Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent
dc.creator | Osmokrović, Andrea | |
dc.creator | Jancić, Ivan | |
dc.creator | Vunduk, Jovana | |
dc.creator | Petrović, Predrag | |
dc.creator | Milenković, Marina | |
dc.creator | Obradović, Bojana | |
dc.date.accessioned | 2020-12-17T22:21:25Z | |
dc.date.available | 2020-12-17T22:21:25Z | |
dc.date.issued | 2018 | |
dc.identifier.issn | 0144-8617 | |
dc.identifier.uri | http://aspace.agrif.bg.ac.rs/handle/123456789/4785 | |
dc.description.abstract | New composites based on Ca-alginate hydrogels were produced that release activated charcoal (AC) particles with adsorbed povidone iodine (PVP-I) as a model antimicrobial substance in a physiological-like environment. Composite beads with different alginate (0.5-1.5% w/w) and AC (1-20% w/w) concentrations were analyzed by FE-SEM and characterized regarding textural parameters, swelling, and AC release kinetics. PVP-I was easily adsorbed onto AC particles within the optimized beads (0.5% w/w alginate, 20% w/w AC) as indicated by UV-vis spectroscopy, EDX and FT-IR analyses. The obtained beads have shown strong bactericidal effects against two standard bacterial strains (Staphylococcus aureus and Pseudomonas aeruginosa) and clinical multi-resistant wound isolates (MRSA, Escherichia coli, Pseudomonas aeruginosa, Enterococcus faecalis and Proteus mirabilis) and, at the same time, exhibited negligible PVP-I desorption in physiological saline solution. Thus, the obtained composites could provide utilization of potent antiseptics such as iodine, in wound dressings, without the concern of systemic absorption. | en |
dc.publisher | Elsevier Sci Ltd, Oxford | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Integrated and Interdisciplinary Research (IIR or III)/45019/RS// | |
dc.rights | restrictedAccess | |
dc.source | Carbohydrate Polymers | |
dc.subject | Alginate | en |
dc.subject | Activated charcoal | en |
dc.subject | Povidone iodine | en |
dc.subject | Antibacterial activity | en |
dc.subject | Wound dressing | en |
dc.title | Achieving high antimicrobial activity: Composite alginate hydrogel beads releasing activated charcoal with an immobilized active agent | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 288 | |
dc.citation.other | 196: 279-288 | |
dc.citation.rank | aM21 | |
dc.citation.spage | 279 | |
dc.citation.volume | 196 | |
dc.identifier.doi | 10.1016/j.carbpol.2018.05.045 | |
dc.identifier.scopus | 2-s2.0-85047260873 | |
dc.identifier.pmid | 29891298 | |
dc.identifier.wos | 000436571600032 | |
dc.type.version | publishedVersion |