Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources
Само за регистроване кориснике
2021
Аутори
Bovo, SamueleSchiavo, Giuseppina
Ribani, Anisa
Utzeri, Valerio J.
Taurisano, Valeria
Ballan, Mohamad
Muñoz, Maria
Alves, Estefania
Araujo, Jose P.
Bozzi, Riccardo
Charneca, Rui
Di Palma, Federica
Djurkin Kušec, Ivona
Etherington, Graham
Fernandez, Ana I.
García, Fabián
García‑Casco, Juan
Karolyi, Danijel
Gallo, Maurizio
Martins, José Manuel
Mercat, Marie‑José
Núñez, Yolanda
Quintanilla, Raquel
Radović, Čedomir
Razmaite, Violeta
Riquet, Juliette
Savić, Radomir
Škrlep, Martin
Usai, Graziano
Zimmer, Christoph
Ovilo, Cristina
Fontanesi, Luca
Чланак у часопису (Објављена верзија)
Метаподаци
Приказ свих података о документуАпстракт
Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a “One Health” perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants were identified in the four candidate genes: 26% of them were not previously described; 29 variants affected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a first step towards a “One Health” perspective that should consider conservation programs of pig genetic resources with tw...ofold objectives: (i) genetic resources could be reservoirs of host gene variability useful to design selection programs to increase resistance to coronaviruses; (ii) the described variability in genes involved in coronavirus infections across many different pig populations might be part of a risk assessment including pig genetic resources
Извор:
Scientific Reports, 2021, 11, 1, 3359-Издавач:
- Nature Research
Финансирање / пројекти:
- Diversity of local pig breeds and production systems for high quality traditional products and sustainable pork chains (EU-H2020-634476)
DOI: 10.1038/s41598-021-82956-0
ISSN: 2045-2322
WoS: 000630007800001
Scopus: 2-s2.0-85100779936
Институција/група
Poljoprivredni fakultetTY - JOUR AU - Bovo, Samuele AU - Schiavo, Giuseppina AU - Ribani, Anisa AU - Utzeri, Valerio J. AU - Taurisano, Valeria AU - Ballan, Mohamad AU - Muñoz, Maria AU - Alves, Estefania AU - Araujo, Jose P. AU - Bozzi, Riccardo AU - Charneca, Rui AU - Di Palma, Federica AU - Djurkin Kušec, Ivona AU - Etherington, Graham AU - Fernandez, Ana I. AU - García, Fabián AU - García‑Casco, Juan AU - Karolyi, Danijel AU - Gallo, Maurizio AU - Martins, José Manuel AU - Mercat, Marie‑José AU - Núñez, Yolanda AU - Quintanilla, Raquel AU - Radović, Čedomir AU - Razmaite, Violeta AU - Riquet, Juliette AU - Savić, Radomir AU - Škrlep, Martin AU - Usai, Graziano AU - Zimmer, Christoph AU - Ovilo, Cristina AU - Fontanesi, Luca PY - 2021 UR - http://aspace.agrif.bg.ac.rs/handle/123456789/5807 AB - Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a “One Health” perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants were identified in the four candidate genes: 26% of them were not previously described; 29 variants affected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a first step towards a “One Health” perspective that should consider conservation programs of pig genetic resources with twofold objectives: (i) genetic resources could be reservoirs of host gene variability useful to design selection programs to increase resistance to coronaviruses; (ii) the described variability in genes involved in coronavirus infections across many different pig populations might be part of a risk assessment including pig genetic resources PB - Nature Research T2 - Scientific Reports T1 - Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources IS - 1 SP - 3359 VL - 11 DO - 10.1038/s41598-021-82956-0 ER -
