Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars
Samo za registrovane korisnike
2020
Autori
Stikić, RadmilaMilincić, Danijel D.
Kostić, Aleksandar
Jovanović, Zorica
Gašić, Uroš M.
Tešić, Živoslav
Djordjević, Nataša Z.
Savić, Sladjana
Czekus, Borisz G.
Pešić, Mirjana
Članak u časopisu (Objavljena verzija)
Metapodaci
Prikaz svih podataka o dokumentuApstrakt
BACKGROUND: and objectives Quinoa is considered to be a "natural functional food" due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health-promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings Thirteen phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration and time-dependent effects were more expressed in Puno extracts. Conclusions The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human col...orectal cancer was expressed in both investigated cultivars. Significance and novelty The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT-116, as well as the presence of 7 new phenolic and flavonoid compounds.
Ključne reči:
antioxidant activity / colon cancer / cytotoxic activity / flavonoids / phenolic acids / quinoa seedIzvor:
Cereal Chemistry, 2020, 97, 3, 626-633Izdavač:
- Wiley, Hoboken
Finansiranje / projekti:
- Savremeni biotehnološki pristup rešavanja problema suše u poljoprivredi Srbije (RS-31005)
- Ispitivanje mogućnosti korišćenja kontaminiranih voda za gajenje alternativnih, zdravstveno bezbednih žita (RS-31006)
- Korišćenje biljnih izvora proteina, dijetalnih vlakana i antioksidanasa u proizvodnji hrane (RS-31069)
- Korelacija strukture i osobina prirodnih i sintetičkih molekula i njihovih kompleksa sa metalima (RS-172017)
- Fiziološka, hemijska i molekularna analiza diverziteta odabranih retkih i ugroženih biljnih vrsta u cilju ex situ zaštite i produkcije biološki aktivnih jedinjenja (RS-173024)
- Molekularno fiziološki biomonitoring aerobnih organizama zasnovan na određivanju biohemijskih biomarkera oksidacionog stresa (RS-173041)
DOI: 10.1002/cche.10278
ISSN: 0009-0352
WoS: 000521447000001
Scopus: 2-s2.0-85082187869
Institucija/grupa
Poljoprivredni fakultetTY - JOUR AU - Stikić, Radmila AU - Milincić, Danijel D. AU - Kostić, Aleksandar AU - Jovanović, Zorica AU - Gašić, Uroš M. AU - Tešić, Živoslav AU - Djordjević, Nataša Z. AU - Savić, Sladjana AU - Czekus, Borisz G. AU - Pešić, Mirjana PY - 2020 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/5367 AB - BACKGROUND: and objectives Quinoa is considered to be a "natural functional food" due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health-promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings Thirteen phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration and time-dependent effects were more expressed in Puno extracts. Conclusions The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. Significance and novelty The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT-116, as well as the presence of 7 new phenolic and flavonoid compounds. PB - Wiley, Hoboken T2 - Cereal Chemistry T1 - Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars EP - 633 IS - 3 SP - 626 VL - 97 DO - 10.1002/cche.10278 ER -
@article{ author = "Stikić, Radmila and Milincić, Danijel D. and Kostić, Aleksandar and Jovanović, Zorica and Gašić, Uroš M. and Tešić, Živoslav and Djordjević, Nataša Z. and Savić, Sladjana and Czekus, Borisz G. and Pešić, Mirjana", year = "2020", abstract = "BACKGROUND: and objectives Quinoa is considered to be a "natural functional food" due to a lot of bioactive compounds that are beneficial for human health by helping prevent the risks of different diseases. The aim of this study was to test the health-promoting characteristics of Puno and Titicaca quinoa seeds grown in Serbia by assessing their phenolic and flavonoid content, antioxidant activities, and potential anticancer effect on human colorectal cancer cells. Findings Thirteen phenolic compounds were identified and quantified in the seeds of both cultivars, but their profile and concentration of individual phenolic compounds differed. Cytotoxic activities were present in both cultivars, whereas the pronounced concentration and time-dependent effects were more expressed in Puno extracts. Conclusions The extracts of the seeds of both cultivars are a rich source of phenolic and flavonoid compounds and with high antioxidant activities. Potent anticancer activity against the human colorectal cancer was expressed in both investigated cultivars. Significance and novelty The study confirmed the health benefit potential of Puno and Titicaca quinoa cultivars, grown in Serbia. These results are the first to demonstrate a potent anticancer activity of quinoa seed extract against the human colorectal cancer cell line HCT-116, as well as the presence of 7 new phenolic and flavonoid compounds.", publisher = "Wiley, Hoboken", journal = "Cereal Chemistry", title = "Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars", pages = "633-626", number = "3", volume = "97", doi = "10.1002/cche.10278" }
Stikić, R., Milincić, D. D., Kostić, A., Jovanović, Z., Gašić, U. M., Tešić, Ž., Djordjević, N. Z., Savić, S., Czekus, B. G.,& Pešić, M.. (2020). Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars. in Cereal Chemistry Wiley, Hoboken., 97(3), 626-633. https://doi.org/10.1002/cche.10278
Stikić R, Milincić DD, Kostić A, Jovanović Z, Gašić UM, Tešić Ž, Djordjević NZ, Savić S, Czekus BG, Pešić M. Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars. in Cereal Chemistry. 2020;97(3):626-633. doi:10.1002/cche.10278 .
Stikić, Radmila, Milincić, Danijel D., Kostić, Aleksandar, Jovanović, Zorica, Gašić, Uroš M., Tešić, Živoslav, Djordjević, Nataša Z., Savić, Sladjana, Czekus, Borisz G., Pešić, Mirjana, "Polyphenolic profiles, antioxidant, and in vitro anticancer activities of the seeds of Puno and Titicaca quinoa cultivars" in Cereal Chemistry, 97, no. 3 (2020):626-633, https://doi.org/10.1002/cche.10278 . .