Biological potential of extracts of the wild edible Basidiomycete mushroom Grifola frondosa
Само за регистроване кориснике
2015
Аутори
Klaus, AnitaKozarski, Maja
Vunduk, Jovana
Todorović, Nina
Jakovljević, Dragica
Zizak, Zeljko
Pavlović, Vladimir
Lević, Steva
Nikšić, Miomir
van Griensven, Leo
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Partially purified polysaccharides (FP) and hot alkali extract (FNa) obtained from fruiting bodies of the wild basidiomycete Grifola frondosa were examined for their antimicrobial, antioxidant and cytotoxic activity. The structural properties of FP and FNa samples were investigated by FT-IR and high resolution 1H- and 13C-NMR spectroscopy. From a group of various G- and G+ bacteria the antibacterial effects were highest against the G + B. cereus. FNa was the better antioxidant shown by the lower EC50 values of DPPH scavenging ability, ferric-reducing antioxidant power and ferrous ion-chelating ability. Ferric-reducing antioxidant power and ferrous ion-chelating ability were mostly linked to total polysaccharides, total- and beta-glucan content, as well as total protein content. Both extracts displayed a moderate dose dependent antiproliferative action towards malignant human breast cancer MDA-MB-453, cervical adenocarcinoma HeLa and myelogenous leukemia K562 cells not observed in the n...on cancer derived MRC-5 fibroblasts. The highest effect was found in HeLa cells for FP extract. The mean diameter of Ca-alginate bead loading FP was 960.7 mu m while the mean diameter of beads encapsulating FNa extract was 1051.7 mu m.
Кључне речи:
Grifola frondosa / Antimicrobial / Antioxidant / Cytotoxicity / SEM / EncapsulationИзвор:
Food Research International, 2015, 67, 272-283Издавач:
- Elsevier Science Bv, Amsterdam
Финансирање / пројекти:
- Advancing research in agricultural and food sciences at Faculty of Agriculture, University of Belgrade (EU-316004)
- Развој и примена нових и традиционалних технологија у производњи конкурентних прехрамбених производа са додатом вредношћу за европско и светско тржиште - Створимо богатство из богатства Србије (RS-46001)
- Развој нових инкапсулационих и ензимских технологија за производњу биокатализатора и биолошки активних компонената хране у циљу повећања њене конкурентности, квалитета и безбедности (RS-46010)
DOI: 10.1016/j.foodres.2014.11.035
ISSN: 0963-9969
WoS: 000348619600034
Scopus: 2-s2.0-84914145988
Институција/група
Poljoprivredni fakultetTY - JOUR AU - Klaus, Anita AU - Kozarski, Maja AU - Vunduk, Jovana AU - Todorović, Nina AU - Jakovljević, Dragica AU - Zizak, Zeljko AU - Pavlović, Vladimir AU - Lević, Steva AU - Nikšić, Miomir AU - van Griensven, Leo PY - 2015 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/3830 AB - Partially purified polysaccharides (FP) and hot alkali extract (FNa) obtained from fruiting bodies of the wild basidiomycete Grifola frondosa were examined for their antimicrobial, antioxidant and cytotoxic activity. The structural properties of FP and FNa samples were investigated by FT-IR and high resolution 1H- and 13C-NMR spectroscopy. From a group of various G- and G+ bacteria the antibacterial effects were highest against the G + B. cereus. FNa was the better antioxidant shown by the lower EC50 values of DPPH scavenging ability, ferric-reducing antioxidant power and ferrous ion-chelating ability. Ferric-reducing antioxidant power and ferrous ion-chelating ability were mostly linked to total polysaccharides, total- and beta-glucan content, as well as total protein content. Both extracts displayed a moderate dose dependent antiproliferative action towards malignant human breast cancer MDA-MB-453, cervical adenocarcinoma HeLa and myelogenous leukemia K562 cells not observed in the non cancer derived MRC-5 fibroblasts. The highest effect was found in HeLa cells for FP extract. The mean diameter of Ca-alginate bead loading FP was 960.7 mu m while the mean diameter of beads encapsulating FNa extract was 1051.7 mu m. PB - Elsevier Science Bv, Amsterdam T2 - Food Research International T1 - Biological potential of extracts of the wild edible Basidiomycete mushroom Grifola frondosa EP - 283 SP - 272 VL - 67 DO - 10.1016/j.foodres.2014.11.035 ER -
@article{ author = "Klaus, Anita and Kozarski, Maja and Vunduk, Jovana and Todorović, Nina and Jakovljević, Dragica and Zizak, Zeljko and Pavlović, Vladimir and Lević, Steva and Nikšić, Miomir and van Griensven, Leo", year = "2015", abstract = "Partially purified polysaccharides (FP) and hot alkali extract (FNa) obtained from fruiting bodies of the wild basidiomycete Grifola frondosa were examined for their antimicrobial, antioxidant and cytotoxic activity. The structural properties of FP and FNa samples were investigated by FT-IR and high resolution 1H- and 13C-NMR spectroscopy. From a group of various G- and G+ bacteria the antibacterial effects were highest against the G + B. cereus. FNa was the better antioxidant shown by the lower EC50 values of DPPH scavenging ability, ferric-reducing antioxidant power and ferrous ion-chelating ability. Ferric-reducing antioxidant power and ferrous ion-chelating ability were mostly linked to total polysaccharides, total- and beta-glucan content, as well as total protein content. Both extracts displayed a moderate dose dependent antiproliferative action towards malignant human breast cancer MDA-MB-453, cervical adenocarcinoma HeLa and myelogenous leukemia K562 cells not observed in the non cancer derived MRC-5 fibroblasts. The highest effect was found in HeLa cells for FP extract. The mean diameter of Ca-alginate bead loading FP was 960.7 mu m while the mean diameter of beads encapsulating FNa extract was 1051.7 mu m.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Food Research International", title = "Biological potential of extracts of the wild edible Basidiomycete mushroom Grifola frondosa", pages = "283-272", volume = "67", doi = "10.1016/j.foodres.2014.11.035" }
Klaus, A., Kozarski, M., Vunduk, J., Todorović, N., Jakovljević, D., Zizak, Z., Pavlović, V., Lević, S., Nikšić, M.,& van Griensven, L.. (2015). Biological potential of extracts of the wild edible Basidiomycete mushroom Grifola frondosa. in Food Research International Elsevier Science Bv, Amsterdam., 67, 272-283. https://doi.org/10.1016/j.foodres.2014.11.035
Klaus A, Kozarski M, Vunduk J, Todorović N, Jakovljević D, Zizak Z, Pavlović V, Lević S, Nikšić M, van Griensven L. Biological potential of extracts of the wild edible Basidiomycete mushroom Grifola frondosa. in Food Research International. 2015;67:272-283. doi:10.1016/j.foodres.2014.11.035 .
Klaus, Anita, Kozarski, Maja, Vunduk, Jovana, Todorović, Nina, Jakovljević, Dragica, Zizak, Zeljko, Pavlović, Vladimir, Lević, Steva, Nikšić, Miomir, van Griensven, Leo, "Biological potential of extracts of the wild edible Basidiomycete mushroom Grifola frondosa" in Food Research International, 67 (2015):272-283, https://doi.org/10.1016/j.foodres.2014.11.035 . .