Carbofuran in water: Subchronic toxicity to rats
Само за регистроване кориснике
2008
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Carbofuran toxicity on rats was studied during subchronic exposure. Female and male rats were administered carbofuran in drinking water in concentrations of 25, 100 and 400ppm for a period of 90 days. Clinical symptoms, water consumption, body weight gain, organ weight, pathological and histopathological changes in the liver and kidneys were observed and biochemical and haematological examinations were carried out. The results obtained show that carbofuran administered to rats caused a significant decrease in water consumption as well as in brain, serum and erythrocyte cholinesterase activities. Statistically significant increases in relation to the control were found in the serum enzyme activities. The haematological data showed that carbofuran had no significant effect on Hb concentration and total RBC, but total WBC showed a significant statistical decrease. The histopathological changes in liver and kidneys were observed. However, cell regeneration in the liver and kidneys was foun...d in all test groups.
Кључне речи:
carbofuran / water / rats / toxicityИзвор:
Environmental Toxicology and Pharmacology, 2008, 25, 3, 334-341Издавач:
- Elsevier Science Bv, Amsterdam
DOI: 10.1016/j.etap.2007.11.002
ISSN: 1382-6689
PubMed: 21783871
WoS: 000254776600008
Scopus: 2-s2.0-39649086907
Институција/група
Poljoprivredni fakultetTY - JOUR AU - Brkić, Dragica AU - Vitorović, Slavoljub Lj. AU - Gašić, Slavica AU - Nešković, Neško PY - 2008 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/1793 AB - Carbofuran toxicity on rats was studied during subchronic exposure. Female and male rats were administered carbofuran in drinking water in concentrations of 25, 100 and 400ppm for a period of 90 days. Clinical symptoms, water consumption, body weight gain, organ weight, pathological and histopathological changes in the liver and kidneys were observed and biochemical and haematological examinations were carried out. The results obtained show that carbofuran administered to rats caused a significant decrease in water consumption as well as in brain, serum and erythrocyte cholinesterase activities. Statistically significant increases in relation to the control were found in the serum enzyme activities. The haematological data showed that carbofuran had no significant effect on Hb concentration and total RBC, but total WBC showed a significant statistical decrease. The histopathological changes in liver and kidneys were observed. However, cell regeneration in the liver and kidneys was found in all test groups. PB - Elsevier Science Bv, Amsterdam T2 - Environmental Toxicology and Pharmacology T1 - Carbofuran in water: Subchronic toxicity to rats EP - 341 IS - 3 SP - 334 VL - 25 DO - 10.1016/j.etap.2007.11.002 ER -
@article{ author = "Brkić, Dragica and Vitorović, Slavoljub Lj. and Gašić, Slavica and Nešković, Neško", year = "2008", abstract = "Carbofuran toxicity on rats was studied during subchronic exposure. Female and male rats were administered carbofuran in drinking water in concentrations of 25, 100 and 400ppm for a period of 90 days. Clinical symptoms, water consumption, body weight gain, organ weight, pathological and histopathological changes in the liver and kidneys were observed and biochemical and haematological examinations were carried out. The results obtained show that carbofuran administered to rats caused a significant decrease in water consumption as well as in brain, serum and erythrocyte cholinesterase activities. Statistically significant increases in relation to the control were found in the serum enzyme activities. The haematological data showed that carbofuran had no significant effect on Hb concentration and total RBC, but total WBC showed a significant statistical decrease. The histopathological changes in liver and kidneys were observed. However, cell regeneration in the liver and kidneys was found in all test groups.", publisher = "Elsevier Science Bv, Amsterdam", journal = "Environmental Toxicology and Pharmacology", title = "Carbofuran in water: Subchronic toxicity to rats", pages = "341-334", number = "3", volume = "25", doi = "10.1016/j.etap.2007.11.002" }
Brkić, D., Vitorović, S. Lj., Gašić, S.,& Nešković, N.. (2008). Carbofuran in water: Subchronic toxicity to rats. in Environmental Toxicology and Pharmacology Elsevier Science Bv, Amsterdam., 25(3), 334-341. https://doi.org/10.1016/j.etap.2007.11.002
Brkić D, Vitorović SL, Gašić S, Nešković N. Carbofuran in water: Subchronic toxicity to rats. in Environmental Toxicology and Pharmacology. 2008;25(3):334-341. doi:10.1016/j.etap.2007.11.002 .
Brkić, Dragica, Vitorović, Slavoljub Lj., Gašić, Slavica, Nešković, Neško, "Carbofuran in water: Subchronic toxicity to rats" in Environmental Toxicology and Pharmacology, 25, no. 3 (2008):334-341, https://doi.org/10.1016/j.etap.2007.11.002 . .