A novel tandem process leading to functionalized glutarimides
Abstract
The synthesis of various functionalized or spirobicyclic glutarimides by a novel tandem process has been disclosed. The reaction involves a base-catalyzed Michael addition of active methylene compounds to secondary conjugated amides, followed by intramolecular N-acylation of the carboxamido group. It provides a relatively general and simple access to useful synthetic intermediaries and potentially active pharmacological compounds. In addition, a novel group of spirobicyclic systems has been synthesized.
Keywords:
synthesis / functionalized or spirobicyclic glutarimides / tandem processSource:
Tetrahedron Letters, 2005, 46, 15, 2611-2614Publisher:
- Pergamon-Elsevier Science Ltd, Oxford
DOI: 10.1016/j.tetlet.2005.02.087
ISSN: 0040-4039
WoS: 000228115600019
Scopus: 2-s2.0-15244347524
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Poljoprivredni fakultetTY - JOUR AU - Popović-Djordjević, Jelena AU - Ivanović, MD AU - Kiricojević, Vesna D. PY - 2005 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/1022 AB - The synthesis of various functionalized or spirobicyclic glutarimides by a novel tandem process has been disclosed. The reaction involves a base-catalyzed Michael addition of active methylene compounds to secondary conjugated amides, followed by intramolecular N-acylation of the carboxamido group. It provides a relatively general and simple access to useful synthetic intermediaries and potentially active pharmacological compounds. In addition, a novel group of spirobicyclic systems has been synthesized. PB - Pergamon-Elsevier Science Ltd, Oxford T2 - Tetrahedron Letters T1 - A novel tandem process leading to functionalized glutarimides EP - 2614 IS - 15 SP - 2611 VL - 46 DO - 10.1016/j.tetlet.2005.02.087 ER -
@article{ author = "Popović-Djordjević, Jelena and Ivanović, MD and Kiricojević, Vesna D.", year = "2005", abstract = "The synthesis of various functionalized or spirobicyclic glutarimides by a novel tandem process has been disclosed. The reaction involves a base-catalyzed Michael addition of active methylene compounds to secondary conjugated amides, followed by intramolecular N-acylation of the carboxamido group. It provides a relatively general and simple access to useful synthetic intermediaries and potentially active pharmacological compounds. In addition, a novel group of spirobicyclic systems has been synthesized.", publisher = "Pergamon-Elsevier Science Ltd, Oxford", journal = "Tetrahedron Letters", title = "A novel tandem process leading to functionalized glutarimides", pages = "2614-2611", number = "15", volume = "46", doi = "10.1016/j.tetlet.2005.02.087" }
Popović-Djordjević, J., Ivanović, M.,& Kiricojević, V. D.. (2005). A novel tandem process leading to functionalized glutarimides. in Tetrahedron Letters Pergamon-Elsevier Science Ltd, Oxford., 46(15), 2611-2614. https://doi.org/10.1016/j.tetlet.2005.02.087
Popović-Djordjević J, Ivanović M, Kiricojević VD. A novel tandem process leading to functionalized glutarimides. in Tetrahedron Letters. 2005;46(15):2611-2614. doi:10.1016/j.tetlet.2005.02.087 .
Popović-Djordjević, Jelena, Ivanović, MD, Kiricojević, Vesna D., "A novel tandem process leading to functionalized glutarimides" in Tetrahedron Letters, 46, no. 15 (2005):2611-2614, https://doi.org/10.1016/j.tetlet.2005.02.087 . .