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Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters
dc.creator | Pantelić, Nebojša | |
dc.creator | Zmejkovski, Bojana B. | |
dc.creator | Stanojković, Tatjana P. | |
dc.creator | Jevtić, Verica V. | |
dc.creator | Radić, Gordana P. | |
dc.creator | Trifunović, Srecko R. | |
dc.creator | Kaludjerović, Goran N. | |
dc.creator | Sabo, Tibor J. | |
dc.date.accessioned | 2020-12-17T20:57:04Z | |
dc.date.available | 2020-12-17T20:57:04Z | |
dc.date.issued | 2014 | |
dc.identifier.issn | 0352-5139 | |
dc.identifier.uri | http://aspace.agrif.bg.ac.rs/handle/123456789/3417 | |
dc.description.abstract | A novel (S,S)-R(2)eddip ester, O,O'-diisopentyl-(S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochloride (1) was synthesized and characterized by IR, H-1- and C-13-NMR spectroscopy, mass spectroscopy and elemental analysis. In vitro antitumor action of 1, and two more R(2)eddip esters, dialkyl (S,S)-ethylenediamine-N,N'-di-2-propanoate dihydrochlorides, obtained before (alkyl = n-Bu or n-Pe, 2 and 3, respectively), was determined against cervix adenocarcinoma (HeLa), human melanoma (Fem-x), human chronic myelogenous leukemia (K562) cells, and a non-cancerous cell line human embryonic lung fibroblast (MRC-5), using the microculture tetrazolium test MTT assay. Esters 1-3 showed higher cytotoxicity and better selectivity in comparison to cisplatin, used as reference compound. The highest activity was expressed by 1, with IC50(Fem-x) value of 1.51 +/- 0.09 mu M. | en |
dc.publisher | Srpsko hemijsko društvo, Beograd | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/172035/RS// | |
dc.relation | info:eu-repo/grantAgreement/MESTD/Basic Research (BR or ON)/175011/RS// | |
dc.rights | openAccess | |
dc.rights.uri | https://creativecommons.org/licenses/by-nc-nd/4.0/ | |
dc.source | JOURNAL OF THE SERBIAN CHEMICAL SOCIETY | |
dc.subject | R(2)edda-type esters | en |
dc.subject | characterization | en |
dc.subject | cytotoxicity | en |
dc.subject | selectivity | en |
dc.title | Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N '-di-2-propanoate dihydrochloride esters | en |
dc.type | article | |
dc.rights.license | BY-NC-ND | |
dc.citation.epage | 658 | |
dc.citation.issue | 6 | |
dc.citation.other | 79(6): 649-658 | |
dc.citation.rank | M23 | |
dc.citation.spage | 649 | |
dc.citation.volume | 79 | |
dc.identifier.doi | 10.2298/JSC130512022P | |
dc.identifier.fulltext | http://aspace.agrif.bg.ac.rs/bitstream/id/2033/3414.pdf | |
dc.identifier.scopus | 2-s2.0-84903140555 | |
dc.identifier.wos | 000338268800003 | |
dc.type.version | publishedVersion |