Biogenic amines content in the serum of patients with non-hodgkin's lymphoma
Само за регистроване кориснике
2019
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
The biosynthetic pathway of biogenic amines is very active during the growth of many tumour cells. Non-Hodgkin lymphoma represents a very heterogeneous group of malignancies. The concentration level of some biogenic amines (putrescine, histamine, spermidine, epinephrine, and spermine) was investigated to elucidate whether they could be observed as markers for the patients with non-Hodgkin's lymphoma. In this study, the method of acidic extraction of five biogenic amines from human serum, dansyl chloride pre-column derivatization, and LC/DAD analysis were used to determine the content of biogenic amines in biological fluids. The results indicate that statistically significant differences exist in putrescine, spermidine and histamine contents in non-Hodgkin's patients versus healthy controls. The concentrations of putrescine, spermidine and epinephrine were elevated, and histamine was lower compared to controls. Based on their content, serum biogenic amines could be considered as potenti...al tumour markers.
Кључне речи:
Biogenic amines / LC/DAD / serum / non-Hodgkin's lymphomaИзвор:
Revue Roumaine de Chimie, 2019, 64, 8, 681-686Издавач:
- Editura Acad Romane, Bucuresti
Финансирање / пројекти:
Институција/група
Poljoprivredni fakultetTY - JOUR AU - Trifunović-Macedoljan, Jelena AU - Pantelić, Nebojša AU - Jadranin, Milka AU - Juranić, Ivan O. PY - 2019 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/4995 AB - The biosynthetic pathway of biogenic amines is very active during the growth of many tumour cells. Non-Hodgkin lymphoma represents a very heterogeneous group of malignancies. The concentration level of some biogenic amines (putrescine, histamine, spermidine, epinephrine, and spermine) was investigated to elucidate whether they could be observed as markers for the patients with non-Hodgkin's lymphoma. In this study, the method of acidic extraction of five biogenic amines from human serum, dansyl chloride pre-column derivatization, and LC/DAD analysis were used to determine the content of biogenic amines in biological fluids. The results indicate that statistically significant differences exist in putrescine, spermidine and histamine contents in non-Hodgkin's patients versus healthy controls. The concentrations of putrescine, spermidine and epinephrine were elevated, and histamine was lower compared to controls. Based on their content, serum biogenic amines could be considered as potential tumour markers. PB - Editura Acad Romane, Bucuresti T2 - Revue Roumaine de Chimie T1 - Biogenic amines content in the serum of patients with non-hodgkin's lymphoma EP - 686 IS - 8 SP - 681 VL - 64 DO - 10.3224/rrch.2019.64.8.05 ER -
@article{ author = "Trifunović-Macedoljan, Jelena and Pantelić, Nebojša and Jadranin, Milka and Juranić, Ivan O.", year = "2019", abstract = "The biosynthetic pathway of biogenic amines is very active during the growth of many tumour cells. Non-Hodgkin lymphoma represents a very heterogeneous group of malignancies. The concentration level of some biogenic amines (putrescine, histamine, spermidine, epinephrine, and spermine) was investigated to elucidate whether they could be observed as markers for the patients with non-Hodgkin's lymphoma. In this study, the method of acidic extraction of five biogenic amines from human serum, dansyl chloride pre-column derivatization, and LC/DAD analysis were used to determine the content of biogenic amines in biological fluids. The results indicate that statistically significant differences exist in putrescine, spermidine and histamine contents in non-Hodgkin's patients versus healthy controls. The concentrations of putrescine, spermidine and epinephrine were elevated, and histamine was lower compared to controls. Based on their content, serum biogenic amines could be considered as potential tumour markers.", publisher = "Editura Acad Romane, Bucuresti", journal = "Revue Roumaine de Chimie", title = "Biogenic amines content in the serum of patients with non-hodgkin's lymphoma", pages = "686-681", number = "8", volume = "64", doi = "10.3224/rrch.2019.64.8.05" }
Trifunović-Macedoljan, J., Pantelić, N., Jadranin, M.,& Juranić, I. O.. (2019). Biogenic amines content in the serum of patients with non-hodgkin's lymphoma. in Revue Roumaine de Chimie Editura Acad Romane, Bucuresti., 64(8), 681-686. https://doi.org/10.3224/rrch.2019.64.8.05
Trifunović-Macedoljan J, Pantelić N, Jadranin M, Juranić IO. Biogenic amines content in the serum of patients with non-hodgkin's lymphoma. in Revue Roumaine de Chimie. 2019;64(8):681-686. doi:10.3224/rrch.2019.64.8.05 .
Trifunović-Macedoljan, Jelena, Pantelić, Nebojša, Jadranin, Milka, Juranić, Ivan O., "Biogenic amines content in the serum of patients with non-hodgkin's lymphoma" in Revue Roumaine de Chimie, 64, no. 8 (2019):681-686, https://doi.org/10.3224/rrch.2019.64.8.05 . .