - JOUR AU - Jovanović, Svetlana P. AU - Syrgiannis, Zois AU - Budimir, Milica D. AU - Milivojević, Dušan D. AU - Jovanović, Dragana J. AU - Pavlović, Vladimir AU - Papan, Jelena M. AU - Bartenwerfer, Malte AU - Mojsin, Marija M. AU - Stevanović, Milena J. AU - Todorović-Marković, Biljana PY - 2020 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/5390 AB - Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HRTEM, SEM-EDS, FTIR, XRD, PL and UV-Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (O-1(2)) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce O-1(2) upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the production of the efficient photosensitizer. On the opposite, GQDs-TU are efficient . OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 mu g/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration. PB - Elsevier, Amsterdam T2 - Materials Science & Engineering C-Materials for Biological Applications T1 - Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea VL - 109 DO - 10.1016/j.msec.2019.110539 ER -
@article{ author = "Jovanović, Svetlana P. and Syrgiannis, Zois and Budimir, Milica D. and Milivojević, Dušan D. and Jovanović, Dragana J. and Pavlović, Vladimir and Papan, Jelena M. and Bartenwerfer, Malte and Mojsin, Marija M. and Stevanović, Milena J. and Todorović-Marković, Biljana", year = "2020", abstract = "Due to their low cost and possible green synthesis, high stability and resistance to photobleaching, graphene quantum dots (GQDs) can be considered as one of the class of carbon nanomaterials which may have great potential as an agent for photosensitized oxygen activation. In such a way, GQDs can be used as a theranostic agent in photodynamic therapy. In this work pristine GQDs, GQDs irradiated with gamma rays and GQDs doped with N and N, S atoms are produced using a simple, green approach. By using different techniques (AFM, HRTEM, SEM-EDS, FTIR, XRD, PL and UV-Vis) we investigated structural and optical properties of the new types of GQDs. We showed that GQDs functionalized with thiourea (GQDs-TU) completely lost the ability to produce singlet oxygen (O-1(2)) upon photoexcitation while functionalization with urea (GQDs-U) improves the capability of GQDs to produce O-1(2) upon the same conditions. Thus, presented GQDs modification with urea seems like a promising approach for the production of the efficient photosensitizer. On the opposite, GQDs-TU are efficient . OH quencher. Due to high singlet oxygen production and low cytotoxicity below 100 mu g/mL against HeLa cells, GQDs-U is a good candidate as an agent in photodynamic therapy at this concentration.", publisher = "Elsevier, Amsterdam", journal = "Materials Science & Engineering C-Materials for Biological Applications", title = "Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea", volume = "109", doi = "10.1016/j.msec.2019.110539" }
Jovanović, S. P., Syrgiannis, Z., Budimir, M. D., Milivojević, D. D., Jovanović, D. J., Pavlović, V., Papan, J. M., Bartenwerfer, M., Mojsin, M. M., Stevanović, M. J.,& Todorović-Marković, B.. (2020). Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea. in Materials Science & Engineering C-Materials for Biological Applications Elsevier, Amsterdam., 109. https://doi.org/10.1016/j.msec.2019.110539
Jovanović SP, Syrgiannis Z, Budimir MD, Milivojević DD, Jovanović DJ, Pavlović V, Papan JM, Bartenwerfer M, Mojsin MM, Stevanović MJ, Todorović-Marković B. Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea. in Materials Science & Engineering C-Materials for Biological Applications. 2020;109. doi:10.1016/j.msec.2019.110539 .
Jovanović, Svetlana P., Syrgiannis, Zois, Budimir, Milica D., Milivojević, Dušan D., Jovanović, Dragana J., Pavlović, Vladimir, Papan, Jelena M., Bartenwerfer, Malte, Mojsin, Marija M., Stevanović, Milena J., Todorović-Marković, Biljana, "Graphene quantum dots as singlet oxygen producer or radical quencher The matter of functionalization with urea/thiourea" in Materials Science & Engineering C-Materials for Biological Applications, 109 (2020), https://doi.org/10.1016/j.msec.2019.110539 . .