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Co(III) complex with (E)-2-(2-(pyridine-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole: structure and activity against 2-D and 3-D cancer cell models
dc.creator | Elshaflu, Hana | |
dc.creator | Bjelogrlić, Snežana | |
dc.creator | Muller, Christian D. | |
dc.creator | Todorović, Tamara R. | |
dc.creator | Rodić, Marko | |
dc.creator | Marinković, Aleksandar | |
dc.creator | Filipović, Nenad | |
dc.date.accessioned | 2020-12-17T21:39:01Z | |
dc.date.available | 2020-12-17T21:39:01Z | |
dc.date.issued | 2016 | |
dc.identifier.issn | 0095-8972 | |
dc.identifier.uri | http://aspace.agrif.bg.ac.rs/handle/123456789/4100 | |
dc.description.abstract | Co(III) complex with a 2-hydrazonylthiazole ligand was synthesized and characterized by single-crystal X-ray diffraction. In the inner sphere of the complex, two monoionic ligands are coordinated tridentately forming octahedral geometry around Co(III). Activity of the complex was investigated on MCF-7 breast cancer cell line, with cisplatin (CDDP) as a reference compound. Results showed that after 24-h incubation, Co(III) complex revealed stronger cytotoxic activity compared to CDDP. Treatment of MCF-7 3-D cell model with the complex at 10M concentration achieved complete suppression of spheroid growth in almost the same extent as at 100M. In combination treatments on MCF-7 spheroids, the complex acted synergistically with CDDP, while additive interaction type was achieved when the complex was applied together with paclitaxel. [GRAPHICS] . | en |
dc.publisher | Taylor & Francis Ltd, Abingdon | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172055/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172013/RS// | |
dc.rights | openAccess | |
dc.source | Journal of Coordination Chemistry | |
dc.subject | Thiazoles | en |
dc.subject | Co(III) complex | en |
dc.subject | X-ray diffraction | en |
dc.subject | anticancer activity | en |
dc.subject | three-drug combination study | en |
dc.title | Co(III) complex with (E)-2-(2-(pyridine-2-ylmethylene)hydrazinyl)-4-(4-tolyl)-1,3-thiazole: structure and activity against 2-D and 3-D cancer cell models | en |
dc.type | article | |
dc.rights.license | ARR | |
dc.citation.epage | 3366 | |
dc.citation.issue | 22 | |
dc.citation.other | 69(22): 3354-3366 | |
dc.citation.rank | M22 | |
dc.citation.spage | 3354 | |
dc.citation.volume | 69 | |
dc.identifier.doi | 10.1080/00958972.2016.1232404 | |
dc.identifier.fulltext | http://aspace.agrif.bg.ac.rs/bitstream/id/2648/4097.pdf | |
dc.identifier.scopus | 2-s2.0-84988615513 | |
dc.identifier.wos | 000386021200005 | |
dc.type.version | publishedVersion |