@article{ author = "Bovo, Samuele and Schiavo, Giuseppina and Ribani, Anisa and Utzeri, Valerio J. and Taurisano, Valeria and Ballan, Mohamad and Muñoz, Maria and Alves, Estefania and Araujo, Jose P. and Bozzi, Riccardo and Charneca, Rui and Di Palma, Federica and Djurkin Kušec, Ivona and Etherington, Graham and Fernandez, Ana I. and García, Fabián and García‑Casco, Juan and Karolyi, Danijel and Gallo, Maurizio and Martins, José Manuel and Mercat, Marie‑José and Núñez, Yolanda and Quintanilla, Raquel and Radović, Čedomir and Razmaite, Violeta and Riquet, Juliette and Savić, Radomir and Škrlep, Martin and Usai, Graziano and Zimmer, Christoph and Ovilo, Cristina and Fontanesi, Luca", year = "2021", abstract = "Coronaviruses silently circulate in human and animal populations, causing mild to severe diseases. Therefore, livestock are important components of a “One Health” perspective aimed to control these viral infections. However, at present there is no example that considers pig genetic resources in this context. In this study, we investigated the variability of four genes (ACE2, ANPEP and DPP4 encoding for host receptors of the viral spike proteins and TMPRSS2 encoding for a host proteinase) in 23 European (19 autochthonous and three commercial breeds and one wild boar population) and two Asian Sus scrofa populations. A total of 2229 variants were identified in the four candidate genes: 26% of them were not previously described; 29 variants affected the protein sequence and might potentially interact with the infection mechanisms. The results coming from this work are a first step towards a “One Health” perspective that should consider conservation programs of pig genetic resources with twofold objectives: (i) genetic resources could be reservoirs of host gene variability useful to design selection programs to increase resistance to coronaviruses; (ii) the described variability in genes involved in coronavirus infections across many different pig populations might be part of a risk assessment including pig genetic resources", publisher = "Nature Research", journal = "Scientific Reports", title = "Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources", number = "1", pages = "3359", volume = "11", doi = "10.1038/s41598-021-82956-0" }
Bovo, S., Schiavo, G., Ribani, A., Utzeri, V. J., Taurisano, V., Ballan, M., Muñoz, M., Alves, E., Araujo, J. P., Bozzi, R., Charneca, R., Di Palma, F., Djurkin Kušec, I., Etherington, G., Fernandez, A. I., García, F., García‑Casco, J., Karolyi, D., Gallo, M., Martins, J. M., Mercat, M., Núñez, Y., Quintanilla, R., Radović, Č., Razmaite, V., Riquet, J., Savić, R., Škrlep, M., Usai, G., Zimmer, C., Ovilo, C.,& Fontanesi, L.. (2021). Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources. in Scientific Reports Nature Research., 11(1), 3359. https://doi.org/10.1038/s41598-021-82956-0
Bovo S, Schiavo G, Ribani A, Utzeri VJ, Taurisano V, Ballan M, Muñoz M, Alves E, Araujo JP, Bozzi R, Charneca R, Di Palma F, Djurkin Kušec I, Etherington G, Fernandez AI, García F, García‑Casco J, Karolyi D, Gallo M, Martins JM, Mercat M, Núñez Y, Quintanilla R, Radović Č, Razmaite V, Riquet J, Savić R, Škrlep M, Usai G, Zimmer C, Ovilo C, Fontanesi L. Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources. in Scientific Reports. 2021;11(1):3359. doi:10.1038/s41598-021-82956-0 .
Bovo, Samuele, Schiavo, Giuseppina, Ribani, Anisa, Utzeri, Valerio J., Taurisano, Valeria, Ballan, Mohamad, Muñoz, Maria, Alves, Estefania, Araujo, Jose P., Bozzi, Riccardo, Charneca, Rui, Di Palma, Federica, Djurkin Kušec, Ivona, Etherington, Graham, Fernandez, Ana I., García, Fabián, García‑Casco, Juan, Karolyi, Danijel, Gallo, Maurizio, Martins, José Manuel, Mercat, Marie‑José, Núñez, Yolanda, Quintanilla, Raquel, Radović, Čedomir, Razmaite, Violeta, Riquet, Juliette, Savić, Radomir, Škrlep, Martin, Usai, Graziano, Zimmer, Christoph, Ovilo, Cristina, Fontanesi, Luca, "Describing variability in pig genes involved in coronavirus infections for a One Health perspective in conservation of animal genetic resources" in Scientific Reports, 11, no. 1 (2021):3359, https://doi.org/10.1038/s41598-021-82956-0 . .